Freeze-drying process design by manometric temperature measurement: Design of a smart freeze-dryer

Pharmaceutical Research

Volumn 22, Issue 4, 2005, Pages 685-700

  Tang, X ^a,c   Nail, Steven L ^b,d   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b PURDUE UNIVERSITY   (United States)

^c CENTOCOR INC   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

End point of primary drying; Freeze dryer overload; Freeze drying process design optimization; Heat and mass transfer; Manometric temperature measurement; Process analytical technology for freeze drying; Radiation effect; Residual moisture content

Indexed keywords

GLYCINE; MANNITOL; SUCROSE; WATER;

ACCURACY; ALGORITHM; ARTICLE; CALCULATION; COMPUTER PROGRAM; DESORPTION; FREEZE DRYING; HEAT TRANSFER; INFORMATION PROCESSING; LABORATORY; MANOMETRY; MOISTURE; PRESSURE; PRIORITY JOURNAL; PROCESS DESIGN; TEMPERATURE MEASUREMENT; THEORY; THERMAL ANALYSIS;

FREEZE DRYING; FREEZING; GLYCINE; MANNITOL; MANOMETRY; SUCROSE; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 18044391843     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-2501-2     Document Type: Article

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