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Volumn 189, Issue 7, 1999, Pages 1083-1091

Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-γ- and tumor necrosis factor (TNF)-α- dependent host resistance to the intracellular pathogen, Toxoplasma gondii

Author keywords

Cell mediated immunity; Inducible nitric oxide synthase; Interferon ; Toxoplasma; Tumor necrosis factor

Indexed keywords

GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033526013     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.7.1083     Document Type: Article
Times cited : (201)

References (50)
  • 1
    • 0029099391 scopus 로고
    • Effects of IL-12 on immune responses to microbial infection: A key mediator in regulating disease outcome
    • Biron, C.A., and R.T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infection: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7:485-496.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 485-496
    • Biron, C.A.1    Gazzinelli, R.T.2
  • 2
    • 0031056838 scopus 로고    scopus 로고
    • Expression pattern and cellular origin of cytokines in normal and Toxoplasma gondii infected brain
    • Schluter, D., N. Kaefer, H. Hof, O. Wiestler, and M.D. Schluter. 1997. Expression pattern and cellular origin of cytokines in normal and Toxoplasma gondii infected brain. Am. J. Pathol. 150:1021-1035.
    • (1997) Am. J. Pathol. , vol.150 , pp. 1021-1035
    • Schluter, D.1    Kaefer, N.2    Hof, H.3    Wiestler, O.4    Schluter, M.D.5
  • 4
    • 0030799302 scopus 로고    scopus 로고
    • Why listeriosis? A perspective on cellular immunity to infection
    • Unanue, E.R. 1997. Why listeriosis? A perspective on cellular immunity to infection. Immunol. Rev. 158:5-9.
    • (1997) Immunol. Rev. , vol.158 , pp. 5-9
    • Unanue, E.R.1
  • 5
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S.L., and R.M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13: 151-177.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 6
    • 0027462422 scopus 로고
    • Immunity to intracellular bacteria
    • Kaufmann, S.H. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129-163.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 129-163
    • Kaufmann, S.H.1
  • 7
    • 0028092958 scopus 로고
    • Nitric oxide synthases: Roles, tolls and controls
    • Nathan, C., and Q. Xie. 1994. Nitric oxide synthases: roles, tolls and controls. Cell. 78:915-918.
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.2
  • 8
    • 0027382381 scopus 로고
    • Host resistance to Toxoplasma gondii: Model for studying the selective induction of cell-mediated immunity to intracellular parasites
    • Gazzinelli, R.T., E.Y. Denkers, and A. Sher. 1993. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity to intracellular parasites. Infect. Agents Dis. 2:139-149.
    • (1993) Infect. Agents Dis. , vol.2 , pp. 139-149
    • Gazzinelli, R.T.1    Denkers, E.Y.2    Sher, A.3
  • 9
    • 0015427327 scopus 로고
    • A role for activated macrophages in resistance to infection with Toxoplasma
    • Remington, J.S., J.L. Krahenbuhl, and J.W. Mendenhall. 1972. A role for activated macrophages in resistance to infection with Toxoplasma. Infect. Immun. 6:829-834.
    • (1972) Infect. Immun. , vol.6 , pp. 829-834
    • Remington, J.S.1    Krahenbuhl, J.L.2    Mendenhall, J.W.3
  • 10
    • 0014427654 scopus 로고
    • Interferon: Protection of cells infected with an intracellular protozoan (Toxoplasma gondii)
    • Remington, J.S., and T.C. Merigan. 1968. Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii). Science. 161:804-806.
    • (1968) Science , vol.161 , pp. 804-806
    • Remington, J.S.1    Merigan, T.C.2
  • 11
    • 0017946996 scopus 로고
    • Mediation of immunity to intracellular infection (Toxoplasma and Besnoitia) within somatic cells
    • Chinchilla, M., and J.K. Frenkel. 1978. Mediation of immunity to intracellular infection (Toxoplasma and Besnoitia) within somatic cells. Infect. Immun. 19:999-1012.
    • (1978) Infect. Immun. , vol.19 , pp. 999-1012
    • Chinchilla, M.1    Frenkel, J.K.2
  • 12
    • 0000056144 scopus 로고
    • Interferon-γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cell to degrade tryptophan
    • Pfefferkorn, E. 1984. Interferon-γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cell to degrade tryptophan. Proc. Natl. Acad. Sci. USA. 81:908-912.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 908-912
    • Pfefferkorn, E.1
  • 13
    • 0020345021 scopus 로고
    • Growth inhibition of Toxoplasma gondii in cell cultures treated with murine type II interferon
    • Shirahata, T., and K. Shimizu. 1982. Growth inhibition of Toxoplasma gondii in cell cultures treated with murine type II interferon. Jpn. J. Vet. Sci. 44:865-871.
    • (1982) Jpn. J. Vet. Sci. , vol.44 , pp. 865-871
    • Shirahata, T.1    Shimizu, K.2
  • 14
    • 0025138795 scopus 로고
    • Interferon-induced proteins and the antiviral state
    • Staeheli, P. 1990. Interferon-induced proteins and the antiviral state. Adv. Virus Res. 38:147-200.
    • (1990) Adv. Virus Res. , vol.38 , pp. 147-200
    • Staeheli, P.1
  • 15
    • 0022088385 scopus 로고
    • How does Toxoplasma gondii enter host cells?
    • Werk, R. 1985. How does Toxoplasma gondii enter host cells? Rev. Infect. Dis. 7:449-457.
    • (1985) Rev. Infect. Dis. , vol.7 , pp. 449-457
    • Werk, R.1
  • 19
    • 0025306614 scopus 로고
    • + immune T cells against toxoplasmosis in mice
    • + immune T cells against toxoplasmosis in mice. J. Immunol. 144:1954-1956.
    • (1990) J. Immunol. , vol.144 , pp. 1954-1956
    • Suzuki, Y.1    Remington, J.S.2
  • 20
    • 0024438401 scopus 로고
    • Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice
    • Suzuki, Y., F.K. Conley, and J.S. Remington. 1989. Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J. Immunol. 143:2045-2050.
    • (1989) J. Immunol. , vol.143 , pp. 2045-2050
    • Suzuki, Y.1    Conley, F.K.2    Remington, J.S.3
  • 21
    • 0027208743 scopus 로고
    • Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation
    • Gazzinelli, R.T., I.A. Eltoum, T. Wynn, and A. Sher. 1993. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J. Immunol. 151:3672-3681.
    • (1993) J. Immunol. , vol.151 , pp. 3672-3681
    • Gazzinelli, R.T.1    Eltoum, I.A.2    Wynn, T.3    Sher, A.4
  • 22
    • 0030294163 scopus 로고    scopus 로고
    • In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection
    • Scharton-Kersten, T.M., T.A. Wynn, E.Y. Denkers, S. Bala, E. Grunvald, S. Hieny, R.T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045-4054.
    • (1996) J. Immunol. , vol.157 , pp. 4045-4054
    • Scharton-Kersten, T.M.1    Wynn, T.A.2    Denkers, E.Y.3    Bala, S.4    Grunvald, E.5    Hieny, S.6    Gazzinelli, R.T.7    Sher, A.8
  • 23
    • 0032055198 scopus 로고    scopus 로고
    • Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
    • Deckert-Schluter, M., H. Bluethmann, A. Rang, H. Hof, and D. Schluter. 1998. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J. Immunol. 160:3427-3436.
    • (1998) J. Immunol. , vol.160 , pp. 3427-3436
    • Deckert-Schluter, M.1    Bluethmann, H.2    Rang, A.3    Hof, H.4    Schluter, D.5
  • 24
    • 0031940206 scopus 로고    scopus 로고
    • Decreased resistance of TNF receptor p55 and p75 deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo
    • Yap, G.S., T. Scharton-Kersten, H. Charest, and A. Sher. 1998. Decreased resistance of TNF receptor p55 and p75 deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. J. Immunol. 160:1340-1345.
    • (1998) J. Immunol. , vol.160 , pp. 1340-1345
    • Yap, G.S.1    Scharton-Kersten, T.2    Charest, H.3    Sher, A.4
  • 25
    • 0032530950 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondii
    • Khan, I.A., T. Matsuura, and L.H. Kasper. 1998. Inducible nitric oxide synthase is not required for long-term vaccine-based immunity against Toxoplasma gondii. J. Immunol. 161: 2994-3000.
    • (1998) J. Immunol. , vol.161 , pp. 2994-3000
    • Khan, I.A.1    Matsuura, T.2    Kasper, L.H.3
  • 26
    • 0030970867 scopus 로고    scopus 로고
    • Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
    • Scharton-Kersten, T.M., G. Yap, J. Magram, and A. Sher. 1997. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 185:1261-1273.
    • (1997) J. Exp. Med. , vol.185 , pp. 1261-1273
    • Scharton-Kersten, T.M.1    Yap, G.2    Magram, J.3    Sher, A.4
  • 29
    • 0027327619 scopus 로고
    • Mice lacking the tumor necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection with Listeria monocytogenes
    • Rothe, J., W. Lesslauer, H. Loetscher, Y. Lang, P. Koebel, F. Kontgen, A. Althage, R. Zinkernagel, M. Steinmetz, and H. Bluethmann. 1993. Mice lacking the tumor necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection with Listeria monocytogenes. Nature. 364:798-802.
    • (1993) Nature , vol.364 , pp. 798-802
    • Rothe, J.1    Lesslauer, W.2    Loetscher, H.3    Lang, Y.4    Koebel, P.5    Kontgen, F.6    Althage, A.7    Zinkernagel, R.8    Steinmetz, M.9    Bluethmann, H.10
  • 31
    • 0028963901 scopus 로고
    • Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4 T cell response
    • Swihart, K., U. Fruth, N. Messmer, K. Hug, R. Behin, S. Huang, G. Del Giudice, M. Aguet, and J. Louis. 1995. Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4 T cell response. J. Exp. Med. 181:961-971.
    • (1995) J. Exp. Med. , vol.181 , pp. 961-971
    • Swihart, K.1    Fruth, U.2    Messmer, N.3    Hug, K.4    Behin, R.5    Huang, S.6    Del Giudice, G.7    Aguet, M.8    Louis, J.9
  • 33
    • 0028943066 scopus 로고
    • Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α
    • Flesch, I.E., J.H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S.H.E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615-1621.
    • (1995) J. Exp. Med. , vol.181 , pp. 1615-1621
    • Flesch, I.E.1    Hess, J.H.2    Huang, S.3    Aguet, M.4    Rothe, J.5    Bluethmann, H.6    Kaufmann, S.H.E.7
  • 34
    • 0030753348 scopus 로고    scopus 로고
    • Listeriosis in p47 (phox -/-) and TNF R p55 -/-mice: Protection despite absence of ROI and susceptibility despite presence of RNI
    • Endres, R., A. Luz, H. Schulze, H. Neubauer, A. Futterer, S.M. Holland, H. Wagner, and K. Pfeffer. 1997. Listeriosis in p47 (phox -/-) and TNF R p55 -/-mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity. 7:419-432.
    • (1997) Immunity , vol.7 , pp. 419-432
    • Endres, R.1    Luz, A.2    Schulze, H.3    Neubauer, H.4    Futterer, A.5    Holland, S.M.6    Wagner, H.7    Pfeffer, K.8
  • 35
    • 0030889207 scopus 로고    scopus 로고
    • The IFNγ receptor: A paradigm for cytokine receptor signalling
    • Bach, E.A., M. Aguet, and R.D. Schreiber. 1997. The IFNγ receptor: a paradigm for cytokine receptor signalling. Annu. Rev. Immunol. 15:563-591.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 563-591
    • Bach, E.A.1    Aguet, M.2    Schreiber, R.D.3
  • 38
    • 0025219762 scopus 로고
    • Microbiostatic effect of murine activated macrophages for Toxoplasma gondii: Role for inorganic nitrogen oxides from L-arginine
    • Adams, L.B., J.B. Hibbs, R.R. Taintor, and J.L. Krahenbuhl. 1990. Microbiostatic effect of murine activated macrophages for Toxoplasma gondii: role for inorganic nitrogen oxides from L-arginine. J. Immunol. 144:2725-2729.
    • (1990) J. Immunol. , vol.144 , pp. 2725-2729
    • Adams, L.B.1    Hibbs, J.B.2    Taintor, R.R.3    Krahenbuhl, J.L.4
  • 39
    • 0031662836 scopus 로고    scopus 로고
    • Effect of cytokines on growth of Toxoplasma gondii in murine astrocytes
    • Halonen, S.K., F.C. Chiu, and L.M. Weiss. 1998. Effect of cytokines on growth of Toxoplasma gondii in murine astrocytes. Infect. Immun. 66:4989-4993.
    • (1998) Infect. Immun. , vol.66 , pp. 4989-4993
    • Halonen, S.K.1    Chiu, F.C.2    Weiss, L.M.3
  • 40
    • 0029797005 scopus 로고    scopus 로고
    • Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells
    • Nagineni, C.N., K. Pardhasaradhi, M. Martins, B. Detrick, and J.J. Hooks. 1996. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. Infect. Immun. 64:4188-4196.
    • (1996) Infect. Immun. , vol.64 , pp. 4188-4196
    • Nagineni, C.N.1    Pardhasaradhi, K.2    Martins, M.3    Detrick, B.4    Hooks, J.J.5
  • 41
    • 0030059619 scopus 로고    scopus 로고
    • Antiparasitic effector mechanisms in human brain tumor cells: Role of interferon-γ and tumor necrosis factor-α
    • Daubener, W., C. Remscheid, S. Nockemann, K. Pilz, S. Seghrouchni, C. Mackenzie, and U. Hadding. 1996. Antiparasitic effector mechanisms in human brain tumor cells: role of interferon-γ and tumor necrosis factor-α Eur. J. Immunol. 26:487-492.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 487-492
    • Daubener, W.1    Remscheid, C.2    Nockemann, S.3    Pilz, K.4    Seghrouchni, S.5    Mackenzie, C.6    Hadding, U.7
  • 42
    • 0028287976 scopus 로고
    • Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-γ primed mononuclear phagocytes
    • Thomas, S.R., D. Mohr, and R. Stocker. 1994. Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-γ primed mononuclear phagocytes. J. Biol. Chem. 269:14457-14464.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14457-14464
    • Thomas, S.R.1    Mohr, D.2    Stocker, R.3
  • 43
    • 0024495089 scopus 로고
    • Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages
    • Murray, H.W., A. Szuro-Sudol, D. Wellner, M.J. Oca, A.M. Granger, D.M. Libby, C.D. Rothermel, and B.Y. Rubin. 1989. Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages. Infect. Immun. 57:845-849.
    • (1989) Infect. Immun. , vol.57 , pp. 845-849
    • Murray, H.W.1    Szuro-Sudol, A.2    Wellner, D.3    Oca, M.J.4    Granger, A.M.5    Libby, D.M.6    Rothermel, C.D.7    Rubin, B.Y.8
  • 44
    • 0025101093 scopus 로고
    • Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts
    • Schwartzman, J.D., S.L. Gonias, and E.R. Pfefferkorn. 1990. Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts. Infect. Immun. 58:833-834.
    • (1990) Infect. Immun. , vol.58 , pp. 833-834
    • Schwartzman, J.D.1    Gonias, S.L.2    Pfefferkorn, E.R.3
  • 45
    • 0031179511 scopus 로고    scopus 로고
    • Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma activated murine macrophages and microglial cells
    • Alberati-Giani, D., P. Malherbe, P. Ricciardi-Castagnoli, C. Kohler, D. Denis-Donini, and A.M. Cesura. 1997. Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma activated murine macrophages and microglial cells. J. Immunol. 159:419-426.
    • (1997) J. Immunol. , vol.159 , pp. 419-426
    • Alberati-Giani, D.1    Malherbe, P.2    Ricciardi-Castagnoli, P.3    Kohler, C.4    Denis-Donini, D.5    Cesura, A.M.6
  • 46
    • 0026015043 scopus 로고
    • Human endothelial cells are activated by IFN-γ to inhibit Toxoplasma gondii replication. Inhibition is due to a different mechanism from that existing in mouse macrophages and human fibroblasts
    • Woodman, J.P., I.H. Dimier, and D. Bout. 1991. Human endothelial cells are activated by IFN-γ to inhibit Toxoplasma gondii replication. Inhibition is due to a different mechanism from that existing in mouse macrophages and human fibroblasts. J. Immunol. 147:2019-2023.
    • (1991) J. Immunol. , vol.147 , pp. 2019-2023
    • Woodman, J.P.1    Dimier, I.H.2    Bout, D.3
  • 48
    • 0028365389 scopus 로고
    • Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts
    • Gupta, S., J.M. Carlin, P. Pyati, W. Dai, E. Pfefferkorn, and M. Murphy. 1994. Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts. Infect. Immun. 62:2277-2284.
    • (1994) Infect. Immun. , vol.62 , pp. 2277-2284
    • Gupta, S.1    Carlin, J.M.2    Pyati, P.3    Dai, W.4    Pfefferkorn, E.5    Murphy, M.6
  • 49
    • 0027230728 scopus 로고
    • Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3 dioxygenase
    • Habara-Ohkubo, A., T. Shirahata, O. Takikawa, and R. Yoshida. 1993. Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3 dioxygenase. Infect. Immun. 61:1810-1813.
    • (1993) Infect. Immun. , vol.61 , pp. 1810-1813
    • Habara-Ohkubo, A.1    Shirahata, T.2    Takikawa, O.3    Yoshida, R.4
  • 50
    • 0030021968 scopus 로고    scopus 로고
    • Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
    • Guidotti, L., T. Ishikawa, M. Hobbs, B. Matzke, R. Schreiber, and F. Chisari. 1996. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity. 4:25-36.
    • (1996) Immunity , vol.4 , pp. 25-36
    • Guidotti, L.1    Ishikawa, T.2    Hobbs, M.3    Matzke, B.4    Schreiber, R.5    Chisari, F.6


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