De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii

Nature

Volumn 415, Issue 6874, 2002, Pages 926-929

  Fox, Barbara A ^a   Bzik, David J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; CELLS; CHEMOTHERAPY; ENZYMES; MICROORGANISMS;

PARASITES; PATHOGENESIS; TOXOPLASMOSIS;

BIOSYNTHESIS;

CARBAMOYL PHOSPHATE SYNTHASE (GLUTAMINE HYDROLYSING); GAMMA INTERFERON; PYRIMIDINE; URACIL PHOSPHORIBOSYLTRANSFERASE;

ENZYME; IMMUNITY; PARASITE; VACCINATION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH DEFECT; CHEMICAL REACTION; CONTROLLED STUDY; ENCEPHALITIS; GROWTH; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PARASITE SURVIVAL; PARASITE VIRULENCE; PATHOGENESIS; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; REACTION ANALYSIS; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CELLS, CULTURED; HUMANS; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PYRIMIDINES; TOXOPLASMA; TOXOPLASMOSIS; URACIL; VIRULENCE;

ANIMALIA; PROTOZOA; TOXOPLASMA GONDII;

EID: 0037148779     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/415926a     Document Type: Article

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