Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: Role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

Biochemical Journal

Volumn 437, Issue 1, 2011, Pages 53-61

  Jin, Yi ^a   Mesaros, A Clementina ^a   Blair, Ian A ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Dihydrosteroid; Hydroxysteroid dehydrogenases; Liquid chromatography MS (LC MS); Steroid metabolism; Tetrahydrosteroid

Indexed keywords

5BETA ANDROSTANOLONE; 5BETA PREGNAN 20ALPHA OL 3 ONE; ALDO KETO REDUCTASE 1C1; ALDO KETO REDUCTASE 1C2; ALDO KETO REDUCTASE 1C3; ALDO KETO REDUCTASE 1C4; OXIDOREDUCTASE; PREGNANEDIONE; PROGESTERONE; STEROID 5BETA REDUCTASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; PROGESTERONE METABOLISM; PROTEIN FUNCTION; STEREOCHEMISTRY; STEREOSPECIFICITY; TESTOSTERONE METABOLISM;

20-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; BINDING SITES; CATALYSIS; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; HYDROXYSTEROID DEHYDROGENASES; KETOSTEROIDS; KINETICS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROGESTERONE; STEREOISOMERISM; TESTOSTERONE;

EID: 79958862747     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101804     Document Type: Article

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