Novel therapeutic strategies for acute lung injury induced by lung damaging agents: The potential role of growth factors as treatment options

Human and Experimental Toxicology

Volumn 30, Issue 7, 2011, Pages 701-724

  Lindsay, Christopher D ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

alternative methods; human toxicology; inhalation toxicology pulmonary toxicology; pathology

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; I KAPPA B; INDUSTRIAL CHEMICAL; KERATINOCYTE GROWTH FACTOR; PALIFERMIN; POLYAMINE; PROTECTIVE AGENT; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; RETINOIC ACID RECEPTOR; SCATTER FACTOR; SUPEROXIDE DISMUTASE; TREFOIL PEPTIDE; VASCULOTROPIN;

ACUTE LUNG INJURY; ACUTE RESPIRATORY FAILURE; ADULT RESPIRATORY DISTRESS SYNDROME; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; CHEMICAL INJURY; ENDOTRACHEAL INTUBATION; EPITHELIUM HYPERPLASIA; HYPOXEMIA; IONIZING RADIATION; LUNG ALVEOLUS CELL TYPE 1; LUNG ALVEOLUS CELL TYPE 2; LUNG EDEMA; LUNG FIBROSIS; LUNG HEMOSIDEROSIS; LUNG PARENCHYMA; LUNG TOXICITY; MOUTH ULCER; MUCOSA INFLAMMATION; NEONATAL RESPIRATORY DISTRESS SYNDROME; NONHUMAN; OXIDATIVE STRESS; OXYGEN THERAPY; PRIORITY JOURNAL; THROAT IRRITATION; TISSUE REPAIR; TREATMENT PLANNING; VENTILATOR ASSOCIATED PNEUMONIA; WOUND HEALING;

ACUTE LUNG INJURY; CHEMICAL WARFARE AGENTS; HUMANS; INHALATION EXPOSURE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PULMONARY EDEMA; RESPIRATORY DISTRESS SYNDROME, ADULT;

LOTUS;

EID: 79959716252     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110376982     Document Type: Article

References (215)

1. Kotton DN, Summer R., and Fine A. Lung stem cells: new paradigms. Exp Hematol 2004 ; 32: 340-343. (Pubitemid 38410909)
2. Hermans C., Bernard A. Lung epithelium-specific proteins. Am J Resp Crit Care Med 1999 ; 159: 646-678.
3. Lesur O., Berthiaume Y., Blaise G., Damas P., Deland E., Guimond JG, et al. Acute respiratory distress syndrome: 30 years later. Can Respir J 1999 ; 6: 71-86. (Pubitemid 29158750)
4. Griffiths GD, Lindsay CD, Allenby AC, Bailey SC, Scawin JW, Rice P., et al. Protection against inhalation toxicity of ricin and abrin by immunisation. Hum Exp Toxicol 1995 a; 14: 155-164.
5. Griffiths GD, Rice P., Allenby AC, Bailey SC, and Upshall DG Inhalation toxicology and histopathology of ricin and abrin toxins. Inhal Toxicol 1995 b; 7: 269-288.
6. Bartelt-Hunt SL, Barlaz MA, Knappe DRU, and Kjeldsen P. Fate of chemical warfare agents and toxic industrial chemicals in landfills. Environ Sci Technol 2006 ; 40: 4219-4225. (Pubitemid 44161676)
7. Hammond MH, Johnson KJ, Rose-Pehrsson SL, Ziegler J., Walker H., Caudy K., et al. A novel chemical detector using cermet sensors and pattern recognition methods for toxic industrial chemicals. Sensors Actuators B Chem 2006 ; 116: 135-144. (Pubitemid 43786276)
8. Jefferies A., Turley A. Crash course: respiratory system. London: Mosby International Ltd, 1999, p. 203.
9. Guidot DM, Roman J. Chronic ethanol ingestion increases susceptibility to acute lung injury. Chest 2002 ; 122: 309S - 314S.
10. Lewis JF, Jobe AH Surfactant and the adult respiratory distress syndrome. Am Rev Respir Dis 1993 ; 147: 218-233. (Pubitemid 23025945)
11. Pittet JF, Mackersie RC, Martin TR, and Matthay MA Biological markers of acute lung injury: prognostic and pathogenic significance. Am J Respir Crit Care Med 1997 ; 155: 1187-1205. (Pubitemid 27172758)
12. Mendez JL, Hubmayr RD New insights into the pathology of acute respiratory failure. Curr Opin Crit Care 2005 ; 11: 29-36. (Pubitemid 40223716)
13. Doyle RL, Szaflarski N., Modin GW, Wiener-Kronish JP, and Matthay MA Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med 1995 ; 152: 1818-1824.
14. Rubenfeld GD Epidemiology of acute lung injury. Crit Care Med 2003 ; 31: S276 - S284.
15. Hudson LD, Steinberg KP Epidemiology of acute lung injury and ARDS. Chest 1999 ; 116: 74S - 82S. (Pubitemid 29340220)
16. Sessler CN Mechanical ventilation of patients with acute lung injury. Crit Care Clin 1998 ; 14: 707-729. (Pubitemid 28465794)
17. Perkett EA Role of growth factors in lung repair and diseases. Curr Opin Pediatr 1995 ; 7: 242-249.
18. Brown RFR, White DE Ultrastructure of rat lung following inhalation of ricin aerosol. Int J Exp Pathol 1997 ; 78: 267-276.
19. Griffiths GD, Phillips GJ, and Bailey SC Comparison of the quality of protection elicited by toxoid and peptide liposomal vaccine formulations against ricin as assessed by markers of inflammation. Vaccine 1999 ; 17: 2562-2568. (Pubitemid 29314449)
20. Jeffery PK Structural and inflammatory changes in COPD: a comparison with asthma. Thorax 1998 ; 53: 129-136. (Pubitemid 28212140)
21. Aarbiou J., Ertmann M., van Wetering S., van Noort P., Rook D., Rabe KF, et al. Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J Leukoc Biol 2002 ; 72: 167-174.
22. Finkelstein JN, Johnston C., Barrett T., and Oberdörster G. Particulate-cell interactions and pulmonary cytokine expression. Environ Health Perspect 1997 ; 105: 1179-1182.
23. Piguet PF, Collart MA, Grau GE, Sappino AP, and Vassalli P. Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis. Nature 1990 ; 334: 245-247.
24. Johnston CJ, Piedboeuf B., Rubin P., Williams JP, Baggs R., and Finkelstein JN Early and persistent alterations in the expression of interleukin-1α, interleukin-1β and tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after thoracic radiation. Radiat Res 1996 ; 145: 762-767.
25. Wright TW, Johnston CJ, Harmson AG, and Finkelstein JN Analysis of cytokine gene expression in the lungs of Pneumocystis carinii-infected mice. Am J Respir Cell Mol Biol 1997 ; 17: 491-500. (Pubitemid 127500982)
26. Johnston CJ, Williams JP, Okunieff P., and Finkelstein JN Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res 2002 ; 157: 256-265. (Pubitemid 34263838)
27. Ware LB, Matthay MA Biological markers of acute lung injury. In: Matalon S, Sznajder JI (ed.) Etiology and treatment of acute lung injury: from bench to bedside. NATO Science Series 1, Life and Behavioural Sciences. Amsterdam: IOS Press, 2001 ; Vol336, p. 103-112.
28. Geiser T., Atabi K., Jarreau PH, Ware LB, Pugin J., and Matthay MA Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1β-dependent mechanism. Am J Respir Crit Care Med 2001 ; 163: 1384-1388. (Pubitemid 32506603)
29. Geiser T. Mechanisms of alveolar epithelial repair in acute lung injury-a translational approach. Swiss Med Wkly 2003 ; 133: 586-590. (Pubitemid 38017061)
30. Weibel ER, Taylor CR Design and structure of the human lung. In: Fishman AP (ed.). Pulmonary diseases and disorders. New York: McGraw-Hill Book Co, 1988, p. 11-61.
31. Leitch AG Respiratory system. In: Forrester JM (ed.) A Companion to medical studies: anatomy, biochemistry and physiology. Oxford: Blackwell Scientific Publications, 1976, p. 27.1-27.28.
32. Freeman W., Bracegirdle B. An atlas of histology. London: Heinemann, 1975, p. 102-103.
33. Wheater PR, Burkitt HG, and Daniels VG Functional histology: a text and colour atlas. Edinburgh, London, Melbourne and New York: Churchill Livingstone, 1987, p. 187-190.
34. Breeze RG, Wheeldon EB The cells of the pulmonary airways. Am Rev Respir Dis 1977 ; 116: 705-777. (Pubitemid 8206010)
35. Piedboeuf B., Frenette J., Petrov P., Welty SE, Kazzaz JA, and Horowitz S. In vivo expression of intercellular adhesion molecule 1 in type II pneumocytes during hyperoxia. Am J Respir Cell Mol Biol 1996 ; 15: 71-77. (Pubitemid 126439857)
36. Griffiths MJD, Bonnet S., and Janes SM Stem cells of the alveolar epithelium. Lancet 2005 ; 366: 249-260.
37. Albertine KH Histopathology of pulmonary edema and the acute respiratory distress syndrome. In: Matthay MA, Ingbar DH (eds) Pulmonary edema. New York: Marcel Dekker, 1998, p. 37-83.
38. Berthiaume Y., Lesur O., and Dagenais A. Treatment of adult respiratory distress syndrome: plea for rue therapy of the alveolar epithelium. Thorax 1999 ; 54: 150-160. (Pubitemid 29101361)
39. Warburton D., Wuenschell C., Flores-Delgado G., and Anderson K. Commitment and differentiation of lung cell lineages. Biochem Cell Biol 1998 ; 76: 971-995. (Pubitemid 29450565)
40. Warburton D., Tefft D., Mailleux A., Bellusci S., Thiery JP, Zhao J., et al. Do lung remodelling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med 2001 ; 164: S59 - S62.
41. Harris JB, Chang LY, and Crapo JD Rat lung alveolar type I epithelial cell injury and response to hyperoxia. Am J Respir Cell Mol Biol 1991 ; 4: 115-125.
42. Schwarze PE, Lag M., Becher R., Thranhe EV, Samuelsen JT, Hetland RB, et al. Role of signal transduction pathways in lung inflammatory responses. Toxicol Lett 2000 ; 112: 165-170. (Pubitemid 30138119)
43. Lesur O., Arsalane K., and Lane D. Lung alveolar epithelial cell migration in vitro: modulators and regulation processes. Am J Physiol 1996 ; 14: L311 - L319.
44. Witschi H. Role of the epithelium in lung repair. Chest 1991 ; 99: S22 - S25.
45. Buckley S., Driscoll B., Anderson KD, and Warburton D. Apoptosis and DNA damage in AEC2 cultured from hyperoxic rats. Am J Physiol 1998 ; 274: L714 - L720.
46. Aliotta JM, Passero M., Meharg J., Klinger J., Dooner MS, Pimentel J., et al. Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration. J Cell Physiol 2005 ; 204: 725-741. (Pubitemid 41099258)
47. Evans MJ, Cabral LJ, Stephens RJ, and Freeman G. Renewal of alveolar epithelium in the rat following exposure to NO2. Am J Pathol 1973 ; 70: 175-198.
48. Uhal BD Cell cycle kinetics in the alveolar epithelium. Am J Physiol 1997 ; 272: L1031 - L1045.
49. Driscoll B., Buckley S., Bui KC, Anderson KD, and Warburton D. Telomerase in alveolar epithelial development and repair. Am J Physiol 2000 ; 279: L1191-1198.
50. Cotran RS, Kumar V., and Robbins SL Robbins Pathologic Basis of Disease. Philadelphia: WB Saunders Company, Harcourt Brace Jovanovich Inc, 1989, p. 253 and 524.
51. McCormack FX Role of pulmonary epithelium and surfactant in the pathogenesis of interstitial lung disease. In: Schwarz MI, King TE Jr, (eds) Interstitial lung disease. Hamilton, London: BC Decker Inc, 1998, p. 165-205.
52. Fang KC Mesenchymal regulation of alveolar repair in pulmonary fibrosis. Am J Respir Cell Mol Biol 2000 ; 23: 142-145. (Pubitemid 30656421)
53. Stevens TP, McBride JT, Peake JL, Pinkerton KE, and Stripp BR Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Am J Physiol 1997 ; 272: L486 - L493.
54. Reynolds LJ, McElroy M., and Richards RJ Density and substrata are important in lung type II cell transdifferentiation in vitro. Int J Biochem Cell Biol 1999 ; 31: 951-960. (Pubitemid 129750080)
55. Dasu MRK, Barrow RE, Spies M., and Herndon DN Matrix metalloproteinase expression in cytokine stimulated human dermal fibroblasts. Burns 2003 ; 29: 527-531.
56. Bitterman PB, Polunovsky VA, and Ingbar DH Repair after acute lung injury. Chest 1994 ; 105: 118S - 121S. (Pubitemid 24085366)
57. Kumar VH, Ryan RM Growth factors in the fetal and neonatal lung. Front Biosci 2004 ; 9: 464-480. (Pubitemid 38930851)
58. Lwebuga-Mukasa JS Matrix-driven pneumocyte differentiation. Am Rev Respir Dis 1991 ; 144: 452-457.
59. Kumar RK, Lykke AWJ. Messages and handshakes: cellular interactions in pulmonary fibrosis. Pathology 1995 ; 27: 18-26.
60. Adamson IYR, Hedgecock C., and Bowden DH Epithelial cell-fibroblast interactions in lung injury and repair. Am J Pathol 1990 ; 137: 385-392.
61. Finkelstein JN Physiologic and toxicologic responses of alveolar type II cells. Toxicology 1990 ; 60: 41-52. (Pubitemid 20080544)
62. Nieman GF, Bredenberg CE, Clark WR, and West NR Alveolar function following surfactant deactivation. J Appl Physiol 1981 ; 51: 895-904. (Pubitemid 11007459)
63. Hastings RH Monitoring alveolar epithelial function in acute lung injury. J Clin Monit Comput 2000 ; 16: 385-392. (Pubitemid 32529692)
64. Matthay MA, Weiner-Kronish JP Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 1990 ; 142: 1250-1257.
65. Martinet Y., Martinet N., and Vignaud JM Cell growth factors and cancer. Rev Mal Respir 1996 ; 3: 123-126. (Pubitemid 26191539)
66. Sugahara K., Mason RJ, and Shannon JM Effects of soluble factors and extracellular matrix on DNA synthesis and surfactant gene expression in primary cultures of rat alveolar type II cells. Cell Tissue Res 1998 a; 291: 295-303. (Pubitemid 28081853)
67. Pollard TD, Earnshaw WC Cell Biology. Philadelphia: Saunders, Elsevier Science, 2002, p. 673-686.
68. Metzler DE Biochemistry: the chemical reactions of living cells. New York: Academic Press, 1977, p. 958-960.
69. Corey JG Purine and pyrimidine nucleotide metabolism. In: Devlin TM (ed.) Textbook of biochemistry: with clinical correlations. New York: Wiley-Liss Inc, 1992, p. 557.
70. Rubenfeld GD, Caldwell E., Peabody E., Weaver J., Martin DP, Neff M., et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005 ; 353: 1685-1693. (Pubitemid 41464707)
71. Chiarugi V., Magnelli L., Cinelli M., and Basi G. Apoptosis and the cell cycle. Cell Mol Biol Res 1994 ; 40: 603-612.
72. Fehrenbach H., Kasper M., Koslowski R., Pan T., Schuh D., Müller M., et al. Alveolar epithelial type II cell apoptosis in vivo during resolution of keratinocyte growth factor-induced hyperplasia in the rat. Histochem Cell Biol 2000 ; 114: 49-61. (Pubitemid 30609856)
73. Bardales RH, Xie SS, Schaefer RF, and Hsu SM Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. Am J Pathol 1996 ; 149: 845-852. (Pubitemid 26334168)
74. Fan SJ, Wang JA, Yuan RQ, Rockwell S., Andres J., Zlatapolskiy A., Goldberg ID, Rosen EM Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene 1998 ; 17: 131-141. (Pubitemid 28371886)
75. Skibinski G., Skibinska A., and James K. Hepatocyte growth factor (HGF) protects c-met-expressing Burkitt's lymphoma cell lines from apoptotic death induced by DNA damaging agents. Eur J Cancer 2001 ; 37: 1562-1569. (Pubitemid 32744689)
76. Kim JC, Ali MA, Nandi A., Mukhopadhyay P., Choy H., Cao C., et al. Correlation of HER1/EGFR expression and degree of radiosensitizing effect of the HER1/ EGFR-tyrosine kinase inhibitor erlotinib. Indian J Biochem Biophys 2005 ; 42: 358-365. (Pubitemid 43962276)
77. Golpon HA, Fadok VA, Taraseviciene-Stewart L., Seerbavicius R., Sauer C., Welte T., et al. Life after corpse engulfment; phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J 2004 ; 18: 1716-1718. (Pubitemid 39561661)
78. Lee J., Reddy R., Barsky L., Weinberg K., and Driscoll B. Contribution of proliferation and DNA damage repair to alveolar epithelial type 2 cell recovery from hyperoxia. Am J Physiol 2006 ; 290: L685 - L694.
79. Barkefors I., Le Jan S., Jakobsson L., Hejll E., Carlson G., Johansson H., et al. Endothelial cell migration in stable gradients of vascular endothelial growth factor A and fibroblast growth factor 2: effects on chemotaxis and chemokinesis. J Biol Chem 2008 ; 283: 13905-13912.
80. Michiels C., Raes M., Toussaint O., and Remacle J. Importance of Se-glutathione peroxidise, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med 1994 ; 17: 235-248.
81. Plopper CG, St. George JA, Read LC, Nishio SJ, Weir AJ, Edwards L., et al. Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF. Am J Physiol 1992 ; 262: L313 - L321.
82. Krein PM, Winston BW Roles for insulin-like growth factor I and transforming growth factor-β in fibrotic lung disease. Chest 2002 ; 122: 289S - 293S. (Pubitemid 36043015)
83. Ryan RM, Mineo-Kuhn MM, Kramer CM, and Finkelstein JN Growth factors alter neonatal typeII alveolar epithelial cell proliferation. Am J Physiol 1994 ; 266: L17 - L22.
84. Kaishi NK Recent information relating to pulmonary fibrosis and growth factors. J Jpn Respir Soc 1998 ; 36: 413-420.
85. Ware LB, Matthay MA The acute respiratory distress syndrome. N Engl J Med 2000 ; 342: 1334-1349. (Pubitemid 30408719)
86. Merck Acute lung injury and acute respiratory distress syndrome, www.merck.com/mmpe/print/sec06/ch066/ch066a.html ( 2005 ).
87. Pittet JF, Griffiths MJD, Geiser T., Kaminski N., Dalton SL, Huang X., et al. TGF-β is a critical mediator of acute lung injury. J Clin Invest 2001 ; 107: 1537-1544. (Pubitemid 32574640)
88. Brower RG, Ware LB, Berthiaume Y., and Matthay MA Treatment of ARDS. Chest 2001 ; 120: 1347-1367. (Pubitemid 32960113)
89. ARDSNet. The Acute Respiratory Distress Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and acute respiratory disress syndrome. N Engl J Med 2000 ; 324: 1301-1308.
90. Ware LB, Matthay MA Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001 a; 163: 1376-1383. (Pubitemid 32506602)
91. Khan A., Milbrandt EB, and Venkataraman R. Albumin and furosamide for acute lung injury. Crit Care 2007 ; 11: 314.
92. ARDSNet. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006 ; 354: 2564-2575.
93. Kapanci Y., Weibel ER, Kaplan HP, and Robinson FR Pathogenesis and reversibiltiy of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies. Lab Invest 1969 ; 20: 101-118.
94. Wu M., He Y., Xu Y., Kobune M., Kelley MR, and Martin WJ Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg. Am J Respir Crit Care Med 2002 ; 166: 192-199. (Pubitemid 34765456)
95. Roper JM, Mazzatti DJ, Watkins RH, Maniscalco WM, Keng PC, and O'Reilly MA In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells. Am J Physiol 2004 ; 286: L1045 - L1054.
96. Savla U., Waters CM Mechanical strain inhibits repair of airway epithelium in vitro. Am J Physiol 1998 ; 274: L883 - L892.
97. Milberg JA, Davis DR, Steinberg KP, and Hudson LD Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995 ; 273: 306-309.
98. Thompson B., Hayden D., Matthay MA, Browser R., and Parsons P. Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS. Chest 2001 ; 120: 1622-1627. (Pubitemid 33078482)
99. Jardin F., Fellahi J., Beauchet A., Vieillard-Baron A., Loubieres Y., and Page B. Improved prognosis of acute respiratory distress syndrome 15 years on. Intensive Care Med 1999 ; 25: 936-941. (Pubitemid 29452538)
100. Noone MR, Pitt TL, Bedder M., Hewlett AM, and Rogers KB Pseudomonas aeruginosa colonisation I an intensive therapy unit - Role of cross infection and host factors. Br Med J 1983 ; 286: 341-344. (Pubitemid 13149390)
101. Finegold SM, Johnson CC Lower respiratory tract infection. Am J Med 1985 ; 79: 73-77. (Pubitemid 16140566)
102. Markowicz P., Wolff M., Djedaini K., Cohen Y., Chastre J., Delclaux C., et al. Multicentre prospective study of ventilator-associated pneumonia during acute respiratory distress syndrome. Incidence, prognosis, and risk factors. ARDS Study Group. Am J Respir Crit Care Med 2000 ; 161: 1942-1948. (Pubitemid 30418134)
103. Jain R., DalNogare A. Pharmacological therapy for acute respiratory distress syndrome. Mayo Clin Proc 2006 ; 81: 205-212. (Pubitemid 43205775)
104. Parkhouse DA, Brown RFR, Jugg BJ, Harban FM, Platt J., Kenward CE, et al. Protective ventilation strategies in the management of phosgene-induced acute lung injury. Mil Med 2007 ; 172: 295-300. (Pubitemid 46411456)
105. Parkhouse DA, Brown RFR, Jugg BJ, and Platt J. Effects of oxygen therapy in the early stages of acute lung injury (ALI) caused by phosgene. Crit Care Med 2003 ; 31: A101.
106. Brown RFR, Jugg BJ, Smith AJ, Parkhouse DA, and Platt J. Steroid treatment of chemically-induced acute lung injury in a porcine model: pathophysiology and oxygenation. Proc Am Thoracic Soc 2006 ; 3: A136.
107. Brown R., Inns RH, Jenner J., Jugg B., Platt J., Scawin J., et al. First report on the management of casualties from inhalation of toxic industrial chemicals. Dstl Report 2008 ; Document No. 31118.
108. Schuster DP Fluid management in ARDS: ''keep them dry'' or does it matter? Int Care Med 1995 ; 21: 101-103.
109. Zambon M., Vincent JL Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest 2008 ; 133: 1120-1127. (Pubitemid 351685515)
110. Guyton AC, Hall JE Textbook of Medical Physiology. Philadelphia, PA: WB Saunders Co, 1996, p. 187-193.
111. Hinds CJ, Watson D. Intensive Care: a concise textbook. London: WB Saunders Co Ltd, 1996, p. 26-27.
112. Zilberberg MD, de Wit M., Pirone JR, and Shorr AF Growth in adult prolonged acute mechanical ventilation: implications for healthcare delivery. Crit Care Med 2008 ; 36: 1451-1455. (Pubitemid 351620642)
113. Chen J., Kasper M., Heck T., Nakagawa K., Humpert PM, Bai L., et al. Tissue factor as a link between wounding and tissue repair. Diabetes 2005 ; 54: 2143-2154. (Pubitemid 40911278)
114. Desai TJ, Cardoso WV Growth factors in lung development and disease: friends or foe? Respir Res 2002 ; 3: 2-5.
115. Li CM, Khosla J., Pagan I., Hoyle P., and Sannes PL TGF-β1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells. Am J Physiol 2000 ; 279: L1038 - L1046.
116. Heger RJ, Baybutt RC Regulation of polyamine synthesis and transport by retinoic acid and epidermal growth factor in cultured adult rat type II pneumocytes. J Nutr Biochem 1999 ; 10: 518-524. (Pubitemid 29440838)
117. Solarin KO, Ballard PL, Guttentag SH, Lomax CA, and Beers MF Expression and glucocorticoid regulation of surfactant protein C in human fetal lung. Pediatr Res 1997 ; 42: 356-364. (Pubitemid 27362733)
118. Raaberg L., Nexø E., Buckley S., Luo S., Snead ML, and Warburton D. Epidermal growth factor transcription, translation, and signal transduction by rat type II pneumocytes in culture. Am J Respir Cell Mol Biol 1992 ; 6: 44-49.
119. Leslie CC, McCormick-Shannon K., and Mason, RJ Heparin-binding growth factors stimulate DNA synthesis in rat alveolar type II cells. Am J Respir Cell Mol Biol 1990 ; 2: 99-106.
120. Nici L., Medina M., and Frackelton AR The epidermal growth factor receptor network in type 2 pneumocytes exposed to hyperoxia in vitro. Am J Physiol 1996 ; 270: L242 - L250.
121. Strandjord TP, Clark JG, Guralnick DE, and Madtes DK Immunolocalization of transforming growth factor-α, epidermal growth factor (EGF), and EGFreceptor in normal and injured developing human lung. Pediatr Res 1995 ; 38: 851-856.
122. Zgleszewski SE, Cilley RE, Krummel TM, and Chinoy MR Effects of dexamethasone, growth factors, and tracheal ligation on the development of nitrofen-exposed hypoplastic murine fetal lungs in organ culture. J Pediatr Surg 1999 ; 34: 1187-1195. (Pubitemid 29383557)
123. Panos RJ, Bak PM, Simonet WS, Rubin JS, and Smith LJ Intratracheal instillation of keratinocyte growth-factor decreases hyperoxia-induced mortality in rats. J Clin Invest 1995 ; 96: 2026-2033.
124. Kuhn C. Patterns of lung repair. A morphologist's view. Chest 1991 ; 99: 11S - 14S.
125. Verghese GM, McCormick-Shannon K., Mason RJ, and Matthay MA Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema of patients with acute lung injury - Biological and clinical significance. Am J Respir Crit Care Med 1998 ; 158: 386-394.
126. Waters CM, Savla U. Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain. J Cell Physiol 1999 ; 181: 424-432. (Pubitemid 29513411)
127. Gillis P., Savla U., Volpert OV, Jimenez B., Waters CM, Panos RJ, et al. Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function. J Cell Sci 1999 ; 112: 2049-2057. (Pubitemid 29338829)
128. Whitsett JA, Zhou L. Use of transgenic mice to study autocrine-paracrine signalling in lung morphogenesis and differentiation. Clin Perinatol 1996 ; 23: 753-769. (Pubitemid 27010321)
129. Henemyre-Harris CL, Adkins AL, Chuang AH, and Graham JS Addition of epidermal growth factor improves the rate of sulphur mustard wound healing in an in vitro model. Eplasty 2008 ; 8: 136-150.
130. Wilson SE, Chen L., Mohan RR, Liang Q., and Liu J. Expression of HGF, KGF and receptor messenger RNAs following corneal epithelial wounding. Exp Eye Res 1999 a; 68: 377-397. (Pubitemid 29185432)
131. Wilson SE, Liang Q., and Kim WJ Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci 1999 ; 40: 2185-2190. (Pubitemid 29418371)
132. Portnoy J., Curran-Everett D., and Mason RJ Keratinocyte growth factor stimulates alveolar type II cell proliferation through the extracellular signal-regulated kinase and phosphatidylinositol 3-OH kinase pathways. Am J Respir Cell Mol Biol 2004 ; 30: 901-907. (Pubitemid 38736916)
133. Mayer E., Cardoso PFG, Puskas JD, De Campos K., Oka T., Dardick I., et al. The effect of basic fibroblast growth factor and omentopexy on revascularization and epithelial regeneration of heterotropic rat tracheal isografts. J Thorac Cardiovasc Surg 1992 ; 104: 180-188.
134. Jimenez PA, Rampy MA Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. J Surg Res 1999 ; 81: 238-242. (Pubitemid 29397817)
135. Grant MM, Koo H-C., and Rosenfeld W. Oxygen affects human endothelial cell proliferation by inactivation of fibroblast growth factors. Am J Physiol 1992 ; 263: L370 - L375.
136. Danan C., Franco ML, Jarreau PH, Dassieu G., Chailley-Heu B., Bourbon J., et al. High concentrations of keratinocyte growth factor in airways of premature infants predicted absence of bronchopulmonary dysplasia. Am J Respir Crit Care Med 2002 ; 165: 1384-1387. (Pubitemid 34522941)
137. Fu XB, Yang YH, Sun TZ, Gu XM, Jiang LX, Sun XQ, et al. Effect of intestinal ischemia-reperfusion on expressions of endogenous basic fibroblast growth factor and transforming growth factor β in lung and its relation with lung repair. World J Gastroenterol 2000 ; 6: 353-355. (Pubitemid 30392128)
138. Blijlevens N., Sonis S. Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis. Ann Oncol 2007 ; 18: 817-826. (Pubitemid 47054077)
139. Anon. Drugs R D 2004 ; 5: 351-354.
140. www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=meds&part=a605017. Accessed 19th April 2010.
141. Schrey D. Palifermin in paediatric oncology. Monatsschr Kinderheilkd 2008 ; 156: 375-378.
142. Blijlevens A., Schwenkglenks M., Bacon P., D'Addio A., Einsele H., Maertens J., et al. Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy - European blood and marrow transplantation mucositis advisory group. J Clin Oncol 2008 ; 26: 1519-1525.
143. Tsirigotis P., Triantafyllou K., Girkas K., Giannopoulou V., Ioannidou E., Chondropoulos S., et al. Keratinocyte growth factor is effective in the prevention of intestinal mucositis in patients with haematological malignancies treated with high-dose chemotherapy and autologous hematopoietic SCT: a video-capsule endoscopy study. Bone Marrow Transplant 2008 ; 42: 337-343.
144. Gil L., Styczynski J., and Komarnicki M. Infectious complication in 314 patients after high-dose therapy and autologous hematopoietic stem cell transplantation: risk factors analysis and outcome. Infection 2007 ; 35: 421-427. (Pubitemid 350307984)
145. Brake R., Starnes C., Lu J., Chen DL, Yang SJ, Radinsky R., et al. Effects of palifermin on antitumor activity of chemotherapeutic and biological agents in human head and neck and colorectal carcinoma xenograft models. Mol Cancer Res 2008 ; 6: 1337-1346.
146. Dorr W., Heider K., Spekl K. Reduction of oral mucositis by palifermin (rHuKGF): dose-effect of rHuKGF. Int J Radiat Biol 2005 ; 81: 557-565. (Pubitemid 41784877)
147. Martin J. British national formulary. BMJ Group and RPS Publishing, 2008, London, UK., p. 451.
148. Sadovsky J., Kuchenbuch T., Ruppert C., Fehrenbach A., Hirschburger M., Padberg W., et al. Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts. Eur Resp J 2008 ; 31: 21-28.
149. Wu KI, Pollack N., Panos RJ, Sporn PHS, and Kamp DW Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure. Am J Physiol 1998 ; 19: L780 - L787.
150. Takeoka M., Ward WF, Pollack H., Kamp DW, and Panos RJ KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am J Physiol 1997 ; 16: L1174 - L1180.
151. Yi ES, Williams ST, Lee H., Malicki DM, Chin EM, Yin S., et al. Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol 1996 ; 149: 1963-1970. (Pubitemid 26415215)
152. Panoskaltsis-Mortari A., Ingbar DH, Jung P., Haddad IY, Bitterman PB, Wangensteen OD, et al. KGF pre-treatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT. Am J Physiol 2000 ; 278: L988 - L999.
153. Ulrich K., Stern M., Goddard ME, Williams J., Zhu J., Dewar A., et al. Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury. Am J Physiol 2005 ; 288: L1179 - L1192.
154. Ulich TR, Yi ES, Longmuir K., Yin S., Blitz R., Morris CF, et al. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest 1994 ; 93: 1298-1306. (Pubitemid 24087188)
155. Jaffré S., Dehoux M., Paugam C., Grenier A., Chollet-Martin S., Stern JB, et al. Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure. Am J Physiol 2002 ; 282: L310 - L315.
156. Stoker M., Gherardi E., Perryman M., and Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987 ; 327: 239-242. (Pubitemid 17071053)
157. Wolf HK, Zarnegar R., and Michalopoulos GK Localization of heptocyte growth factor in human and rat tissues: an immunological study. Hepatology 1991 ; 14: 488-494.
158. Yanagita K., Nagaike M., Ishibashi H., Niho Y., Matsumoto K., and Nakamura T. Lung may have endocrine function producing hepatocyte growth factor in response to injury of distal organs. Biochem Biophys Res Commun 1992 ; 182: 802-809.
159. Sugahara K., Matsumoto M., Babe T., Nakamura T., and Kawamoto T. Elevation of serum hepatocyte growth factor (HGF) level in patients with pneumonectomy during a perioperative period. Int Care Med 1998 b; 24: 434-437. (Pubitemid 28274154)
160. Zahm JM, Debordeaux C., Raby B., Klossek JM, Bonnet N., and Puchelle E. Mitogenic effect of recombinant HGF on airway epithelial cells during the in vitro wound repair of the respiratory epithelium. J Cell Physiol 2000 ; 185: 447-453.
161. Dohi M., Hasegawa T., Yamamoto K., and Marshall BC Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000 ; 162: 2302-2307. (Pubitemid 32051704)
162. Naldini L., Vigna E., Narsimhan R., Gaudino G., Zarnegar R., Michalopoulos G., et al. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 1991 ; 6: 501-504. (Pubitemid 21924112)
163. Shen B-Q., Panos RJ, Hansen-Guzmán K., Widdicombe JH, and Mrsny RJ Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro. Am J Physiol 1997 ; 272: L1115 - L1120.
164. Stern J. -B, Jaffré S., Dehoux M., and Crestani B. Keratinocyte growth factor and hepatocyte growth factors: their roles in alveolar epithelial repair. Rev Mal Respir 2003 ; 20: 896-903. (Pubitemid 38133201)
165. Matsumoto K., Nakamura T. Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration. J Gastroenterol Hepatol 1991 ; 6: 509-519.
166. Fan S., Ma YX, Gao M., Yuan RQ, Meng Q., Goldberg ID, et al. The multisubstrate adaptor Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signalling for cell survival and DNA repair. Mol Cell Biol 2001 ; 21: 4968-4984. (Pubitemid 32656395)
167. Okada M., Sugita K., Inukai T., Goi K., Kagami K., Kawasaki K., et al. Hepatocyte growth factor protects small airways epithelial cells from apoptosis
168. Fan S., Ma YX, Wang JA, Yuan RQ, Meng Q., Cao Y., et al. The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signalling through phosphatidylinositol- 3'-kinase. Oncogene 2000 ; 19: 2212-2223. (Pubitemid 30307187)
169. Kakazu A., Chandrasekher G., and Bazan HE HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad but not the ERK1/2-mediated signalling pathway. Invest Ophthalmol Vis Sci 2004 ; 45: 3485-3492. (Pubitemid 39298566)
170. Chandrasekher G., Kakazu AH, and Bazan HEP. HGF- and KGF-induced activation of PI-3K/p70 S6 kinase pathway in corneal epithelial cells: its relevance in wound healing. Exp Eye Res 2001 ; 73: 191-202. (Pubitemid 32977949)
171. Fan S., Gao M., Meng Q., Laterra JJ, Symons MH, Coniglio S., et al. Role of NF-κB signalling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene 2005 ; 24: 1749-1766. (Pubitemid 40461131)
172. Siu D. Activity-dependent hepatocyte growth factor expression and its role in organogenesis and cancer growth suppression. Med Hypotheses 2004 ; 63: 62-70. (Pubitemid 38898651)
173. Jiang WG, Hallett MB, and Puntis MC Hepatocyte growth factor/scatter factor, liver regeneration and cancer metastasis. Br J Surg 1993 ; 80: 1368-1373.
174. Vaccaro CA, Brody JS Structural features of alveolar wall basement membrane in the adult rat lung. J Cell Biol 1981 ; 91: 427-437. (Pubitemid 12215631)
175. Adamson IYR. Relationship of mesenchymal changes to alveolar epithelial cell differentiation in fetal rat lung. Anat Embryol 1992 ; 185: 275-280.
176. Ambalavanan N., Novak Z. Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. Pediatr Res 2003 ; 53: 240-244. (Pubitemid 36177119)
177. Ludovini V., Gregorc V., Pistola L., Mihaylova Z., Floriani I., Darwish S., et al. Vascular endothelial growth factor, p53, Rb, Bcl-2 expression and response to chemotherapy in advanced non-small cell lung cancer. Lung Cancer 2004 ; 46: 77-85. (Pubitemid 39201386)
178. Shweiki D., Itin A., Soffer D., and Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-induced angiogenesis. Nature 1992 ; 359: 843-845.
179. le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, and Akeson AL VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol 2004 ; 287: L134 - L142.
180. Kaner RJ, Ladetto JV, Singh R., Fukuda N., Matthay MA, and Crystal RG Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol 2000 ; 22: 657-664. (Pubitemid 30400243)
181. Mallamaci F., Benedetto FA, Tripepi G., Cutrupi S., Pizzini P., Stancanelli B., et al. Vascular endothelial growth factor, left ventricular dysfunction and mortality in haemodialysis patients. J Hypertens 2008 ; 26: 1875-1882.
182. Gilbert M., Mousa S., and Mousa S. A. Current status of anti-vascular endothelial growth factor (VEGF) strategies and future directions. Drugs Fut 2008 ; 33: 515-525.
183. Lassus P., Turanlahti M., Heikkilä P., Andersson LC, Nupponen I., Sarnesto A., et al. Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 2001 ; 164: 1981-1987. (Pubitemid 33152339)
184. Lassus P., Ristimäki A., Ylikorkala O., Viinikka L., and Andersson S. Vascular endothelial growth factor in human preterm lung. Am J Respir Crit Care Med 1999 ; 159: 1429-1433. (Pubitemid 29227849)
185. Frank S., Hubner G., Breier G., Longaker MT, Greenhalgh DG, and Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes: implications for normal and impaired wound healing. J Biol Chem 1995 ; 270: 12607-12613.
186. Voelkel NF, Vandivier RW, and Tuder RM Vascular endothelial growth factor in the lung. Am J Physiol 2006 ; 290: L209 - L221.
187. Laufs U., Werner N., Link A., Endres M., Wassmann S., Jurgens K., et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 2004 ; 109: 220-226. (Pubitemid 38114143)
188. Tuder RM, Petrache I., Elias JA, Voekel NF, and Hen-son P. Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol 2003 ; 28: 551-554. (Pubitemid 36543401)
189. Boussat S., Eddahibe S., Coste A., Fataccioli V., Gouge M., Housset B., et al. Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol 2000 ; 279: L371 - L378.
190. Gerritsen ME HGF and VEGF: a dynamic duo. Circ Res 2005 ; 96: 272-273. (Pubitemid 40279899)
191. Geiser T., Jarreau PH, Atabai K., and Matthay MA Interleukin-1β augments in vitro alveolar epithelial repair. Am J Physiol 2000 ; 279: L1184 - L1190.
192. Edelson JD, Chan S., Jassal D., Post M., and Transwell AK Vitamin D stimulates DNA synthesis in alveolar type-II cells. Biochim Biophys Acta 1994 ; 1221: 159-166.
193. Hossain WA, D'Sa C., and Morest DK Interactive roles of fibroblast growth factor 2 and neurotropin 3 in the sequence of migration, process outgrowth, and axonal differentiation of mouse cochlear ganglion cells. J Neurosci Res 2008 ; 86: 2376-2391.
194. Nabeyrat E., Besnard V., Corroyer S., Cazals V., and Clement A. Retinoic acid-induced proliferation of lung alveolar epithelial cells: relation with the IGF system. Am J Physiol 1998 ; 275: L71 - L79.
195. Nabeyrat E., Corroyer S., Epaud R., Besnard V., Cazals V., and Clement A. Retinoic acid-induced proliferation of lung alveolar epithelial cells is linked to p21CIP1 downregulation. Am J Physiol 2000 ; 278: L42 - L50.
196. Belloni PN, Garvin L., Mao CP, Bailey-healy I., and Leaffer D. Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000 ; 117: 235S - 241S. (Pubitemid 30326965)
197. Xiao S., Jin H., Korn T., Liu SM, Oukka M., Lim B., et al. Retinoic acid increases Foxp3(+) regulatory T cells and inhibits development of T17 cells by enhancing TGF-beta-driven Smad3 signalling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 2008 ; 181: 2277-2284.
198. McGowan. Contributions of retinoids to the generation and repair of the pulmonary alveolus. Chest 2002 ; 121: 206S - 208S. (Pubitemid 34497342)
199. Shanker G., Olson D., Bone R., and Sawhney R. Regulation of extracellular matrix proteins by transforming growth factor β1 in cultured pulmonary endothelial cells. Cell Biol Int 1999 ; 23: 61-72. (Pubitemid 29516354)
200. Yao J., Bone RC, and Sawhney RS Differential effects of tumor necrosis factor-alpha on the expression of fibronectin and collagen genes in cultured bovine endothelial cells. Cell Mol Biol Res 1995 ; 41: 17-28.
201. Kumar NM, Sigurdson SL, Sheppard D., and Lwebuga-Mukasa JS Differential modulation of itegrin receptors and extracellular matrix laminin by transforming growth factor-β1 in rat alveolar epithelial cells. Exp Cell Res 1995 ; 221: 385-394.
202. Haralson MA Transforming growth factor-beta, other growth factors, and the extracellular matrix. J Lab Clin Med 1997 ; 130: 455-458.
203. Yoo J., Lotz MM, and Matthews JB Cytokines in restitution. In: Cho CH, Wang JY (eds). Gastrointestinal mucosal repair and experimental therapeutics. Frontiers in Gastrointestinal Research. vol. 25. Basel: Karger, 2002, p. 14-28.
204. Hoffman W. Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more. Peptides 2004 ; 25: 727-730.
205. Hoffman W. TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution. Cell Mol Life Sci 2005 ; 62: 2932-2938.
206. Al-azzeh E., Dittrich O., Vervoorts J., Blin N., Gött P., and Lüscher B. Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells. Gut 2002 ; 51: 685-690.
207. Farrell JJ, Taupin D., Koh TJ, Chen D., Zhao CM, Podolsky DK, et al. TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest 2002 ; 109: 193-204. (Pubitemid 34083739)
208. Jansen A., Varoga D., Woon CW, Podolsky D., Barker N., and Paulsen F. Restitution of wounded cornea by TFF-peptides. Invest Opthamol Vis Sci 2004 ; 45: U554.
209. Kalabis J., Rosenberg I., and Podolsky DK Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium. J Biol Chem 2006 ; 281: 6434-6441. (Pubitemid 43847575)
210. Tebbutt NC, Giraud AS, Inglese M., Jenkins B., Waring P., Clay FJ, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002 ; 8: 1089-1097. (Pubitemid 35175963)
211. Oertel M., Graness A., Thim L., Bühling F., Kalbacher H., and Hoffman W. Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor. Am J Respir Cell Mol Biol 2001 ; 25: 418-424. (Pubitemid 33037673)
212. Loncar MB, Al-azzeh E., Sommer PSM, Marinovic M., Schmehl K., Kruschewski M., et al. Tumour necrosis factor α and nuclear factor κB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 2003 ; 51: 1297-1303. (Pubitemid 37026462)
213. Dossinger V., Kayademir T., Blin N., and Gött P. Down-regulation of TFF expression in gastrointestinal cell lines by cytokines and nuclear factors. Cell Physiol Biochem 2002 ; 12: 197-206.
214. Rodrigues S., van Aken E., van Bocxlaer S., Attoub S., Nguyen QD, Bruyneel E., et al. Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signalling. FASEB J 2003 ; 17: 7-16. (Pubitemid 36119830)
215. Lian X., Qin Y., Hossain SA, Yang L., White A., Xu H., et al. Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury. J Immunol 2005 ; 174: 7250-7256. (Pubitemid 40705694)