Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 546-554

  Duarte, Noélia ^a   Varga, Andras ^b   Cherepnev, Georg ^b   Radics, Rita ^c   Molnár, Joseph ^c   Ferreira, Maria José U ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Antiproliferative; Apoptosis; Euphorbia lagascae; Macrocyclic lathyrane diterpenes; Multidrug resistance; P glycoprotein

Indexed keywords

DITERPENE; DITERPENOID; DOXORUBICIN; EUPHORBIA EXTRACT; GLYCOPROTEIN P; JOLKINOL B; LATIGASCENE B; LATIGASCENE D; LATIGASCENE E; LATIGASCENE F; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; APOPTOSIS; ARTICLE; COMBINATION CHEMOTHERAPY; DRUG ACTIVITY; EUPHORBIA; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; LYMPHOMA CELL; METHODOLOGY; MULTIDRUG RESISTANCE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; DITERPENES; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; EUPHORBIA; GENES, MDR; HUMANS; LYMPHOMA; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL;

EUPHORBIA LAGASCAE;

EID: 33750953574     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.028     Document Type: Article

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