Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: Implications for phase I and phase II steroid hormone metabolism

Journal of Biological Chemistry

Volumn 284, Issue 15, 2009, Pages 10013-10022

  Jin, Yi ^a   Duan, Ling ^a   Lee, Seon Hwa ^a   Kloosterboer, Helenius J ^b   Blair, Ian A ^a   Penning, Trevor M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NV Organon   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC EFFICIENCIES; CYTOSOLIC; DIHYDROTESTOSTERONE; GLUCURONIDE; HYDROXYSTEROID DEHYDROGENASE; ISOFORM; ISOFORMS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PHASE I; PHASE II; PRODRUG; SEQUENTIAL REACTION; STEROID HORMONE; SULFATE GROUPS; SYNTHETIC STEROIDS;

BIOCHEMISTRY; CATALYSTS; CHROMATOGRAPHIC ANALYSIS; HORMONES; LIPIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; ORGANIC POLYMERS;

ENZYMES;

ALDO KETOREDUCTASE 1C; ANDROSTANOLONE; ESTRADIOL 17 GLUCURONIDE; HYDROXYSTEROID DEHYDROGENASE; ISOENZYME; OXIDOREDUCTASE; PROTEIN AKR1C; STEROID HORMONE; TIBOLONE; UNCLASSIFIED DRUG; HORMONE; ISOPROTEIN; STEROID;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CYTOSOL; DRUG DETERMINATION; DRUG STRUCTURE; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FAMILY; STEREOCHEMISTRY; STEROID BINDING; STEROID METABOLISM; STRUCTURE ANALYSIS; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; ENZYMOLOGY; KINETICS; LIVER; METABOLISM; METHODOLOGY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CHROMATOGRAPHY, LIQUID; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; HORMONES; HUMANS; HYDROXYSTEROID DEHYDROGENASES; KINETICS; LIVER; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN ISOFORMS; STEROIDS;

EID: 65649152952     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809465200     Document Type: Article

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