Effects of chronic central leptin infusion on proopiomelanocortin and neurotensin gene expression in the rat hypothalamus

Neuroscience Letters

Volumn 440, Issue 2, 2008, Pages 125-129

  Sahu, Abhiram ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Hypothalamus; Leptin; Leptin resistance; NT; POMC

Indexed keywords

LEPTIN; MESSENGER RNA; NEUROTENSIN; PEPTIDE HORMONE; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; HYPOTHALAMUS; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APPETITE REGULATION; BODY WEIGHT; EATING; GENE EXPRESSION; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; NEURONS; NEUROTENSIN; NUCLEASE PROTECTION ASSAYS; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS;

EID: 45449097234     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.083     Document Type: Article

References (49)

1. Bai Y., Zhang S., Kim K.S., Lee J.K., and Kim K.H. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J. Biol. Chem. 271 (1996) 13939-13942
2. Banks W.A. Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr. Pharm. Des. 7 (2001) 125-133
3. Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., Banks A.S., Lavery H.J., Haq A.K., Maratos-Flier E., Neel B.G., Schwartz M.W., and Myers Jr. M.G. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 (2003) 856-859
4. Bjorbak C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., and Myers Jr. M.G. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275 (2000) 40649-40657
5. Bluher S., Ziotopoulou M., Bullen Jr. J.W., Moschos S.J., Ungsunan L., Kokkotou E., Maratos-Flier E., and Mantzoros C.S. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes 53 (2004) 82-90
6. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H., Lynn R.B., Zhang P.L., Sinha M.K., and Considine R.V. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348 (1996) 159-161
7. Cone R.D. The central melanocortin system and energy homeostasis. Trends Endocrinol. Metab. 10 (1999) 211-216
8. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., and Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334 (1996) 292-295
9. Elias C.F., Aschkenasi C., Lee C., Kelly J., Ahima R.S., Bjorbaek C., Flier J.S., Saper C.B., and Elmquist J.K. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23 (1999) 775-786
10. Enriori P.J., Evans A.E., Sinnayah P., Jobst E.E., Tonelli-Lemos L., Billes S.K., Glavas M.M., Grayson B.E., Perello M., Nillni E.A., Grove K.L., and Cowley M.A. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab. 5 (2007) 181-194
11. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
12. Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., and Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 8878-8883
13. Heymsfield S.B., Greenberg A.S., Fujioka K., Dixon R.M., Kushner R., Hunt T., Lubina J.A., Patane J., Self B., Hunt P., and McCamish M. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282 (1999) 1568-1575
14. Howard J.K., Cave B.J., Oksanen L.J., Tzameli I., Bjorbaek C., and Flier J.S. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat. Med. 10 (2004) 734-738
15. Hubschle T., Thom E., Watson A., Roth J., Klaus S., and Meyerhof W. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J. Neurosci. 21 (2001) 2413-2424
16. Jakubowski M., and Roberts J.L. Multiplex solution hybridization-ribonuclease protection assay for quantification of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J. Neuroendocrinol. 4 (1992) 79-89
17. Kahn D., Abrams G.M., Zimmerman E.A., Carraway R., and Leeman S.E. Neurotensin neurons in the rat hypothalamus: an immunocytochemical study. Endocrinology 107 (1980) 47-54
18. Kislauskis E., Bullock B., McNeil S., and Dobner P.R. The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. J. Biol. Chem. 263 (1988) 4963-4968
19. Krebs D.L., and Hilton D.J. SOCS: physiological suppressors of cytokine signalling. J. Cell Sci. 113 Pt 16 (2000) 2813-2819
20. Levin B.E., and Dunn-Meynell A.A. Reduced central leptin sensitivity in rats with diet-induced obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283 (2002) R941-948
21. Levine A.S., Kneip J., Grace M., and Morley J.E. Effect of centrally administered neurotensin on multiple feeding paradigms. Pharmacol. Biochem. Behav. 18 (1983) 19-23
22. Lin S., Thomas T.C., Storlien L.H., and Huang X.F. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int. J. Obes. Relat. Metab. Disord. 24 (2000) 639-646
23. Luttinger D., King R.A., Sheppard D., Strupp J., Nemeroff C.B., and Prange Jr. A.J. The effect of neurotensin on food consumption in the rat. Eur. J. Pharmacol. 81 (1982) 499-503
24. Mori H., Hanada R., Hanada T., Aki D., Mashima R., Nishinakamura H., Torisu T., Chien K.R., Yasukawa H., and Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat. Med. 10 (2004) 739-743
25. Munzberg H., Flier J.S., and Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145 (2004) 4880-4889
26. Munzberg H., Huo L., Nillni E.A., Hollenberg A.N., and Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144 (2003) 2121-2131
27. Niswender K.D., Morton G.J., Stearns W.H., Rhodes C.J., Myers Jr. M.G., and Schwartz M.W. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413 (2001) 794-795
28. Ogawa Y., Masuzaki H., Hosoda K., Aizawa-Abe M., Suga J., Suda M., Ebihara K., Iwai H., Matsuoka N., Satoh N., Odaka H., Kasuga H., Fujisawa Y., Inoue G., Nishimura H., Yoshimasa Y., and Nakao K. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 48 (1999) 1822-1829
29. Ohinata K., Shimano T., Yamauchi R., Sakurada S., Yanai K., and Yoshikawa M. The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice. Peptides 25 (2004) 2135-2138
30. Pal R., and Sahu A. Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 144 (2003) 3789-3798
31. Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 139 (1998) 795-798
32. Sahu A. Quantification of NPY mRNA by ribonuclease protection assay. Methods Mol. Biol. 153 (2000) 219-230
33. Sahu A., Carraway R.E., and Wang Y.P. Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res. 888 (2001) 343-347
34. Sahu A. Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones. J. Neuroendocrinol. 14 (2002) 796-804
35. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol. 24 (2003) 225-253
36. Sahu A., and Metlakunta A.S. Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion. J. Neuroendocrinol. 17 (2005) 720-726
37. A. Sahu, A.R. Metlakunta, M. Sahu, Suppressor of cytokine signaling-3 interacts with the phosphatidylinositol 3-kinase pathway of leptin signaling in the hypothalamus. Program No. 60.10. 2006 Neuroscience Meeting Planner, Atlanta, GA, Society for Neuroscience, 2006 (Online).
38. Scarpace P.J., Matheny M., Zolotukhin S., Tumer N., and Zhang Y. Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology 45 (2003) 211-219
39. Schwartz M.W., Peskind E., Raskind M., Boyko E.J., and Porte Jr. D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2 (1996) 589-593
40. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
41. Stanley B.G., Hoebel B.G., and Leibowitz S.F. Neurotensin: effects of hypothalamic and intravenous injections on eating and drinking in rats. Peptides 4 (1983) 493-500
42. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272 (1997) 6093-6096
43. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J. Clin. Pathol. 22 (1969) 158-161
44. Van Heek M., Compton D.S., France C.F., Tedesco R.P., Fawzi A.B., Graziano M.P., Sybertz E.J., Strader C.D., and Davis Jr. H.R. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J. Clin. Invest. 99 (1997) 385-390
45. Wang M.Y., Lee Y., and Unger R.H. Novel form of lipolysis induced by leptin. J. Biol. Chem. 274 (1999) 17541-17544
46. Wang Z.W., Zhou Y.T., Lee Y., Higa M., Kalra S.P., and Unger R.H. Hyperleptinemia depletes fat from denervated fat tissue. Biochem. Biophys. Res. Commun. 260 (1999) 653-657
47. Widdowson P.S., Upton R., Buckingham R., Arch J., and Williams G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 46 (1997) 1782-1785
48. Zhao A.Z., Huan J.N., Gupta S., Pal R., and Sahu A. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat. Neurosci. 5 (2002) 727-728
49. Ziotopoulou M., Mantzoros C.S., Hileman S.M., and Flier J.S. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E838-845