Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra®) in treatment of patients with trigeminal neuralgia

European Journal of Neurology

Volumn 16, Issue 6, 2009, Pages 740-744

  Jorns, T P ^a,b   Johnston, A ^b   Zakrzewska, J M ^c  

^a KHON KAEN UNIVERSITY   (Thailand)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antineuralgic; Levetiracetam; Side effect; Tolerability; Trigeminal neuralgia

Indexed keywords

ANTICONVULSIVE AGENT; ETIRACETAM; LAMOTRIGINE; OXCABARZEPINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DROWSINESS; DRUG BLOOD LEVEL; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; FATIGUE; FEMALE; HUMAN; MALE; PAIN; PILOT STUDY; PRIORITY JOURNAL; QUESTIONNAIRE; RECOMMENDED DRUG DOSE; SCORING SYSTEM; TREATMENT OUTCOME; TRIGEMINUS NEURALGIA; VISUAL ANALOG SCALE;

AGED; AGED, 80 AND OVER; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE; DRUG TOXICITY; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PATIENT SATISFACTION; PILOT PROJECTS; PIRACETAM; PROSPECTIVE STUDIES; TREATMENT OUTCOME; TRIGEMINAL NEURALGIA;

EID: 65449130768     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02585.x     Document Type: Article

References (15)

1. McQuay H, Carroll D, Jadad AR, Wiffen P, Moore A. Anticonvulsant drugs for management of pain: a systematic review. BMJ 1995 311 : 1047 1052.
2. Jorns TP, Zakrzewska JM. Evidence-based approach to the medical management of trigeminal neuralgia. Br J Neurosurg 2007 21 : 253 261. (Pubitemid 47035249)
3. Lukyanetz EA, Shkryl VM, Kostyuk PG. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia 2002 43 : 9 18. (Pubitemid 34215447)
4. Hovinga CA. Levetiracetam: a novel antiepileptic drug. Pharmacotherapy 2001 21 : 1375 1388. (Pubitemid 33051250)
5. Patsalos PN. The pharmacokinetic characteristics of levetiracetam. Methods Find Exp Clin Pharmacol 2003 25 : 123 129. (Pubitemid 36406972)
6. Patsalos PN. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol Ther 2000 85 : 77 85. (Pubitemid 30069478)
7. Brockmoller J, Thomsen T, Wittstock M, Coupez R, Lochs H, Roots I. Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): characterization by dynamic liver function tests. Clin Pharmacol Ther 2005 77 : 529 541. (Pubitemid 40824966)
8. Zakrzewska JM. Consumer views on management of trigeminal neuralgia. Headache 2001 41 : 369 376. (Pubitemid 33728583)
9. Loscher W, Honack D, Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther 1998 284 : 474 479. (Pubitemid 28086631)
10. Edwards KR, O'Connor JT, Button J. Levetiracetam for the treatment of trigeminal neuralgia. Epilepsia 2004 45 (Suppl. 7 306.
11. Rowbotham MC, Manville NS, Ren J. Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia. Neurology 2003 61 : 866 867. (Pubitemid 37174499)
12. Anonymous. The International Classification of Headache Disorders: Second edition. Cephalalgia 2004 24 (Suppl 1 9 160.
13. Melzack R, Terrence C, Fromm G, Amsel R. Trigeminal neuralgia and atypical facial pain: use of the McGill Pain Questionnaire for discrimination and diagnosis. Pain 1986 27 : 297 302. (Pubitemid 17226871)
14. Turp JC, Kowalski CJ, Stohler CS. Pain descriptors characteristic of persistent facial pain. J Orofac Pain 1997 11 : 285 290. (Pubitemid 127711493)
15. Katz N. Methodological issues in clinical trials of opioids for chronic pain. Neurology 2005 65 : S32 S49. (Pubitemid 43755490)