Preemptive levetiracetam decreases postoperative pain in rats

Neuroendocrinology Letters

Volumn 29, Issue 6, 2008, Pages 953-957

  Sliva, Jiri ^a   Dolezal, Tomas ^a   Prochazkova, Michaela ^a   Votava, Martin ^a   Krsiak, Miloslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Anticonvulsants; Gabapentin; Levetiracetam; Morphine; Postoperative pain; Preemptive analgesia

Indexed keywords

ETIRACETAM; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HYPERALGESIA; MALE; NONHUMAN; PAIN THRESHOLD; POSTOPERATIVE PAIN; RAT; STIMULUS RESPONSE; THERMAL STIMULATION;

EID: 59849091831     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Al Mujadi H, Refai AR, Katzarov MG, Dehrab NA, Batra YK, Al Qattan AR (2006). Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie. 53: 268-273.
2. Archer DP, Lamberty Y, Wang B, Davis MJ, Samanani N, Roth SH (2007). Levetiracetarn reduces anesthetic-induced hyperalgesia in rats. Anesthesia and Analgesia. 104: 180-185.
3. Ardid D, Lamberty Y, Alloui A, Coudore-Civiale MA, Klitgaard H, Eschalier A (2003). Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats. European Journal of Pharmacology. 473: 27-33.
4. Beilin B, Bessler H, Mayburd E, Smirnov G, Dekel A, Yardeni I, Shavit Y (2003). Effects of preemptive analgesia on pain and cytokine production in the postoperative period. Anesthesiology. 98: 151-155.
5. Beyreuther B, Callizot N, Stohr T (2006). Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy. European Journal of Pharmacology. 539: 64-70.
6. Brennan TJ, Vandermeulen EP, Gebhart GF (1996). Characterization of a rat model of incisional pain. Pain. 64: 493-501.
7. Carreno M (2007). Levetiracetam. Drugs of Today. 43: 769-794.
8. Enggaard TP, Klitgaard NA, Sindrup SH (2006). Specific effect of levetiracetam in experimental human pain models. European Journal of Pain. 10: 193-198.
9. Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988). A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia. Pain. 32: 77-88.
10. Hurley RW, Cohen SP, Williams KA, Rowlingson AJ, Wu CL (2006). The analgesic effects of perioperative gabapentin on postoperative pain: A meta-analysis. Regional Anesthesia and Pain Medicine. 31: 237-247.
11. Klitgaard H, Matagne A, Gobert J, Wulfert E (1998). Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. European Journal of Pharmacology. 353: 191-206.
12. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (2004). The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proceedings of the National Academy of Sciences of the United States of America. 101: 9861-9866.
13. Mcquay HJ, Poon KH, Derry S, Moore RA (2008). Acute pain: combination treatments and how we measure their efficacy. British Journal of Anaesthesia. 101: 69-76.
14. Moiniche S, Kehlet H, Dahl JB (2002). A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief - The role of timing of analgesia. Anesthesiology. 96: 725-741.
15. Ong KS, Seymour RA, Yeo JF, Ho KH, Lirk P (2005). The efficacy of preoperative versus postoperative rofecoxib for preventing acute postoperative dental pain - A prospective randomized crossover study using bilateral symmetrical oral surgery. Clinical Journal of Pain. 21: 536-542.
16. Prabhakar H, Arora R, Bithal PK, Rath GP, Dash HH (2007). The analgesic effects of preemptive gabapentin in patients undergoing surgery for brachial plexus injury - A preliminary study. Journal of Neurosurgical Anesthesiology. 19: 235-238.
17. Price MJ (2004). Levetiracetam in the treatment of neuropathic pain: Three case studies. Clinical Journal of Pain. 20: 33-36.
18. Tiippana EM, Hamunen K, Kontinen VK, Kalso E (2007). Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesthesia and Analgesia. 104: 1545-1556.
19. Van Elstraete AC, Tirault M, Lebrun T, Sandefo I, Bernard JC, Polin B, Vally P, Mazoit JX (2008). The median effective dose of preemptive gabapentin on postoperative morphine consumption after posterior lumbar spinal fusion. Anesthesia and Analgesia. 106: 305-308.
20. Wiffen P, Collins S, Mcquay H, Carroll D, Jadad A, Moore A (2005). Anticonvulsant drugs for acute and chronic pain. Cochrane Data-base of Systematic Reviews.
21. Woolf CJ (1983). Evidence for A Central Component of Post-Injury Pain Hypersensitivity. Nature. 306: 686-688.
22. Xie WR, Strong JA, Meij JTA, Zhang JM, Yu L (2005). Neuropathic pain: Early spontaneous afferent activity is the trigger. Pain. 116: 243-256.
23. Zimmermann M (1983). Ethical Guidelines for Investigations of Experimental Pain in Conscious Animals. Pain. 16: 109-110.