The anticonvulsant levetiracetam for the treatment of pain in polyneuropathy: A randomized, placebo-controlled, cross-over trial

European Journal of Pain

Volumn 15, Issue 6, 2011, Pages 608-614

  Holbech, Jakob V ^a   Otto, Marit ^c   Bach, Flemming W ^b   Jensen, Troels S ^c   Sindrup, Søren H ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Levetiracetam; Neuropathic pain; Pharmacological treatment; Polyneuropathy

Indexed keywords

ETIRACETAM; NOOTROPIC AGENT; PARACETAMOL; PLACEBO; TRAMADOL;

6 POINT VERBAL SCALE; ADULT; AGED; ANALGESIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG SAFETY; DRUG TREATMENT FAILURE; FATIGUE; FEMALE; HUMAN; MALE; MENTAL DISEASE; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PATIENT COMPLIANCE; POLYNEUROPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SLEEP DISORDER; SYMPTOM; TREATMENT DURATION;

ADULT; AGED; ANTICONVULSANTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURALGIA; PAIN MEASUREMENT; PIRACETAM; POLYNEUROPATHIES; TREATMENT OUTCOME;

EID: 79959376036     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2010.11.007     Document Type: Article

References (39)

1. D.P. Archer, Y. Lamberty, B. Wang, M.J. Davis, N. Samanani, and S.H. Roth Levetiracetam reduces anesthetic-induced hyperalgesia in rats Anesth Analg 104 1 2007 180 185 (Pubitemid 46360444)
2. D. Ardid, Y. Lamberty, A. Alloui, and A. Eschalier Levetiracetam (Keppra), a new antiepileptic drug is effective in neuropathic but not acute pain models in rats Neurology 56 suppl. 3 2001 P05
3. D. Ardid, Y. Lamberty, A. Alloui, M.A. Coudore-Civiale, H. Klitgaard, and A. Eschalier Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats Eur J Pharmacol 473 2003 27 33 (Pubitemid 36851625)
4. N. Attal, G. Cruccu, M. Haanpää, P. Hansson, T.S. Jensen, and T. Nurmikko EFNS task force. EFNS guidelines on pharmacological treatment of neuropathic pain Eur J Neurol 13 2006 1153 1189
5. Bjorner J, Damsgaard M, Watt T, Bech P, Rasmussen N, Kristensen T, et al. Dansk manual til SF-36. Et spørgeskema om helbredsstatus. København: Lægemiddelindustriforeningen; 1997.
6. 2+-induced exocytosis J Neurosci 29 4 2009 883 897
7. K.M. Crowder, J.M. Gunther, T.A. Jones, B.D. Hale, H.Z. Zhang, and M.R. Peterson Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A) Proc Natl Acad Sci USA 96 26 1999 15268 15273 (Pubitemid 30019801)
8. S. Dogra, S. Beydoun, J. Mazzola, M. Hopwood, and Y. Wan Oxcarbazepine in painful diabetic neuropathy: a randomized, placebo-controlled study Eur J Pain 9 5 2005 543 554 (Pubitemid 41219786)
9. 2+ channel alpha2delta ligands: novel modulators of neurotransmission Trends Pharmacol Sci 28 2 2007 75 82 (Pubitemid 46161838)
10. R.H. Dworkin, A.B. O'Connor, M. Backonja, J.T. Farrar, N.B. Finnerup, and T.S. Jensen Pharmacological management of neuropathic pain: evidence-based recommendations Pain 132 2007 237 251 (Pubitemid 350051570)
11. N.B. Finnerup, M. Otto, H.J. McQuay, T.S. Jensen, and S.H. Sindrup Algorithm for neuropathic pain treatment: an evidence based proposal Pain 118 2005 289 305 (Pubitemid 41752987)
12. N.B. Finnerup, J. Grydehøj, J. Bing, I.L. Johannesen, F. Biering-Sørensen, and S.H. Sindrup Levetiracetam in spinal cord injury pain: a randomized controlled trial Spinal Cord 47 12 2009 861 867
13. F. Frediani Anticonvulsant drugs in primary headaches prophylaxis Neurol Sci 25 2004 161 166
14. P.T. Hansson, and A.H. Dickenson Pharmacological treatment of peripheral neuropathic pain conditions based on shared commonalities despite multiple etiologies Pain 113 3 2005 251 254 (Pubitemid 40127504)
15. P. Hansson Difficulties in stratifying neuropathic pain by mechanisms Eur J Pain 7 4 2003 353 357 (Pubitemid 36858234)
16. T.P. Jorns, A. Johnston, and J.M. Zakrzewska Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra®) in treatment of patients with trigeminal neuralgia Eur J Neurol 16 6 2009 74074-4
17. J. Katz, N.B. Finnerup, and R.H. Dworkin Clinical trial outcome in neuropathic pain: relationship to study characteristics Neurology 70 2008 263 272 (Pubitemid 351156805)
18. D.K. Kochar, N. Jain, R.P. Agarwal, T. Srivastava, P. Agarwal, and S. Gupta Sodium valproate in the management of painful neuropathy in type 2 diabetes - a randomized placebo controlled study Acta Neurol Scand 106 2002 248 252 (Pubitemid 35177990)
19. E.A. Lukyanetz, V.M. Shkryl, and P.G. Kostyuk Selective blockade of N-type calcium channels by levetiracetam Epilepsia 43 1 2002 9 18 (Pubitemid 34215447)
20. Z.D. Luo, S.R. Chaplan, E.S. Higuera, L.S. Sorkin, K.A. Stauderman, and M.E. Williams Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats J Neurosci. 21 6 2001 1868 1875 Mar 15 (Pubitemid 32221370)
21. Z.D. Luo, N.A. Calcutt, E.S. Higuera, C.R. Valder, Y.H. Song, and C.I. Svensson Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin J Pharmacol Exp Ther 303 3 2002 1199 1205 (Pubitemid 35424406)
22. B.A. Lynch, N. Lambeng, K. Nocka, P. Kensel-Hammes, S.M. Bajjalieh, and A. Matagne The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam Proc Natl Acad Sci USA 101 26 2004 9861 9866 (Pubitemid 38869327)
23. N. Nagarkatti, L.S. Deshpande, and R.J. Delorenzo Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture Neurosci Lett 436 3 2008 289 293
24. M. Otto, F.W. Bach, T.S. Jensen, and S.H. Sindrup Valproic acid has no effect on pain in polyneuropathy. a randomized controlled trial Neurology 62 2004 285 288 (Pubitemid 38167141)
25. M. Otto, F.W. Bach, T.S. Jensen, K. Brøsen, and S.H. Sindrup Escitalopram in painful polyneuropathy: a randomized placebo-controlled, cross-over trial Pain 139 2008 275 283
26. P.N. Patsalos Clinical pharmacokinetics of levetiracetam Clin Pharmacokinet 43 11 2004 707 724 (Pubitemid 39159001)
27. M.J. Price Levetiracetam in the treatment of neuropathic pain: three case studies Clin J Pain 20 2004 33 36 (Pubitemid 38030117)
28. P. Raskin, P.D. Donofrio, N.R. Rosenthal, D.J. Hewitt, D.M. Jordan, and J. Xiang CAPSS-141 study group. Topiramate vs. placebo in painful diabetic neuropathy: analgesic and metabolic effects Neurology 63 2004 865 873 (Pubitemid 39297649)
29. J.M. Rigo, G. Hans, L. Nguyen, V. Rocher, S. Belachew, and B. Malgrange The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents Br J Pharmacol 136 5 2002 659 672 (Pubitemid 34785708)
30. S. Rossi, G. Mataluni, C. Codec, S. Fiore, F. Buttari, and A. Musella Effects of levetiracetam on chronic pain in multiple sclerosis: results of a pilot, randomized, placebo-controlled study Eur J Neurol 16 3 2009 360 366
31. M.C. Rowbotham, N.S. Manville, and J. Ren Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia Neurology 61 2003 866 867 (Pubitemid 37174499)
32. J. Scholz, R.J. Mannion, D.E. Hord, R.S. Griffin, B. Rawal, and H. Zheng A novel tool for the assessment of pain: validation in low back pain PloS Med 6 4 2009 e1000047
33. G.J. Sills The mechanisms of action of gabapentin and pregabalin Curr Opin Pharmacol 6 1 2006 108 113 (Pubitemid 43103827)
34. J. Sliva, T. Dolezal, M. Prochazkova, M. Votava, and M. Krsiak Preemptive levetiracetam decreases postoperative pain in rats Neuro Endocrinol Lett 29 6 2008 953 957
35. U. Thienel, W. Neto, S.K. Schwabe, and U. Vijapurkar Topiramate diabetic neuropathic pain study group. Topiramate in painful diabetic polyneuropathy: findings from three double-blind placebo-controlled trials Acta Neurol Scand 110 2004 221 231 (Pubitemid 39274056)
36. O.J. Vilholm, S. Cold, L. Rasmussen, and S.H. Sindrup Effect of levetiracetam on the postmastectomy pain syndrome Eur J Neurol 15 8 2008 851 857
37. A.L. Vinik, M. Tuchman, B. Safirstein, C. Corder, L. Kirby, and K. Wilks Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies Pain 128 2007 169 179 (Pubitemid 46216610)
38. C.J. Woolf Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy Life Sci 74 21 2004 2605 2610 (Pubitemid 38369357)
39. 2+ currents Seizure 10 4 2001 279 286 (Pubitemid 32705452)