Rapid determination of dry layer mass transfer resistance for various pharmaceutical formulations during primary drying using product temperature profiles

International Journal of Pharmaceutics

Volumn 313, Issue 1-2, 2006, Pages 99-113

  Kuu, Wei Y ^a   Hardwick, Lisa M ^b   Akers, Michael J ^b  

^a BAXTER HEALTHCARE CORPORATION   (United States)

^b BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

5 Mannitol; Collapse temperature; Dry layer product resistance parameters; FORTRAN; Lactose dehydrogenase (LDH); Mass transfer resistance; Micro collapse; Newton Ralphson iteration; Powell's optimization algorithm; Primary drying; Primary drying subroutine

Indexed keywords

LACTOSE; LACTOSE DEHYDROGENASE; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; DRUG FORMULATION; DRUG STORAGE; FREEZE DRYING; HEAT TRANSFER; LABORATORY TEST; MANOMETRY; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; SIMULATION; STORAGE TEMPERATURE; TEMPERATURE DEPENDENCE; WATER VAPOR;

ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; EXCIPIENTS; FREEZE DRYING; MANNITOL; MODELS, CHEMICAL; SUCROSE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; WATER;

EID: 33645325915     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.01.036     Document Type: Article

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