The possible functions of duplicated ets (GGAA) motifs located near transcription start sites of various human genes

Cellular and Molecular Life Sciences

Volumn 68, Issue 12, 2011, Pages 2039-2051

  Uchiumi, Fumiaki ^a   Miyazaki, Satoru ^a   Tanuma, Sei Ichi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Differentiation; Ets family proteins; GGAA motif; TATA box; TATA less promoters; TF SEARCH; TSS

Indexed keywords

CD31 ANTIGEN; CD40 ANTIGEN; COMPLEMENTARY DNA; FIBRINOGEN RECEPTOR; INITIATION FACTOR 3; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1BETA; PHORBOL 13 ACETATE 12 MYRISTATE; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN S 100; RETINOBLASTOMA BINDING PROTEIN 1; SCLEROPROTEIN; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR ETS;

CD31 GENE; CD40 GENE; CD41 GENE; CELL STRAIN HL 60; DNA FLANKING REGION; DNA SEQUENCE; ECM GENE; EIF3A GENE; GENE CLUSTER; GENE DUPLICATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC TRANSCRIPTION; HUMAN; IL 1BETA GENE; IL 1R1 GENE; IL 1R2 GENE; IL 1RAPL2 GENE; ISG15 GENE; PDCD1 GENE; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN MOTIF; RB GENE; REVIEW; S100A3 GENE; TRANSCRIPTION INITIATION SITE;

BASE SEQUENCE; BINDING SITES; HL-60 CELLS; HUMANS; MODELS, GENETIC; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-ETS; REPETITIVE SEQUENCES, NUCLEIC ACID; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION INITIATION SITE;

EID: 79958253681     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0674-x     Document Type: Review

References (135)

1. E Huberman MF Callaham 1979 Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents Proc Natl Acad Sci USA 76 1293 1297 286311 1:CAS:528:DyaE1MXktVWju7c%3D (Pubitemid 9143726)
2. HP Koeffler 1986 Human acute myeloid leukemia lines: models of leukemogenesis Semin Hematol 23 223 236 3092357 1:STN:280:DyaL28zhsF2hsQ%3D%3D
3. SJ Collins 1987 The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression Blood 70 1233 1244 3311197 1:CAS:528:DyaL1cXjsFGmtg%3D%3D (Pubitemid 18026122)
4. X Zheng R Ravatn Y Lin W-C Shih A Rabson R Strair E Huberman A Conney KV Chin 2002 Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis Nucleic Acids Res 30 4489 4499 12384596 1:CAS:528: DC%2BD38Xot1Cisrg%3D (Pubitemid 35277259)
5. ZT Han XX Zhu RY Yang JZ Sun GF Tian XJ Liu GS Cao HL Newmark AH Conney RL Chang 1998 Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13- acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity Proc Natl Acad Sci USA 95 5357 5361 9560280 1:CAS:528:DyaK1cXivV2jtbw%3D (Pubitemid 28208602)
6. ZT Han YK Tong LM He Y Zhang JZ Sun TY Wang H Zhang YL Cui HL Newmark AH Conney RL Chang 1998 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs Proc Natl Acad Sci USA 95 5362 5365 9560281 1:CAS:528:DyaK1cXivV2jtb0%3D (Pubitemid 28208603)
7. RK Strair D Schaar L Goodell J Aisner KV Chin J Eid R Senzon XX Cui ZT Han B Knox AB Rabson R Chang A Conney 2002 Administration of a phorbol ester to patients with hematological malignancies: preliminary results from a phase I clinical trial of 12-O-tetradecanoylphorbol-13-acetate Clin Cancer Res 8 2512 2518 12171877 1:CAS:528:DC%2BD38XmvVaiu7Y%3D (Pubitemid 34856333)
8. K Takahashi S Yamanaka 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 663 676 16904174 1:CAS:528:DC%2BD28Xpt1aktbs%3D (Pubitemid 44233629)
9. K Takahashi K Tanabe M Ohnuki M Narita T Ichisaka K Tomoda S Yamanaka 2007 Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 861 872 18035408 1:CAS:528:DC%2BD2sXhsVCntbbK (Pubitemid 350138099)
10. F Uchiumi G Sakakibara J Sato S Tanuma 2008 Characterization of the promoter region of the human PARG gene and its response to PU.1 during differentiation of HL-60 cells Genes Cells 13 1229 1247 19076642 1:CAS:528:DC%2BD1MXnslek
11. F Uchiumi M Komuro R Mizuta S Tanuma 2004 Characterization of Smubp-2 as a mouse mammary tumor virus promoter-binding protein Biochem Biophys Res Commun 321 355 363 15358184 1:CAS:528:DC%2BD2cXmtVajs7c%3D (Pubitemid 39055754)
12. F Uchiumi K Enokida T Shiraishi A Masumi S Tanuma 2010 Characterization of the promoter region of the human IGHMBP2 (Sμbp-2) gene and its response to TPA in HL-60 cells Gene 463 8 17 20441787 1:CAS:528:DC%2BC3cXovFSksLs%3D
13. J-X Lin NK Bhat S John WS Queale WJ Leonard 1993 Characterization of the human interleukin-2 receptor β-chain gene promoter: regulation of promoter activity by ets gene products Mol Cell Biol 13 6201 6210 8413220 1:CAS:528:DyaK3sXms1Cjtbs%3D (Pubitemid 23292614)
14. F Uchiumi T Watanabe S Tanuma 2010 Characterization of various promoter regions of human DNA helicase-encoding genes and identification of duplicated ets (GGAA) motifs as an essential transcription regulatory element Exp Cell Res 316 1523 1534 20302858 1:CAS:528:DC%2BC3cXmtFCgurw%3D
15. D O'Reilly CM Quinn T El-Shanawany S Gordon DR Greaves 2003 Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner J Biol Chem 278 21909 21919 12676954 (Pubitemid 36792598)
16. JR Sevinsky AM Whalen NG Ahn 2004 Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler Mol Cell Biol 24 4534 4545 15121870 1:CAS:528:DC%2BD2cXjvFChur4%3D (Pubitemid 44109136)
17. DR Phillips IF Charo LV Parise LA Fitzgerald 1988 The platelet membrane glycoprotein IIb-IIIa complex Blood 71 831 843 2833328 1:CAS:528: DyaL1cXitF2gsrc%3D
18. JF Dorsey JM Cunnick SM Mane J Wu 2002 Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2 Blood 99 1388 1397 11830491 1:CAS:528:DC%2BD38XhtlWqt78%3D (Pubitemid 34547096)
19. A Masumi I Hamaguchi M Kuramitsu T Mizukami K Takizawa H Momose S Naito K Yamaguchi 2009 Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells FEBS Lett 583 3493 3500 19818776 1:CAS:528:DC%2BD1MXhtlGhsr%2FI
20. E Stellacci U Testa E Petrucci E Bendetti R Orsatti T Feccia M Stafsnes G Marziali A Battistini 2004 Interferon regulatory factor-2 drives megakaryocytic differentiation Biochem J 377 367 378 14505489 1:CAS:528:DC%2BD2cXis1ajtg%3D%3D (Pubitemid 38142192)
21. HY Cho SW Lee SK Seo IW Choi I Choi SW Lee 2008 Interferon-sensitive response element (ISRE) is mainly responsible for IFN-α-induced upregulation of programmed death-1 (PD-1) in macrophages Biochim Biophys Acta 1779 811 819 18771758 1:CAS:528:DC%2BD1cXhsVWmtL%2FL
22. L Chen 2004 Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity Nat Rev Immunol 4 336 347 15122199 1:CAS:528: DC%2BD2cXjsFChsrY%3D (Pubitemid 38649276)
23. DJ Perry KJ Austin TR Hansen 1999 Cloning of interferon-stimulated gene 17: the promoter and nuclear proteins that regulate transcription Mol Endocrinol 13 1197 1206 10406469 1:CAS:528:DyaK1MXktFKgtro%3D (Pubitemid 30644306)
24. VT Nguyen EN Benveniste 2000 Involvement of STAT-1 and Ets family members in interferon-γ induction of CD40 transcription in microglia/macrophages J Biol Chem 275 23674 23684 10823830 1:CAS:528:DC%2BD3cXls12mtbY%3D (Pubitemid 30624652)
25. MC Rouyez M Lestingi M Charon S Fichelson A Buzyn I Dusanter-Fourt 2005 IFN regulatory factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity J Immunol 174 3948 3958 15778351 1:CAS:528:DC%2BD2MXisVChsrg%3D (Pubitemid 40395969)
26. MPR Berry CM Graham FW McNab Z Xu SAA Bloch T Oni KA Wilkinson R Banchereau J Skinner RJ Wilkinson C Quinn D Blankenship R Dhawan JJ Cush A Mejias O Ramilo OM Kon V Pascual J Banchereau D Chaussabel A O'Garra 2010 An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis Nature 466 973 977 20725040 1:CAS:528:DC%2BC3cXhtVyks7bN
27. MR Zaidi S Davis FP Noonan C Graff-Cherry TS Hawley RL Walker L Feigenbaum E Fuchs L Lyakh HA Young TJ Hornyak H Arnheiter G Trinchieri PS Meltzer EC De Fabo G Merlino 2011 Interferon-γ links ultraviolet radiation to melanomagenesis in mice Nature 469 548 553 21248750 1:CAS:528: DC%2BC3MXnsFaqtg%3D%3D
28. Z Yang N Wara-Aswapati C Chen J Tsukada PE Auron 2000 NF-IL6 (C/EBPβ) vigorously activates il1b gene expression via a Spi-1 (PU.1) protein-protein tether J Biol Chem 275 21272 21277 10801783 1:CAS:528: DC%2BD3cXkvFGju70%3D (Pubitemid 30481824)
29. A Avots A Hoffmeyer E Flory A Cimanis UR Rapp E Serfling 1997 GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction Mol Cell Biol 17 4381 4389 9234696 1:CAS:528:DyaK2sXkvVeqtLY%3D (Pubitemid 27318115)
30. A Kasza P Wyrzykowska I Horwacik P Tymoszuk D Mizgalska K Palmer H Rokita AD Sharrocks J Jura 2010 Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression BMC Mol Biol 11 14 20137095
31. HH Xue J Bollenbacher V Rovella R Tripuraneni YB Du CY Liu A Williams JP McCoy WJ Leonard 2004 GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells Nat Immunol 5 1036 1044 15361867 1:CAS:528:DC%2BD2cXnvFCgs78%3D (Pubitemid 41057723)
32. R Grenningloh TS Tai N Frahm TC Hongo AT Chicoine C Brander DE Kaufmann IC Ho 2011 Ets-1 maintains IL-7 receptor expression in peripheral T cells J Immunol 186 969 976 21148801 1:CAS:528:DC%2BC3MXjs1OntQ%3D%3D
33. S Yu DM Zhao R Jothi HH Xue 2010 Critical requirement of GABPalpha for normal T cell development J Biol Chem 285 10179 10188 20139079 1:CAS:528:DC%2BC3cXjvFajtrs%3D
34. A Guitierrez-Hartmann DL Duval AP Bradford 2007 ETS transcription factors in endocrine systems Trends Endocrinol Metab 18 150 158 (Pubitemid 46629025)
35. A Fernández-Alvarez M Soledad Alvarez C Cucarella M Casado 2010 Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs J Biol Chem 285 11765 11774 20145255
36. RLC Hoo JYS Chu Y Yuan CM Yeung KYY Chan BKC Chow 2010 Functional identification of an intronic promoter of the human glucose-dependent insulinotropic peptide gene Gene 463 29 40 20452407 1:CAS:528: DC%2BC3cXovFSksLw%3D
37. EH Blackburn 2000 The end of the (DNA) line Nat Struct Biol 7 847 850 11017190 1:CAS:528:DC%2BD3cXns1eiu74%3D
38. PE Warburton 2001 Epigenetic analysis of kinetochore assembly on variant human centromeres Trends Genet 17 243 247 11335021 1:CAS:528: DC%2BD3MXjtFCltbg%3D (Pubitemid 32378741)
39. K Sugimoto A Shibata M Himeno 1998 Nucleotide specificity at the boundary and size requirement of the target sites recognized by human centromere protein (CENP-B) in vitro Chromosome Res 6 133 140 9543016 1:CAS:528:DyaK1cXitVWnsrs%3D (Pubitemid 28121897)
40. J Ohzeki M Nakano T Okada H Masumoto 2002 CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA J Cell Biol 159 765 775 12460987 1:CAS:528:DC%2BD38XpsFCqtbs%3D (Pubitemid 36008359)
41. O Delattre J Zucman B Plougastel C Desmaze T Melot M Peter H Kovar I Joubert P de Jong G Rouleau A Aurias G Thomas 1992 Gene function with an ETS DNA-binding domain caused by chromosome translocation in human tumors Nature 359 162 165 1522903 1:CAS:528:DyaK3sXkvFantL0%3D
42. K Gangwal S Sankar PC Hollenhorst M Kinsey SC Haroldsen AA Shah KM Boucher WS Watkins LB Jorde BJ Graves L Lessnick 2008 Microsatellites as EWS/FLI response elements in Ewing's sarcoma Proc Natl Acad Sci USA 105 10149 10154 18626011 1:CAS:528:DC%2BD1cXptF2rsb8%3D
43. N Guillon F Tirode V Boeva A Zynovyev E Barillot O Delattre 2009 The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function PLoS One 4 e4932 19305498
44. H Kovar 2010 Downstream EWS/FLI1-upstream Ewing's sarcoma Genome Med 2 8 20156317
45. W Luo K Gangwal S Sankar KM Boucher D Thomas SL Lessnick 2009 GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance Oncogene 28 4126 4132 19718047 1:CAS:528: DC%2BD1MXhtVKhs7jJ
46. E Garcia-Aragoncillo J Carrillo E Lalli N Agra G Gomez-Lopez A Pestana J Alonso 2008 DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells Oncogene 27 6034 6043 18591936 1:CAS:528:DC%2BD1cXht1WmtLjN
47. K Gangwal D Close CA Enriquez CP Hill SL Lessnick 2010 Emergent properties of EWS/FLI regulation via GGAA microsatellites in Ewing's sarcoma Genes Cancer 1 177 187 20827386 1:CAS:528:DC%2BC3cXhtV2ntrzM
48. PC Hollenhorst AA Shah C Hopkins BJ Graves 2007 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family Genes Dev 21 1882 1894 17652178 1:CAS:528:DC%2BD2sXps1alsr0%3D (Pubitemid 47204928)
49. P Moffatt M-H Gaumond P Salois K Sellin M-C Bessette E Godin PT de Oliveira GJ Atkins A Nanci G Thomas 2008 Bril: A novel bone-specific modulator of mineralization J Bone Mineral Res 23 1497 1508 1:CAS:528:DC%2BD1cXhtFSlurvF
50. M Riemenschneider R Buschges M Wolter J Reifenberger J Bostrom JA Kraus U Schlegel G Reifenberger 1999 Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification Cancer Res 59 6091 6096 10626796 1:CAS:528: DC%2BD3cXktFyitQ%3D%3D (Pubitemid 30035626)
51. EJ Lowenstein RJ Daly AG Batzer W Li B Margolis R Lammers A Ullrich EY Skolnik D Bar-Sagi J Schlessinger 1992 The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling Cell 70 431 442 1322798 1:CAS:528:DyaK3sXkt1ajtbg%3D
52. R Geiss-Friedlander F Melchior 2007 Concepts in sumoylation: a decade on Nat Rev Mol Cell Biol 8 947 956 18000527 1:CAS:528:DC%2BD2sXhtlCrsbrN (Pubitemid 350176509)
53. HD Ulrich H Walden 2010 Ubiquitin signaling in DNA replication and repair Nat Rev Mol Cell Biol 11 479 489 20551964 1:CAS:528:DC%2BC3cXnsVymtL0%3D
54. G MacDonald M Stramwasser CR Mueller 2007 Characterization of a negative transcription element in the BRCA1 promoter Breast Cancer Res 9 R49 17663789
55. KM Baker G Wei AE Schaffner MC Ostrowski 2003 Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter J Biol Chem 278 17876 17884 12637547 1:CAS:528:DC%2BD3sXjs1KitLs%3D (Pubitemid 36799393)
56. MSY Huen SMH Sy J Chen 2010 BRCA1 and its toolbox for the maintenance of genome integrity Nat Rev Mol Cell Biol 11 138 148 20029420 1:CAS:528: DC%2BD1MXhsF2hs7fF
57. JR Morris C Boutell M Keppler R Densham D Weekes A Alamshah L Butler Y Galanty L Pangon T Kiuchi T Ng E Solomon 2009 The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress Nature 462 886 890 20016594 1:CAS:528:DC%2BD1MXhsFOhtLnL
58. AF Alpi KJ Patel 2009 Monoubiquitylation in the Fanconi anaemia DNA damage response pathway DNA Repair 8 430 435 19264559 1:CAS:528: DC%2BD1MXktFWrsLs%3D
59. S Nakada I Tai S Panier A Al-Hakim S Iemura Y-C Juang L O'Donnell A Kumakubo M Munro F Sicheri A-C Gingras T Natsume T Suda D Durocher 2010 Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 Nature 466 941 946 20725033 1:CAS:528:DC%2BC3cXhtVyks7nO
60. NK Lee SY Lee 2002 Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs) J Biochem Mol Biol 35 61 66 16248971 (Pubitemid 35216582)
61. SP Fortin MJ Ennis BA Savitch D Carpentieri WS McDonough JA Winkles JC Loftus C Kingsley G Hostetter NL Tran 2009 Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function Mol Cancer Res 7 1871 1881 19861406 1:CAS:528:DC%2BD1MXhsVamsr3M
62. RD Petty LM Samuel GI Murray G MacDonald T O'Kelly M Loudon N Binnie E Aly A McKinlay W Wang F Gilbert S Semple ESR Collie-Duguid 2009 APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling BMC Cancer 9 434 20003335
63. JH Steer KM Kroeger LJ Abraham DA Joyce 2000 Glucocorticoids suppress tumor necrosis factor-α expression by human monocytic THP-1 cells by suppressing transactivation through adjacent NF-κB and c-Jun-activating transcription factor-2 binding sites in the promoter J Biol Chem 275 18432 18440 10748079 1:CAS:528:DC%2BD3cXktlylsr4%3D (Pubitemid 30414801)
64. B Amir-Ahmady LM Salati 2001 Regulation of the processing of glucose-6-phosphate dehydrogenase mRNA by nutritional status J Biol Chem 276 10514 10523 11124967 1:CAS:528:DC%2BD3MXis1Okuro%3D
65. JM Irimia CM Meyer CL Peper L Zhai CB Bock SF Previs OP McGuinness A DePaoli-Roach PJ Roach 2010 Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knockout mice J Biol Chem 285 12851 12861 20178984 1:CAS:528:DC%2BC3cXkvVGju7k%3D
66. +/myo-inositol transporter HMIT BMC Cell Biol 10 54 19607714
67. M Nilsson K Dahlman-Wright C Karelmo J Gustafsson KR Steffensen 2007 Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter Nucleic Acids Res 35 4858 4868 17626048 1:CAS:528:DC%2BD2sXpt1CitLw%3D (Pubitemid 47260296)
68. NE Faulkner JM Hilfinger DM Markovitz 2001 Protein phosphatase 2A activates the HIV-2 promoter through enhancer elements that include the pets site J Biol Chem 276 25804 25812 11320078 1:CAS:528:DC%2BD3MXlsVKgtb8%3D
69. Y-T Juang L Sumibcay M Tolnay Y Wang VC Kyttaris GC Tsokos 2007 Elf-1 binds to GGAA elements on the FcRγ promoter and represses its expression J Immunol 179 4884 4889 17878388 1:CAS:528:DC%2BD2sXhtVCrurbK
70. VI Sementchenko DK Watson 2000 Ets target genes: past, present and future Oncogene 19 6533 6548 11175369 1:CAS:528:DC%2BD3MXptVelsQ%3D%3D (Pubitemid 32108443)
71. M Bina P Wyss W Ren W Szpankowski E Thomas R Randhawa S Reddy PM John EI Pares-Matos A Stein H Xu SA Lazarus 2004 Exploring the characteristics of sequence elements in proximal promoters of human genes Genomics 84 929 940 15533710 1:CAS:528:DC%2BD2cXptlyktr0%3D (Pubitemid 39469118)
72. PC FitzGerald A Shlyakhtenko AA Mir C Vinson 2004 Clustering of DNA sequences in human promoters Genome Res 14 1562 1574 15256515 1:CAS:528:DC%2BD2cXmvFaqsbY%3D (Pubitemid 39193407)
73. X Xie J Lu EJ Kulbokas TR Golub V Mootha K Lindblad-Toh ES Lander M Kellis 2005 Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals Nature 434 338 345 15735639 1:CAS:528:DC%2BD2MXit1yqsrk%3D (Pubitemid 40469170)
74. GH Wei G Badis MF Berger T Kivioja K Palin M Enge M Bonke A Jolma M Varjosalo AR Gehrke J Yan S Talukder M Turunen M Taipale HG Stunnenberg E Ukkonen TR Hughes ML Bulyk J Taipale 2010 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo EMBO J 29 2147 2160 20517297 1:CAS:528:DC%2BC3cXmslWmt7w%3D
75. T Oikawa T Yamada 2003 Molecular biology of the Ets family of transcription factors Gene 303 11 34 12559563 1:CAS:528:DC%2BD3sXmtVGmug%3D%3D (Pubitemid 36151767)
76. T Hsu M Trojanowska DK Watson 2004 Ets proteins in biological control and cancer J Cell Biochem 91 896 903 15034925 1:CAS:528:DC%2BD2cXivFyrt7k%3D
77. FO Bartel T Higuchi DD Spyropoulos 2000 Mouse models in the study of the Ets family of transcription factors Oncogene 19 6443 6454 11175360 1:CAS:528:DC%2BD3MXptVemtg%3D%3D (Pubitemid 32108434)
78. J Dwyer H Li D Xu JP Liu 2007 Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family Ann N Y Acad Sci 1114 36 47 17986575 1:CAS:528:DC%2BD2sXhsVGqu7nL (Pubitemid 350070389)
79. BS Goueli R Janknecht 2004 Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf Mol Cell Biol 24 25 35 14673140 1:CAS:528:DC%2BD2cXhtVWgsQ%3D%3D (Pubitemid 38010032)
80. D Xu J Dwyer H Li W Duan JP Liu 2008 Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc J Biol Chem 283 23567 23580 18586674 1:CAS:528:DC%2BD1cXhtVWktr7M
81. CP Hsu NY Hsu LW Lee JL Ko 2006 Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter-effect on telomerase expression and telomerase length maintenance in non-small cell lung cancer Eur J Cancer 42 1466 1474 16737810 1:CAS:528:DC%2BD28XlvF2jsLY%3D
82. D Baillat C Laitem G Leprivier C Margerin M Aumercier 2009 Ets-1 binds cooperatively to the palindromic Ets-binding sites in the p53 promoter Biochem Biophys Res Commun 378 213 217 19022222 1:CAS:528:DC%2BD1cXhsVOisL3M
83. D Xu TJ Watson D Chan E De Luca J Zhou PJ Herzog I Kola 2002 Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells EMBO J 21 4081 4093 12145208 1:CAS:528:DC%2BD38XnvVGnur8%3D (Pubitemid 34857440)
84. T Kawase H Ichikawa T Ohta N Nozaki F Tashiro R Ohki Y Taya 2008 p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis Oncogene 27 3797 3810 18264133 1:CAS:528:DC%2BD1cXntlCqu7o%3D (Pubitemid 351862059)
85. WAF1 J Mol Biol 337 115 128 15001356 1:CAS:528:DC%2BD2cXhsV2ns7o%3D (Pubitemid 38292047)
86. JD Bosman F Yehiely JR Evans VL Cryns 2010 Regulation of alphaB-crystallin gene expression by the transcription factor Ets1 in breast cancer Breast Cancer Res Treat 119 63 70 19205872 1:CAS:528:DC%2BD1MXhsFaqtr3F
87. JD Prescott KS Koto M Singh A Gutierrez-Hartmann 2004 The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism Mol Cell Biol 24 5548 5564 15169914 1:CAS:528:DC%2BD2cXkvFOqtbs%3D (Pubitemid 38738185)
88. P Chi Y Chen L Zhang X Guo J Wongvipat T Shamu JA Fletcher S Dewell RG Maki D Zheng CR Antonescu CD Allis CL Sawyers 2010 ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours Nature 467 849 853 20927104 1:CAS:528:DC%2BC3cXht1elu73N
89. MF Berger MS Lawrence F Demichelis Y Drier K Cibulskis AY Sivachenko A Sboner R Esgueva D Pflueger C Sougnez R Onofrio SL Carter K Park L Habegger L Ambrogio T Fennell M Parkin G Saksena D Voet AH Ramos TJ Pugh J Wilkinson S Fisher W Winckler S Mahan K Ardlie J Baldwin JW Simons N Kitabayashi TY MacDonald PW Kantoff L Chin SB Gabriel MB Gerstein TR Golub M Meyerson A Tewari ES Lander G Getz MA Rubin LA Garraway 2011 The genomic complexity of primary human prostate cancer Nature 470 214 220 21307934 1:CAS:528:DC%2BC3MXhslWrsrs%3D
90. VA Soldatenkov A Albor BK Patel R Dreszer A Dritschilo V Notario 1999 Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor Oncogene 18 3954 3962 10435618 1:CAS:528:DyaK1MXkvVKksrY%3D (Pubitemid 29361333)
91. Cip-1/WAF1/mda6 protein levels in primary hepatocytes Mol Biol Cell 11 2915 2932 10982390 1:CAS:528:DC%2BD3cXmvFSiurk%3D (Pubitemid 32107074)
92. B Zhivotovsky S Orrenius 2010 Cell death mechanisms: cross-talk and role in disease Exp Cell Res 316 1374 1383 20211164 1:CAS:528:DC%2BC3cXlvVartbw%3D
93. P Li H Allen S Banerjee S Franklin L Herzog C Johnston J McDowell M Paskind L Rodman J Salfeld E Towne D Tracey S Wardwell F-Y Wei W Wong R Kamen T Seshadri 1995 Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock Cell 80 401 411 7859282 1:CAS:528:DyaK2MXjslWkt7k%3D
94. K Kuida JA Lippke G Ku MW Harding DJ Livingston MS-S Su RA Flavell 1995 Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme Science 267 2000 2003 7535475 1:CAS:528:DyaK2MXkslOkurw%3D
95. M Miura H Zhou R Rotello EA Hartwieg Y Yuan 1993 Induction of apoptosis in fibroblasts by IL-1β -converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 Cell 75 653 660 8242741 1:CAS:528: DyaK2cXltFShtA%3D%3D (Pubitemid 23346364)
96. S Kondo BP Barna T Morimura J Takeuchi J Yuan A Akbasak GH Barnett 1995 Interleukin-1 β-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells Cancer Res 55 6166 6171 8521409 1:CAS:528: DyaK2MXhtVShtLzF
97. H Pei C Li Y Adereth T Hsu DK Watson R Li 2005 Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis Cancer Res 65 7205 7213 16103071 1:CAS:528:DC%2BD2MXns1Wrtbc%3D (Pubitemid 41161251)
98. F Kihara-Negishi T Yamada Y Kubota N Kondoh H Yamamoto M Abe T Shirai Y Hashimoto T Oikawa 1998 Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells Int J Cancer 76 523 530 9590129 1:CAS:528:DyaK1cXjtVWnt78%3D (Pubitemid 28227996)
99. T Oikawa T Yamada F Kihara-Negishi H Yamamoto N Kondoh Y Hitomi Y Hashimoto 1999 The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis Cell Death Differ 6 599 608 10453070 1:CAS:528:DyaK1MXltlOhtbw%3D (Pubitemid 29366649)
100. GM Birdsey NH Dryden V Amsellem F Gebhardt K Sahnan DO Haskard E Dejana JC Mason AM Randi 2008 Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin Blood 111 3498 3506 18195090 1:CAS:528:DC%2BD1cXktlWms7c%3D
101. G Wei R Srinivasan CZ Cantemir-Stone SM Sharma R Santhanam M Weinstein N Muthusamy AK Man RG Oshima G Leone MC Ostrowski 2009 Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis Blood 114 1123 1130 19411629 1:CAS:528:DC%2BD1MXps1eitb0%3D
102. S Gory J Dalmon M Prandini T Kortulewski Y de Launoit P Huber 1998 Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription J Biol Chem 273 6750 6755 9506975 1:CAS:528:DyaK1cXitVCqsbk%3D (Pubitemid 28160336)
103. X Cao J Littlejohn C Rodarte L Zhang B Martino P Rascoe K Hamid D Jupiter WR Smythe 2009 Up-regulation of Bcl-xl by hepatocyte growth factor in human mesothelioma cells involves ETS transcription factors Am J Pathol 175 2207 2216 19834061 1:CAS:528:DC%2BC3cXhslSjur0%3D
104. K Hashiguchi H Tsuchiya A Tomita C Ueda Y Akechi T Sakabe A Kurimasa M Nozaki T Yamada S Tsuchida G Shiota 2010 Involvement of ETS1 in thioredoxin-binding protein 2 transcription induced by a synthetic retinoid CD437 in human osteosarcoma cells Biochem Biophys Res Commun 391 621 626 19932085 1:CAS:528:DC%2BC3cXpsVGk
105. S Matsuoka H Tsuchiya T Sakabe Y Watanabe Y Hoshikawa A Kurimasa H Itamochi T Harada N Terakawa H Masutani J Yodoi G Shiota 2008 Involvement of thioredoxin-binding protein 2 in the antitumor activity of CD437 Cancer Sci 99 2485 2490 19018770 1:CAS:528:DC%2BD1MXisF2nug%3D%3D
106. YY Li Y Wu K Tsuneyama T Baba N Mukaida 2009 Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells Cancer Sci 100 396 404 19154409 1:CAS:528:DC%2BD1MXjt1WrtL8%3D
107. K Omata R Suzuki T Masaki T Miyamura T Satoh T Suzuki 2008 Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter Apoptosis 13 929 937 18500556 1:CAS:528:DC%2BD1cXntVWhs78%3D
108. J Frampton T Ramqvist T Graf 1996 v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells Genes Dev 10 2720 2731 8946913 1:CAS:528:DyaK28XmvFSjtbc%3D (Pubitemid 26384492)
109. XR Li AS Chong J Wu KA Roebuck A Kumar JE Parrillo UR Rapp RP Kimberly JW Williams X Xu 1999 Transcriptional regulation of Fas gene expression by GA-binding protein and AP-1 in T cell antigen receptor-CD3 complex-stimulated T cells J Biol Chem 274 35203 35210 10575005 1:CAS:528:DyaK1MXnvFyruro%3D (Pubitemid 129509578)
110. W Chow J Fang J Yee 2000 The IFN regulatory factor family participates in regulation of Fas ligand gene expression in T cells J Immunol 164 3512 3518 10725705 1:CAS:528:DC%2BD3cXitFOqsrY%3D (Pubitemid 30169802)
111. Carey MF, Peterson CL, Smale ST (2009) Transcription and preinitiation complex assembly in vitro. In: Transcriptional regulation in eukaryotes, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 439-538
112. Turner BM (2001) Transcription in eukaryotes: The problems of complexity. In: Chromatin and gene regulation: mechanisms in epigenetics. Blackwell, Oxford, pp 25-43
113. C Yang E Bolotin T Jiang FM Sladek E Martinez 2007 Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters Gene 389 52 65 17123746 1:CAS:528:DC%2BD2sXntFSjuw%3D%3D (Pubitemid 46107776)
114. CE Foulds DK Hawley 1997 Analysis of the human TATA binding protein promoter and identification of an ets site critical for activity Nucleic Acids Res 25 2485 2494 9171103 1:CAS:528:DyaK2sXktlSlur8%3D (Pubitemid 27303711)
115. J Boros IJ Donaldson A O'Donnell ZA Odrowaz L Zeef M Lupien CA Meyer X Shirley Liu M Brown 2009 Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery Genome Res 19 1963 1973 19687146 1:CAS:528:DC%2BD1MXhsVSmtLnM
116. CH Chang GK Scott MA Baldwin CC Benz 1999 Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP) Oncogene 18 3682 3695 10391676 1:CAS:528:DyaK1MXkslCktr8%3D (Pubitemid 29338501)
117. PA Defossez JL Baert M Monnot Y de Launoit 1997 The ETS family member ERM contains an α-helical acidic activation domain that contacts TAFII60 Nucleic Acids Res 25 4455 4463 9358152 1:CAS:528:DyaK1cXhsVKqtw%3D%3D (Pubitemid 27500754)
118. M Yaneva S Kippenberger N Wang Q Su M McGarvey A Nazarian L Lacomis H Erdjument-Bromage P Tempst 2006 PU.1 and a TTTAAA element in the myeloid Defensin-1 promoter create an operational TATA box that can impose cell specificity onto TFIID function J Immunol 176 6906 6917 16709851 1:CAS:528:DC%2BD28XkslWhtbs%3D (Pubitemid 43791971)
119. VB Agarkar ND Babayeva PJ Wilder A Rizzino TH Tahirov 2010 Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-β receptor promoter DNA J Mol Biol 397 278 289 20079749 1:CAS:528:DC%2BC3cXis1aiurY%3D
120. S Marecki CJ Riendeau MD Liang MJ Fenton 2001 PU.1 and multiple IFN regulatory factor proteins synergize to mediate transcriptional activation of the human IL-1β gene J Immunol 166 6829 6838 11359842 1:CAS:528: DC%2BD3MXjvFaqsrw%3D (Pubitemid 32467228)
121. I Wieratra 2008 Sp1: Emerging roles-beyond constitutive activation of TATA-less housekeeping genes Biochem Biophys Res Commun 372 1 13
122. M Pastorcic HK Das 2004 Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells Eur J Biochem 271 4485 4494 15560789 1:CAS:528:DC%2BD2cXhtVKmtbzI
123. P Kumar R Garg G Bolden KN Pandey 2010 Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase/atrial natriuretic peptide receptor-A gene transcription J Biol Chem 285 37521 37530 20864529 1:CAS:528:DC%2BC3cXhsVCrt7%2FF
124. P Jiang A Kumar JE Parrillo LA Dempsey JL Platt RA Prinz X Xu 2002 Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity J Biol Chem 277 8989 8998 11779847 1:CAS:528:DC%2BD38Xitl2lu78%3D (Pubitemid 34952971)
125. RA Sturm JL Cassady G Das A Romo GA Evans 1993 Chromosomal structure and expression of the human OTF1 locus encoding the Oct-1 protein Genomics 16 333 341 8314572 1:CAS:528:DyaK3sXlvFKqtLs%3D (Pubitemid 23170886)
126. I Kemler W Schaffner 1990 Octamer transfaction factors and the cell type-specificity of immunoglobulin gene expression FASEB J 4 1444 1449 2407588 1:CAS:528:DyaK3cXhvFaqtL8%3D
127. UK Kwon PH Yen T Collins RA Wells 2006 Differential lineage-specific regulation of murine CD45 transcription by Oct-1 and PU.1 Biochem Biopys Res Commun 344 146 154 1:CAS:528:DC%2BD28XjvFWns7g%3D
128. M Liu JL Leibowitz DA Clark M Mendicino Q Ning JW Ding C D'Abreo L Fung PA Marsden GA Levy 2003 Gene transcription of fgl2 in epithelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 Eur J Biochem 270 2274 2286 12752447 1:CAS:528:DC%2BD3sXjvFOrt7Y%3D (Pubitemid 36605577)
129. M Liu M Mendicino Q Ning A Ghanekar W He I McGilvray I Shalev DA Clark GA Phillips MJ GA Levy 2006 Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: the role of Sp1/Sp3 and STAT1/PU.1 composite cis elements J Immunol 176 7028 7038 16709865 1:CAS:528:DC%2BD28XkslWgsrk%3D (Pubitemid 43787884)
130. S Muller A Maas TC Islam P Sideras G Suske S Philipsen KG Xanthopoulos RW Hendriks CIE Smith 1999 Synergistic activation of the human Btk promoter by transcription factors Sp1/3 and PU.1 Biochem Biopys Res Commun 259 364 369 1:CAS:528:DyaK1MXjs1SmtL4%3D (Pubitemid 29281238)
131. C Brunner T Wirth 2006 Btk expression is controlled by Oct and BOB.1/OBF.1 Nucleic Acids Res 34 1807 1815 16582106 1:CAS:528: DC%2BD28XjslOjsrY%3D
132. AP Bradford KE Conrad C Wasylyk B Wasylyk A Gutierrez-Hartmann 1995 Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain Mol Cell Biol 15 2849 2857 7739565 1:STN:280:DyaK2M3lsl2ltQ%3D%3D
133. EC Turner BT Kinsella 2009 Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells J Mol Biol 386 579 597 19118563 1:CAS:528: DC%2BD1MXitVCqsbk%3D
134. PC Hollenhorst KJ Chandler RL Poulsen WE Johnson NA Speck BJ Graves 2009 DNA specificity determinants associate with distinct transcription factor functions PLoS Genet 5 e1000778 20019798
135. T Oikawa 2003 ETS transcription factors: possible targets for cancer therapy Cancer Sci 95 626 633