Synthetic modulators of TRP channel activity

Advances in Experimental Medicine and Biology

Volumn 704, Issue , 2011, Pages 87-106

  Harteneck, Christian ^a   Klose, Chihab ^a   Krautwurst, Dietmar ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b DEUTSCHE FORSCHUNGSANSTALT FÜR LEBENSMITTELCHEMIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 2 MINOETHOXYDIPHENYL BORATE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; CAPSAZEPINE; CLOTRIMAZOLE; ECONAZOLE; GADOLINIUM; GADOLINIUM CHLORIDE; GSK 1016790A; LANTHANUM; MICONAZOLE; N (3 AMINOPROPYL) 2 [[(3 METHYLPHENYL)METHYL]OXY] N (2 THIENYLMETHYL)BENZAMIDE; N (4 AMYLCINNAMOYL)ANTHRANILIC ACID; N [1 [[4 [2 [[(2,4 DICHLOROPHENYL)SULFONYL]AMINO] 3 HYDROXYPROPANOYL] 1 PIPERAZINYL]CARBONYL] 3 METHYLBUTYL] 1 BENZOTHIOPHENE 2 CARBOXAMIDE; PHLOROGLUCINOL DERIVATIVE; PHOSPHOLIPASE A2; PINOKALANT; RESINIFERATOXIN; RN 1734; RN 1747; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

CALCIUM SIGNALING; CALCIUM TRANSPORT; CHANNEL GATING; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG MECHANISM; ENZYME INHIBITION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECT; HUMAN; REVIEW;

ANIMALIA;

ANIMALS; HUMANS; MOLECULAR STRUCTURE; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 79959798418     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-0265-3_4     Document Type: Conference Paper

References (106)

1. Harteneck C, Reiter B (2007) TRP channels activated by extracellular hypo-osmoticity in epithelia. Biochem Soc Trans 35:91-95
2. Harteneck C (2005) Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol 371:307-314
3. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829
4. Caspani O, Heppenstall PA (2009) TRPA1 and cold transduction: An unresolved issue? J Gen Physiol 133:245-249
5. Zhou J (2009) Polycystins and primary cilia: Primers for cell cycle progression. Annu Rev Physiol 71:83-113
6. Krautwurst D, Hescheler J, Arndts D, Losel W, Hammer R, Schultz G (1993) Novel potent inhibitor of receptor-activated nonselective cation currents in HL-60 cells. Mol Pharmacol 43:655-659
7. Krautwurst D, Degtiar VE, Schultz G, Hescheler J (1994) The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol 349:301-307
8. Clementi E, Meldolesi J (1996) Pharmacological and functional properties of voltageindependent Ca2+ channels. Cell Calcium 19:269-279
9. Leung YM, Kwan CY (1999) Current perspectives in the pharmacological studies of storeoperated Ca2+ entry blockers. Jpn J Pharmacol 81:253-258
10. Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, Jaxa-Chamiec A, Leigh BK, McCarthy SA, Moores KE, Rink TJ (1990) SK&F 96365, a novel inhibitor of receptormediated calcium entry. Biochem J 271:515-522
11. Fasolato C, Pizzo P, Pozzan T (1990) Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways. J Biol Chem 265:20351-20355
12. Morgan AJ, Jacob R (1994) Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem J 300(Pt 3): 665-672
13. Tornquist K (1993) Activation of calcium entry by cyclopiazonic acid in thyroid FRTL-5 cells. Cell Calcium 14:411-417
14. Demaurex N, Lew DP, Krause KH (1992) Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells. J Biol Chem 267:2318-2324
15. Shlykov SG, Yang M, Alcorn JL, Sanborn BM (2003) Capacitative cation entry in human myometrial cells and augmentation by hTrpC3 overexpression. Biol Reprod 69:647-655
16. Torihashi S, Fujimoto T, Trost C, Nakayama S (2002) Calcium oscillation linked to pacemaking of interstitial cells of Cajal: Requirement of calcium influx and localization of TRP4 in caveolae. J Biol Chem 277:19191-19197
17. Boulay G, Zhu X, PeytonM, Jiang M, Hurst R, Stefani E, Birnbaumer L (1997) Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J Biol Chem 272:29672-29680
18. Chyb S, Raghu P, Hardie RC (1999) Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 397:255-259
19. Jörs S, Kazanski V, Foik A, Krautwurst D, Harteneck C (2006) Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids. J Biol Chem 281:29693-29702
20. Zhu X, Jiang M, Birnbaumer L (1998) Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. J Biol Chem 273:133-142
21. Jung S, Strotmann R, Schultz G, Plant TD (2002) TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. Am J Physiol Cell Physiol 282:C347-C359
22. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389:816-824
23. Bootman MD, Collins TJ, Mackenzie L, Roderick HL, Berridge MJ, Peppiatt CM (2002) 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. FASEB J 16:1145-1150
24. Varnai P, Hunyady L, Balla T:STIM (2009) Orai: The long-awaited constituents of storeoperated calcium entry. Trends Pharmacol Sci 30:118-128
25. Lis A, Peinelt C, Beck A, Parvez S, Monteilh-ZollerM, Fleig A, Penner R (2007) CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties. Curr Biol 17:794-800
26. Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD (2008) Store-dependent and -independent modes regulating Ca2+ releaseactivated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem 283:17662-17671
27. Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C (2008) 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size. J Biol Chem 283:20261-20267
28. Tesfai Y, Brereton HM, Barritt GJ (2001) A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein. Biochem J 358:717-726
29. van Rossum DB, Patterson RL, Ma HT, Gill DL (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J Biol Chem 275:28562-28568
30. Xu SZ, Zeng F, Boulay G, Grimm C, Harteneck C, Beech DJ (2005) Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: A differential, extracellular and voltage-dependent effect. Br J Pharmacol 145:405-414
31. Zagranichnaya TK, Wu X, Villereal ML (2005) Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem 280:29559-29569
32. Wicher D, Agricola HJ, Schönherr R, Heinemann SH, Derst C (2006) TRPg channels are inhibited by cAMP and contribute to pacemaking in neurosecretory insect neurons. J Biol Chem 281:3227-3236
33. Togashi K, Inada H, Tominaga M (2008) Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol 153:1324-1330
34. Hanano T, Hara Y, Shi J, Morita H, Umebayashi C, Mori E, Sumimoto H, Ito Y, Mori Y, Inoue R (2004) Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci 95:403-419
35. Li M, Jiang J, Yue L (2006) Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol 127:525-537
36. Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ (2004) 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci 24:5177-5182
37. Gu Q, Lin RL, Hu HZ, Zhu MX, Lee LY (2005) 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels. Am J Physiol Lung Cell Mol Physiol 288:L932-L941
38. Yue L, Peng JB, Hediger MA, Clapham DE (2001) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410:705-709
39. Voets T, Prenen J, Fleig A, Vennekens R, Watanabe H, Hoenderop JG, Bindels RJ, Droogmans G, Penner R, Nilius B (2001) CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J Biol Chem 276:47767-47770
40. Neeper MP, Liu Y, Hutchinson TL, Wang Y, Flores CM, Qin N (2007) Activation properties of heterologously expressed mammalian TRPV2: Evidence for species dependence. J Biol Chem 282:15894-15902
41. Hu H, Grandl J, Bandell M, Petrus M, Patapoutian A (2009) Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci USA 106:1626-1631
42. Van Der Stelt M, Di Marzo V (2004) Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur J Biochem 271:1827-1834
43. Harteneck C, Frenzel H, Kraft R (2007) N-p-amylcinnamoyl)anthranilic acid (ACA): A phospholipase A2 inhibitor and TRP channel blocker. Cardiovasc Drug Rev 25:61-75
44. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702
45. Tinel H, Wehner F, Kinne RK (1997) Arachidonic acid as a second messenger for hypotonicity-induced calcium transients in rat IMCD cells. Pflügers Arch 433:245-253
46. Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434-438
47. Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, Nilius B (2005) Modulation of the Ca2+ permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97:908-915
48. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+- permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163-173
49. Kraft R, Grimm C, Frenzel H, Harteneck C (2006) Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol 148:264-273
50. Bari MR, Akbar S, Eweida M, Kuhn FJ, Gustafsson AJ, Lückhoff A, Islam MS (2009) H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: Involvement of TRPM2 channels. J Cell Mol Med 13:3260-3267
51. Pantaler E, Lückhoff A (2009) Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. Naunyn Schmiedebergs Arch Pharmacol 380:497-507
52. Bai JZ, Lipski J (2010) Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology 31:204-214
53. Hill K, McNulty S, Randall AD (2004) Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol 370:227-237
54. Meseguer V, Karashima Y, Talavera K, D'Hoedt D, Donovan-Rodriguez T, Viana F, Nilius B, Voets T (2008) Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J Neurosci 28:576-586
55. Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y (2009) Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci USA 106:5400-5405
56. Leuner K, Heiser JH, Derksen S, Mladenov MI, Fehske CJ, Schubert R, Gollasch M, Schneider G, Harteneck C, Chatterjee SS, Müller WE (2010) Simple 2,4- diacylphloroglucinols as classic transient receptor potential-6 activators - identification of a novel pharmacophore. Mol Pharmacol 77:368-377
57. Tada M, Chiba K, Takakuwa T, Kojima E (1992) Analogues of natural phloroglucinols as antagonists against both thromboxane A2 and leukotriene D4. J Med Chem 35:1209-1212
58. Verotta L, Lovaglio E, Sterner O, Appendino G, Bombardelli E (2004) Modulation of chemoselectivity by protein additives. Remarkable effects in the oxidation of hyperforin. J Org Chem 69:7869-7874
59. McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-58
60. Eccles R (1994) Menthol and related cooling compounds. J Pharm Pharmacol 46: 618-630
61. Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol 141:737-745
62. Beck B, Bidaux G, Bavencoffe A, Lemonnier L, Thebault S, Shuba Y, Barrit G, Skryma R, Prevarskaya N (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41:285-294
63. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM (2006) More than cool: Promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 32:335-343
64. Lashinger ES, Steiginga MS, Hieble JP, Leon LA, Gardner SD, Nagilla R, Davenport EA, Hoffman BE, Laping NJ, Su X (2008) AMTB, a TRPM8 channel blocker: Evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol 295:F803-F810
65. Birder LA, Nakamura Y, Kiss S, Nealen ML, Barrick S, Kanai AJ,Wang E, Ruiz G, De Groat WC, Apodaca G, Watkins S, Caterina MJ (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5:856-860
66. Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, Owsianik G, Liedtke W, Daelemans D, Dewachter I, Van Leuven F, Voets T, De Ridder D, Nilius B (2007) Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest 117:3453-3462
67. Birder L, Kullmann FA, Lee H, Barrick S, de Groat W, Kanai A, Caterina M (2007) Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13- didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther 323:227-235
68. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Dufer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (2008) Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 10:1421-1430
69. Gavva NR (2008) Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol Sci 29:550-557
70. Szallasi A, Cortright DN, Blum CA, Eid SR (2007) The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 6:357-372
71. Walpole CS, Bevan S, Bovermann G, Boelsterli JJ, Breckenridge R, Davies JW, Hughes GA, James I, Oberer L, Winter J et al (1994) The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. J Med Chem 37:1942-1954
72. Seabrook GR, Sutton KG, Jarolimek W, Hollingworth GJ, Teague S, Webb J, Clark N, Boyce S, Kerby J, Ali Z, Chou M, Middleton R, Kaczorowski G, Jones AB (2002) Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4- hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther 303:1052-1060
73. Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Luis Hannan S, Lappin SC, Egerton J, Smith GD, Worby A, Howett L, Owen D, Nasir S, Davies CH, Thompson M, Wyman PA, Randall AD, Davis JB (2004) Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 46:133-149
74. Thorneloe KS, Sulpizio AC, Lin Z, Figueroa DJ, Clouse AK, McCafferty GP, Chendrimada TP, Lashinger ES, Gordon E, Evans L, Misajet BA, Demarini DJ, Nation JH, Casillas LN, Marquis RW, Votta BJ, Sheardown SA, Xu X, Brooks DP, Laping NJ, Westfall TD (2008) N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl] amino}-3-hydroxypropa noyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1- benzothiophene-2-carboxamid e (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther 326:432-442
75. Hartmannsgruber V, Heyken WT, Kacik M, Kaistha A, Grgic I, Harteneck C, Liedtke W, Hoyer J, Kohler R (2007) Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One 2:e827
76. Earley S, Pauyo T, Drapp R, Tavares MJ, Liedtke W, Brayden JE (2009) TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. Am J Physiol Heart Circ Physiol 297:H1096-H1102
77. Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX (2010) TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol 298:H466-H476
78. Willette RN, Bao W, Nerurkar S, Yue TL, Doe CP, Stankus G, Turner GH, Ju H, Thomas H, Fishman CE, Sulpizio A, Behm DJ, Hoffman S, Lin Z, Lozinskaya I, Casillas LN, Lin M, Trout RE, Votta BJ, Thorneloe K, Lashinger ES, Figueroa DJ, Marquis R, Xu X (2008) Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2. J Pharmacol Exp Ther 326:443-452
79. Vincent F, Acevedo A, Nguyen MT, Dourado M, DeFalco J, Gustafson A, Spiro P, Emerling DE, Kelly MG, Duncton MA (2009) Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun 389:490-494
80. Montell C, Rubin GM (1989) Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction. Neuron 2: 1313-1323
81. Hardie RC, Minke B (1992) The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors. Neuron 8:643-651
82. Vaca L, Sinkins WG, Hu Y, Kunze DL, Schilling WP (1994) Activation of recombinant trp by thapsigargin in Sf9 insect cells. Am J Physiol 267:C1501-C1505
83. Hu Y, Vaca L, Zhu X, Birnbaumer L, Kunze DL, Schilling WP (1994) Appearance of a novel Ca2+ influx pathway in Sf9 insect cells following expression of the transient receptor potential-like (trpl) protein of Drosophila. Biochem Biophys Res Commun 201:1050-1056
84. Harteneck C, Obukhov AG, Zobel A, Kalkbrenner F, Schultz G (1995) The Drosophila cation channel trpl expressed in insect Sf9 cells is stimulated by agonists of G-proteincoupled receptors. FEBS Lett 358:297-300
85. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259-263
86. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370
87. Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: Mechanism of pheromone transduction. Neuron 40:551-561
88. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, Imoto K, Mori Y (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273:10279-10287
89. Kamouchi M, Philipp S, Flockerzi V, Wissenbach U, Mamin A, Raeymaekers L, Eggermont J, Droogmans G, Nilius B (1999) Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells. J Physiol 518(Pt 2):345-358
90. McKay RR, Szymeczek-Seay CL, Lievremont JP, Bird GS, Zitt C, Jungling E, Luckhoff A, Putney JW Jr (2000) Cloning and expression of the human transient receptor potential 4 (TRP4) gene: Localization and functional expression of human TRP4 and TRP3. Biochem J 351(Pt 3):735-746
91. Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN (2002) Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem 277:12302-12309
92. Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, Schultz G (2000) Receptormediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275:17517-17526
93. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645-655
94. Jung S, Muhle A, Schaefer M, Strotmann R, Schultz G, Plant TD (2003) Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem 278:3562-3571
95. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436-441
96. Hoenderop JG, Vennekens R, Muller D, Prenen J, Droogmans G, Bindels RJ, Nilius B (2001) Function and expression of the epithelial Ca2+ channel family: Comparison of mammalian ECaC1 and 2. J Physiol 537:747-761
97. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A (2002) A heat-sensitive TRP channel expressed in keratinocytes. Science 296:2046-2049
98. Voets T, Nilius B, Hoefs S, van der Kemp AW, Droogmans G, Bindels RJ, Hoenderop JG (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279:19-25
99. Nagata K, Duggan A, Kumar G, Garcia-Anoveros J (2005) Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 25:4052-4061
100. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-857
101. Tousova K, Vyklicky L, Susankova K, Benedikt J, Vlachova V (2005) Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites. Mol Cell Neurosci 30:207-217
102. Leffler A, Linte RM, Nau C, Reeh P, Babes A (2007) A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. Eur J Neurosci 26:12-22
103. Nakaya K, Harbidge DG, Wangemann P, Schultz BD, Green ED, Wall SM, Marcus DC (2007) Lack of pendrin HCO3-transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels. Am J Physiol Renal Physiol 292:F1314-F1321
104. Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, Schultz G, Harteneck C (2004) Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol 286:C129-C137
105. Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493-21501
106. Chuang HH, Neuhausser WM, Julius D (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 43:859-869