Alveolar epithelial type II cell apoptosis in vivo during resolution of keratinocyte growth factor-induced hyperplasia in the rat

Histochemistry and Cell Biology

Volumn 114, Issue 1, 2000, Pages 49-61

  Fehrenbach, Heinz ^a   Kasper, Michael ^c   Koslowski, Roland ^c   Pan, Tianli ^b   Schuh, Dieter ^a   Müller, Martin ^a   Mason, Robert J ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Alveolar epithelium; Apoptosis; Bax; Bcl 2; Caspase 3; Fas; Fas ligand; Hyperplasia; Keratinocyte growth factor; Type II cell

Indexed keywords

CASPASE 3; CELL MEMBRANE PROTEIN; FAS ANTIGEN; FAS LIGAND; KERATINOCYTE GROWTH FACTOR; PRO CASPASE 3; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL HYPERPLASIA; CELL MEMBRANE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS MACROPHAGE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE REPAIR;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; EPITHELIAL CELLS; FAS LIGAND PROTEIN; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GROWTH SUBSTANCES; HYPERPLASIA; IN SITU NICK-END LABELING; MEMBRANE GLYCOPROTEINS; MICROSCOPY, IMMUNOELECTRON; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PULMONARY ALVEOLI; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS;

ANIMALIA;

EID: 0033863132     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180000157     Document Type: Article

References (56)

1. Adamson IYR (1984) Drug-induced pulmonary fibrosis. Environ Health Perspect 55:25-36
2. Barazzone C, Donati YR, Rochat AF, Vesin C, Kan CD, Pache JC, Piguet PF (1999) Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice. Am J Pathol 154:1479-1487
3. Bardales RH, Xie SS, Schaefer RF, Hsu SM (1996) Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. Am J Pathol 149:845-852
4. Bitterman PB, Polunovsky VA, Ingbar DH (1994) Repair after acute lung injury. Chest 105:118S-121S
5. Brambilla E, Negoescu A, Gazzeri S, Lantuejoul S, Moro D, Brambilla C, Coll JL (1996) Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol 149:1941-1952
6. Bruce MC, Honaker CE, Cross RJ (1999) Lung fibroblasts undergo apoptosis following alveolarization. Am J Respir Cell Mol Biol 20:228-236
7. Buckley S, Barsky L, Driscoll B, Weinberg K, Anderson KD, Warburton D (1998) Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats. Am J Physiol 274:L714-L720
8. Crouch E (1990) Pathobiology of pulmonary fibrosis. Am J Physiol 259:L159-L184
9. Deterding RR, Havill AM, Yano T, Middleton SC, Jacoby CR, Shannon JM, Simonet WS, Mason RJ (1997) Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor. Proc Assoc Am Physicians 109:254-268
10. Duvall E, Wyllie AH, Morris RG (1985) Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunology 56:351-358
11. Fadok VA, Henson PM (1998) Apoptosis: getting rid of the bodies. Curr Biol 8:R693-R695
12. Fehrenbach H, Kasper M, Tschernig T, Shearman MS, Schuh D, Müller M (1998) Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung. Cell Mol Biol (Noisy-legrand) 44:1147-1157
13. Fehrenbach H, Kasper M, Tschernig T, Pan T, Schuh D, Shannon JM, Müller M, Mason RJ (1999) Keratinocyte growth factor-induced hyperplasia of rat alveolar type II cells in vivo is resolved by differentiation into type I cells and by apoptosis. Eur Respir J 14:534-544
14. Fine A, Anderson NL, Rothstein TL, Williams MC, Gochuico BR (1997) Fas expression in pulmonary alveolar type II cells. Am J Physiol 273:L64-L71
15. French LE, Hahne M, Viard I, Radlgruber G, Zanone R, Becker K, Muller C, Tschopp J (1996) Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Biol 133:335-343
16. Gräper L (1914) Eine neue Anschauung über physiologische Zellausschaltung. Arch Zellforsch 12:373-394
17. Guinee D Jr, Brambilla E, Fleming M, Hayashi T, Rahn M, Koss M, Ferrans V, Travis W (1997) The potential role of BAX and BCL-2 expression in diffuse alveolar damage. Am J Pathol 151:999-1007
18. Guo J, Yi ES, Havill AM, Sarosi I, Whitcomb L, Yin S, Middleton SC, Piguet P, Ulich TR (1998) Intravenous keratinocyte growth factor protects against experimental pulmonary injury. Am J Physiol 275:L800-L805
19. Hagimoto N, Kuwano K, Miyazaki H, Kunitake R, Fujita M, Kawasaki M, Kaneko Y, Hara N (1997a) Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen. Am J Respir Cell Mol Biol 17:272-278
20. Hagimoto N, Kuwano K, Nomoto Y, Kunitake R, Hara N (1997b) Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol 16:91-101
21. Hamann KJ, Dorscheid DR, Ko FD, Conforti AE, Sperling AI, Rabe KF, White SR (1998) Expression of fas (CD95) and FasL (CD95L) in human airway epithelium. Am J Respir Cell Mol Biol 19:537-542
22. Huppertz B, Frank HG, Kingdom JC, Reister F, Kaufmann P (1998) Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol 110:495-508
23. Huppertz B, Frank HG, Kaufmann P (1999) The apoptosis cascade - morphological and immunohistochemical methods for its visualization. Anat Embryol (Berl) 200:1-18
24. Kasper M, Haroske G (1996) Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis. Histol Histopathol 11:463-483
25. Kasper M, Singh G (1995) Epithelial lung cell marker: current tools for cell typing. Histol Histopathol 10:155-169
26. Kasper M, Rudolf T, Hahn R, Peterson I, Müller M (1993) Immuno- and lectin histochemistry of epithelial subtypes and their changes in a radiation-induced lung fibrosis model of the mini pig. Histochemistry 100:367-377
27. Kasper M, Huber O, Grossmann H, Rudolph B, Tränkner C, Müller M (1995) Immunocytochemical distribution of Ecadherin in normal and injured lung tissue of the rat. Histochem Cell Biol 104:383-390
28. Kasper M, Reimann T, Hempel U, Wenzel K-W, Bierhaus A, Schuh D, Dimmer V, Haroske G, Müller M (1998) Loss of caveolin expression in type I pneumocytes as an indicator of subcellular alterations during lung fibrogenesis. Histochem Cell Biol 109:41-48
29. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257
30. Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, Oltvai ZN (1993) Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol 4:327-332
31. Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC (1994) Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 145:1323-1336
32. Kresch MJ, Christian C, Wu F, Hussain N (1998) Ontogeny of apoptosis during lung development. Pediatr Res 43:426-431
33. Kuhn C (1991) Patterns of lung repair. A morphologist's view. Chest 99:11S-14S
34. Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, Suda T, Kunitake R, Maeyama T, Miyazaki H, Hara N (1999) Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest 104:13-19
35. Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3-15
36. Mason CM, Guery BP, Summer WR, Nelson S (1996) Keratinocyte growth factor attenuates lung leak induced by alpha-naphthylthiourea in rats. Crit Care Med 24:925-931
37. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
38. Otter I, Conus S, Ravn U, Rager M, Olivier R, Monney L, Fabbro D, Borner C (1998) The binding properties and biological activities of Bcl-2 and Bax in cells exposed to apoptotic stimuli. J Biol Chem 273:6110-6120
39. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6
40. Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (1989) Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 86:802-806
41. Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cheon G, Taylor WG, Fortney E, Sakata H, Finch PW, et al (1995) Keratinocyte growth factor. Cell Biol Int 19:399-411
42. Savill J (1998) Apoptosis. Phagocytic docking without shocking. Nature 392:442-443
43. Scavo LM, Ertsey R, Chapin CJ, Allen L, Kitterman JA (1998) Apoptosis in the development of rat and human fetal lungs. Am J Respir Cell Mol Biol 18:21-31
44. Schittny JC, Djonov V, Fine A, Burri PH (1998) Programmed cell death contributes to postnatal lung development. Am J Respir Cell Mol Biol 18:786-793
45. Soini Y, Paakko P, Lehto VP (1998) Histopathological evaluation of apoptosis in cancer. Am J Pathol 153:1041-1053
46. Stennicke HR, Salvesen GS (1998) Properties of the caspases. Biochim Biophys Acta 1387:17-31
47. Uhal BD, Gidea C, Bargout R, Bifero A, Ibarra-Sunga O, Papp M, Flynn K, Filippatos G (1998a) Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism. Am J Physiol 275:L1013-L1017
48. Uhal BD, Joshi I, Hughes WF, Ramos C, Pardo A, Selman M (1998b) Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung. Am J Physiol 275:L1192-L1199
49. Ulich TR, Yi ES, Longmuir K, Yin S, Biltz R, Morris CF, Housley RM, Pierce GF (1994) Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest 93:562-572
50. Wang Y, Toury R, Hauchecorne M, Baimain N (1997) Expression of Bcl-2 protein in the epiphyseal plate cartilage and trabecular bone of growing rats. Histochem Cell Biol 108:45-55
51. 2 exposure. Am J Physiol 275:L780-L787
52. Wyllie AH (1987) Apoptosis: cell death in tissue regulation. J Pathol 153:313-316
53. Yang E, Korsmeyer SJ (1996) Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 88:386-401
54. Yano T, Deterding RR, Simonet WS, Shannon JM, Mason RJ (1996) Keratinocyte growth factor reduces lung damage due to acid instillation in rats. Am J Respir Cell Mol Biol 15: 433-442
55. Yi ES, Williams ST, Lee H, Malicki DM, Chin EM, Yin S, Tarpley J, Ulich TR (1996) Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol 149:1963-1970
56. Yi ES, Salgado M, Williams S, Kim SJ, Masliah E, Yin S, Ulich TR (1998) Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB expression, and alveolar type II cell loss in bleomycin-induced lung injury. Inflammation 22:315-325