The BRCA1 C-terminal domain: Structure and function

Mutation Research - DNA Repair

Volumn 460, Issue 3-4, 2000, Pages 319-332

  Huyton, Trevor ^a   Bates, Paul A ^a   Zhang, Xiaodong ^a   Sternberg, Michael J E ^a   Freemont, Paul S ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

BRCA1; BRCT; DNA damage repair; Protein interaction module; XRCC1

Indexed keywords

ONCOPROTEIN;

AMINO ACID SEQUENCE; DNA DAMAGE; DNA DETERMINATION; DNA REPAIR; GENE FUNCTION; GENE STRUCTURE; HUMAN; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW;

EID: 0034734384     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(00)00034-3     Document Type: Article

References (51)

1. Kaufmann W.K., Paules R.S. DNA damage and cell cycle checkpoints. FASEB J. 10:1996;238-247. (Review).
2. Bork P., Hofmann K., Butcher P., Neuwald A.F., Altschul S.F., Koonin E.V. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11:1997;68-76.
3. Koonin E.V., Altscul S.F., Bork P. BRCA1 protein products...functional motifs. Nat. Gen. 13:1996;266-267.
4. Callebaut I., Mornon J.P. From BRCA1 to RAP1 a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400:1997;25-30.
5. Bork P., Gibson T. Applying motif and profile searches. Methods Enzymol. 266:1996;162-184.
6. Koonin E.V., Tatusov R.L., Rudd K.E. Genone-scale comparison of protein sequences. Methods Enzymol. 266:1996;295-322.
7. Zhang X., Morera S., Bates P.A., Whitehead P.C., Coffer A.I., Hainbucher K., Nash R.A., Sternberg M.J.E., Lindahl T., Freemont P.S. Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J. 17:1988;6404-6411.
8. Sonnhammer E.L.L., Eddy S.R., Durbin R. Pfam: a comprehensive database of protein domain families based on seed alignments. Proteins. 28:1997;405-420.
9. Caldecott K.W., Tucker J.D., Stanker L.H., Thompson L.H. Characterisation of the XRCC1-DNA ligase III complex in vitro and it's absence from mutant hamster cells. Nucleic Acids Res. 23:1995;4836-4843.
10. Nash R.A., Caldecott K.W., Barnes D.E., Lindahl T. XRCC1 protein interacts with one of the two distinct forms of DNA ligase III. Biochemistry. 36:1997;5207-5211.
11. Taylor R.M., Wickstead B., Cronin S., Caldecott K.W. Role of a BRCT domain in the interaction of DNA ligase III-α with the DNA repair protein XRCC1. Curr. Biol. 8:1998;877-880.
12. Masson M., Niedergang C., Screiber V., Muller S., Menissier-deMurcier J., Menissier-deMurcier G. XRCC1 is specifically associated with poly (ADP-ribose) polymerase and negatively regulates it's activity following DNA damage. Mol. Cell. Biol. 18:1998;3563-3571.
13. Kubota Y., Nash R.A., Klungland A., Schar P., Barnes D.E., Lindahl T. Reconstitution of DNA base excision repair with purified human proteins: interaction between DNA polymerase β and the XRCC1 protein. EMBO J. 15:1996;6662-6670.
14. Couch F.J., DeShano M.L., Blackwood M.A., Calzone K., Stopfer J., Campeau L., Ganguly A., Rebbeck T., Webber B.L. BRCA1 mutations in women attending clinics that evaluate the risk of breast cancer. New Eng. J. Med. 336:1997;1409-1415.
15. Gayther S.A.et al. Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation. Nat. Genet. 11:1995;428-433.
16. Miki Y.et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 266:1994;66-71.
17. Holt J.T., Thompson M.E., Szabo C., Robinson-Benion C., Artteaga C.L., King M.C., Jensen R.A. Growth retardation and tumor inhibition by BRCA1. Nat. Genet. 12:1996;298-302.
18. Jensen D.R., Rauscher F.J. III BAP1, a candidate tumor suppressor protein that interacts with BRCA1. Ann. N. Y. Acad. Sci. 886:1999;1-4.
19. Scully R., Chen J., Plug A., Xiao Y., Weaver D., Feunteun J., Ashley T., Livingston D.M. Association of BRCA1 with Rad51 in mitotoc and meiotic cells. Cell. 88:1997;265-275.
20. Scully R., Chen J., Ochs R.L., Leegan K., Hoekstra M., Feunteun J., Livingston D.M., Parvin J.D. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 90:1997;225-235.
21. Scully R., Ganesan S., Brown M., De Caprio J.A., Cannistra S.A., Feunteun J. Localisation of BRCA1 in human breast and ovarian cancer cells. Science. 272:1996;123-124.
22. Scully R., Anderson S.F., Chao D.M., Wei W., Ye L., Young R.A., Livingston D.M. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl Acad. Sci. U.S.A. 94:1997;5605-5610.
23. Anderson S.F., Schlegel B.P., Nakajima T., Wolpin E.S., Parvin J.D. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet. 19:1998;254-256.
24. Monteiro A.N.A., August A., Hanafusa H. Evidence for transcription activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. U.S.A. 93:1996;13595-13599.
25. Chapman M.S., Verma I.M. Transcriptional activation by BRCA1. Nature. 382:1996;678-679.
26. Yu X., Wu L.C., Bowcock A.M., Aronheim A., Baer R. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of trabscriptional repression. J. Biol. Chem. 273:1998;25388-25392.
27. Zhang H., Somasundaram K., Peng Y., Tian H., Zhang H., Bi D., Webber B.L., El-Deiry W.S. BRCA1 physically associates with p53 and stimulates it's transcriptional activity. Oncogene. 16:1998;1713-1721.
28. Crook T., Brooks L.A., Crossland S., Osin P., Barker K.T., Waller J., Philp E., Smith P.D., Yulug I., Peto J., Allday M.J., Crompton M.R., Gusterson B.A. p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1 and BRCA2-associated breast tumours. Oncogene. 13:1998;1681-1689.
29. Smith P.D., Crossland S., Parker G., Osin P., Brooks L., Waller J., Philp E., Crompton M.R., Gusterson B.A., Allday M.J., Crook T. Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation supression from other wild-type p53 functions. Oncogene. 18:1999;2451-2459.
30. Ouchi T., Monteiro A.N.A., August A., Aronson S.A., Hanafusa H. BRCA1 regulates p53-dependent gene expression. Proc. Natl. Acad. Sci. U.S.A. 95:1998;13595-13599.
31. Somasunduram K., Zhang H., Zeng Y.X., Houvras H., Peng Y., Zhang H., Wu G.S., Licht J.D., Webber B.L., El-Deiry W.S. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature. 389:1997;187-190.
32. Yamane K., Tsuruo T. Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. Oncogene. 18:1999;5194-5203.
33. Wu L.C., Wang Z.W., Tsan J.T., Spillman M.A., Phung A., Xu X.L., Yang M.C., Hwang L.Y., Bowcock A.M., Braer R. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 14:1996;430-440.
34. Ayi T.-C., Tsan J.T., Hwang L.-Y., Bowcock A.M., Baer R. Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene. 17:1998;2143-2148.
35. Kleiman F.E., Manley J.L. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science. 285:1999;1576-1579.
36. G. Chu, Double strand break repair. J. Biol. Chem. 272, 24097-24100.
37. Wu X., Lieber M.R. Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol. Cell. Biol. 16:1996;5186-5193.
38. Mahajan K.N., Gangi-Peterson L., Sorscher D.H., Wang J., Gathy K.N., Mahajan N.P., Reeves W.H., Mitchell B.S. Association of terminal deoxynucleotidyl transferase with Ku. Proc. Natl. Acad. Sci. U.S.A. 96:1999;13926-13931.
39. Yamane K., Kawabata M., Tsuruo T. A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. Eur. J. Biochem. 250:1997;749-794.
40. Cappelli E., Taylor R., Cevasco M., Abbondandolo A., Caldecott K., Frosina G. Involvement of XRCC1 and DNA ligase III gene products in DNA base excission repair. J. Biol. Chem. 272:1997;23970-23975.
41. Ljungquist S., Kenne K., Olsson L., Sandstrom M. Altered DNA ligase III activity in the CHO EM9 mutant. Mutat. Res. 314:1994;177-186.
42. Shen M.R., Zdzienicka M.Z., Mohrenweiser H., Thompson L.H., Thelen M.P. Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair. Nucleic Acids Res. 26:1998;1032-1037.
43. Critchlow S.E., Bowater R.P., Jackson S.P. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7:1997;588-598.
44. Garwunder U., Wilm M., Wu X., Kulesza P., Wilson T.E., Mann M., Lieber M.R. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature. 388:1997;492-495.
45. Garwunder U., Zimmer D., Lieber M.R. DNA ligase IV binds to XRCC4 via a motif located between rarther than within its BRCT domains. Curr. Biol. 8:1998;873-876.
46. Teo S.-H., Jackson S.P. Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks. Curr. Biol. 10:1900;165-168.
47. Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1996;1664-1672.
48. Soulier J., Lowndes N.F. The BRCT domain of the S. cerivisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage. Curr. Biol. 9:1999;551-554.
49. Bates P.A., Sternberg M.J.E. Model building by comparison at CASP3: using expert knowledge and computer automation. Proteins. 3:1999;30-46.
50. Nicholls A., Sharp K.A., Honig B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins. 11:1991;281-296.
51. Janin J. Specific versus non-specific contacts in protein crystals. Nat. Struct. Biol. 4:1997;973-974.