Sodium valproate in the management of painful neuropathy in type 2 diabetes - A randomized placebo controlled study

Acta Neurologica Scandinavica

Volumn 106, Issue 5, 2002, Pages 248-252

  Kochar, D K ^a,b   Jain, N ^a   Agarwal, R P ^a   Srivastava, T ^a   Agarwal, P ^a   Gupta, S ^a  

^a S P MEDICAL COLLEGE   (India)

^b C 54 Sadul Ganj   (India)

Author keywords

Glycemic control; Painful neuropathy; Sodium valproate

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; PLACEBO; VALPROIC ACID;

ADULT; AGED; ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ELECTROPHYSIOLOGY; FEMALE; HOFFMANN REFLEX; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR NERVE CONDUCTION; NEUROPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; SENSORY NERVE CONDUCTION;

ADULT; AGED; ANTICONVULSANTS; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; DOUBLE-BLIND METHOD; ELECTROPHYSIOLOGY; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR NEURONS; NEURONS, AFFERENT; PAIN; PAIN MEASUREMENT; TIME FACTORS; VALPROIC ACID;

EID: 0036838156     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0404.2002.01229.x     Document Type: Article

References (15)

1. Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973. Diabetes Care 1978;1:168-88.
2. Partanen J, Niskanen L, Lehtinen J et al. Natural history of peripheral neuropathy in patients with non-insulin dependent diabetes mellitus. N Eng J Med 1995;333:89-94.
3. Fedele D, Comi G, Coscelli C et al. A multicentre study on the prevalence of diabetic neuropathy in Italy. Diabetes Care 1997;20:836-43.
4. Benbow S, MacFarlane IA, William G. Painful diabetic neuropathy and its relationships to other painful neuroenic conditions. Pract Diabetes 1992;9:62-5.
5. Boulton AJM, Knight G, Drury J et al. The prevalence of symptomatic, diabetic neuropathy in an insulin treated population. Diabetes Care 1985;8:125-8.
6. Melzach R. The short form McGill Pain Questionnaire. Pain 1987;30:191-7.
7. Dorfman LJ, Cummins KL, Reaven GM, Ceranski J, Greenfield MS, Doberne L. Studies of diabetic polyneuropathy using conduction velocity distribution (DCV) analysis. Neurology 1983;33:773-9.
8. Lachman T, Shahani BT, Yung RR. Late responses as aids in the diagnosis in peripheral neuropathy. J Neurol Neurosurg Psychiatry 1980;43:156-62.
9. Noel P. Diabetic neuropathy. In: Desmedt JE, ed. New developments in electromyography and clinical neurophysiology, Vol. 2. Basal: S Karger, 1973;318-32.
10. Shahani BT, Sumner AJ. Electrophysiological studies in peripheralneuropathy. Early detection and monitoring. In: Stalberg E, Young R, eds. Clinical neurophysiology. London: Butterworths, 1981;117-44.
11. Shahani BT, Young RR. Studies of reflex activity from a clinical viewpoint. In: Aminoff MJ, ed. Electrodiagnosis in clinical neurology. London: Churchill Livingstone, 1980;290-304.
12. Boulton AJM, Levin S, Comstock J. A multicentre trial of the aldose reductase inhibitor tolerastat in patients with symptomatic neuropathy. Diabetologia 1990;33:431.
13. Moore A. Anticonvulsant drugs for management of pain: a systemic review. BMJ 1995;311:1047-52.
14. Backonja M, Beydown A, Edwards KR et al. Gabapentine for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus. J Am Med Assoc 1998;280:1831-6.
15. Eisenberg E, Alon N, Ishay A et al. Lamotrigine in the treatment of diabetic painful neuropathy. Eur J Neurol. 1988;5:167-73.