Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents

Seizure

Volumn 10, Issue 4, 2001, Pages 279-286

  Zona, Cristina ^a   Niespodziany, Isabelle ^b   Marchetti, Caterina ^a   Klitgaard, Henrik ^b   Bernardi, Giorgio ^a   Margineanu, Doru Georg ^b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UCB PHARMA   (Belgium)

Author keywords

Antiepileptic drugs; Levetiracetam; Low voltage gated calcium current; Rat; Sodium current

Indexed keywords

ANTICONVULSIVE AGENT; CALCIUM CHANNEL T TYPE; CALCIUM ION; ETIRACETAM; SODIUM CHANNEL; SODIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN SLICE; CALCIUM CURRENT; CELL CULTURE; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; HIPPOCAMPUS; KINETICS; NEOCORTEX; NERVE CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SODIUM CURRENT; STEADY STATE; VOLTAGE CLAMP;

EID: 0034883899     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1053/seiz.2000.0504     Document Type: Article

References (31)

1. Profile of ucb L059, a novel anti-convulsant drug, in models of partial and generalized epilepsy in mice and rats
2. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy
3. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
4. Levetiracetam
5. The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes
6. Levetiracetam (ucb L059) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission
7. Inhibition of neuronal hyper-synchrony in vitro differentiates levetiracetam from classical antiepileptic drugs
8. Review of the mechanisms of action of antiepileptic drugs
9. Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture
10. Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture
11. Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells
12. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons
13. + channel in rat cortical neurons in culture
14. 2+ current in rat CA1 hippocampal neurons
15. Pharmacokinetic profile of levetiracetam: Toward ideal characteristics
16. Riluzole interacts with voltage-activated sodium and potassium currents in cultured rat cortical neurons
17. Characterization of a phenytoin-resistant mouse seizure model
18. Only certain antiepileptic drugs prevent seizures induced by pilocarpine
19. Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy
20. ucb L059, a novel anti-convulsant drug: Pharmacological profile in animals
21. The binding of the anticonvulsant levetiracetam to rat brain membranes distinguishes a novel site relevant to antiepileptic drug activity
22. A receptor-associated epileptiform effect of bicuculline in rat hippocampus
23. On the action of the anti-absence drug ethosuximide in the rat and cat thalamus
24. The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata
25. The basal ganglia, the deep piriform cortex, and seizure spread: Bicuculline is anticonvulsant in the rat striatum
26. Progression and generalization of seizure discharge: Anatomical and neurochemical substrates
27. Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain
28. Levetiracetam fails to influence GABA transport and metabolism in rat astrocyte culture
29. 2+ current in CA1 pyramidal neurons of rat hippocampal slices
30. Levetiracetam: Novel modulation of ionotropic inhibitory receptors
31. Levetiracetam: No relevant effect on ionotropic excitatory glutamate receptors