New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6942-6951

  Ramalhete, Cátia ^a   Molnár, Joseph ^b   Mulhovo, Silva ^c   Rosário, Virgílio E ^d   Ferreira, Maria José U ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b UNIVERSITY OF SZEGED   (Hungary)

^c Polytechnic Institute of Gaza ISPG   (Mozambique)

^d INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Cucurbitane type triterpenes; Momordica balsamina; Multidrug resistance; P glycoprotein MDR modulators; Synergism

Indexed keywords

25 METHOXYCUCURBITA 5,23 DIEN 3BETA OL 7 O BETA DEXTRO ALLOPYRANOSIDE; 25 METHOXYCURCUBITA 5,23 DIENE 3BETA,7BETA,29 TRIOL; 7BETA METHOXYCUCURBITA 5,24 DIENE 3BETA,23 DIOL; ANTINEOPLASTIC AGENT; BALSAMINAGENIN A; BALSAMINAGENIN B; BALSAMINOSIDE A; CUCURBITACIN KARAVELAGENIN C; CUCURBITANE; CURCUBITA 5,23 DIENE 3BETA,7BETA,25,29 TETRAOL; DOXORUBICIN; GLYCOPROTEIN P; KARAVELAGENIN C; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; COMBINATION CHEMOTHERAPY; DRUG ACTIVITY; EXPERIMENT; GENETIC TRANSFECTION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; LYMPHOMA CELL; METHODOLOGY; MOMORDICA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CUCURBITACINS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GLYCOSIDES; HUMANS; LYMPHOMA; MICE; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TRITERPENES;

MOMORDICA BALSAMINA;

EID: 69949133418     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.020     Document Type: Article

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