메뉴 건너뛰기




Volumn 5, Issue 5, 2010, Pages

Absence of Both IL-7 and IL-15 Severely Impairs the Development of CD8+ T Cell Response against Toxoplasma gondii

Author keywords

[No Author keywords available]

Indexed keywords

CD44V ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; PROTEIN BCL 2; ANTIBODY; BROXURIDINE; GAMMA INTERFERON; INTERLEUKIN 7 RECEPTOR;

EID: 77956269219     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010842     Document Type: Article
Times cited : (34)

References (61)
  • 1
    • 0028269564 scopus 로고
    • Antigen-specific CD8+ T cell clone protects against acute Toxoplasma gondii infection in mice
    • Khan IA, Ely KH, Kasper LH (1994) Antigen-specific CD8+ T cell clone protects against acute Toxoplasma gondii infection in mice. J Immunol 152: 1856-1860.
    • (1994) J Immunol , vol.152 , pp. 1856-1860
    • Khan, I.A.1    Ely, K.H.2    Kasper, L.H.3
  • 2
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns KS, Lefrancois L (2003) Cytokine control of memory T-cell development and survival. Nat Rev Immunol 3: 269-279.
    • (2003) Nat Rev Immunol , vol.3 , pp. 269-279
    • Schluns, K.S.1    Lefrancois, L.2
  • 3
    • 0026749880 scopus 로고
    • Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii
    • Gazzinelli R, Xu Y, Hieny S, Cheever A, Sher A (1992) Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 149: 175-180.
    • (1992) J Immunol , vol.149 , pp. 175-180
    • Gazzinelli, R.1    Xu, Y.2    Hieny, S.3    Cheever, A.4    Sher, A.5
  • 4
    • 0025949660 scopus 로고
    • CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells
    • Hakim FT, Gazzinelli RT, Denkers E, Hieny S, Shearer GM, et al. (1991) CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. J Immunol 147: 2310-2316.
    • (1991) J Immunol , vol.147 , pp. 2310-2316
    • Hakim, F.T.1    Gazzinelli, R.T.2    Denkers, E.3    Hieny, S.4    Shearer, G.M.5
  • 5
    • 0031571269 scopus 로고    scopus 로고
    • Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii
    • Denkers EY, Yap G, Scharton-Kersten T, Charest H, Butcher BA, et al. (1997) Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. J Immunol 159: 1903-1908.
    • (1997) J Immunol , vol.159 , pp. 1903-1908
    • Denkers, E.Y.1    Yap, G.2    Scharton-Kersten, T.3    Charest, H.4    Butcher, B.A.5
  • 6
    • 0028841850 scopus 로고
    • IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii
    • Kasper LH, Matsuura T, Khan IA (1995) IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii. J Immunol 155: 4798-4804.
    • (1995) J Immunol , vol.155 , pp. 4798-4804
    • Kasper, L.H.1    Matsuura, T.2    Khan, I.A.3
  • 7
    • 33646242047 scopus 로고    scopus 로고
    • Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite
    • Combe CL, Moretto MM, Schwartzman JD, Gigley JP, Bzik DJ, et al. (2006) Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proc Natl Acad Sci U S A 103: 6635-6640.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6635-6640
    • Combe, C.L.1    Moretto, M.M.2    Schwartzman, J.D.3    Gigley, J.P.4    Bzik, D.J.5
  • 8
    • 0037124329 scopus 로고    scopus 로고
    • Multiple choices: Regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15
    • Prlic M, Lefrancois L, Jameson SC (2002) Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J Exp Med 195: F49-52.
    • (2002) J Exp Med , vol.195
    • Prlic, M.1    Lefrancois, L.2    Jameson, S.C.3
  • 9
    • 0037093844 scopus 로고    scopus 로고
    • Cutting edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
    • Schluns KS, Williams K, Ma A, Zheng XX, Lefrancois L (2002) Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168: 4827-4831.
    • (2002) J Immunol , vol.168 , pp. 4827-4831
    • Schluns, K.S.1    Williams, K.2    Ma, A.3    Zheng, X.X.4    Lefrancois, L.5
  • 10
    • 33646186619 scopus 로고    scopus 로고
    • Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    • Ma A, Koka R, Burkett P (2006) Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 24: 657-679.
    • (2006) Annu Rev Immunol , vol.24 , pp. 657-679
    • Ma, A.1    Koka, R.2    Burkett, P.3
  • 11
    • 0037013884 scopus 로고    scopus 로고
    • Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response
    • Khan IA, Moretto M, Wei XQ, Williams M, Schwartzman JD, et al. (2002) Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response. J Exp Med 195: 1463-1470.
    • (2002) J Exp Med , vol.195 , pp. 1463-1470
    • Khan, I.A.1    Moretto, M.2    Wei, X.Q.3    Williams, M.4    Schwartzman, J.D.5
  • 12
    • 0032853312 scopus 로고    scopus 로고
    • IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii
    • Khan IA, Casciotti L (1999) IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii. J Immunol 163: 4503-4509.
    • (1999) J Immunol , vol.163 , pp. 4503-4509
    • Khan, I.A.1    Casciotti, L.2
  • 13
    • 33947730608 scopus 로고    scopus 로고
    • Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    • Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, et al. (2007) Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 315: 1687-1691.
    • (2007) Science , vol.315 , pp. 1687-1691
    • Chang, J.T.1    Palanivel, V.R.2    Kinjyo, I.3    Schambach, F.4    Intlekofer, A.M.5
  • 14
    • 0030240622 scopus 로고    scopus 로고
    • IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice
    • Khan IA, Kasper LH (1996) IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice. J Immunol 157: 2103-2108.
    • (1996) J Immunol , vol.157 , pp. 2103-2108
    • Khan, I.A.1    Kasper, L.H.2
  • 15
    • 0024403666 scopus 로고
    • Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction
    • Burg JL, Grover CM, Pouletty P, Boothroyd JC (1989) Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction. J Clin Microbiol 27: 1787-1792.
    • (1989) J Clin Microbiol , vol.27 , pp. 1787-1792
    • Burg, J.L.1    Grover, C.M.2    Pouletty, P.3    Boothroyd, J.C.4
  • 16
    • 0035339916 scopus 로고    scopus 로고
    • A role for CD44 in the production of IFN-gamma and immunopathology during infection with Toxoplasma gondii
    • Blass SL, Pure E, Hunter CA (2001) A role for CD44 in the production of IFN-gamma and immunopathology during infection with Toxoplasma gondii. J Immunol 166: 5726-5732.
    • (2001) J Immunol , vol.166 , pp. 5726-5732
    • Blass, S.L.1    Pure, E.2    Hunter, C.A.3
  • 17
    • 0037124366 scopus 로고    scopus 로고
    • Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    • Tan JT, Ernst B, Kieper WC, LeRoy E, Sprent J, et al. (2002) Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 195: 1523-1532.
    • (2002) J Exp Med , vol.195 , pp. 1523-1532
    • Tan, J.T.1    Ernst, B.2    Kieper, W.C.3    Leroy, E.4    Sprent, J.5
  • 18
    • 0001585396 scopus 로고    scopus 로고
    • Control of homeostasis of CD8+ memory T cells by opposing cytokines
    • Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P (2000) Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288: 675-678.
    • (2000) Science , vol.288 , pp. 675-678
    • Ku, C.C.1    Murakami, M.2    Sakamoto, A.3    Kappler, J.4    Marrack, P.5
  • 19
    • 0032707637 scopus 로고    scopus 로고
    • Immune CD8(+) T cells prevent reactivation of Toxoplasma gondii infection in the immunocompromised host
    • Khan IA, Green WR, Kasper LH, Green KA, Schwartzman JD (1999) Immune CD8(+) T cells prevent reactivation of Toxoplasma gondii infection in the immunocompromised host. Infect Immun 67: 5869-5876.
    • (1999) Infect Immun , vol.67 , pp. 5869-5876
    • Khan, I.A.1    Green, W.R.2    Kasper, L.H.3    Green, K.A.4    Schwartzman, J.D.5
  • 20
    • 0038665233 scopus 로고    scopus 로고
    • IL-15 promotes the survival of naive and memory phenotype CD8+ T cells
    • Berard M, Brandt K, Bulfone-Paus S, Tough DF (2003) IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J Immunol 170: 5018-5026.
    • (2003) J Immunol , vol.170 , pp. 5018-5026
    • Berard, M.1    Brandt, K.2    Bulfone-Paus, S.3    Tough, D.F.4
  • 21
    • 0034992146 scopus 로고    scopus 로고
    • T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo
    • Vivien L, Benoist C, Mathis D (2001) T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol 13: 763-768.
    • (2001) Int Immunol , vol.13 , pp. 763-768
    • Vivien, L.1    Benoist, C.2    Mathis, D.3
  • 22
    • 33645064841 scopus 로고    scopus 로고
    • IL-7 promotes T cell proliferation through destabilization of p27Kip1
    • Li WQ, Jiang Q, Aleem E, Kaldis P, Khaled AR, et al. (2006) IL-7 promotes T cell proliferation through destabilization of p27Kip1. J Exp Med 203: 573-582.
    • (2006) J Exp Med , vol.203 , pp. 573-582
    • Li, W.Q.1    Jiang, Q.2    Aleem, E.3    Kaldis, P.4    Khaled, A.R.5
  • 23
    • 33646552426 scopus 로고    scopus 로고
    • C-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis
    • Bianchi T, Gasser S, Trumpp A, MacDonald HR (2006) c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis. Blood 107: 3992-3999.
    • (2006) Blood , vol.107 , pp. 3992-3999
    • Bianchi, T.1    Gasser, S.2    Trumpp, A.3    Macdonald, H.R.4
  • 24
    • 0030061063 scopus 로고    scopus 로고
    • The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression
    • Starborg M, Gell K, Brundell E, Hoog C (1996) The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci 109(Pt1): 143-153.
    • (1996) J Cell Sci , vol.109 , Issue.Pt1 , pp. 143-153
    • Starborg, M.1    Gell, K.2    Brundell, E.3    Hoog, C.4
  • 25
    • 44449145582 scopus 로고    scopus 로고
    • IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection
    • Wilson DC, Matthews S, Yap GS (2008) IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. J Immunol 180: 5935-5945.
    • (2008) J Immunol , vol.180 , pp. 5935-5945
    • Wilson, D.C.1    Matthews, S.2    Yap, G.S.3
  • 26
    • 0029820279 scopus 로고    scopus 로고
    • CD4-mediated and CD8-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans
    • Purner MB, Berens RL, Nash PB, van Linden A, Ross E, et al. (1996) CD4-mediated and CD8-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans. Infect Immun 64: 4330-4338.
    • (1996) Infect Immun , vol.64 , pp. 4330-4338
    • Purner, M.B.1    Berens, R.L.2    Nash, P.B.3    van Linden, A.4    Ross, E.5
  • 27
    • 0034655122 scopus 로고    scopus 로고
    • Cutting edge: Increased expression of Bcl-2 in antigen-specific memory CD8+ T cells
    • Grayson JM, Zajac AJ, Altman JD, Ahmed R (2000) Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J Immunol 164: 3950-3954.
    • (2000) J Immunol , vol.164 , pp. 3950-3954
    • Grayson, J.M.1    Zajac, A.J.2    Altman, J.D.3    Ahmed, R.4
  • 28
  • 29
    • 0030873556 scopus 로고    scopus 로고
    • Differential requirements for survival and proliferation of CD8 naive or memory T cells
    • Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B (1997) Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276: 2057-2062.
    • (1997) Science , vol.276 , pp. 2057-2062
    • Tanchot, C.1    Lemonnier, F.A.2    Perarnau, B.3    Freitas, A.A.4    Rocha, B.5
  • 30
    • 0028267677 scopus 로고
    • Turnover of naive- and memory-phenotype T cells
    • Tough DF, Sprent J (1994) Turnover of naive- and memory-phenotype T cells. J Exp Med 179: 1127-1135.
    • (1994) J Exp Med , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 31
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, et al. (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5
  • 32
    • 0027427492 scopus 로고
    • Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopig-mented hair
    • Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopig-mented hair. Cell 75: 229-240.
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3    Korsmeyer, S.J.4
  • 33
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, et al. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 4: 1191-1198.
    • (2003) Nat Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5
  • 34
    • 0030063341 scopus 로고    scopus 로고
    • IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms
    • Borger P, Kauffman HF, Postma DS, Vellenga E (1996) IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms. J Immunol 156: 1333-1338.
    • (1996) J Immunol , vol.156 , pp. 1333-1338
    • Borger, P.1    Kauffman, H.F.2    Postma, D.S.3    Vellenga, E.4
  • 35
    • 34547474575 scopus 로고    scopus 로고
    • Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection
    • Hand TW, Morre M, Kaech SM (2007) Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci U S A 104: 11730-11735.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 11730-11735
    • Hand, T.W.1    Morre, M.2    Kaech, S.M.3
  • 36
    • 0029959459 scopus 로고    scopus 로고
    • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    • Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, et al. (1996) In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157: 798-805.
    • (1996) J Immunol , vol.157 , pp. 798-805
    • Gazzinelli, R.T.1    Wysocka, M.2    Hieny, S.3    Scharton-Kersten, T.4    Cheever, A.5
  • 37
    • 68649115555 scopus 로고    scopus 로고
    • Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node
    • Chtanova T, Han SJ, Schaeffer M, van Dooren GG, Herzmark P, et al. (2009) Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity 31: 342-355.
    • (2009) Immunity , vol.31 , pp. 342-355
    • Chtanova, T.1    Han, S.J.2    Schaeffer, M.3    van Dooren, G.G.4    Herzmark, P.5
  • 38
    • 0037148779 scopus 로고    scopus 로고
    • De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii
    • Fox BA, Bzik DJ (2002) De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature 415: 926-929.
    • (2002) Nature , vol.415 , pp. 926-929
    • Fox, B.A.1    Bzik, D.J.2
  • 39
    • 33846224790 scopus 로고    scopus 로고
    • Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice
    • Nakazato K, Yamada H, Yajima T, Kagimoto Y, Kuwano H, et al. (2007) Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice. J Immunol 178: 757-764.
    • (2007) J Immunol , vol.178 , pp. 757-764
    • Nakazato, K.1    Yamada, H.2    Yajima, T.3    Kagimoto, Y.4    Kuwano, H.5
  • 40
    • 0034235117 scopus 로고    scopus 로고
    • Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia
    • Karawajew L, Ruppert V, Wuchter C, Kosser A, Schrappe M, et al. (2000) Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia. Blood 96: 297-306.
    • (2000) Blood , vol.96 , pp. 297-306
    • Karawajew, L.1    Ruppert, V.2    Wuchter, C.3    Kosser, A.4    Schrappe, M.5
  • 41
    • 33749131253 scopus 로고    scopus 로고
    • Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development
    • Klonowski KD, Williams KJ, Marzo AL, Lefrancois L (2006) Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development. J Immunol 177: 4247-4251.
    • (2006) J Immunol , vol.177 , pp. 4247-4251
    • Klonowski, K.D.1    Williams, K.J.2    Marzo, A.L.3    Lefrancois, L.4
  • 42
    • 42449106871 scopus 로고    scopus 로고
    • IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis
    • Oh S, Perera LP, Terabe M, Ni L, Waldmann TA, et al. (2008) IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proc Natl Acad Sci U S A 105: 5201-5206.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5201-5206
    • Oh, S.1    Perera, L.P.2    Terabe, M.3    Ni, L.4    Waldmann, T.A.5
  • 43
    • 14544288632 scopus 로고    scopus 로고
    • CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    • Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, et al. (2005) CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434: 88-93.
    • (2005) Nature , vol.434 , pp. 88-93
    • Janssen, E.M.1    Droin, N.M.2    Lemmens, E.E.3    Pinkoski, M.J.4    Bensinger, S.J.5
  • 44
    • 0035902513 scopus 로고    scopus 로고
    • IL-7 is critical for homeostatic proliferation and survival of naive T cells
    • Tan JT, Dudl E, LeRoy E, Murray R, Sprent J, et al. (2001) IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98: 8732-8737.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8732-8737
    • Tan, J.T.1    Dudl, E.2    Leroy, E.3    Murray, R.4    Sprent, J.5
  • 45
    • 70349232418 scopus 로고    scopus 로고
    • Memory-Like CD8+ T Cells Generated during Homeostatic Proliferation Defer to Antigen-Experienced Memory Cells
    • Cheung KP, Yang E, Goldrath AW (2009) Memory-Like CD8+ T Cells Generated during Homeostatic Proliferation Defer to Antigen-Experienced Memory Cells. J Immunol.
    • (2009) J Immunol
    • Cheung, K.P.1    Yang, E.2    Goldrath, A.W.3
  • 46
    • 66649114758 scopus 로고    scopus 로고
    • High antigen levels are the cause of T cell exhaustion during chronic viral infection
    • Mueller SN, Ahmed R (2009) High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A 106: 8623-8628.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8623-8628
    • Mueller, S.N.1    Ahmed, R.2
  • 47
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ (2009) A vital role for interleukin-21 in the control of a chronic viral infection. Science 324: 1572-1576.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 48
    • 0023895411 scopus 로고
    • Interferon-gamma: The major mediator of resistance against Toxoplasma gondii
    • Suzuki Y, Orellana MA, Schreiber RD, Remington JS (1988) Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240: 516-518.
    • (1988) Science , vol.240 , pp. 516-518
    • Suzuki, Y.1    Orellana, M.A.2    Schreiber, R.D.3    Remington, J.S.4
  • 49
    • 0023937107 scopus 로고
    • Absence of a role for natural killer cells in the control of acute infection by Toxoplasma gondii oocysts
    • Hughes HP, Kasper LH, Little J, Dubey JP (1988) Absence of a role for natural killer cells in the control of acute infection by Toxoplasma gondii oocysts. Clin Exp Immunol 72: 394-399.
    • (1988) Clin Exp Immunol , vol.72 , pp. 394-399
    • Hughes, H.P.1    Kasper, L.H.2    Little, J.3    Dubey, J.P.4
  • 50
    • 34250890029 scopus 로고    scopus 로고
    • NK cells enhance dendritic cell response against parasite antigens via NKG2D pathway
    • Guan H, Moretto M, Bzik DJ, Gigley J, Khan IA (2007) NK cells enhance dendritic cell response against parasite antigens via NKG2D pathway. J Immunol 179: 590-596.
    • (2007) J Immunol , vol.179 , pp. 590-596
    • Guan, H.1    Moretto, M.2    Bzik, D.J.3    Gigley, J.4    Khan, I.A.5
  • 51
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CD8 T cell memory
    • Shedlock DJ, Shen H (2003) Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339.
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.J.1    Shen, H.2
  • 52
    • 0036155973 scopus 로고    scopus 로고
    • CD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4(+) T cells
    • Casciotti L, Ely KH, Williams ME, Khan IA (2002) CD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4(+) T cells. Infect Immun 70: 434-443.
    • (2002) Infect Immun , vol.70 , pp. 434-443
    • Casciotti, L.1    Ely, K.H.2    Williams, M.E.3    Khan, I.A.4
  • 53
  • 54
    • 0028358799 scopus 로고
    • Impairment of the cellular immune response in acute murine toxoplasmosis: Regulation of interleukin 2 production and macrophage-mediated inhibitory effects
    • Haque S, Khan I, Haque A, Kasper L (1994) Impairment of the cellular immune response in acute murine toxoplasmosis: regulation of interleukin 2 production and macrophage-mediated inhibitory effects. Infect Immun 62: 2908-2916.
    • (1994) Infect Immun , vol.62 , pp. 2908-2916
    • Haque, S.1    Khan, I.2    Haque, A.3    Kasper, L.4
  • 55
    • 0028348042 scopus 로고
    • Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates
    • Candolfi E, Hunter CA, Remington JS (1994) Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates. Infect Immun 62: 1995-2001.
    • (1994) Infect Immun , vol.62 , pp. 1995-2001
    • Candolfi, E.1    Hunter, C.A.2    Remington, J.S.3
  • 56
    • 0028954204 scopus 로고
    • IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice
    • Khan IA, Matsuura T, Kasper LH (1995) IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice. Parasite Immunol 17: 185-195.
    • (1995) Parasite Immunol , vol.17 , pp. 185-195
    • Khan, I.A.1    Matsuura, T.2    Kasper, L.H.3
  • 57
    • 34548027168 scopus 로고    scopus 로고
    • Generation of CD8 T cell memory is regulated by IL-12
    • Pearce EL, Shen H (2007) Generation of CD8 T cell memory is regulated by IL-12. J Immunol 179: 2074-2081.
    • (2007) J Immunol , vol.179 , pp. 2074-2081
    • Pearce, E.L.1    Shen, H.2
  • 58
    • 0036172707 scopus 로고    scopus 로고
    • IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages
    • Carvalho LH, Sano G, Hafalla JC, Morrot A, Curotto de Lafaille MA, et al. (2002) IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. Nat Med 8: 166-170.
    • (2002) Nat Med , vol.8 , pp. 166-170
    • Carvalho, L.H.1    Sano, G.2    Hafalla, J.C.3    Morrot, A.4    de Lafaille, M.A.C.5
  • 59
    • 23944434020 scopus 로고    scopus 로고
    • IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites
    • Morrot A, Hafalla JC, Cockburn IA, Carvalho LH, Zavala F (2005) IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med 202: 551-560.
    • (2005) J Exp Med , vol.202 , pp. 551-560
    • Morrot, A.1    Hafalla, J.C.2    Cockburn, I.A.3    Carvalho, L.H.4    Zavala, F.5
  • 60
    • 19944434230 scopus 로고    scopus 로고
    • Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    • Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, et al. (2005) Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 201: 139-148.
    • (2005) J Exp Med , vol.201 , pp. 139-148
    • Zeng, R.1    Spolski, R.2    Finkelstein, S.E.3    Oh, S.4    Kovanen, P.E.5
  • 61
    • 36348991440 scopus 로고    scopus 로고
    • Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation
    • Allard EL, Hardy MP, Leignadier J, Marquis M, Rooney J, et al. (2007) Overexpression of IL-21 promotes massive CD8+ memory T cell accumulation. Eur J Immunol 37: 3069-3077.
    • (2007) Eur J Immunol , vol.37 , pp. 3069-3077
    • Allard, E.L.1    Hardy, M.P.2    Leignadier, J.3    Marquis, M.4    Rooney, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.