Effect of controlled ice nucleation on primary drying stage and protein recovery in vials cooled in a modified freeze-dryer

Journal of Biomechanical Engineering

Volumn 131, Issue 7, 2009, Pages

  Passot, Stéphanie ^a   Tréléa, Ioan Cristian ^a   Marin, Michèle ^a   Galan, Miquel ^b   Morris, G John ^c   Fonseca, Fernanda ^a  

^a AGROPARISTECH   (France)

^b Telstar Industrial SL   (Spain)

^c ST JOHN S COLLEGE   (United Kingdom)

Author keywords

Freeze drying; Lyophilization; Nucleation temperature; Protein; Sublimation rates homogeneity

Indexed keywords

ACTIVITY RECOVERY; CONTROLLED NUCLEATION; COOLING RATES; ENZYMATIC ACTIVITIES; FREEZE-DRYING; FREEZING METHODS; ICE NUCLEATION; LYOPHILIZATION; MALTODEXTRINS; MODEL PROTEINS; NUCLEATING AGENTS; NUCLEATION TEMPERATURE; PRIMARY DRYING; PROTECTIVE AGENTS; PROTEIN RECOVERY; PROTEIN STABILITY; RESIDUAL WATER CONTENT; SUBLIMATION RATES; SUBLIMATION RATES HOMOGENEITY; THERMAL PROPERTIES; ULTRASOUND TECHNOLOGY; VISUAL ASPECTS;

COOLING; DRYERS (EQUIPMENT); ENZYME ACTIVITY; FREEZING; ICE; LOW TEMPERATURE DRYING; PROTEINS; RECOVERY; SUBLIMATION; SUGAR (SUCROSE); THERMODYNAMIC PROPERTIES; ULTRASONIC TRANSMISSION; ULTRASONICS; WATER CONTENT;

NUCLEATION;

CATALASE; MALTODEXTRIN; SUCROSE; ICE;

ARTICLE; ENZYME ACTIVITY; FREEZE DRYING; FREEZING; ICE NUCLEATION; INTERMETHOD COMPARISON; PROTEIN STABILITY; PSEUDOMONAS SYRINGAE; STORAGE; ULTRASOUND; WATER CONTENT; CHEMISTRY; CRYSTALLIZATION; DRUG STORAGE; ENZYME ACTIVATION; ENZYME STABILITY; METHODOLOGY; RADIATION EXPOSURE;

CATALASE; CRYSTALLIZATION; DRUG STORAGE; ENZYME ACTIVATION; ENZYME STABILITY; FREEZE DRYING; ICE; SONICATION;

EID: 70349932496     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.3143034     Document Type: Article

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