Sipholane triterpenoids: Chemistry, reversal of ABCB1/P-glycoprotein- mediated multidrug resistance, and pharmacophore modeling

Journal of Natural Products

Volumn 72, Issue 7, 2009, Pages 1291-1298

  Jain, Sandeep ^a   Abraham, Ioana ^b   Carvalho, Paulo ^c,f   Kuang, Ye Hong ^b,d   Shaala, Lamiaa A ^e   Youssef, Diaa T A ^e   Avery, Mitchell A ^c   Chen, Zhe Sheng ^b   El Sayed, Khalid A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b ST JOHN'S UNIVERSITY   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d CENTRAL SOUTH UNIVERSITY   (China)

^e Suez Canal University   (Egypt)

^f NOTRE DAME OF MARYLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; SIPHOLANE TRITERPENOID DERIVATIVE; SIPHOLENOL A; SIPHOLENOL L; SIPHOLENONE E; SIPHONELLINOL D; TRITERPENOID; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CALLYSPONGIA SIPHONELLA; CANCER CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; MULTIDRUG RESISTANCE; NONHUMAN; PHARMACOPHORE; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CALLYSPONGIA; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDIAN OCEAN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; TRITERPENES;

CALLYSPONGIA; SIPHONELLA; SIPHONOCHALINA;

EID: 68049096272     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np900091y     Document Type: Article

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