Cancer predisposing mutations in BRCT domains

IUBMB Life

Volumn 63, Issue 7, 2011, Pages 503-512

  Di Masi, Alessandra ^a   Gullotta, Francesca ^b,c   Cappadonna, Valentina ^a   Leboffe, Loris ^a   Ascenzi, Paolo ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

BRCT domains; BRCT mutations; cancer susceptibility; familial breast and ovarian cancer syndrome; Nijmegen breakage syndrome; primary microcephaly

Indexed keywords

ALANINE; ANTIINFECTIVE AGENT; ARGININE; ATM PROTEIN; ATR PROTEIN; BREAST CANCER 1; CYSTEINE; DNA BINDING PROTEIN; GLUTAMINE; GLYCINE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; ISOLEUCINE; LYSINE; METHIONINE; MICROCEPHALIN1; NIBRIN; PHENYLALANINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOPEPTIDE; PHOSPHOPROTEIN; PROTEIN; SERINE; TRYPTOPHAN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VALINE; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; AUTOSOMAL RECESSIVE INHERITANCE; BREAST CANCER; BREAST CANCER 1 CARBOXY TERMINAL; CANCER GROWTH; CANCER RISK; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CARBOXY TERMINAL SEQUENCE; CAUSE OF DEATH; CELL CYCLE REGULATION; CHROMOSOME 1; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE MUTATION; GENE REPLICATION; GENETIC TRANSCRIPTION; GROWTH DISORDER; HODGKIN DISEASE; HUMAN; IMMUNE DEFICIENCY; IONIZING RADIATION; LYMPHATIC LEUKEMIA; MICROCEPHALY; NONHODGKIN LYMPHOMA; OVARY CANCER; OVERALL SURVIVAL; PROGNOSIS; REVIEW;

AMINO ACID SEQUENCE; BRCA1 PROTEIN; DNA DAMAGE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; NIJMEGEN BREAKAGE SYNDROME; PROTEIN STRUCTURE, TERTIARY;

EID: 79959583326     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.472     Document Type: Review

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