-
2
-
-
33748992313
-
Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
-
Tilg H, Moschen AR 2006 Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772-783
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 772-783
-
-
Tilg, H.1
Moschen, A.R.2
-
3
-
-
27844545767
-
Signalling role of adipose tissue: Adipokines and inflammation in obesity
-
Trayhurn P, Wood IS 2005 Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33(Pt 5):1078-1081
-
(2005)
Biochem Soc Trans
, vol.33
, Issue.PART 5
, pp. 1078-1081
-
-
Trayhurn, P.1
Wood, I.S.2
-
4
-
-
37549022688
-
Inflammation and insulin resistance
-
de Luca C, Olefsky JM 2008 Inflammation and insulin resistance. FEBS Lett 582:97-105
-
(2008)
FEBS Lett
, vol.582
, pp. 97-105
-
-
de Luca, C.1
Olefsky, J.M.2
-
5
-
-
0037283601
-
The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes
-
Kahn SE 2003 The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3-19
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
6
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
-
Shepherd PR, Withers DJ, Siddle K 1998 Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333(Pt 3):471-490
-
(1998)
Biochem J
, vol.333
, Issue.PART 3
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
7
-
-
0035825643
-
Adipose-selective targeting of the GLUT4 gene impair insulin action in muscle and liver
-
Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB 2001 Adipose-selective targeting of the GLUT4 gene impair insulin action in muscle and liver. Nature 409:729-733
-
(2001)
Nature
, vol.409
, pp. 729-733
-
-
Abel, E.D.1
Peroni, O.2
Kim, J.K.3
Kim, Y.B.4
Boss, O.5
Hadro, E.6
Minnemann, T.7
Shulman, G.I.8
Kahn, B.B.9
-
8
-
-
33847060409
-
Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-α-induced insulin resistance
-
Nieto-Vazquez I, Fernandez-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M 2007 Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-α-induced insulin resistance. Diabetes 56:404-413
-
(2007)
Diabetes
, vol.56
, pp. 404-413
-
-
Nieto-Vazquez, I.1
Fernandez-Veledo, S.2
de Alvaro, C.3
Rondinone, C.M.4
Valverde, A.M.5
Lorenzo, M.6
-
9
-
-
33750900770
-
Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression
-
Fernandez-Veledo S, Nieto-Vazquez I, Rondinone CM, Lorenzo M 2006 Liver X receptor agonists ameliorate TNFα-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression. Diabetologia 49:3038-3048
-
(2006)
Diabetologia
, vol.49
, pp. 3038-3048
-
-
Fernandez-Veledo, S.1
Nieto-Vazquez, I.2
Rondinone, C.M.3
Lorenzo, M.4
-
10
-
-
0034672394
-
LiSa-2, a novel human liposarcoma cell line with a high capacity for terminal adipose differentiation
-
Wabitsch M, Bruderlein S, Melzner I, Braun M, Mechtersheimer G, Moller P 2000 LiSa-2, a novel human liposarcoma cell line with a high capacity for terminal adipose differentiation. Int J Cancer 88:889-894
-
(2000)
Int J Cancer
, vol.88
, pp. 889-894
-
-
Wabitsch, M.1
Bruderlein, S.2
Melzner, I.3
Braun, M.4
Mechtersheimer, G.5
Moller, P.6
-
11
-
-
33646512418
-
Roles of skeletal muscle and peroxisome proliferator-activated receptors in the development and treatment of obesity
-
Lopez-Soriano J, Chiellini C, Maffei M, Grimaldi PA, Argiles JM 2006 Roles of skeletal muscle and peroxisome proliferator-activated receptors in the development and treatment of obesity. Endocr Rev 27:318-329
-
(2006)
Endocr Rev
, vol.27
, pp. 318-329
-
-
Lopez-Soriano, J.1
Chiellini, C.2
Maffei, M.3
Grimaldi, P.A.4
Argiles, J.M.5
-
12
-
-
8744259926
-
Uncoupling insulin signalling by serine/threonine phosphorylation: A molecular basis for insulin resistance
-
Zick Y 2004 Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance. Biochem Soc Trans 32(Pt 5): 812-816
-
(2004)
Biochem Soc Trans
, vol.32
, Issue.PART 5
, pp. 812-816
-
-
Zick, Y.1
-
13
-
-
0032765395
-
Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: Is cellular insulin resistance a secondary phenomenon?
-
Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA 1999 Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon? Diabetes 48:1572-1578
-
(1999)
Diabetes
, vol.48
, pp. 1572-1578
-
-
Eriksson, J.W.1
Smith, U.2
Waagstein, F.3
Wysocki, M.4
Jansson, P.A.5
-
14
-
-
0033656672
-
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: Evidence for a pathogenic role of relative hyperinsulinemia
-
Weyer C, Hanson RL, Tataranni PA, Bogardus C, Pratley RE 2000 A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes 49:2094-2101
-
(2000)
Diabetes
, vol.49
, pp. 2094-2101
-
-
Weyer, C.1
Hanson, R.L.2
Tataranni, P.A.3
Bogardus, C.4
Pratley, R.E.5
-
16
-
-
9444250464
-
The central role of perilipin a in lipid metabolism and adipocyte lipolysis
-
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C 2004 The central role of perilipin a in lipid metabolism and adipocyte lipolysis. IUBMB Life 56:379-385
-
(2004)
IUBMB Life
, vol.56
, pp. 379-385
-
-
Tansey, J.T.1
Sztalryd, C.2
Hlavin, E.M.3
Kimmel, A.R.4
Londos, C.5
-
17
-
-
25644446102
-
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
-
Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY 2005 Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes. Nature 437:569-573
-
(2005)
Nature
, vol.437
, pp. 569-573
-
-
Zhang, J.1
Hupfeld, C.J.2
Taylor, S.S.3
Olefsky, J.M.4
Tsien, R.Y.5
-
18
-
-
1642323623
-
Perilipin expression in human adipose tissue is elevated with obesity
-
Kern PA, Di GG, Lu T, Rassouli N, Ranganathan G 2004 Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab 89:1352-1358
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 1352-1358
-
-
Kern1
PA, D.G.2
Lu, T.3
Rassouli, N.4
Ranganathan, G.5
-
19
-
-
14544271905
-
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
-
Gual P, Le Marchand-Brustel Y, Tanti JF 2005 Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie (Paris) 87:99-109
-
(2005)
Biochimie (Paris)
, vol.87
, pp. 99-109
-
-
Gual, P.1
Le Marchand-Brustel, Y.2
Tanti, J.F.3
-
20
-
-
0029071293
-
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes
-
Ricort JM, Tanti JF, Van OE, Le Marchand-Brustel Y 1995 Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes. Diabetologia 38:1148-1156
-
(1995)
Diabetologia
, vol.38
, pp. 1148-1156
-
-
Ricort, J.M.1
Tanti, J.F.2
Van, O.E.3
Le Marchand-Brustel, Y.4
-
21
-
-
19944430614
-
Muscle-specific Pten deletion protects against insulin resistance and diabetes
-
Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M 2005 Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25:1135-1145
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1135-1145
-
-
Wijesekara, N.1
Konrad, D.2
Eweida, M.3
Jefferies, C.4
Liadis, N.5
Giacca, A.6
Crackower, M.7
Suzuki, A.8
Mak, T.W.9
Kahn, C.R.10
Klip, A.11
Woo, M.12
-
22
-
-
0036231778
-
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice
-
Butler M, McKay RA, Popoff IJ, Gaarde WA, Witchell D, Murray SF, Dean NM, Bhanot S, Monia BP 2002 Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 51:1028-1034
-
(2002)
Diabetes
, vol.51
, pp. 1028-1034
-
-
Butler, M.1
McKay, R.A.2
Popoff, I.J.3
Gaarde, W.A.4
Witchell, D.5
Murray, S.F.6
Dean, N.M.7
Bhanot, S.8
Monia, B.P.9
-
23
-
-
0035039227
-
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
-
Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y 2001 Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133
-
(2001)
Diabetes
, vol.50
, pp. 1126-1133
-
-
Hotta, K.1
Funahashi, T.2
Bodkin, N.L.3
Ortmeyer, H.K.4
Arita, Y.5
Hansen, B.C.6
Matsuzawa, Y.7
-
24
-
-
0344443732
-
Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice
-
Takahashi K, Mizuarai S, Araki H, Mashiko S, Ishihara A, Kanatani A, Itadani H, Kotani H 2003 Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J Biol Chem 278:46654-46660
-
(2003)
J Biol Chem
, vol.278
, pp. 46654-46660
-
-
Takahashi, K.1
Mizuarai, S.2
Araki, H.3
Mashiko, S.4
Ishihara, A.5
Kanatani, A.6
Itadani, H.7
Kotani, H.8
-
25
-
-
0035023128
-
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
-
Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G 2001 Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Kern, P.A.1
Ranganathan, S.2
Li, C.3
Wood, L.4
Ranganathan, G.5
-
26
-
-
3042841952
-
How free fatty acids inhibit glucose utilization in human skeletal muscle
-
Roden M 2004 How free fatty acids inhibit glucose utilization in human skeletal muscle. News Physiol Sci 19:92-96
-
(2004)
News Physiol Sci
, vol.19
, pp. 92-96
-
-
Roden, M.1
-
27
-
-
3142701401
-
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
-
Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T 2004 Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 279:30817-30822
-
(2004)
J Biol Chem
, vol.279
, pp. 30817-30822
-
-
Tsuchida, A.1
Yamauchi, T.2
Ito, Y.3
Hada, Y.4
Maki, T.5
Takekawa, S.6
Kamon, J.7
Kobayashi, M.8
Suzuki, R.9
Hara, K.10
Kubota, N.11
Terauchi, Y.12
Froguel, P.13
Nakae, J.14
Kasuga, M.15
Accili, D.16
Tobe, K.17
Ueki, K.18
Nagai, R.19
Kadowaki, T.20
more..
-
28
-
-
1842531067
-
Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes
-
Fasshauer M, Klein J, Kralisch S, Klier M, Lossner U, Bluher M, Paschke R 2004 Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 317:598-604
-
(2004)
Biochem Biophys Res Commun
, vol.317
, pp. 598-604
-
-
Fasshauer, M.1
Klein, J.2
Kralisch, S.3
Klier, M.4
Lossner, U.5
Bluher, M.6
Paschke, R.7
-
29
-
-
0034042720
-
Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans
-
Pratley RE, Ren K, Milner MR, Sell SM 2000 Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans. Mol Genet Metab 70:19-26
-
(2000)
Mol Genet Metab
, vol.70
, pp. 19-26
-
-
Pratley, R.E.1
Ren, K.2
Milner, M.R.3
Sell, S.M.4
-
30
-
-
0034019050
-
Downregulation of leptin by free fatty acids in rat adipocytes: Effects of triacsin C, palmitate, and 2-bromopalmitate
-
Shintani M, Nishimura H, Yonemitsu S, Masuzaki H, Ogawa Y, Hosoda K, Inoue G, Yoshimasa Y, Nakao K 2000 Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate. Metabolism 49:326-330
-
(2000)
Metabolism
, vol.49
, pp. 326-330
-
-
Shintani, M.1
Nishimura, H.2
Yonemitsu, S.3
Masuzaki, H.4
Ogawa, Y.5
Hosoda, K.6
Inoue, G.7
Yoshimasa, Y.8
Nakao, K.9
-
31
-
-
33846331236
-
-
McAinch AJ, Steinberg GR, Mollica J, O'Brien PE, Dixon JB, Macaulay SL, Kemp BE, Cameron-Smith D 2006 Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals. Obesity (Silver Spring) 14:1898-1904
-
McAinch AJ, Steinberg GR, Mollica J, O'Brien PE, Dixon JB, Macaulay SL, Kemp BE, Cameron-Smith D 2006 Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals. Obesity (Silver Spring) 14:1898-1904
-
-
-
-
32
-
-
33645888426
-
Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle
-
Sell H, Dietze-Schroeder D, Kaiser U, Eckel J 2006 Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle. Endocrinology 147:2458-2467
-
(2006)
Endocrinology
, vol.147
, pp. 2458-2467
-
-
Sell, H.1
Dietze-Schroeder, D.2
Kaiser, U.3
Eckel, J.4
-
33
-
-
33845444350
-
Time-dependent effects of fatty acids on skeletal muscle metabolism
-
Hirabara SM, Silveira LR, Abdulkader F, Carvalho CR, Procopio J, Curi R 2007 Time-dependent effects of fatty acids on skeletal muscle metabolism. J Cell Physiol 210:7-15
-
(2007)
J Cell Physiol
, vol.210
, pp. 7-15
-
-
Hirabara, S.M.1
Silveira, L.R.2
Abdulkader, F.3
Carvalho, C.R.4
Procopio, J.5
Curi, R.6
-
34
-
-
12144290761
-
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
-
Kim HJ, Higashimori T, Park SY, Choi H, Dong J, Kim YJ, Noh HL, Cho YR, Cline G, Kim YB, Kim JK 2004 Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53:1060-1067
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
Higashimori, T.2
Park, S.Y.3
Choi, H.4
Dong, J.5
Kim, Y.J.6
Noh, H.L.7
Cho, Y.R.8
Cline, G.9
Kim, Y.B.10
Kim, J.K.11
-
35
-
-
0037965630
-
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
-
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P 2003 Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 100:5419-5424
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5419-5424
-
-
Laffitte, B.A.1
Chao, L.C.2
Li, J.3
Walczak, R.4
Hummasti, S.5
Joseph, S.B.6
Castrillo, A.7
Wilpitz, D.C.8
Mangelsdorf, D.J.9
Collins, J.L.10
Saez, E.11
Tontonoz, P.12
-
36
-
-
11144356074
-
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression
-
Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MG, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, Kim JB 2004 Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression. Mol Cell Biol 24: 3430-3444
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3430-3444
-
-
Seo, J.B.1
Moon, H.M.2
Kim, W.S.3
Lee, Y.S.4
Jeong, H.W.5
Yoo, E.J.6
Ham, J.7
Kang, H.8
Park, M.G.9
Steffensen, K.R.10
Stulnig, T.M.11
Gustafsson, J.A.12
Park, S.D.13
Kim, J.B.14
-
37
-
-
1642465503
-
Liver X receptors are regulators of adipocyte gene expression but not differentiation: Identification of apoD as a direct target
-
Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P 2004 Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res 45:616-625
-
(2004)
J Lipid Res
, vol.45
, pp. 616-625
-
-
Hummasti, S.1
Laffitte, B.A.2
Watson, M.A.3
Galardi, C.4
Chao, L.C.5
Ramamurthy, L.6
Moore, J.T.7
Tontonoz, P.8
-
38
-
-
33846821853
-
Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes
-
Zhang-Gandhi CX, Drew PD 2007 Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes. J Neuroimmunol 183:50-59
-
(2007)
J Neuroimmunol
, vol.183
, pp. 50-59
-
-
Zhang-Gandhi, C.X.1
Drew, P.D.2
-
39
-
-
0035655245
-
Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats
-
Kramer D, Shapiro R, Adler A, Bush E, Rondinone CM 2001 Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats. Metabolism 50:1294-1300
-
(2001)
Metabolism
, vol.50
, pp. 1294-1300
-
-
Kramer, D.1
Shapiro, R.2
Adler, A.3
Bush, E.4
Rondinone, C.M.5
-
40
-
-
15944392288
-
Rosiglitazone improves postprandial triglyceride and free fatty acid metabolism in type 2 diabetes
-
van Wijk JP, de Koning EJ, Castro CM, Rabelink TJ 2005 Rosiglitazone improves postprandial triglyceride and free fatty acid metabolism in type 2 diabetes. Diabetes Care 28:844-849
-
(2005)
Diabetes Care
, vol.28
, pp. 844-849
-
-
van Wijk, J.P.1
de Koning, E.J.2
Castro, C.M.3
Rabelink, T.J.4
|