HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad- but not the ERK1/2-mediated signaling pathway

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 10, 2004, Pages 3485-3492

  Kakazu, Azucena ^a   Chandrasekher, Gudiseva ^a   Bazan, Haydee E P ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CALCIMYCIN; CALCIUM IONOPHORE; DNA FRAGMENT; GLYCOGEN SYNTHASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; SCATTER FACTOR; SMALL INTERFERING RNA; STAUROSPORINE; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; DNA STRUCTURE; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CALCIMYCIN; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; ENZYME INHIBITORS; EPITHELIUM, CORNEAL; HEPATOCYTE GROWTH FACTOR; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAUROSPORINE;

EID: 4644230829     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0372     Document Type: Article

References (41)

1. Wilson SE, Walker JW, Chwang EL, He Y. Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea. Invest Ophthalmol Vis Sci. 1993;34:2544-2561.
2. Wilson SE, Liang Q, Kim WJ. Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci. 1999;40:2185-2190.
3. Wilson S, Chen L, Mohan R, Liang Q, Liu J. Expression of HGF, KGF, EGF and receptor messengers RNAs following corneal epithelial wounding. Exp Eye Res. 1999;68:377-397.
4. Tervo T, Vesaluoma M, Bennett GL, et al. Tear hepatocyte growth factor (HGF) availability increases markedly after excimer laser surface ablation. Exp Eye Res. 1997;64:501-504.
5. Chandrasekher G, Kakazu AH, Bazan HEP. HGF- and KGF-induced activation of PI-3K/p70S6 kinase pathway in corneal epithelial cells: its relevance in wound healing. Exp Eye Res. 2001;73:191-202.
6. Sharma GD, He J, Bazan HEP. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascade. J Biol Chem. 2003;278:21989-21997.
7. Chandrasekher G, Bazan HEP. Corneal epithelial wound healing increases the expression but not long lasting activation of the p85α subunit of phosphatidylinositol 3-kinase. Curr Eye Res. 1999;18:168-176.
8. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene. 2003;22:8983-8998.
9. Ren H, Wilson G. Apoptosis in the corneal epithelium. Invest Ophthalmol Vis Sci. 1996;37:1017-1025.
10. Chandrasekher G, Ma X, Lallier TE, Bazan HEP. Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor. Invest Ophthalmol Vis Sci. 2002;43:1422-1428.
11. Ma X, Bazan HEP. Platelet activating factor (PAF) enhances apoptosis by ultraviolet radiation in corneal epithelial cells through cytochrome c-caspase activation. Curr Eye Res. 2001;23:326-335.
12. Hurst J, Ma X, Bazan HEP. PAF binding to a single receptor in corneal epithelium plasma membrane. Invest Ophthalmol Vis Sci. 1999;40:790-795.
13. Kim JM, McOptom FS, Willcox MD. Induction of apoptosis in human corneal epithelial cells in vitro. Aust NZ J Ophthalmol. 1999;27:214-217.
14. Lin N, Bazan HEP. Protein kinase C substrates in corneal epithelium during wound healing: the phosphorylation of growth associated protein-43 (GAP-43). Exp Eye Res. 1995;61:451-460.
15. Kohn AD, Summers SA, Birnbaum MJ, Roth RA. Expression of constitutively active Akt Ser/Thr in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem. 1996;271:31372-31378.
16. Liang Q, Rajiv RM, Chen L, Wilson SE. Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways. Invest Ophthalmol Vis Sci. 1998;39:1329-1338.
17. Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 1995;376:599-602.
18. Franke TF, Yang SI, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995;81:727-736.
19. Brazil DP, Hemmings BA. Ten years of protein kinase B signaling: a hard Akt to follow. Trends Biochem Sci. 2001;26:657-664.
20. Sasaki K, Sato M, Umezawa Y. Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J Biol Chem. 2003;278:30945-30951.
21. Romanshkova JA, Makarov SS. NF-6B is a target of Akt in antiapoptotic PDGF signaling. Nature. 1999;401:86-90.
22. Ozes ON, Mayo LD Gustin JA, Pfeffer SR, Pfeffer LM Donner DB. NF-6B activation by tumor necrosis factor requires the Akt serine-threonine kinase. Nature. 1999;401:82-85.
23. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378:785-789.
24. Grimes CA, Jope RE. The multifaceted roles of glycogen synthase kinase- 3beta in cellular signaling. Prog Neurobiol. 2001;65:391-426.
25. Frame S, Cohen P. GSK3 takes centre stage more than 20 years after its discovery. Biochem J. 2001;359:1-16.
26. Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231-241.
27. Pastorino JG, Tafani M, Farber JL. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. J Biol Chem. 1999;274:19411-19416.
28. Takeuchi K, Ito F. Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3′-OH kinase-Akt pathway. J Biol Chem. 2004;279:892-900.
29. Bennet NT, Schultz GS. Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg. 1993;165:728-737.
30. Zieske JD, Takahashi H, Hutcheon AEK, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci. 2000;41:1346-1355.
31. Imanishi J, Kamiyama K, Iguchi I, Kita M, Sotozono C, Kinoshita S. Growth factors: importance in wound healing and maintenance of transparency in the cornea. Prog Retin Eye Res. 2000;19:113-129.
32. Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Woude GFV, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA. 2001;98:247-252.
33. Mildner M, Eckhart L, Lengauer B, Tschachler E. Hepatocyte growth factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the phosphatidylinositol 3-kinase/AKT pathway. J Biol Chem. 2002;277:14146-14152.
34. Wilson SE, Li Q, Weng J, et al. The Fas-Fas ligand system and other modulators of apoptosis in the cornea. Invest Ophthalmol Vis Sci. 1996;37:1582-1592.
35. Yamamoto K, Ladage PM, Ren DH, et al. Bcl-2 expression in the human cornea. Exp Eye Res. 2001;73:247-255.
36. Parker MA, Bazan HEP, Marcheselli VL, Rodriguez de Turco EB, Bazan NG. Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. J Neurosci Res. 2002;68:39-50.
37. Pap M, Cooper GM. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem. 1998;273:19929-19932.
38. Cross DA, Culbert AA, Chalmers KA, Facer L, Skaper SD, Reith AD. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protects primary neurons from death. J Neurochem. 2001;77:94-102.
39. Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK. Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation of two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta. J Chem. 1998;273:18640-18646.
40. Fiol CJ, Williams JS, Chou CH, Wang QM, Roach PJ, Andrisani OM. A secondary phosphorylation of CREB341 at Ser 129 is required for the cAMP-mediated control of gene expression: a role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem. 1994;269:32187-32193.
41. Friend J, Hassell JR. Biochemistry of the cornea. In: Smolin G, Thoft RA, eds. The Cornea. 3rd ed. Boston: Little, Brown; 1994:47-67.