Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids

Molecular Pharmacology

Volumn 56, Issue 4, 1999, Pages 752-759

  Morris, Kendall D W ^a   Moorefield, Charles N ^b   Amin, Jahanshah ^a,c  

^a Inst for Biomolecular Science   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; 5BETA DIHYDROPROGESTERONE; ALFAXALONE; ALLOTETRAHYDRODEOXYCORTICOSTERONE; ELTANOLONE; STEROID; TETRAHYDRODEOXYCORTICOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; NEUROTRANSMISSION; PRIORITY JOURNAL; REGULATORY MECHANISM;

5-ALPHA-DIHYDROPROGESTERONE; ANIMALS; ANTI-INFLAMMATORY AGENTS; DESOXYCORTICOSTERONE; GAMMA-AMINOBUTYRIC ACID; HUMANS; OOCYTES; PATCH-CLAMP TECHNIQUES; PREGNANEDIONES; PREGNANOLONE; RECEPTORS, GABA; RECEPTORS, PURINERGIC P1; XENOPUS LAEVIS;

EID: 0032881379     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Amin J (1999) A single hydrophobic residue confers barbiturate sensitivity to γ-aminobutyric acid type C receptor. Mol Pharmacol 366:565-569.
2. 1 GABA channels: Activation properties and domains. Recept Channels 2:227-236.
3. Amin J and Weiss DS (1996) Insights into the activation mechanism of ρ1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. Proc R Soc Lond 263:273-282.
4. Barker JL Harrison NL, Lange GD and Owen DG (1987) Potentiation of γ-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones. J Physiol 386:485-501.
5. Belelli D, Lambert JJ, Peters JA, Wafford K and Whiting PJ (1997) The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci USA 94:11031-11036.
6. A receptor by progesterone metabolites Proc R Soc Lond 231:359-369.
7. A receptor of bovine chromaffin cells in culture by some progesterone metabolites. J Physiol 381:117.
8. A receptor activity by alphaxalone. Br J Pharmacol 90:491-500.
9. Enz R, Brandstatter JH, Hartveit E, Wassle H and Bormann J (1995) Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat. Eur J Neurosci 7:1495-1501.
10. - channels in the rat retina. Progr Retinal Eye Res 17:99-126.
11. Gee KW, Bolger MB, Brinton RE, Coirini H and McEwen BS (1988) Steroid modulation of the chloride ionophore in rat brain: Structure-activity requirements, regional dependence and mechanism of action. J Pharmacol Exp Ther 248:960-966.
12. A receptor complex. J Pharmacol Exp Ther 241:346-353.
13. Harrison NL and Simmonds MA (1984) Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Res 323:287-292.
14. A receptors. Mol Pharmacol 37:429-434.
15. C receptors: Relatively simple transmitter-gated ion channels? Trends Pharmacol Sci 17:319-323.
16. Kokate TG, Svensson BE and Rogawski MA (1994) Anticonvulsant activity of neurosteroids: Correlation with γ-aminobutyric acid-evoked chloride current potentiation. J Pharmacol Exp Ther 270:1223-1229.
17. A receptor function. Trends Pharmacol Sci 16:295-303.
18. A receptor in frog pituitary melanotrophs. J Physiol 504:387-400.
19. C receptors in the vertebrate retina. Mol Neurobiol 12:181-194.
20. A receptor channels. Annu Rev Neurosci 17:569-602.
21. A receptor function by neuroactive steroids. Brain Res 819:75-82.
22. Majewska MD, Harrison NL, Schwartz RD, Barker JL and Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science (Wash DC) 232:1004-1007.
23. AA and glycine receptors. Nature (Lond) 389:385-389.
24. Morrow AL, Pace JR, Purdy RH and Paul SM (1990) Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: Evidence for multiple steroid recognition sites. Mol Pharmacol 37:263-270.
25. Morrow AL, Suzdak PD and Paul SM (1987) Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. Eur J Pharmacol 142:483-485.
26. Negri-Cesi P, Poletti A and Celotti F (1996) Metabolism of steroids in the brain: A new insight into the role of 5α-reductase and aromatase in brain differentiation and functions. J Steroid Biochem Mol Biol 58:455-466.
27. Paul SM and Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322.
28. A receptor by depressant barbiturates and pregnane steroids. Br J Pharmacol 94:1257-1269.
29. A receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model. J Physiol 500:475-485.
30. A receptors. Neuron 4:759-765.
31. Purdy RH, Morrow AL, Blinn JR and Paul SM (1990) Synthesis, metabolism, and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. J Med Chem 33:1572-1581.
32. Purdy RH, Morrow AL, Moore PH Jr and Paul SM (1991) Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain. Proc Natl Acad Sci USA 88:4553-4557.
33. Reith CA and Sillar KT (1997) Pre-and postsynaptic modulation of spinal GABAergic neurotransmission by the neurosteroid, 5α-pregnan-3α-ol-20-one. Brain Res 770:202-212.
34. Turner DM, Ransom RW, Yang SS-J and Olsen RW (1989) Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturate. J Pharmacol Exp Ther 248:960-966.
35. A receptor single channel kinetic properties of mouse spinal cord neurons in culture. J Physiol 456:215-245.
36. Wittmer LL, Hu Y, Kalkbrenner M, Evers AS, Zorumski CF and Covey DF (1996) Enantioselectivity of steroid-induced γ-aminobutyric acid A receptor modulation and anesthesia. Mol Pharmacol 50:1581-1586.
37. + RNA from mammalian brain and retina. Mol Pharmacol 41:89-103.
38. A receptor neurosteroid site. J Pharmacol Exp Ther 281:1095-1101.