Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii

Infection and Immunity

Volumn 77, Issue 9, 2009, Pages 3894-3901

  Jordan, Kimberly A ^a   Wilson, Emma H ^b   Tait, Elia D ^a   Fox, Barbara A ^c   Roos, David S ^a   Bzik, David J ^c   Dzierszinski, Florence ^d   Hunter, Christopher A ^a,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e SVM Hill Pavilion   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; INTERLEUKIN 7 RECEPTOR; L SELECTIN; ONCOPROTEIN; OVALBUMIN; PERFORIN; PROTEIN KLRG1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOLYSIS; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXOPLASMA GONDII; UPREGULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; IMMUNIZATION; IMMUNOPHENOTYPING; KINETICS; MICE; MICE, INBRED C57BL; OVALBUMIN; PROTOZOAN VACCINES; TOXOPLASMA;

EID: 69049085640     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00024-09     Document Type: Article

References (37)

1. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198-1215.
2. Badovinac, V. P., and J. T. Harty. 2000. Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J. Immunol. 164:6444-6452.
3. Barber, D. L., E. J. Wherry, and R. Ahmed. 2003. Rapid in vivo killing by memory CD8 T cells. J. Immunol. 171:27-31.
4. Barry, M., and R. C. Bleackley. 2002. Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2:401-409.
5. Bhopale, G. M. 2003. Development of a vaccine for toxoplasmosis: current status. Microbes Infect. 5:457-462.
6. Bixby, L. M., and R. L. Tarleton. 2008. Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J. Immunol. 181:2644-2650.
7. Blanchard, N., F. Gonzalez, M. Schaeffer, N. T. Joncker, T. Cheng, A. J. Shastri, E. A. Robey, and N. Shastri. 2008. Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum. Nat. Immunol. 9:937-944.
8. Bustamante, J. M., L. M. Bixby, and R. L. Tarleton. 2008. Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat. Med. 14:542-550.
9. Candolfi, E., C. A. Hunter, and J. S. Remington. 1994. Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates. Infect. Immun. 62:1995-2001.
10. Carbone, F. R., and M. J. Bevan. 1989. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169:603-612.
11. + T cells. Infect. Immun. 70:434-443.
12. Denkers, E. Y., G. Yap, T. Scharton-Kersten, H. Charest, B. A. Butcher, P. Caspar, S. Heiny, and A. Sher. 1997. Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. J. Immunol. 159:1903-1908.
13. Fox, B. A., and D. J. Bzik. 2002. De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature 415:926-929.
14. Frickel, E. M., N. Sahoo, J. Hopp, M. J. Gubbels, M. P. Craver, L. J. Knoll, H. L. Ploegh, and G. M. Grotenbreg. 2008. Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8(+) T cell epitopes. J. Infect. Dis. 198:1625-1633.
15. Gavrilescu, L. C., and E. Y. Denkers. 2001. IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection. J. Immunol. 167:902-909.
16. Gazzinelli, R., Y. Xu, S. Hieny, A. Cheever, and A. Sher. 1992. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J. Immunol. 149:175-180.
17. Gazzinelli, R. T., F. T. Hakim, S. Hieny, G. M. Shearer, and A. Sher. 1991. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286-292.
18. Gigley, J. P., B. A. Fox, and D. J. Bzik. 2009. Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th-1 host immune responses in the absence of parasite replication. J. Immunol. 182:1069-1078.
19. Hakim, F. T., R. T. Gazzinelli, E. Denkers, S. Hieny, G. M. Shearer, and A. Sher. 1991. CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. J. Immunol. 147:2310-2316.
20. Joshi, N. S., W. Cui, A. Chandele, H. K. Lee, D. R. Urso, J. Hagman, L. Gapin, and S. M. Kaech. 2007. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27:281-295.
21. Kaech, S. M., J. T. Tan, E. J. Wherry, B. T. Konieczny, C. D. Surh, and R. Ahmed. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4:1191-1198.
22. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
23. Khan, I. A., T. Matsuura, and L. H. Kasper. 1995. IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice. Parasite Immunol. 17:185-195.
24. Kwok, L. Y., S. Lutjen, S. Soltek, D. Soldati, D. Busch, M. Deckert, and D. Schluter. 2003. The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis. J. Immunol. 170:1949-1957.
25. Luft, B. J., R. G. Brooks, F. K. Conley, R. E. McCabe, and J. S. Remington. 1984. Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome. JAMA 252:913-917.
26. Lutjen, S., S. Soltek, S. Virna, M. Deckert, and D. Schluter. 2006. Organand disease-stage-specific regulation of Toxoplasma gondii-specific CD8-T-cell responses by CD4 T cells. Infect. Immun. 74:5790-5801.
27. + T cells. Infect. Immun. 75:231-235.
28. Parker, S. J., C. W. Roberts, and J. Alexander. 1991. CD8+ T cells are the major lymphocyte subpopulation involved in the protective immune response to Toxoplasma gondii in mice. Clin. Exp. Immunol. 84:207-212.
29. +-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis. Infect. Immun. 72:7240-7246.
30. Sayles, P. C., and L. L. Johnson. 1996. Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii. Infect. Immun. 64:3088-3092.
31. + T cells to control acute Toxoplasma gondii infection. Infect. Immun. 71:309-316.
32. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300:337-339.
33. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300:339-342.
34. Suzuki, Y., and J. S. Remington. 1988. Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice. J. Immunol. 140:3943-3946.
35. Wilson, D. C., S. Matthews, and G. S. Yap. 2008. IL-12 signaling drives CD8+ T cell IFN-γ production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii infection. J. Immunol. 180:5935-5945.
36. Wilson, E. H., U. Wille-Reece, F. Dzierszinski, and C. A. Hunter. 2005. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J. Neuroimmunol. 165:63-74.
37. Yap, G. S., T. Scharton-Kersten, D. J. Ferguson, D. Howe, Y. Suzuki, and A. Sher. 1998. Partially protective vaccination permits the development of latency in a normally virulent strain of Toxoplasma gondii. Infect. Immun. 66:4382-4388.