Quantitative analysis of influenza M2 channel blockers

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 1, 2011, Pages 394-398

  Astrahan, Peleg ^a   Flitman Tene, Ravenna ^a,b   Bennett, Estelle R ^a   Krugliak, Miriam ^a   Gilon, Chaim ^a   Arkin, Isaiah T ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b Edmund J Safra Campus ^*  (Israel)

Author keywords

Channel; Channel blocker; Influenza

Indexed keywords

AMANTADINE; ION CHANNEL; PROTEIN M2; RIMANTADINE;

ANIMAL CELL; ANTIVIRAL RESISTANCE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ESCHERICHIA COLI; GENETIC MANIPULATION; GROWTH RETARDATION; HIGH THROUGHPUT SCREENING; INFLUENZA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; VIRUS INFECTIVITY; VIRUS STRAIN;

AMANTADINE; ANIMALS; ANTIVIRAL AGENTS; BLOTTING, WESTERN; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MUTATION; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RIMANTADINE; TIME FACTORS; VIRAL MATRIX PROTEINS;

ESCHERICHIA COLI; SUIDAE;

EID: 78649770729     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.08.021     Document Type: Article

References (20)

1. A. Helenius Unpacking the incoming influenza virus Cell 69 4 1992 577 578
2. L.H. Pinto, L.J. Holsinger, and R.A. Lamb Influenza virus M2 protein has ion channel activity Cell 69 3 1992 517 528
3. A.L. Stouffer, R. Acharya, D. Salom, A.S. Levine, L. Di Costanzo, C.S. Soto, V. Tereshko, V. Nanda, S. Stayrook, and W.F. DeGrado Structural basis for the function and inhibition of an influenza virus proton channel Nature 451 7178 2008 596 599
4. K. Nishimura, S. Kim, L. Zhang, and T.A. Cross The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR Biochemistry 41 44 2002 13170 13177
5. J.R. Schnell, and J.J. Chou Structure and mechanism of the M2 proton channel of influenza A virus Nature 451 7178 2008 591 595
6. C. Wang, K. Takeuchi, L.H. Pinto, and R.A. Lamb Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block J. Virol. 67 9 1993 5585 5594
7. A.J. Hay, A.J. Wolstenholme, J.J. Skehel, and M.H. Smith The molecular basis of the specific anti-influenza action of amantadine EMBO J. 4 11 1985 3021 3024
8. Astrahan P., Arkin I.T.: Biochem. Biophys. Acta (in press).
9. S. Kurtz, G. Luo, K.M. Hahnenberger, C. Brooks, O. Gecha, K. Ingalls, K. Numata, and M. Krystal Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae: identification of a novel inhibitor of influenza virus Antimicrob. Agents Chemother. 39 10 1995 2204 2209
10. J.A. Mould, R.G. Paterson, M. Takeda, Y. Ohigashi, P. Venkataraman, R.A. Lamb, and L.H. Pinto Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes Dev. Cell 5 1 2003 175 184
11. R. Grisshammer, and C.G. Tate Overexpression of integral membrane proteins for structural studies Q. Rev. Biophys. 28 3 1995 315 422
12. Y. Suzuki, R. Saito, H. Zaraket, C. Dapat, I. Caperig-Dapat, and H. Suzuki Rapid and specific detection of amantadine-resistant influenza A viruses with a Ser31Asn mutation by the cycling probe method J. Clin. Microbiol. 48 1 2010 57 63
13. P.E. Aldrich, E.C. Hermann, W.E. Meier, M. Paulshock, W.W. Prichard, J.A. Snyder, and J.C. Watts Antiviral agents. 2. Structure-activity relationships of compounds related to 1-adamantanamine J. Med. Chem. 14 6 1971 535 543
14. F.G. Hayden, K.M. Cote, and R.G. Douglas Jr Plaque inhibition assay for drug susceptibility testing of influenza viruses Antimicrob. Agents Chemother. 17 5 1980 865 870
15. X. Jing, C. Ma, Y. Ohigashi, F.A. Oliveira, T.S. Jardetzky, L.H. Pinto, and R.A. Lamb Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel Proc. Natl Acad. Sci. USA 105 31 2008 10967 10972
16. V. Balannik, V. Carnevale, G. Fiorin, B.G. Levine, R.A. Lamb, M.L. Klein, W.F. Degrado, and L.H. Pinto Biochemistry 49 4 2009 696 708
17. S. Kashiwagi Advances in influenza treatment J. Infect. Chemother. 7 4 2001 199 204
18. G. Zoidis, A. Tsotinis, N. Kolocouris, J.M. Kelly, S.R. Prathalingam, L. Naesens, and E. De Clercq Design and synthesis of bioactive 1, 2-annulated adamantane derivatives Org. Biomol. Chem. 6 17 2008 3177 3185
19. D. Salom, B.R. Hill, J.D. Lear, and W.F. DeGrado pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus Biochemistry 39 46 2000 14160 14170
20. P. Astrahan, I. Kass, M.A. Cooper, and I.T. Arkin A novel method of resistance for influenza against a channel-blocking antiviral drug Proteins 55 2 2004 251 257