Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality

American Journal of Pathology

Volumn 149, Issue 6, 1996, Pages 1963-1970

  Yi, Eunhee S ^a   Williams, Scott T ^a   Lee, Hyesun ^a   Malicki, Denise M ^a   Chin, Elaine M ^b   Yin, Songmei ^c   Tarpley, John ^c   Ulich, Thomas R ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN SULFATE; BROXURIDINE; KERATINOCYTE GROWTH FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG INDUCED DISEASE; HISTOLOGY; LUNG ALVEOLUS CELL TYPE 2; LUNG FIBROSIS; LUNG INJURY; MORTALITY; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION INJURY; RAT; RESPIRATORY DISTRESS;

ANIMALS; BLEOMYCIN; BROMODEOXYURIDINE; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GROWTH SUBSTANCES; INTUBATION, INTRATRACHEAL; LUNG; LUNG DISEASES; MALE; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, INBRED LEW;

EID: 0029851485     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Kuhn C: Normal anatomy and histology. Pathology of the Lung. (Edited by WM Thurlbeck, AM Churg. New York, Thieme Medical Publishers, 1995, pp 15-20
2. Panos RJ: Cytokines and alveolar type II cells. Cytokines of the Lung: Lung Biology in Health and Disease. Edited by J Kelly. New York, Marcel Dekker, 1993, pp 417-458
3. Adamson IYR, Bowden DH: Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 1988, 130:377-383
4. Adamson IYR, Bowden DH: The type 2 cell as progenitor of alveolar epithelial regeneration: a cytodynamic study in mice after exposure to oxygen. Lab Invest 1974, 30:35-42
5. Thet LA, Parra SC, Shelburne JD: Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats. Exp Lung Res 1986, 11:209-228
6. Witschi H: Proliferation of type II alveolar cells: a review of common responses in toxic lung injury. Toxicology 1976, 5:267-277
7. Witschi H: Role of the epithelium in lung repair: patterns of epithelial repair and pulmonary fibrosis. Chest 1991, 99:22S-25S
8. Crouch E: Pathobiology of pulmonary fibrosis. Am J Physiol 1990, 259:L159-L184
9. Panos RJ, Suwabe A, Leslie CC, Mason RJ: Hypertrophic alveolar type II cells from silica-treated rats are committed to DNA synthesis in vitro. Am J Respir Cell Mol Biol 1990, 3:51-59
10. Finch PW, Rubin SS, Miki T, Ron D, Aaronson SA: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 1989, 245:752-755
11. Ulich TR, Yi ES, Longmuir K, Yin S, Blitz R, Morris CF, Housley RM, Pierce GF: Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest 1994, 93:1298-1236
12. Panos RJ, Rubin JS, Aaronson SA, Mason RJ: Keratinocyte growth factor and hepatocyte growth factor scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium. J Clin Invest 1993, 92:969-977
13. Sugahara K, Rubin JS, Mason RJ, Aronson EL, Shannon JM: Keratinocyte growth factor increases mRNAs for SP-A and SP-B in adult rat alveolar type II cells in culture. Am J Physiol 1995, 269:L344-L350
14. Mason IJ, Fuller-Pace F, Smith R, Dickson C: FGF-7 (keratinocyte growth factor) expression during mouse development suggests role in myogenesis, forebrain regionalisation, and epithelial-mesenchymal interactions. Mech Dev 1994, 45:15-30
15. Finch PW, Cunha GR, Rubin JS, Wong J, Ron D: Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions. Dev Dynamics 1995, 203:223-240
16. Werner S, Peters KG, Longaker MT, Fuller-Pace F, Banda MJ, Williams LT: Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci USA 1992, 89:6896-6900
17. Brauchle M, Angermeyer K, Hubner G, Werner S: Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene 1994, 9:3199-3204
18. Panos RJ, Bak PM, Simonet WS, Rubin JS, Smith LJ: Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. J Clin Invest 1995, 96:2026-2033
19. Deterding RR, Yano T, Havill AM, Jacoby CR, Shannon JM, Simonet WS, Mason RJ: Keratinocyte growth factor prevents bleomycin lung injury in rats. Am J Respir Crit Care Med 1995, 151:A198
20. Woessner JF: Determination of hydroxyproline in connective tissue. The Methodology of Connective Tissue Research. Edited by DS Hall. Oxford, Joynson-Bruvvers, 1976, pp 227-233
21. Kamp DW, Pollack IN, Nadeem M, Panos RJ: Keratinocyte growth factor attenuates hydrogen peroxide-induced DNA damage in cultured epithelial cells. J Invest Med 1995, 43:246a
22. Haschek WM, Reiser KM, Klein-Szanto AKP: Potentiation of butylated hydroxytoluene-induced acute lung damage by oxygen: cell kinetics and collagen metabolism. Am Rev Respir Dis 1983, 127:28-34
23. Rubin P, Constine LS, Nelson DF: Late effects of cancer treatment, radiation and drug toxicity. Principles and Practices of Radiation Oncology. Edited by CA Perez, LW Brady. New York, Lippincott, 1992, pp 131-134
24. Rosiello RA, Merrill WW: Radiation-induced lung injury. Clin Chest Med 1990, 11:65-71
25. Moseley PL, Shasby DM, Brady M, Hunninghake G and W: Lung parenchymal injury induced by bleomycin. Am Rev Respir Dis 1984, 130:1082-1086