Evaluation of tunable diode laser absorption spectroscopy for in-process water vapor mass flux measurements during freeze drying

Journal of Pharmaceutical Sciences

Volumn 96, Issue 7, 2007, Pages 1776-1793

  Gieseler, Henning ^a   Kessler, William J ^b   Finson, Michael ^b   Davis, Steven J ^b   Mulhall, Phillip A ^b   Bons, Vincent ^c   Debo, David J ^c   Pikal, Michael J ^d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b PHYSICAL SCIENCES INC   (United States)

^c BOC Edwards Pharmaceutical Systems   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Freeze drying; Heat and mass transfer in freeze drying; Laser technology; Operational qualification (OQ); Process analytical technology (PAT); Scale up

Indexed keywords

MANNITOL; WATER;

ABSORPTION SPECTROSCOPY; ARTICLE; DIODE LASER; FLOW RATE; FREEZE DRYING; GRAVIMETRY; HEAT TRANSFER; LABORATORY APPARATUS, EQUIPMENT AND SUPPLIES; PRESSURE; TEMPERATURE; WATER VAPOR;

EID: 34547212342     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20827     Document Type: Article

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