CD8 T cells and toxoplasma gondii: A new paradigm

Journal of Parasitology Research

Volumn 2011, Issue , 2011, Pages

  Gigley, Jason P ^a   Bhadra, Rajarshi ^a   Khan, Imtiaz A ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; EFFECTOR CELL; INFECTION RESISTANCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

MUS MUSCULUS; TOXOPLASMA GONDII;

EID: 79959254771     PISSN: 20900023     EISSN: 20900031     Source Type: Journal    
DOI: 10.1155/2011/243796     Document Type: Review

References (115)

1. Williams M. A., Bevan M. J., Effector and memory CTL differentiation Annual Review of Immunology 2007 25 171 192 (Pubitemid 46697906)
2. Mescher M. F., Curtsinger J. M., Agarwal P., Casey K. A., Gerner M., Hammerbeck C. D., Popescu F., Xiao Z., Signals required for programming effector and memory development by CD8 + T cells Immunological Reviews 2006 211 81 92 (Pubitemid 43882963)
3. Sharpe A. H., Mechanisms of costimulation Immunological Reviews 2009 229 1 5 11
4. Frenkel J. K., Adoptive immunity to intracellular infection Journal of Immunology 1967 98 6 1309 1319
5. Pfefferkorn E. R., Pfefferkorn L. C., Toxoplasma gondii. Isolation and preliminary characterization of temperature sensitive mutants Experimental Parasitology 1976 39 3 365 376
6. Suzuki Y., Remington J. S., Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2 + and Lyt-1 +, L3T4 + T cells in mice Journal of Immunology 1988 140 11 3943 3946
7. Suzuki Y., Orellana M. A., Schreiber R. D., Remington J. S., Interferon- : the major mediator of resistance against Toxoplasma gondii Science 1988 240 4851 516 518
8. Khan I. A., Smith K. A., Kasper L. H., Induction of antigen-specific parasiticidal cytotoxic T cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii Journal of Immunology 1988 141 10 3600 3605
9. Suzuki Y., Remington J. S., The effect of anti-IFN- antibody on the protective effect of Lyt-2 + immune T cells against toxoplasmosis in mice Journal of Immunology 1990 144 5 1954 1956 (Pubitemid 20094033)
10. Luft B. J., Hafner R., Korzun A. H., Leport C., Antoniskis D., Bosler E. M., Bourland D. D. III, Uttamchandani R., Fuhrer J., Jacobson J., Morlat P., Vilde J. -L., Remington J. S., Phillips C., Glauser M., Chave J., Clifford D., Powderly W., Klebert M., Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome The New England Journal of Medicine 1993 329 14 995 1000 (Pubitemid 23307907)
11. Dubey J. P., Advances in the life cycle of Toxoplasma gondii International Journal for Parasitology 1998 28 7 1019 1024 (Pubitemid 28364729)
12. Sibley L. D., Howe D. K., Genetic basis of pathogenicity in toxoplasmosis Current Topics in Microbiology and Immunology 1996 219 3 15 (Pubitemid 26272940)
13. Grigg M. E., Bonnefoy S., Hehl A. B., Suzuki Y., Boothroyd J. C., Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries Science 2001 294 5540 161 165 (Pubitemid 32952969)
14. Frazo-Teixeira E., Sundar N., Dubey J. P., Grigg M. E., de Oliveira F. C. R., Multi-locus DNA sequencing of Toxoplasma gondii isolated from Brazilian pigs identifies genetically divergent strains Veterinary Parasitology 2011 175 1-2 33 39
15. Dubey J. P., Rajendran C., Costa D. G. C., Ferreira L. R., Kwok O. C. H., Qu D., Su C., Marvulo M. F. V., Alves L. C., Mota R. A., Silva J. C.R., New Toxoplasma gondii genotypes isolated from free-range chickens from the Fernando de Noronha, Brazil: unexpected findings Journal of Parasitology 2010 96 4 709 712
16. Mercier A., Devillard S., Ngoubangoye B., Bonnabau H., Bauls A. -L., Durand P., Salle B., Ajzenberg D., Dard M. -L., Additional haplogroups of Toxoplasma gondii out of Africa: population structure and mouse-virulence of strains from Gabon PLoS Neglected Tropical Diseases 2010 4 11, article e876
17. Habek M., Ozreti D., arkovi K., Djakovi V., Mubrin Z., Unusual cause of dementia in an immunocompetent host: toxoplasmic encephalitis Neurological Sciences 2009 30 1 45 49
18. Flegr J., Novotn M., Fialov A., Kolbekov P., Gaov Z., The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors Folia Parasitologica 2010 57 2 143 150
19. Holland G. N., Ocular toxoplasmosis: the influence of patient age Memorias do Instituto Oswaldo Cruz 2009 104 2 351 357
20. Holliman R. E., Toxoplasmosis, behaviour and personality Journal of Infection 1997 35 2 105 110 (Pubitemid 27464677)
21. Lindov J., Novotn M., Havlek J., Jozfkov E., Skallov A., Kolbekov P., Hodn Z., Kodym P., Flegr J., Gender differences in behavioural changes induced by latent toxoplasmosis International Journal for Parasitology 2006 36 14 1485 1492 (Pubitemid 44751745)
22. Webster J. P., Lamberton P. H., Donnelly C. A., Torrey E. F., Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii's ability to alter host behaviour Proceedings of the Royal Society B 2006 273 1589 1023 1030 (Pubitemid 46768431)
23. Araujo F. G., Williams D. M., Grumet F. C., Remington J. S., Strain dependent differences in murine susceptibility to toxoplasma Infection and Immunity 1976 13 5 1528 1530
24. McLeod R., Eisenhauer P., Mack D., Brown C., Filice G., Spitalny G., Immune responses associated with early survival after peroral infection with Toxoplasma gondii Journal of Immunology 1989 142 9 3247 3255 (Pubitemid 19129950)
25. Deckert-Schluter M., Schluter D., Schmidt D., Schwendemann G., Wiestler O. D., Hof H., Toxoplasma encephalitis in congenic B10 and BALB mice: impact of genetic factors on the immune response Infection and Immunity 1994 62 1 221 228 (Pubitemid 24011963)
26. Brown C. R., McLeod R., Class I MHC genes and CD8 + T cells determine cyst number in Toxoplasma gondii infection Journal of Immunology 1990 145 10 3438 3441
27. Suzuki Y., Joh K., Kwon O. C., Yang Q., Conley F. K., Remington J. S., MHC class I gene(s) in the D/L region but not the TNF- gene determines development of toxoplasmic encephalitis in mice Journal of Immunology 1994 153 10 4649 4654 (Pubitemid 24346860)
28. Brown C. R., Hunter C. A., Estes R. G., Beckmann E., Forman J., David C., Remington J. S., McLeod R., Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis Immunology 1995 85 3 419 428
29. Brown C. R., David C. S., Khare S. J., McLeod R., Effects of human class I transgenes on Toxoplasma gondii cyst formation Journal of Immunology 1994 152 9 4537 4541 (Pubitemid 24134411)
30. Dzierszinski F., Pepper M., Stumhofer J. S., LaRosa D. F., Wilson E. H., Turka L. A., Halonen S. K., Hunter C. A., Roos D. S., Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells Infection and Immunity 2007 75 11 5200 5209 (Pubitemid 350041458)
31. Teixeiro E., Daniels M. A., Hamilton S. E., Schrum A. G., Bragado R., Jameson S. C., Palmer ED., Different T cell receptor signals determine CD8 + memory versus effector development Science 2009 323 5913 502 505
32. Zehn D., Lee S. Y., Bevan M. J., Complete but curtailed T-cell response to very low-affinity antigen Nature 2009 458 7235 211 214
33. Blanchard N., Gonzalez F., Schaeffer M., Joncker N. T., Cheng T., Shastri A. J., Robey E. A., Shastri N., Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum Nature Immunology 2008 9 8 937 944
34. Frickel E. M., Sahoo N., Hopp J., Gubbels M. J., Craver M. P. J., Knoll L. J., Ploegh H. L., Grotenbreg G. M., Parasite stage-specific recognition of endogenous Toxoplasma gondii -derived CD8 + T cell epitopes Journal of Infectious Diseases 2008 198 11 1625 1633
35. Wilson D. C., Grotenbreg G. M., Liu K., Zhao Y., Frickel E. M., Gubbels M. J., Ploegh H. L., Yap G. S., Differential regulation of effector- and central-memory responses to Toxoplasma gondii infection by IL-12 revealed by tracking of Tgd057-specific CD8 + T cells PLoS Pathogens 2010 6 3
36. Kirak O., Frickel E. M., Grotenbreg G. M., Suh H., Jaenisch R., Ploegh H. L., Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT Science 2010 328 5975 243 248
37. Galea I., Bernardes-Silva M., Forse P. A., Van Rooijen N., Liblau R. S., Perry V. H., An antigen-specific pathway for CD8 + T cells across the blood-brain barrier Journal of Experimental Medicine 2007 204 9 2023 2030 (Pubitemid 47360864)
38. Greenwald R. J., Freeman G. J., Sharpe A. H., The B7 family revisited Annual Review of Immunology 2005 23 515 548 (Pubitemid 40563179)
39. Keir M. E., Butte M. J., Freeman G. J., Sharpe A. H., PD-1 and its ligands in tolerance and immunity Annual Review of Immunology 2008 26 677 704 (Pubitemid 351600389)
40. Subauste C. S., de Waal Malefyt R., Fuh F., Role of CD80 (B7.1) and CD86 (B7.2) in the immune response to an intracellular pathogen Journal of Immunology 1998 160 4 1831 1840 (Pubitemid 28106471)
41. Subauste C. S., Wessendarp M., Sorensen R. U., Leiva L. E., CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxoplasma gondii: patients with hyper IgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer Journal of Immunology 1999 162 11 6690 6700 (Pubitemid 29309394)
42. Reichmann G., Villegas E. N., Craig L., Peach R., Hunter C. A., The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology Journal of Immunology 1999 163 6 3354 3362 (Pubitemid 29431837)
43. Villegas E. N., Elloso M. M., Reichmann G., Peach R., Hunter C. A., Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii Journal of Immunology 1999 163 6 3344 3353 (Pubitemid 29431836)
44. Yoshinaga S. K., Whorlskey J. S., Khare S. D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M. A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dal T., Duncan G., Elliott G. S., Hul A., McCabe S. M., Scully S., Shahinlan A., Shaklee C. L., Van G., Mak T. W., Senaidi G., T-cell co-stimulation through B7RP-1 and ICOS Nature 1999 402 6763 827 830 (Pubitemid 30012531)
45. Wilson E. H., Zaph C., Mohrs M., Welcher A., Siu J., Artis D., Hunter C. A., B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4 + Th1 and Th2 responses Journal of Immunology 2006 177 4 2365 2372 (Pubitemid 44200997)
46. Nishanth G., Sakowicz-Burkiewicz M., Hndel U., Kliche S., Wang X., Naumann M., Deckert M., Schlter D., Protective Toxoplasma gondii -specific T-cell responses require T-cell-specific expression of protein kinase C-theta Infection and Immunity 2010 78 8 3454 3464
47. Yokosuka T., Kobayashi W., Sakata-Sogawa K., Takamatsu M., Hashimoto-Tane A., Dustin M. L., Tokunaga M., Saito T., Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C translocation Immunity 2008 29 4 589 601
48. Scharton-Kersten T. M., Wynn T. A., Denkers E. Y., Bala S., Grunvald E., Hieny S., Gazzinelli R. T., Sher A., In the absence of endogenous IFN-, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection Journal of Immunology 1996 157 9 4045 4054 (Pubitemid 126449315)
49. Bliss S. K., Butcher B. A., Denkers E. Y., Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection Journal of Immunology 2000 165 8 4515 4521
50. Yap G. S., Sher A., Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function Immunobiology 1999 201 2 240 247
51. Aliberti J., Reis e Sousa C., Schito M., Hieny S., Wells T., Huffnagle G. B., Sher A., CCR5 provides a signal for microbial induced production of IL-12 by CD8 + dendritic cells Nature Immunology 2000 1 1 83 87
52. Bliss S. K., Gavrilescu L. C., Alcaraz A., Denkers E. Y., Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology Infection and Immunity 2001 69 8 4898 4905 (Pubitemid 32674471)
53. Del Rio L., Bennouna S., Salinas J., Denkers E. Y., CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection Journal of Immunology 2001 167 11 6503 6509 (Pubitemid 33081585)
54. Borges J. S., Johnson W. D., Inhibition of multiplication of Toxoplasma gondii by human monocytes exposed to T lymphocyte products Journal of Experimental Medicine 1975 141 2 483 496
55. Remington J. S., Krahenbuhl J. L., Mendenhall J. W., A role for activated macrophages in resistance to infection with Toxoplasma Infection and Immunity 1972 6 5 829 834
56. Liu C. H., Fan Y. T., Dias A., Esper L., Corn R. A., Bafica A., Machado F. S., Aliberti J., Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice Journal of Immunology 2006 177 1 31 35 (Pubitemid 43939111)
57. Robben P. M., LaRegina M., Kuziel W. A., Sibley L. D., Recruitment of Gr-1 + monocytes is essential for control of acute toxoplasmosis Journal of Experimental Medicine 2005 201 11 1761 1769 (Pubitemid 41002895)
58. Gazzinelli R. T., Hieny S., Wynn T. A., Wolf S., Sher A., Interleukin 12 is required for the T-lymphocyte-independent induction of interferon by an intracellular parasite and induces resistance in T-cell- deficient hosts Proceedings of the National Academy of Sciences of the United States of America 1993 90 13 6115 6119 (Pubitemid 23191465)
59. Gazzinelli R. T., Wysocka M., Hayashi S., Denkers E. Y., Hieny S., Caspar P., Trinchieri G., Sher A., Parasite-induced IL-12 stimulates early IFN- synthesis and resistance during acute infection with Toxoplasma gondii Journal of Immunology 1994 153 6 2533 2543 (Pubitemid 24278122)
60. Khan I. A., Matsuura T., Kasper L. H., Interleukin-12 enhances murine survival against acute toxoplasmosis Infection and Immunity 1994 62 5 1639 1642 (Pubitemid 24136957)
61. Yap G., Pesin M., Sher A., Cutting edge: IL-12 is required for the maintenance of IFN- production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii Journal of Immunology 2000 165 2 628 631 (Pubitemid 30484726)
62. Trinchieri G., Interleukin-12 and the regulation of innate resistance and adaptive immunity Nature Reviews Immunology 2003 3 2 133 146 (Pubitemid 37328691)
63. Cooper A. M., Khader S. A., IL-12p40: an inherently agonistic cytokine Trends in Immunology 2007 28 1 33 38 (Pubitemid 44960157)
64. Scharton-Kersten T., Caspar P., Sher A., Denkers E. Y., Toxoplasma gondii: evidence for interleukin-12-dependent and -independent pathways of interferon- production induced by an attenuated parasite strain Experimental Parasitology 1996 84 2 102 114 (Pubitemid 26399777)
65. Robben P. M., Mordue D. G., Truscott S. M., Takeda K., Akira S., Sibley L. D., Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype Journal of Immunology 2004 172 6 3686 3694 (Pubitemid 38337952)
66. Gigley J. P., Fox B. A., Bzik D. J., Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication Journal of Immunology 2009 182 2 1069 1078
67. Pearce E. L., Shen H., Generation of CD8 + T cell memory is regulated by IL-12 Journal of Immunology 2007 179 4 2074 2081
68. Joshi N. S., Cui W., Chandele A., Lee H. K., Urso D. R., Hagman J., Gapin L., Kaech S. M., Inflammation directs memory precursor and short-lived effector CD8 + T cell fates via the graded expression of T-bet transcription factor Immunity 2007 27 2 281 295 (Pubitemid 47284924)
69. Wilson D. C., Matthews S., Yap G. S., IL-12 signaling drives CD8 + T cell IFN- production and differentiation of KLRG1 + effector subpopulations during Toxoplasma gondii infection Journal of Immunology 2008 180 9 5935 5945
70. Waldmann T. A., The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design Nature Reviews Immunology 2006 6 8 595 601 (Pubitemid 44134092)
71. Khan I. A., Kasper L. H., IL-15 augments CD8 + T cell-mediated immunity against Toxoplasma gondii infection in mice Journal of Immunology 1996 157 5 2103 2108 (Pubitemid 126449687)
72. Khan I. A., Casciotti L., IL-15 prolongs the duration of CD8 + T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii Journal of Immunology 1999 163 8 4503 4509 (Pubitemid 29474520)
73. Khan I. A., Moretto M., Wei X. Q., Williams M., Schwartzman J. D., Liew F. Y., Treatment with soluble interleukin-15R exacerbates intracellular parasitic infection by blocking the development of memory CD8 + T cell response Journal of Experimental Medicine 2002 195 11 1463 1470 (Pubitemid 34602823)
74. Lieberman L. A., Villegas E. N., Hunter C. A., Interleukin-15-deficient mice develop protective immunity to Toxoplasma gondii Infection and Immunity 2004 72 11 6729 6732 (Pubitemid 39425462)
75. Combe C. L., Moretto M. M., Schwartzman J. D., Gigley J. P., Bzik D. J., Khan I. A., Lack of IL-15 results in the suboptimal priming of CD4 + T cell response against an intracellular parasite Proceedings of the National Academy of Sciences of the United States of America 2006 103 17 6635 6640
76. Bhadra R., Guan H., Khan I. A., Absence of both IL-7 and IL-15 severely impairs the development of CD8 + T cell response against Toxoplasma gondii PLoS ONE 2010 5 5, article e10842
77. Cui W., Kaech S. M., Generation of effector CD8 + T cells and their conversion to memory T cells Immunological Reviews 2010 236 1 151 166
78. Gazzinelli R. T., Hakim F. T., Hieny S., Shearer G. M., Sher A., Synergistic role of CD4 + and CD8 + T lymphocytes in IFN- production and protective immunity induced by an attenuated Toxoplasma gondii vaccine Journal of Immunology 1991 146 1 286 292
79. Sher A., Oswald I. P., Hieny S., Gazzinelli R. T., Toxoplasma gondii induces a T-independent IFN- response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor- Journal of Immunology 1993 150 9 3982 3989 (Pubitemid 23129780)
80. Kang H., Suzuki Y., Requirement of non-T cells that produce gamma interferon for prevention of reactivation of Toxoplasma gondii infection in the brain Infection and Immunity 2001 69 5 2920 2927 (Pubitemid 32332183)
81. Kasper L. H., Matsuura T., Fonseka S., Arruda J., Channon J. Y., Khan I. A., Induction of T cells during acute murine infection with Toxoplasma gondii Journal of Immunology 1996 157 12 5521 5527 (Pubitemid 126448973)
82. Sharma S. D., Catterall J. R., Remington J. S., Parasiticidal activity of macrophages against Toxoplasma Methods in Enzymology 1986 132 626 637 (Pubitemid 17233608)
83. Remington J. S., Merigan T. C., Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii) Science 1968 161 3843 804 806
84. Krahenbuhl J. L., Remington J. S., In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes Infection and Immunity 1971 4 4 337 343
85. Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y., Identification of interferon- as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity Journal of Experimental Medicine 1983 158 3 670 689 (Pubitemid 13051337)
86. Pfefferkorn E. R., Interferon blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan Proceedings of the National Academy of Sciences of the United States of America 1984 81 3 908 912 (Pubitemid 14197611)
87. Murray H. W., Spitalny G. L., Nathan C. F., Activation of mouse peritoneal macrophages in vitro and in vivo by interferon- Journal of Immunology 1985 134 3 1619 1622 (Pubitemid 15130280)
88. Plefferkorn E. R., Rebhun S., Eckel M., Characterization of an indoleamine 2,3-dioxygenase induced by gamma-interferon in cultured human fibroblasts Journal of Interferon Research 1986 6 3 267 279 (Pubitemid 16039051)
89. Anderson S. E., Remington J. S., Effect of normal and activated human macrophages on Toxoplasma gondii Journal of Experimental Medicine 1974 139 5 1154 1174
90. Adams L. B., Hibbs J. B., Taintor R. R., Krahenbuhl J. L., Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine Journal of Immunology 1990 144 7 2725 2729 (Pubitemid 20136682)
91. Fox B. A., Gigley J. P., Bzik D. J., Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation International Journal for Parasitology 2004 34 3 323 331 (Pubitemid 38299182)
92. Jordan K. A., Wilson E. H., Tait E. D., Fox B. A., Roos D. S., Bzik D. J., Dzierszinski F., Hunter C. A., Kinetics and phenotype of vaccine-induced CD8 + T-cell responses to Toxoplasma gondii Infection and Immunity 2009 77 9 3894 3901
93. Gazzinelli R., Xu Y., Hieny S., Cheever A., Sher A., Simultaneous depletion of CD4 + and CD8 + T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii Journal of Immunology 1992 149 1 175 180
94. Fox B. A., Bzik D. J., De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii Nature 2002 415 6874 926 929 (Pubitemid 34174756)
95. Weaver C. T., Harrington L. E., Mangan P. R., Gavrieli M., Murphy K. M., Th17: an effector CD4 T cell lineage with regulatory T cell ties Immunity 2006 24 6 677 688 (Pubitemid 43867371)
96. Badovinac V. P., Harty J. T., Detection and analysis of antigen-specific CD8 + T cells Immunologic Research 2001 24 3 325 332 (Pubitemid 33064390)
97. Sibley L. D., Adams L. B., Fukutomi Y., Krahenbuhl J. L., Tumor necrosis factor- triggers antitoxoplasmal activity of IFN- primed macrophages Journal of Immunology 1991 147 7 2340 2345
98. Johnson L. L., A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection Infection and Immunity 1992 60 5 1979 1983
99. Gazzinelli R. T., Eltoum I., Wynn T. A., Sher A., Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF- and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation Journal of Immunology 1993 151 7 3672 3681 (Pubitemid 23282679)
100. Hunter C. A., Abrams J. S., Beaman M. H., Remington J. S., Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii Infection and Immunity 1993 61 10 4038 4044 (Pubitemid 23298551)
101. Yap G. S., Sher A., Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)- -and tumor necrosis factor (TNF)- -dependent host resistance to the intracellular pathogen, Toxoplasma gondii Journal of Experimental Medicine 1999 189 7 1083 1091 (Pubitemid 29169825)
102. Suzuki Y., Kang H., Parmley S., Lim S., Park D., Induction of tumor necrosis factor- and inducible nitric oxide synthase fails to prevent toxoplasmic encephalitis in the absence of interferon- in genetically resistant BALB/c mice Microbes and Infection 2000 2 5 455 462 (Pubitemid 30387199)
103. Schlter D., Kwok L. Y., Ltjen S., Soltek S., Hoffmann S., Krner H., Deckert M., Both lymphotoxin- and TNF are crucial for control of Toxoplasma gondii in the central nervous system Journal of Immunology 2003 170 12 6172 6182 (Pubitemid 36682601)
104. Hakim F. T., Gazzinelli R. T., Denkers E., Hieny S., Shearer G. M., Sher A., CD8 + T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells Journal of Immunology 1991 147 7 2310 2316
105. Kasper L. H., Khan I. A., Ely K. H., Buelow R., Boothroyd J. C., Antigen-specific (p30) mouse CD8 + T cells are cytotoxic against Toxoplasma gondii -infected peritoneal macrophages Journal of Immunology 1992 148 5 1493 1498
106. Montoya J. G., Lowe K. E., Clayberger C., Moody D., Do D., Remington J. S., Talib S., Subauste C. S., Human CD4 + and CD8 + T lymphocytes are both cytotoxic to Toxoplasma gondii -infected cells Infection and Immunity 1996 64 1 176 181 (Pubitemid 26009356)
107. Purner M. B., Berens R. L., Nash P. B., Van Linden A., Ross E., Kruse C., Krug E. C., Curiel T. J., CD4-mediated and CD8-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans Infection and Immunity 1996 64 10 4330 4338 (Pubitemid 26318161)
108. Denkers E. Y., Yap G., Scharton-Kersten T., Charest H., Butcher B. A., Caspar P., Heiny S., Sher A., Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii Journal of Immunology 1997 159 4 1903 1908 (Pubitemid 127484179)
109. Wang X., Kang H., Kikuchi T., Suzuki Y., Gamma interferon production, but not perforin-mediated cytolytic activity, of T cells is required for prevention of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease Infection and Immunity 2004 72 8 4432 4438 (Pubitemid 38989299)
110. Suzuki Y., Wang X., Jortner B. S., Payne L., Ni Y., Michie S. A., Xu B., Kudo T., Perkins S., Removal of Toxoplasma gondii cysts from the brain by perforin-mediated activity of CD8 + T cells American Journal of Pathology 2010 176 4 1607 1613
111. Tait E. D., Jordan K. A., Dupont C. D., Harris T. H., Gregg B., Wilson E. H., Pepper M., Dzierszinski F., Roos D. S., Hunter C. A., Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8 + T cells Journal of Immunology 2010 185 3 1502 1512
112. Casciotti L., Ely K. H., Williams M. E., Khan I. A., CD8 + -T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4 + T cells Infection and Immunity 2002 70 2 434 443 (Pubitemid 34083799)
113. Sun J. C., Bevan M. J., Defective CD8 + T cell memory following acute infection without CD4 + T cell help Science 2003 300 5617 339 342 (Pubitemid 36433727)
114. Shedlock D. J., Shen H., Requirement for CD4 + T cell help in generating functional CD8 + T cell memory Science 2003 300 5617 337 339 (Pubitemid 36433726)
115. Wherry E. J., Ha S. J., Kaech S. M., Haining W. N., Sarkar S., Kalia V., Subramaniam S., Blattman J. N., Barber D. L., Ahmed R., Molecular signature of CD8 + T cell exhaustion during chronic viral infection Immunity 2007 27 4 670 684 (Pubitemid 47615511)