Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 20, 2008, Pages 9323-9330

  Duarte, Noélia ^a   Járdánházy, Anett ^b   Molnár, Joseph ^b   Hilgeroth, Andreas ^c   Ferreira, Maria José U ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF SZEGED   (Hungary)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Lathyrane and jatrophane diterpenes; Molecular orbital energies; Multidrug resistance; P glycoprotein

Indexed keywords

DITERPENE; EPIRUBICIN; EUPHOTUCKEYANOL; GLYCOPROTEIN P; LATILAGASCENE G; LATILAGASCENE H; LATILAGASCENE I; TUKEYANOL A; TUKEYANOL B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG POTENTIATION; DRUG STRUCTURE; EUPHORBIA; LYMPHOMA CELL LINE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; EPIRUBICIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EUPHORBIA LAGASCAE; EUPHORBIA TUCKEYANA;

EID: 53249105258     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.071     Document Type: Article

References (27)

1. Molnár J., Gyémánt N., Tanaka M., Hohmann J., Bergmann-Leitner E., Molnár P., Deli J., Didiziapetris R., and Ferreira M.J.U. Curr. Pharm. Des. 12 (2006) 287
2. Teodori E., Dei S., Martelli C., Scapecchi C., and Gualtieri F. Curr. Drug Targets 7 (2006) 893
3. Szakács G., Paterson J., Ludwig J., Genthe C., and Gottesman M. Nat. Rev. Drug Discov. 5 (2006) 219
4. Srinivas E., Murthy J., Rao A., and Sastry G. Curr. Drug Metab. 7 (2006) 205
5. Borowski E., Bontemps-Gracz M., and Picokowska A. Acta Biochim. Pol. 52 (2005) 609
6. Tsuruo T., Iida H., Tsukagoshi S., and Sakurai Y. Cancer Res. 41 (1981) 1967
7. Pajeva I.K., and Wiese M. J. Med. Chem. 45 (2002) 5671
8. Wang R.B., Kuo C.L., and Lien L.L. J. Clin. Pharm. Ther. 28 (2003) 203
9. Duarte N., Gyémánt N., Abreu P.M., Molnár J., and Ferreira M.J.U. Planta Med. 72 (2006) 162
10. Duarte N., Varga A., Radics R., Molnár J., and Ferreira M.J.U. Bioorg. Med. Chem. 15 (2007) 546
11. Ferreira M.J.U., Duarte N., Gyémánt N., Radics R., Chepernev G., Varga A., and Molnár J. Anticancer Res. 26 (2006) 3541
12. Ferreira M.J.U., Gyemant N., Madureira A.M., Tanaka M., Koos K., Didziapetris R., and Molnár J. Anticancer Res. 25 (2005) 4173
13. Madureira A.M., Ferreira M.J., Gyemant N., Ugocsai K., Ascenso J.R., Abreu P.M., Hohmann J., and Molnár J. Planta Med. 70 (2004) 45
14. Duarte N., Lage H., and Ferreira M.J.U. Planta Med. 74 (2008) 61
15. Corea G., Fattorusso E., Lanzotti V., Taglialatela-Scafati O., Appendino G., Ballero M., Simon P.N., Dumontet C., and Di Pietro A. J. Med. Chem. 46 (2003) 3395
16. Corea G., Fattorusso E., Lanzotti V., Motti R., Simon P.N., Dumontet C., and Di Pietro A. J. Med. Chem. 47 (2004) 988
17. Wiese M., and Pajeva I. Curr. Med. Chem. 8 (2001) 685
18. Robert J., and Jarry C. J. Med. Chem. 46 (2003) 4805
19. Marco J., Sanz-Cervera J., Yuste A., Jakupovic J., and Jeske F. Phytochemistry 47 (1998) 1621
20. Jakupovic J., Morgenstern T., Bittner M., and Silva M. Phytochemistry 47 (1998) 1601
21. Jakupovic J., Morgenstern T., Marco J., and Berendohn W. Phytochemistry 47 (1998) 1611
22. Kuroda H., Kobayashi M., Kinoshita M., and Takemoto S. J. Chem. Phys. 36 (1962) 457
23. Hilgeroth A., Molnár A., Molnár J., and Voigt B. Eur. J. Med. Chem. 41 (2006) 548
24. Engi H., Vasas A., Rédei D., Molnár J., and Hohmann J. Anticancer Res. 27 (2007) 3451
25. Hohmann J., Molnar J., Redei D., Evanics F., Forgo P., Kalman A., Argay G., and Szabo P. J. Med. Chem. 45 (2002) 2425
26. Barile E., Borriello M., Di Pietro A., Doreau A., Fattorusso C., Fattorusso E., and Lanzotti V. Org. Biomol. Chem. 6 (2008) 1756
27. Cornwell M.M., Pastan I., and Gottesmann M.M. J. Biol. Chem. 262 (1987) 2166