Effect of ultrasound-controlled nucleation on structural and morphological properties of freeze-dried mannitol solutions

Chemical Engineering Research and Design

Volumn 86, Issue 2, 2008, Pages 193-200

  Hottot, Aurélie ^a   Nakagawa, Kyuya ^b   Andrieu, Julien ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITY OF HYOGO   (Japan)

Author keywords

Controlled nucleation; Freeze drying; Polymorphism; Ultrasound

Indexed keywords

MECHANICAL PERMEABILITY; NUCLEATION; POLYMORPHISM; SUBLIMATION; SURFACE ACTIVE AGENTS; ULTRASONICS;

FREEZE-DRIED MANNITOL SYSTEMS; FREEZE-DRYING;

DRYING;

DRYING; MECHANICAL PERMEABILITY; NUCLEATION; POLYMORPHISM; SUBLIMATION; SURFACE ACTIVE AGENTS; ULTRASONICS;

EID: 44249121743     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2007.11.009     Document Type: Article

References (21)

1. Acton, E., Morris, G.J., 1992, Method and apparatus for the control of solidification in liquids, W0/92/20420.
2. Burger A., Henck J.O., Hetz S., Rollinger J.M., and Stottner H. Energy/temperature diagram and compression behaviour of the polymorphs of d-mannitol. J Pharm Sci 89 (2000) 457-468
3. Cannon A.J., and Trapper E.H. The influence of lyophilization on the polymorphic behaviour of mannitol, PDA. J Pharm Sci Technol 54 (2000) 13-22
4. Carpenter J.F., Chang B.S., Garzon-Rodriguez W., and Randolph T.W. Rational design of stable lyophilized protein formulations: theory and practice. Pharm Biotechnol 43 (2002) 109-133
5. Gatlin L.A., and Nail S.L. Freeze drying overview. In: Harrison R.G. (Ed). Protein Purification Process Engineering vol. 18 (1994), CRC Press 317-367
6. Haikala R., Eerola R., Tanninen V.P., and Yliruss J. Polymorphic changes of mannitol during freeze drying: effect of surface active agents, PDA. J Pharm Sci Technol 51 2 (1997) 96-101
7. Hottot A., Vessot S., and Andrieu J. Determination of heat and mass transfer parameters during freeze drying cycle of pharmaceutical products, PDA. J Pharm Sci Technol 59 (2005) 138-153
8. Hottot A., Andrieu J., and Vessot S. Sublimation kinetics during freeze-drying of pharmaceutical protein formulation. Dry Technol 25 (2007) 753-758
9. Inada T., Zhang X., Yabe A., and Kozawa Y. Active control of phase change from supercooled water to ice by ultrasonics vibration 1. Control of freezing temperature. Int J Heat Mass Transfer 44 (2001) 4523-4531
10. Izutsu K., Ocheda S.A., Aoyagi N., and Kojima S. Effects of sodium tetraborate and boric acid on nonisothermal mannitol crystallization in frozen solutions and freeze dried solid. Int J Pharmaceutics 173 (2004) 85-93
11. Kim A.I., Akers M.J., and Nail S.L. The physical state of mannitol after freeze drying: effects of mannitol concentration, freezing rate and a non crystallizing cosolute. J Pharm Sci 87 8 (1998) 931-935
12. Li B., and Sun D.W. Effect of power ultrasound on freezing rate during immersion freezing of potatoes. J Food Eng 55 (2002) 277-282
13. Nail S.L., Jiang S., Chongprasert S., and Knopp S.A. Fundamentals of freeze drying. Pharm Biotechnol 14 (2002) 281-360
14. Nakagawa K., Hottot A., Vessot S., and Andrieu J. Influence of controlled nucleation by ultrasounds on ice morphology of frozen formulations for pharmaceutical protein freeze-drying. Chem Eng Process 45 (2006) 783-791
15. Nakagawa K., Hottot A., Vessot S., and Andrieu J. Modeling of freezing step during freeze drying of drugs in vials. AIChE J 53 5 (2007) 1362-1372
16. Searles J.A., Carpenter J.F., and Randolph T.W. The ice nucleation temperature determines the primary drying rate of lyophilization for sample frozen on a temperature controlled shelf. J Pharm Sci 90 7 (2001) 860-870
17. Sharma V.K., and Kalonia D.S. Effect of vacuum drying on protein-mannitol interactions: the physical state of mannitol and protein structure in the dried state. AAPS PharmSciTech 5 1 (2004) 1-12
18. Walter-Levy L. les variétés cristallines du d-mannitol. CR Acad Sc Paris Ser C 267 (décembre 23, 1968) 1779-1782
19. Zhang X., Inada T., Yabe A., Lu S., and Kozawa Y. Active control of phase change from supercooled water to ice by ultrasonics vibration 2. Generation of ice slurries and effect of bubble nuclei. Int J Heat Mass Transfer 44 (2001) 4533-4539
20. Zhang X., Inada T., and Tezuka A. Ultrasonic induced nucleation of ice in water containing air bubbles. Ultrason Sonochem 10 (2003) 71-76
21. Zheng L., and Sun D.W. Innovative applications of power ultrasound during food freezing processes-a review. Trends Food Sci Technol. 17 (2006) 16-23