Product mass transfer resistance directly determined during freeze-drying cycle runs using tunable diode laser absorption spectroscopy (TDLAS) and pore diffusion model

Pharmaceutical Development and Technology

Volumn 16, Issue 4, 2011, Pages 343-357

  Kuu, Wei Y ^a   Obryan, Kevin R ^a   Hardwick, Lisa M ^a   Paul, Timothy W ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

Freeze drying; Mass transfer; Mathematical modeling; Pore diffusion; Product resistance; Tunable diode laser absorption spectroscopy

Indexed keywords

LACTOSE; MANNITOL; SUCROSE;

ABSORPTION SPECTROSCOPY; ARTICLE; DIFFUSION; DIODE LASER; FREEZE DRYING; HEAT TRANSFER; PARENTERAL NUTRITION; PRIORITY JOURNAL; PRODUCT MASS TRANSFER RESISTANCE; PRODUCT PARAMETERS; TEMPERATURE; TUNABLE DIODE LASER ABSORPTION SPECTROSCOPY; WATER VAPOR;

ALGORITHMS; DIFFUSION; EXCIPIENTS; FREEZE DRYING; LACTOSE; LASERS, SEMICONDUCTOR; MANNITOL; MODELS, CHEMICAL; SPECTRUM ANALYSIS; SUBLIMATION; SUCROSE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; VITAMINS; WATER;

EID: 79958802781     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837451003739263     Document Type: Article

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