Controlled nucleation in freeze-drying: Effects on pore size in the dried product layer, mass transfer resistance, and primary drying rate

Journal of Pharmaceutical Sciences

Volumn 100, Issue 8, 2011, Pages 3453-3470

  Konstantinidis, Alex K ^a   Kuu, Wei ^b   Otten, Lori ^a   Nail, Steven L ^b   Sever, Robert R ^a  

^a PRAXAIR INC   (United States)

^b BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

Algorithm; Controlled nucleation; Freeze drying; Heat transfer; Lyophilization; Mass transfer resistance; Mathematical modeling; Pore diffusion; Pore radius

Indexed keywords

MANNITOL; SUCROSE;

ARTICLE; DIFFUSION; DRUG FORMULATION; FREEZE DRYING; FREEZING; MODEL; NONLINEAR SYSTEM; POROSITY; TEMPERATURE DEPENDENCE;

EID: 79958824043     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22561     Document Type: Article

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