메뉴 건너뛰기




Volumn 11, Issue 5, 2011, Pages 391-400

Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia

Author keywords

Atherosclerosis; Cyp; Dementia; Diabetes; Endoplasmic reticulum; Gene activation; HDL; LXR

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ABC TRANSPORTER; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; APOLIPOPROTEIN; APOLIPOPROTEIN A1; ARYLBUTYRIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRIC ACID DERIVATIVE; GLITAZONE DERIVATIVE; GLUCOKINASE; GW 4046; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIVER ENZYME; LIVER X RECEPTOR AGONIST; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; NICOTINIC ACID; PHENOBARBITAL; PHENYTOIN; PHOSPHOLIPID; RESIN; RIFAMPICIN; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT;

EID: 79959302999     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652411795976556     Document Type: Review
Times cited : (7)

References (102)
  • 1
    • 0037167664 scopus 로고    scopus 로고
    • The international burden of cardiovascular disease: Responding to the emerging global epidemic
    • Bonow RO, Smaha LA, Smith SC Jr, Mensah GA, Lenfant C. The international burden of cardiovascular disease: responding to the emerging global epidemic. Circulation 2002; 106: 1602-5.
    • (2002) Circulation , vol.106 , pp. 1602-1605
    • Bonow, R.O.1    Smaha, L.A.2    Smith Jr., S.C.3    Mensah, G.A.4    Lenfant, C.5
  • 2
    • 77956842715 scopus 로고    scopus 로고
    • Overcoming challenges in type 2 diabetes management to improve patient outcomes
    • Brown MT, LeRoith D. Overcoming challenges in type 2 diabetes management to improve patient outcomes. Expert Rev Endocrinol Metab 2010; 5: 741-51.
    • (2010) Expert Rev Endocrinol Metab , vol.5 , pp. 741-751
    • Brown, M.T.1    Leroith, D.2
  • 5
    • 50849119434 scopus 로고
    • Plasma high density lipoprotein and liver microsomal enzyme activity in man
    • Pilli-Sihvola AS, Laaksovirta T, Eds. Helsinki: The Academy of Finland
    • Luoma PV, Sotaniemi EA, Pelkonen RO, Ehnholm C. Plasma high density lipoprotein and liver microsomal enzyme activity in man. In: The Medical Research Council 1977-1979; Pilli-Sihvola AS, Laaksovirta T, Eds. Helsinki: The Academy of Finland 1980. p. 71.
    • (1980) The Medical Research Council 1977-1979 , pp. 71
    • Luoma, P.V.1    Sotaniemi, E.A.2    Pelkonen, R.O.3    Ehnholm, C.4
  • 6
    • 0030787747 scopus 로고    scopus 로고
    • Gene activation, apolipoprotein A-I/ high density lipoprotein, atherosclerosis prevention and longevity
    • Luoma PV. Gene activation, apolipoprotein A-I/ high density lipoprotein, atherosclerosis prevention and longevity. Pharmacol Toxicol 1997; 81: 57-64.
    • (1997) Pharmacol Toxicol , vol.81 , pp. 57-64
    • Luoma, P.V.1
  • 7
    • 0020640515 scopus 로고
    • Sutinen Sirkka. Treatment of noninsulin-dependent diabetes mellitus with enzyme inducers
    • Sotaniemi EA, Arranto AJ, Sutinen S, Stengård JH, Sutinen Sirkka. Treatment of noninsulin-dependent diabetes mellitus with enzyme inducers. Clin Pharmacol Ther 1983; 33: 826-835.
    • (1983) Clin Pharmacol Ther , vol.33 , pp. 826-835
    • Sotaniemi, E.A.1    Arranto, A.J.2    Sutinen, S.3    Stengård, J.H.4
  • 8
    • 0021850197 scopus 로고
    • Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects
    • Lahtela JT, Arranto AJ, Sotaniemi EA. Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects. Diabetes 1985; 34: 911-6.
    • (1985) Diabetes , vol.34 , pp. 911-916
    • Lahtela, J.T.1    Arranto, A.J.2    Sotaniemi, E.A.3
  • 9
    • 34547531201 scopus 로고    scopus 로고
    • Attenuation of neuroinflam-mation and Alzheimer's disease pathology by liver X receptors
    • Zelcer N, Khanlou N, Clare R, et al. Attenuation of neuroinflam-mation and Alzheimer's disease pathology by liver X receptors. PNAS 2007; 104: 10601-6.
    • (2007) PNAS , vol.104 , pp. 10601-10606
    • Zelcer, N.1    Khanlou, N.2    Clare, R.3
  • 10
    • 77953258151 scopus 로고    scopus 로고
    • The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration
    • Koldamova R, Fitz NF, Lefterov I. The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration. Biochim Biophys Acta 2010; 1801: 824-830.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 824-830
    • Koldamova, R.1    Fitz, N.F.2    Lefterov, I.3
  • 11
    • 77955870204 scopus 로고    scopus 로고
    • Designing prevention programmes to reduce of dementia: Prospective cohort study of modifiable risk factors
    • Ritchie K, Carrière I, Ritchie CW, et al. Designing prevention programmes to reduce of dementia: prospective cohort study of modifiable risk factors. BMJ 2010; 341: c3885.
    • (2010) BMJ , vol.341
    • Ritchie, K.1    Carrière, I.2    Ritchie, C.W.3
  • 12
    • 8044243063 scopus 로고
    • Enzyme induction, lipids and apolipoproteins
    • Sotaniemi EA, Pelkonen RO, Eds. London: Francis & Taylor
    • Luoma PV. Enzyme induction, lipids and apolipoproteins. In: Enzyme Induction in Man; Sotaniemi EA, Pelkonen RO, Eds. London: Francis & Taylor 1987; pp. 231-42.
    • (1987) Enzyme Induction in Man , pp. 231-242
    • Luoma, P.V.1
  • 14
    • 0014191919 scopus 로고
    • Die Induktion arzneimittelabbauender Enzyme im endoplasmatischen Retikulum der Leberzelle durch Pharmaka
    • Remmer H. Die Induktion arzneimittelabbauender Enzyme im endoplasmatischen Retikulum der Leberzelle durch Pharmaka. Dtsch Med Wochenschr 1967; 92: 2001-8.
    • (1967) Dtsch Med Wochenschr , vol.92 , pp. 2001-2008
    • Remmer, H.1
  • 15
    • 84994983355 scopus 로고
    • Further studies on the induction of the drughydroxylating enzyme system of liver microsomes
    • Orrenius S. Further studies on the induction of the drughydroxylating enzyme system of liver microsomes. J Cell Biol 1965; 26: 725-33.
    • (1965) J Cell Biol , vol.26 , pp. 725-733
    • Orrenius, S.1
  • 16
    • 0014125542 scopus 로고
    • Pharmacological implications of microsomal enzyme induction
    • Conney AH. Pharmacological implications of microsomal enzyme induction. Pharmacol Revs 1967; 19: 317-66.
    • (1967) Pharmacol Revs , vol.19 , pp. 317-366
    • Conney, A.H.1
  • 17
    • 0020559718 scopus 로고
    • Plasma high density lipoprotein and liver lipids and proteins in man. Relation to Hepatic Histology and Microsomal Enzyme Induction
    • Luoma PV, Savolainen MJ, Sotaniemi EA, Pelkonen RO, Arranto AJ, Ehnholm C. Plasma high density lipoprotein and liver lipids and proteins in man. Relation to hepatic histology and microsomal enzyme induction.Acta Med Scand 1983; 214: 103-9.
    • (1983) Acta Med Scand , vol.214 , pp. 103-109
    • Luoma, P.V.1    Savolainen, M.J.2    Sotaniemi, E.A.3    Pelkonen, R.O.4    Arranto, A.J.5    Ehnholm, C.6
  • 19
    • 0021833979 scopus 로고
    • Plasma HDL cholesterol and glucose in noninsulin- dependent diabetics related to liver lipids and micromal enzyme activity
    • Luoma PV, Savolainen MJ, Sotaniemi EA, Arranto AJ, Pelkonen RO. Plasma HDL cholesterol and glucose in noninsulin- dependent diabetics related to liver lipids and micromal enzyme activity. Acta Med Scand 1985; 217: 473-479.
    • (1985) Acta Med Scand , vol.217 , pp. 473-479
    • Luoma, P.V.1    Savolainen, M.J.2    Sotaniemi, E.A.3    Arranto, A.J.4    Pelkonen, R.O.5
  • 20
    • 0024469569 scopus 로고
    • Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non insulin dependent diabetes mellitus
    • Karvonen I, Stengård JH, Huupponen R, Stenbäck FG, Sotaniemi EA. Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non insulin dependent diabetes mellitus. Diabetes Res 1989; 10: 85-92.
    • (1989) Diabetes Res , vol.10 , pp. 85-92
    • Karvonen, I.1    Stengård, J.H.2    Huupponen, R.3    Stenbäck, F.G.4    Sotaniemi, E.A.5
  • 21
    • 33846208252 scopus 로고    scopus 로고
    • The nuclear receptor LXR is a glucose sensor
    • Mitro N, Mak PA, Vargas L, et al. The nuclear receptor LXR is a glucose sensor. Nature 2007; 445: 219-23.
    • (2007) Nature , vol.445 , pp. 219-223
    • Mitro, N.1    Mak, P.A.2    Vargas, L.3
  • 22
    • 84914591590 scopus 로고
    • On the relationship of liver glucose- 6 -phosphatase to the proliferation of endoplasmic reticulum in Phenobarbital induction
    • Orrenius S, Ericsson LE. On the relationship of liver glucose- 6 -phosphatase to the proliferation of endoplasmic reticulum in Phenobarbital induction. J Cell Biol 1966; 21: 243-256.
    • (1966) J Cell Biol , vol.21 , pp. 243-256
    • Orrenius, S.1    Ericsson, L.E.2
  • 24
    • 33748681287 scopus 로고    scopus 로고
    • Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
    • Kontush A, Chapman MJ. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Revs 2006; 58: 342-73.
    • (2006) Pharmacol Revs , vol.58 , pp. 342-373
    • Kontush, A.1    Chapman, M.J.2
  • 26
    • 77950021400 scopus 로고    scopus 로고
    • HDL superphospholipidation enhances key steps in reverse cholesterol transport
    • Tchoua U, Gillard BK, Pownall HJ. HDL superphospholipidation enhances key steps in reverse cholesterol transport. Atherosclerosis 2010; 209: 430-5.
    • (2010) Atherosclerosis , vol.209 , pp. 430-435
    • Tchoua, U.1    Gillard, B.K.2    Pownall, H.J.3
  • 27
    • 0037503924 scopus 로고    scopus 로고
    • Liver X receptor signaling pathways in cardiovascular disease
    • Tontonoz P, Mangelsdorf DJ. Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 2003; 17: 985-93.
    • (2003) Mol Endocrinol , vol.17 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 28
    • 36048984001 scopus 로고    scopus 로고
    • HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease
    • Brewer BH Jr. HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease. Curr Cardiol Rep 2007; 9: 486-92.
    • (2007) Curr Cardiol Rep , vol.9 , pp. 486-492
    • Brewer Jr., B.H.1
  • 31
    • 34547887264 scopus 로고    scopus 로고
    • Cytochrome P450 - physiological key factor against cholesterol accumulation and the atherosclerotic vascular process
    • Luoma PV. Cytochrome P450 - physiological key factor against cholesterol accumulation and the atherosclerotic vascular process. Ann Med 2007; 39: 359-70.
    • (2007) Ann Med , vol.39 , pp. 359-370
    • Luoma, P.V.1
  • 32
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross R. Atherosclerosis-an inflammatory disease. New Engl J Med 1999; 340: 115-26.
    • (1999) New Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 33
    • 2542460047 scopus 로고    scopus 로고
    • The oxidation hypothesis of atherogenesis; the role of oxidized phospholipids and HDL
    • Navab M, Ananthramaiah GM, Reddy ST, et al. The oxidation hypothesis of atherogenesis; the role of oxidized phospholipids and HDL. J Lipid Res 2004; 45: 993-1006.
    • (2004) J Lipid Res , vol.45 , pp. 993-1006
    • Navab, M.1    Ananthramaiah, G.M.2    Reddy, S.T.3
  • 35
    • 0031863735 scopus 로고    scopus 로고
    • Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A-I: Purification of the hydroperoxide-reducing proteins from human blood
    • Mashima R, Yamamoto Y, Yoshimura S. Reduction of phosphatidylcholine hydroperoxide by apolipoprotein A-I: purification of the hydroperoxide-reducing proteins from human blood. J Lipid Res 1998; 39: 1133-40.
    • (1998) J Lipid Res , vol.39 , pp. 1133-1140
    • Mashima, R.1    Yamamoto, Y.2    Yoshimura, S.3
  • 37
    • 0038311032 scopus 로고    scopus 로고
    • Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein
    • Bisoendial RJ, Hovingh K, Levels JHM, et al. Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein. Circulation 2003; 107: 2944-8.
    • (2003) Circulation , vol.107 , pp. 2944-2948
    • Bisoendial, R.J.1    Hovingh, K.2    Levels, J.H.M.3
  • 38
    • 0025312732 scopus 로고
    • High-density lipoprotein subfractions, apolipoproteins and antipyrine clearance in normal subjects
    • Luoma PV, Rautio A, Stengård J, Sotaniemi EA, Marniemi J. High-density lipoprotein subfractions, apolipoproteins and antipyrine clearance in normal subjects. Eur J Clin Pharmacol 1990; 38: 625-7.
    • (1990) Eur J Clin Pharmacol , vol.38 , pp. 625-627
    • Luoma, P.V.1    Rautio, A.2    Stengård, J.3    Sotaniemi, E.A.4    Marniemi, J.5
  • 39
    • 78649328225 scopus 로고    scopus 로고
    • Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism
    • Xiao L, Xie X, Zhai Y. Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism. Adv Drug Deliv Rev 2010; 62: 1316-21.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 1316-1321
    • Xiao, L.1    Xie, X.2    Zhai, Y.3
  • 40
    • 0021017278 scopus 로고
    • Serum LDL cholesterol, the LDL/HDL cholesterol ratio and liver microsomal enzyme induction evaluated by antipyrine kinetics
    • Luoma PV, Sotaniemi EA, Arranto AJ. Serum LDL cholesterol, the LDL/HDL cholesterol ratio and liver microsomal enzyme induction evaluated by antipyrine kinetics. Scand J Clin Lab Invest 1983; 43: 671-5.
    • (1983) Scand J Clin Lab Invest , vol.43 , pp. 671-675
    • Luoma, P.V.1    Sotaniemi, E.A.2    Arranto, A.J.3
  • 44
    • 38349092277 scopus 로고    scopus 로고
    • Hepatic CTP:Phosphocholine cytidylyltransferase-?? is a critical predictor of plasma high density lipoprotein and very low density lipoprotein
    • Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE. Hepatic CTP:phosphocholine cytidylyltransferase-?? is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. J Biol Chem 2008; 283: 2143-55.
    • (2008) J Biol Chem , vol.283 , pp. 2143-2155
    • Jacobs, R.L.1    Lingrell, S.2    Zhao, Y.3    Francis, G.A.4    Vance, D.E.5
  • 45
    • 59849107063 scopus 로고    scopus 로고
    • Ridgway ND.Oxysterol activation of phosphatidylcholine synthesis involves CTP:Phosphocholine cytidylyltransferase α translocation to the nucleus
    • Gehrig K, Lagace TA, Ridgway ND.Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase α translocation to the nucleus. Biochem J 2009; 418: 209-17.
    • (2009) Biochem J , vol.418 , pp. 209-217
    • Gehrig, K.1    Lagace, T.A.2
  • 46
    • 44349119733 scopus 로고    scopus 로고
    • HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid- rich HDL2b particles
    • Mäkelä SM, Jauhiainen M, Ala-Korpela M, et al. HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid- rich HDL2b particles. Alcoholism: Clin Exper Res 2008; 32: 991-1000.
    • (2008) Alcoholism: Clin Exper Res , vol.32 , pp. 991-1000
    • Mäkelä, S.M.1    Jauhiainen, M.2    Ala-Korpela, M.3
  • 47
    • 33646593221 scopus 로고    scopus 로고
    • ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I
    • Gelissen IC, Harris M, Rye KA, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler Thromb Vasc Biol 2006; 26: 534-40.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 534-540
    • Gelissen, I.C.1    Harris, M.2    Rye, K.A.3
  • 48
    • 0034763557 scopus 로고    scopus 로고
    • Intravenous apoAI/ lecithin discs increase pre-??-HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans
    • Nanjee MN, Cooke CJ, Garvin R, et al. Intravenous apoAI/ lecithin discs increase pre-??-HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans. J Lipid Res 2001; 42: 1586-93.
    • (2001) J Lipid Res , vol.42 , pp. 1586-1593
    • Nanjee, M.N.1    Cooke, C.J.2    Garvin, R.3
  • 49
    • 0343825199 scopus 로고    scopus 로고
    • Serum levels of highdensity lipoprotein phospholipids correlate with severity of angiographically defined coronary disease
    • Hsia SL, Duncan R, Schob AH, et al. Serum levels of highdensity lipoprotein phospholipids correlate with severity of angiographically defined coronary disease. Atherosclerosis 2000; 152: 469-73.
    • (2000) Atherosclerosis , vol.152 , pp. 469-473
    • Hsia, S.L.1    Duncan, R.2    Schob, A.H.3
  • 50
    • 77955036273 scopus 로고    scopus 로고
    • Gene activation regresses atherosclerosis, promotes health, and enhances longevity
    • Luoma PV. Gene activation regresses atherosclerosis, promotes health, and enhances longevity. Lipids in Health and Disease 2010; 9: 67.
    • (2010) Lipids in Health and Disease , vol.9 , pp. 67
    • Luoma, P.V.1
  • 51
    • 69849112228 scopus 로고    scopus 로고
    • Interrelationships among HDL metabolism, aging, and atherosclerosis
    • Walter M. Interrelationships among HDL metabolism, aging, and atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29: 1244-50.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1244-1250
    • Walter, M.1
  • 52
    • 16644369819 scopus 로고    scopus 로고
    • Aging and HDL metabolism in elderly people more than 100 years old
    • Arai Y, Hirose N. Aging and HDL metabolism in elderly people more than 100 years old. J Atheroscler Thromb 2004; 11: 246-52.
    • (2004) J Atheroscler Thromb , vol.11 , pp. 246-252
    • Arai, Y.1    Hirose, N.2
  • 54
    • 0022545407 scopus 로고
    • Insulinmediated glucose metabolism is related to liver structure and microsomal function
    • Lahtela JT, Arranto AJ, Stenbäck F, Sotaniemi EA. Insulinmediated glucose metabolism is related to liver structure and microsomal function. Scand J Gastroent 1986; 21: 737-43.
    • (1986) Scand J Gastroent , vol.21 , pp. 737-743
    • Lahtela, J.T.1    Arranto, A.J.2    Stenbäck, F.3    Sotaniemi, E.A.4
  • 55
    • 0037965630 scopus 로고    scopus 로고
    • Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
    • Laffitte BA, Mangelsdorf DJ, Tontonoz P. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. PNAS 2003; 100: 5419-24.
    • (2003) PNAS , vol.100 , pp. 5419-5424
    • Laffitte, B.A.1    Mangelsdorf, D.J.2    Tontonoz, P.3
  • 56
    • 67649682161 scopus 로고    scopus 로고
    • Adiposity, type 2 diabetes and Alzheimer's disease
    • Luchsinger JA, Gustafson DR. Adiposity, type 2 diabetes and Alzheimer's disease. J Alzheimers Dis 2009; 16: 693-704.
    • (2009) J Alzheimers Dis , vol.16 , pp. 693-704
    • Luchsinger, J.A.1    Gustafson, D.R.2
  • 57
    • 77953259435 scopus 로고    scopus 로고
    • Lipids and Alzheimer's disease
    • Garner B. Lipids and Alzheimer's disease. Biochim Biophys Acta 2010; 1801; 747-9.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 747-749
    • Garner, B.1
  • 59
    • 0037108819 scopus 로고    scopus 로고
    • Lipid X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration
    • Wang I, Schuster GU, Hultenby K, Zhang Q, Andersson S, Gustafsson JA. Lipid X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. PNAS 2002; 99: 13878-83.
    • (2002) PNAS , vol.99 , pp. 13878-83
    • Wang, I.1    Schuster, G.U.2    Hultenby, K.3    Zhang, Q.4    Andersson, S.5    Gustafsson, J.A.6
  • 61
    • 69149109381 scopus 로고    scopus 로고
    • Greasing the wheels of Aβ clearance in Alzheimer's disease: The role of lipids and apolipoprotein E
    • Fan J, Donkin J, Wellington C. Greasing the wheels of Aβ clearance in Alzheimer's disease: The role of lipids and apolipoprotein E. Biofactors 2009; 35: 239-48.
    • (2009) Biofactors , vol.35 , pp. 239-248
    • Fan, J.1    Donkin, J.2    Wellington, C.3
  • 62
    • 77951078680 scopus 로고    scopus 로고
    • Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-?? in a mouse model of Alzheimer's disease
    • Hartz AMS, Miller DS, Bauer B. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-?? in a mouse model of Alzheimer's disease. Mol Pharmacol 2010; 77: 715-23.
    • (2010) Mol Pharmacol , vol.77 , pp. 715-723
    • Hartz, A.M.S.1    Miller, D.S.2    Bauer, B.3
  • 65
    • 62449142597 scopus 로고    scopus 로고
    • The role of metabolic disorders in Alzheimer disease and vascular dementia
    • Craft S. The role of metabolic disorders in Alzheimer disease and vascular dementia. Arch Neurol 2009; 66: 300-5.
    • (2009) Arch Neurol , vol.66 , pp. 300-305
    • Craft, S.1
  • 66
    • 33751096969 scopus 로고    scopus 로고
    • Crossing the barrier: Oxysterols as cholesterol transporters and metabolic modulators in the brain
    • Björkhem I. Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J Intern Med 2006; 260: 493-508.
    • (2006) J Intern Med , vol.260 , pp. 493-508
    • Björkhem, I.1
  • 67
    • 0037227538 scopus 로고    scopus 로고
    • Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with intronic CYP46 polymorphism
    • Papassotiropoulos A, Streffer JR, Tsolaki M, et al. Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with intronic CYP46 polymorphism. Arch Neurol 2003; 60: 29-35.
    • (2003) Arch Neurol , vol.60 , pp. 29-35
    • Papassotiropoulos, A.1    Streffer, J.R.2    Tsolaki, M.3
  • 68
    • 77950525966 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and atherosclerosis
    • Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nature Med 2010; 16: 396-9.
    • (2010) Nature Med , vol.16 , pp. 396-399
    • Hotamisligil, G.S.1
  • 69
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Özcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306: 457-61.
    • (2004) Science , vol.306 , pp. 457-461
    • Özcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 70
    • 77957316569 scopus 로고    scopus 로고
    • Restoring endoplasmic reticulum function by chemical chaperones: An emerging therapeutic approach for metabolic disease
    • Engin F, Hotamisligil GS. Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic disease. Diabetes Obes Metab 2010; 12 (Suppl 2) 108-15.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL. 2 , pp. 108-115
    • Engin, F.1    Hotamisligil, G.S.2
  • 71
    • 73349106233 scopus 로고    scopus 로고
    • Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response
    • Schuck S, Prinz WA, Thorn KS, Voss C, Walter P. Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol 2009; 187: 525-36.
    • (2009) J Cell Biol , vol.187 , pp. 525-536
    • Schuck, S.1    Prinz, W.A.2    Thorn, K.S.3    Voss, C.4    Walter, P.5
  • 72
    • 34147172715 scopus 로고    scopus 로고
    • Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis
    • Sciburi R, Bommiasamy, H, Buldak GL, et al. Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis. J Biol Chem 2007; 282:7024-34.
    • (2007) J Biol Chem , vol.282 , pp. 7024-7034
    • Sciburi, R.1    Bommiasamy, H.2    Buldak, G.L.3
  • 73
    • 71549152580 scopus 로고    scopus 로고
    • Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    • Erbay E, Babaev VR, Mayers JR, et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med 2009; 15: 1383-91.
    • (2009) Nat Med , vol.15 , pp. 1383-1391
    • Erbay, E.1    Babaev, V.R.2    Mayers, J.R.3
  • 74
    • 62749178966 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
    • Gregor MF, Yang L, Fabbrini E, et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009; 58: 693-700.
    • (2009) Diabetes , vol.58 , pp. 693-700
    • Gregor, M.F.1    Yang, L.2    Fabbrini, E.3
  • 75
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostais in a mouse model of type 2 diabetes
    • Özcan U, Ylimaz E, Özcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostais in a mouse model of type 2 diabetes. Science. 2006; 313: 1137-1140.
    • (2006) Science , vol.313 , pp. 1137-1140
    • Özcan, U.1    Ylimaz, E.2    Özcan, L.3
  • 76
    • 77955411159 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    • Kars M, Yang L, Gregor MF, et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 2010; 59: 1899-905.
    • (2010) Diabetes , vol.59 , pp. 1899-1905
    • Kars, M.1    Yang, L.2    Gregor, M.F.3
  • 77
    • 56649085322 scopus 로고    scopus 로고
    • SIRT1: Roles in aging and cancer
    • Kim EJ, Um SJ. SIRT1: roles in aging and cancer. BMB Reports 2008; 41: 751-6.
    • (2008) BMB Reports , vol.41 , pp. 751-756
    • Kim, E.J.1    Um, S.J.2
  • 78
    • 34547906123 scopus 로고    scopus 로고
    • Fasting -dependent glucose and lipid metabolic response through hepatic sirtuin 1
    • Rodgers JT, Puigserver P. Fasting -dependent glucose and lipid metabolic response through hepatic sirtuin 1. PNAS 2007; 104: 12861-6.
    • (2007) PNAS , vol.104 , pp. 12861-12866
    • Rodgers, J.T.1    Puigserver, P.2
  • 79
    • 35548996710 scopus 로고    scopus 로고
    • DisSirting on LXR and cholesterol metabolism
    • Feige JM, Auwerx J. DisSirting on LXR and cholesterol metabolism. Cell Metab 2007; 6: 343-5.
    • (2007) Cell Metab , vol.6 , pp. 343-345
    • Feige, J.M.1    Auwerx, J.2
  • 81
    • 51649127816 scopus 로고    scopus 로고
    • Extended - release niacin alters the metabolism of plasma apoliprotein (apo) A-I and apo-B containing lipoproteins
    • Lamon-Fava S, Diffenderfer MR, Barrett PHR, et al. Extended - release niacin alters the metabolism of plasma apoliprotein (apo) A-I and apo-B containing lipoproteins. Arterioscler Thromb Vasc Biol 2008; 28: 1672-8.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1672-1678
    • Lamon-Fava, S.1    Diffenderfer, M.R.2    Barrett, P.H.R.3
  • 82
    • 4444278680 scopus 로고    scopus 로고
    • CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafesterol interventions in humans
    • Hofman MK, Weggemans RM, Zock PL, Schouten EG, Katan MB, Princen HMG. CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafesterol interventions in humans. J Nutr 2004; 134: 2200-4.
    • (2004) J Nutr , vol.134 , pp. 2200-2204
    • Hofman, M.K.1    Weggemans, R.M.2    Zock, P.L.3    Schouten, E.G.4    Katan, M.B.5    Princen, H.M.G.6
  • 83
    • 70350031574 scopus 로고    scopus 로고
    • The constitutive androstane receptor is an antiobesity nuclear receptor that improves insulin sensitivity
    • Gao J. The constitutive androstane receptor is an antiobesity nuclear receptor that improves insulin sensitivity. J Biol Chem 2009; 284: 25984-92.
    • (2009) J Biol Chem , vol.284 , pp. 25984-92
    • Gao, J.1
  • 84
    • 73249140987 scopus 로고    scopus 로고
    • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease
    • Dong B, Saha PK, Huang W, et al. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. PNAS 2009; 106: 18831-6.
    • (2009) PNAS , vol.106 , pp. 18831-18836
    • Dong, B.1    Saha, P.K.2    Huang, W.3
  • 85
    • 33747397954 scopus 로고    scopus 로고
    • Cardiovascular disease and Alzheimer's disease: Common links
    • Stampfer MJ. Cardiovascular disease and Alzheimer's disease: common links. J Intern Med 2006; 260: 211-23.
    • (2006) J Intern Med , vol.260 , pp. 211-223
    • Stampfer, M.J.1
  • 86
    • 33745475669 scopus 로고    scopus 로고
    • Effects of a Mediterranien-style diet on cardiovascular risk factors. A randomized trial
    • Estruch R, Martinez-Gonzalez MA, Corella D, et al. Effects of a Mediterranien-style diet on cardiovascular risk factors. A randomized trial. Ann Intern Med 2006; 145: 1-11.
    • (2006) Ann Intern Med , vol.145 , pp. 1-11
    • Estruch, R.1    Martinez-Gonzalez, M.A.2    Corella, D.3
  • 88
    • 77956604044 scopus 로고    scopus 로고
    • A lowfat, high-complex carbohydrate diet supplemented with longchain[n-3] fatty acids alters the postprandial lipoprotein profile in patients with metabolic syndrome
    • Jimènez-Gomèz J, Marin C, Pèrez-Martinèz P, et al. A lowfat, high-complex carbohydrate diet supplemented with longchain[n-3] fatty acids alters the postprandial lipoprotein profile in patients with metabolic syndrome. J Nutr 2010; 140: 1595-1601.
    • (2010) J Nutr , vol.140 , pp. 1595-1601
    • Jimènez-Gomèz, J.1    Marin, C.2    Pèrez-Martinèz, P.3
  • 89
    • 0030935652 scopus 로고    scopus 로고
    • Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance
    • Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. Diab Care 1997; 20: 537-44.
    • (1997) Diab Care , vol.20 , pp. 537-544
    • Pan, X.R.1    Li, G.W.2    Hu, Y.H.3
  • 90
    • 74949111301 scopus 로고    scopus 로고
    • Physical exercise, aging, and mild cognitive impairment
    • Geda YE, Roberts RO, Knopman DS, et al. Physical exercise, aging, and mild cognitive impairment. Arch Neurol 2010; 67: 80-6.
    • (2010) Arch Neurol , vol.67 , pp. 80-86
    • Geda, Y.E.1    Roberts, R.O.2    Knopman, D.S.3
  • 91
    • 63249123500 scopus 로고    scopus 로고
    • Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in Zucker diabetic fatty rats
    • Torres TP, Catlin RL, Chan R, et al. Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in Zucker diabetic fatty rats. Diabetes 2009; 58: 78-86.
    • (2009) Diabetes , vol.58 , pp. 78-86
    • Torres, T.P.1    Catlin, R.L.2    Chan, R.3
  • 92
    • 37349114118 scopus 로고    scopus 로고
    • Nuclear receptors: Decoding Metabolic Disease
    • Sonoda J, Pei L, Evans RM. Nuclear receptors: Decoding metabolic disease. FEBS Lett 2008; 582: 2-9.
    • (2008) FEBS Lett , vol.582 , pp. 2-9
    • Sonoda, J.1    Pei, L.2    Evans, R.M.3
  • 93
    • 9944265844 scopus 로고    scopus 로고
    • Regulatory network of lipid-sensing nuclear receptors: Roles of CAR, PXR, LXR, and FXR
    • Handschin C, Meyer UA. Regulatory network of lipid-sensing nuclear receptors: roles of CAR, PXR, LXR, and FXR. Arch Biochem Biophys 2005; 433: 387-96.
    • (2005) Arch Biochem Biophys , vol.433 , pp. 387-396
    • Handschin, C.1    Meyer, U.A.2
  • 94
    • 36849032904 scopus 로고    scopus 로고
    • Dissection of the insulin-sensitizing effect of liver X receptor ligands
    • Commerford RS, Vargas L, Dorfman SE, et al. Dissection of the insulin-sensitizing effect of liver X receptor ligands. Mol Endocrinol 2007; 21: 3002-12.
    • (2007) Mol Endocrinol , vol.21 , pp. 3002-3012
    • Commerford, R.S.1    Vargas, L.2    Dorfman, S.E.3
  • 95
    • 34249655208 scopus 로고    scopus 로고
    • Peroxisome prolifertor-activated receptors mediate pleiotrophic actions of statins
    • Paumelle R, Staels B. Peroxisome prolifertor-activated receptors mediate pleiotrophic actions of statins. Circ Res 2007; 100: 1394-5.
    • (2007) Circ Res , vol.100 , pp. 1394-1395
    • Paumelle, R.1    Staels, B.2
  • 96
    • 14544297438 scopus 로고    scopus 로고
    • Cholesterol detoxification by nuclear pregnane X receptor
    • Kliewer SA. Cholesterol detoxification by nuclear pregnane X receptor. PNAS 2005; 102: 2675-6.
    • (2005) PNAS , vol.102 , pp. 2675-2676
    • Kliewer, S.A.1
  • 97
    • 26244441014 scopus 로고    scopus 로고
    • The farnesoid X receptor - a molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, Staels B, Kuipers F. The farnesoid X receptor - a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 2005; 25: 2020-2030.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 99
    • 33750986759 scopus 로고    scopus 로고
    • Midlife risk factors and healthy survival in man
    • Willcox BJ, He Q, Chen R, et al. Midlife risk factors and healthy survival in man. JAMA 2006; 296: 2343-50.
    • (2006) JAMA , vol.296 , pp. 2343-2350
    • Willcox, B.J.1    He, Q.2    Chen, R.3
  • 100
    • 70350450959 scopus 로고    scopus 로고
    • Promising strategies for the prevention of dementia
    • Middleton LE, Yaffe K. Promising strategies for the prevention of dementia. Arch Neurol 2009; 66: 1210-15.
    • (2009) Arch Neurol , vol.66 , pp. 1210-1215
    • Middleton, L.E.1    Yaffe, K.2
  • 101
    • 70449725268 scopus 로고    scopus 로고
    • Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease
    • Wendell CR, Zonderman AB, Metter JM, Najjar SS, Wadstein SR. Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease. Stroke 2009; 40: 3180-5.
    • (2009) Stroke , vol.40 , pp. 3180-3185
    • Wendell, C.R.1    Zonderman, A.B.2    Metter, J.M.3    Najjar, S.S.4    Wadstein, S.R.5
  • 102
    • 77955290197 scopus 로고    scopus 로고
    • Atherosclerosis, dementia, and Alzheimer disease in the Baltimore longitudinal study of aging cohort
    • Dolan H, Crain B, Troncoso J, Resnick SM, Zonderman AB, Obrien RJ. Atherosclerosis, dementia, and Alzheimer disease in the Baltimore longitudinal study of aging cohort. Ann Neurol 2010; 68: 231-40.
    • (2010) Ann Neurol , vol.68 , pp. 231-240
    • Dolan, H.1    Crain, B.2    Troncoso, J.3    Resnick, S.M.4    Zonderman, A.B.5    Obrien, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.