Determination of end point of primary drying in freeze-drying process control

AAPS PharmSciTech

Volumn 11, Issue 1, 2010, Pages 73-84

  Patel, Sajal M ^a   Doen, Takayuki ^a,b   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b Takeda Pharmaceuticals   (Japan)

Author keywords

End point; Freeze drying; PAT; Primary drying; Residual water

Indexed keywords

MANNITOL; SUCROSE;

ABSORPTION SPECTROSCOPY; ARTICLE; CALIBRATION; CONSTANT COMPARATIVE METHOD; CONTROLLED STUDY; DIODE LASER; ELECTRIC CAPACITANCE; FREEZE DRYING; MANOMETRY; OXIDATION; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROCESS CONTROL; THERMOGRAVIMETRY; WATER ANALYSIS; WATER VAPOR;

DESICCATION; FREEZE DRYING; HUMIDITY; ICE; MANNITOL; MANOMETRY; PRESSURE; SPECTRUM ANALYSIS; SUCROSE; TEMPERATURE; WATER;

EID: 77950918345     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9362-7     Document Type: Article

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