Levetiracetam reduces anesthetic-induced hyperalgesia in rats

Anesthesia and Analgesia

Volumn 104, Issue 1, 2007, Pages 180-185

  Archer, David P ^a,c   Lamberty, Yves ^b   Wang, Bing ^a   Davis, Melinda J ^a   Samanani, Naaznin ^a   Roth, Sheldon H ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UCB PHARMA   (Belgium)

^c FOOTHILLS HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ETIRACETAM; MIDAZOLAM; PENTOBARBITAL; PROPOFOL; SODIUM CHLORIDE; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; PIRACETAM;

ANESTHESIA; ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPERALGESIA; HYPERREFLEXIA; MALE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; REFLEX; SEDATION; ANIMAL; ANIMAL MODEL; CHEMICALLY INDUCED DISORDER; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANESTHESIA; ANIMALS; ANTICONVULSANTS; HYPERALGESIA; MALE; MODELS, ANIMAL; PAIN THRESHOLD; PIRACETAM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33847628732     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000247788.57318.1f     Document Type: Article

References (24)

1. Fuks B, Gillard M, Michel P, et al. Localization and photoaffinity labellling of the levetiracetam binding sit in rat brain and certain cell lines. Eur J Pharmacol 2003;478:11-19.
2. Lambeng L, Gillard M, Vertogen P, et al. Characterization of [(3)H]ucb 30889 binding to synaptic vesicle protein 2A in the rat spinal cord. Eur J Pharmacol 2005;520:70-6.
3. Niespodziany I, Klitgaard H, Margineanu DG. Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices. Neuroreport 2003;14:1273-6.
4. Archer DP, Roth SH. Pharmacodynamics of thiopentone: nocifensive reflex threshold changes correlate with hippocampal electroencephalography. Br J Anaesth 1997;79:744-9.
5. Ardid D, Lamberty Y, Alloui A, et al. Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats. Eur J Pharmacol 2003;473:27-33.
6. Jordt SE, McKemy DD, Julius D. Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol 2003;13:487-92.
7. Wang B, Samanani N, Roth SH, Archer DP. Spinal carbonic anhydrase contributes to nociceptive reflex enhancement by midazolam, pentobarbital and propofol. Anesthesiology 2003;98:921-7.
8. Ewen A, Archer DP, Samanani N, Roth SH. Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. Can J Anaesth 1995;42:532-40.
9. Doheny HC, Ratnaraj N, Whittington MA, et al. Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (UCB L059) in the rat. Epilepsy Res 1999;34:161-8.
10. Shannon HE, Eberle EL, Peters SC. Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats. Neuropharmacology 2005;48:1012-20.
11. Arora MV, Carson IW, Dundee JW. Alterations in response to somatic pain associated with anaesthesia. XXI. Althesin (CT1341). Br J Anaesth 1972;44:590-2.
12. Dundee JW, Moore J. Alterations in response to somatic pain associated with anaesthesia. II. The effect of thiopentone and pentobarbitone. Br J Anaesth 1960;32:407-14.
13. Dundee JW, Moore J. Alterations in response to somatic pain associated with anaesthesia. IV. The effect of subanaesthetic concentrations of inhalation agents. Br J Anaesth 1960;32:453-9.
14. Briggs LP, Dundee JW, Bahar M, Clarke RS. Comparison of the effects of diisopropyl phenol (ICI 35868) and thiopentone on response to somatic pain. Br J Anaesth 1982;54:307-11.
15. Anker-Moller E, Spangsberg N, Arendt-Nielsen L, et al. Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally induced acute pain. Br J Anaesth 1991;66:185-8.
16. Archer DP, Ewen A, Roth SH, Samanani N. Plasma, brain, and spinal cord concentrations of thiopental associated with hyperalgesia in the rat. Anesthesiology 1994;80:168-76.
17. Zhang Y, Eger EI II, Dutton RC, Sonner JM. Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. Anesth Analg 2000;91:462-6.
18. Archer DP, Samanani N, Roth SH. Pentobarbital induces nocifensive hyperreflexia, not hyperalgesia in rats. Can J Anaesth 2000;47:687-92.
19. Archer DP, Samanani N, Roth SH. Nocifensive reflex thresholds in rats: measures of central nervous system effects of barbiturates. Can J Anaesth 1997;44:765-74.
20. Guedel AE. Inhalation anesthesia. New York: Macmillan, 1951:10-15.
21. Stanski DR. Pharmacodynamic modeling of anesthetic EEG drug effects. Annu Rev Pharmacol Toxicol 1992;32:423-7.
22. Archer DP, Samanani N, Roth SH. Small-dose pentobarbital enhances synaptic transmission in rat hippocampus. Anesth Analg 2001;93:1521-5.
23. Stein V, Nicoll RA. GABA generates excitement. Neuron 2003;37:375-8.
24. Klitgaard H, Matagne A, Gobert J, Wulfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur J Pharmacol 1998;473:191-206.