How do aminoadamantanes block the influenza M2 channel, and how does resistance develop?

Journal of the American Chemical Society

Volumn 133, Issue 25, 2011, Pages 9903-9911

  Leonov, Hadas ^a,b   Astrahan, Peleg ^a   Krugliak, Miriam ^a   Arkin, Isaiah T ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTYL MOIETY; AMANTADINE; AMINO GROUP; BINDING POCKETS; BLOCKING MECHANISMS; CHANNEL ACTIVITY; COMPUTATIONAL ANALYSIS; DRUG BINDING; EXPERIMENTAL VERIFICATION; M2 CHANNEL; POSITIVELY CHARGED; RIMANTADINE;

ELECTROSTATICS;

VIRUSES;

ADAMANTANE DERIVATIVE; ADAMANTANOL; AMANTADINE; INFLUENZA M2 CHANNEL; RIMANTADINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIVIRAL RESISTANCE; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTRIC CONDUCTIVITY; HYDROPHOBICITY; INFLUENZA; MOLECULAR DYNAMICS; NONHUMAN; PHARMACOLOGICAL BLOCKING; THERMODYNAMICS;

ADAMANTANE; AMANTADINE; ANTIVIRAL AGENTS; BINDING SITES; DRUG RESISTANCE, VIRAL; HUMANS; ION CHANNELS; MUTATION; RIMANTADINE; STATIC ELECTRICITY; VIRAL MATRIX PROTEINS;

EID: 79959520070     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja202288m     Document Type: Article

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