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Volumn 2, Issue 1, 2010, Pages

Downstream EWS/FLI1 - Upstream Ewing's sarcoma

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; HYBRID PROTEIN; MICRORNA; MICROSATELLITE DNA; RNA BINDING PROTEIN EWS; RNA BINDING PROTEIN EWS TRANSCRIPTION FACTOR FLI 1 FUSION PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR NKX2.2; UNCLASSIFIED DRUG;

EID: 78650720634     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm129     Document Type: Review
Times cited : (55)

References (64)
  • 2
    • 0002502298 scopus 로고
    • Diffuse endothelioma of bone.
    • Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc 1921, 21:17-24.
    • (1921) Proc NY Pathol Soc , vol.21 , pp. 17-24
    • Ewing, J.1
  • 3
    • 0031878238 scopus 로고    scopus 로고
    • Ewing's sarcoma and peripheral primitive neuroectodermal tumors after their genetic union.
    • 10.1097/00001622-199807000-00010, 9702401
    • Kovar H. Ewing's sarcoma and peripheral primitive neuroectodermal tumors after their genetic union. Curr Opin Oncol 1998, 10:334-342. 10.1097/00001622-199807000-00010, 9702401.
    • (1998) Curr Opin Oncol , vol.10 , pp. 334-342
    • Kovar, H.1
  • 6
    • 0038662666 scopus 로고    scopus 로고
    • Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription.
    • 10.1074/jbc.M210234200, 12459554
    • Araya N, Hirota K, Shimamoto Y, Miyagishi M, Yoshida E, Ishida J, Kaneko S, Kaneko M, Nakajima T, Fukamizu A. Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. J Biol Chem 2003, 278:5427-5432. 10.1074/jbc.M210234200, 12459554.
    • (2003) J Biol Chem , vol.278 , pp. 5427-5432
    • Araya, N.1    Hirota, K.2    Shimamoto, Y.3    Miyagishi, M.4    Yoshida, E.5    Ishida, J.6    Kaneko, S.7    Kaneko, M.8    Nakajima, T.9    Fukamizu, A.10
  • 7
    • 0031935157 scopus 로고    scopus 로고
    • EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.
    • 108863, 9488465
    • Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. Mol Cell Biol 1998, 18:1489-1497. 108863, 9488465.
    • (1998) Mol Cell Biol , vol.18 , pp. 1489-1497
    • Bertolotti, A.1    Melot, T.2    Acker, J.3    Vigneron, M.4    Delattre, O.5    Tora, L.6
  • 8
    • 20344371441 scopus 로고    scopus 로고
    • Stimulation of Oct-4 activity by Ewing's sarcoma protein.
    • 10.1634/stemcells.2004-0375, 15917470
    • Lee J, Rhee BK, Bae GY, Han YM, Kim J. Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 2005, 23:738-751. 10.1634/stemcells.2004-0375, 15917470.
    • (2005) Stem Cells , vol.23 , pp. 738-751
    • Lee, J.1    Rhee, B.K.2    Bae, G.Y.3    Han, Y.M.4    Kim, J.5
  • 9
    • 43149105398 scopus 로고    scopus 로고
    • Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer.
    • 10.1073/pnas.0710748105, 2329709, 18413612
    • Sanchez G, Bittencourt D, Laud K, Barbier J, Delattre O, Auboeuf D, Dutertre M. Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer. Proc Natl Acad Sci USA 2008, 105:6004-6009. 10.1073/pnas.0710748105, 2329709, 18413612.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6004-6009
    • Sanchez, G.1    Bittencourt, D.2    Laud, K.3    Barbier, J.4    Delattre, O.5    Auboeuf, D.6    Dutertre, M.7
  • 10
    • 0037101807 scopus 로고    scopus 로고
    • Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway.
    • Spahn L, Petermann R, Siligan C, Schmid JA, Aryee DN, Kovar H. Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway. Cancer Res 2002, 62:4583-4587.
    • (2002) Cancer Res , vol.62 , pp. 4583-4587
    • Spahn, L.1    Petermann, R.2    Siligan, C.3    Schmid, J.A.4    Aryee, D.N.5    Kovar, H.6
  • 11
    • 70349972615 scopus 로고    scopus 로고
    • Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes.
    • 10.1021/pr900235t, 19673543
    • Pahlich S, Quero L, Roschitzki B, Leemann-Zakaryan RP, Gehring H. Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes. J Proteome Res 2009, 8:4455-4465. 10.1021/pr900235t, 19673543.
    • (2009) J Proteome Res , vol.8 , pp. 4455-4465
    • Pahlich, S.1    Quero, L.2    Roschitzki, B.3    Leemann-Zakaryan, R.P.4    Gehring, H.5
  • 13
    • 34248203558 scopus 로고    scopus 로고
    • Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.
    • 10.1172/JCI31222, 1838927, 17415412
    • Li H, Watford W, Li C, Parmelee A, Bryant MA, Deng C, O'Shea J, Lee SB. Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest 2007, 117:1314-1323. 10.1172/JCI31222, 1838927, 17415412.
    • (2007) J Clin Invest , vol.117 , pp. 1314-1323
    • Li, H.1    Watford, W.2    Li, C.3    Parmelee, A.4    Bryant, M.A.5    Deng, C.6    O'Shea, J.7    Lee, S.B.8
  • 14
    • 34548806398 scopus 로고    scopus 로고
    • Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions.
    • 10.2353/jmoldx.2007.070053, 1975108, 17690209
    • Wang L, Bhargava R, Zheng T, Wexler L, Collins MH, Roulston D, Ladanyi M. Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions. J Mol Diagn 2007, 9:498-509. 10.2353/jmoldx.2007.070053, 1975108, 17690209.
    • (2007) J Mol Diagn , vol.9 , pp. 498-509
    • Wang, L.1    Bhargava, R.2    Zheng, T.3    Wexler, L.4    Collins, M.H.5    Roulston, D.6    Ladanyi, M.7
  • 15
    • 0028209984 scopus 로고
    • DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.
    • 358690, 8164678
    • Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M, Thomas G, Ghysdael J. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol 1994, 14:3230-3241. 358690, 8164678.
    • (1994) Mol Cell Biol , vol.14 , pp. 3230-3241
    • Bailly, R.A.1    Bosselut, R.2    Zucman, J.3    Cormier, F.4    Delattre, O.5    Roussel, M.6    Thomas, G.7    Ghysdael, J.8
  • 16
    • 0027230568 scopus 로고
    • Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.
    • 10.1073/pnas.90.12.5752, 46800, 8516324
    • May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, Zucman J, Thomas G, Denny CT. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci USA 1993, 90:5752-5756. 10.1073/pnas.90.12.5752, 46800, 8516324.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3    Lunsford, L.B.4    Lewis, B.C.5    Delattre, O.6    Zucman, J.7    Thomas, G.8    Denny, C.T.9
  • 17
    • 0027136095 scopus 로고
    • EWS/Fli-1 chimeric protein is a transcriptional activator.
    • Ohno T, Rao VN, Reddy ES. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res 1993, 53:5859-5863.
    • (1993) Cancer Res , vol.53 , pp. 5859-5863
    • Ohno, T.1    Rao, V.N.2    Reddy, E.S.3
  • 18
    • 0029004567 scopus 로고
    • Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis.
    • 230703, 7623854
    • Braun BS, Frieden R, Lessnick SL, May WA, Denny CT. Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis. Mol Cell Biol 1995, 15:4623-4630. 230703, 7623854.
    • (1995) Mol Cell Biol , vol.15 , pp. 4623-4630
    • Braun, B.S.1    Frieden, R.2    Lessnick, S.L.3    May, W.A.4    Denny, C.T.5
  • 19
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
    • 10.1158/0008-5472.CAN-04-2857, 15930281
    • Hu-Lieskovan S, Zhang J, Wu L, Shimada H, Schofield DE, Triche TJ. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res 2005, 65:4633-4644. 10.1158/0008-5472.CAN-04-2857, 15930281.
    • (2005) Cancer Res , vol.65 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.2    Wu, L.3    Shimada, H.4    Schofield, D.E.5    Triche, T.J.6
  • 20
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human 3 fibroblasts.
    • 10.1016/S1535-6108(02)00056-9, 12086853
    • Lessnick SL, Dacwag CS, Golub TR. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human 3 fibroblasts. Cancer Cell 2002, 1:393-401. 10.1016/S1535-6108(02)00056-9, 12086853.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 21
    • 1242293672 scopus 로고    scopus 로고
    • The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to ewing sarcoma/peripheral primitive neuroectodermal tumors.
    • 10.1158/0008-5472.CAN-03-3274, 14973077
    • Rorie CJ, Thomas VD, Chen P, Pierce HH, O'Bryan JP, Weissman BE. The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res 2004, 64:1266-1277. 10.1158/0008-5472.CAN-03-3274, 14973077.
    • (2004) Cancer Res , vol.64 , pp. 1266-1277
    • Rorie, C.J.1    Thomas, V.D.2    Chen, P.3    Pierce, H.H.4    O'Bryan, J.P.5    Weissman, B.E.6
  • 22
    • 0033398391 scopus 로고    scopus 로고
    • EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts.
    • Teitell MA, Thompson AD, Sorensen PH, Shimada H, Triche TJ, Denny CT. EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts. Lab Invest 1999, 79:1535-1543.
    • (1999) Lab Invest , vol.79 , pp. 1535-1543
    • Teitell, M.A.1    Thompson, A.D.2    Sorensen, P.H.3    Shimada, H.4    Triche, T.J.5    Denny, C.T.6
  • 23
    • 65549090018 scopus 로고    scopus 로고
    • A molecular function map of Ewing's sarcoma.
    • 10.1371/journal.pone.0005415, 2671847, 19404404
    • Kauer M, Ban J, Kofler R, Walker B, Davis S, Meltzer P, Kovar H. A molecular function map of Ewing's sarcoma. PLoS ONE 2009, 4:e5415. 10.1371/journal.pone.0005415, 2671847, 19404404.
    • (2009) PLoS ONE , vol.4
    • Kauer, M.1    Ban, J.2    Kofler, R.3    Walker, B.4    Davis, S.5    Meltzer, P.6    Kovar, H.7
  • 25
    • 0037742405 scopus 로고    scopus 로고
    • Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells.
    • Torchia EC, Jaishankar S, Baker SJ. Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res 2003, 63:3464-3468.
    • (2003) Cancer Res , vol.63 , pp. 3464-3468
    • Torchia, E.C.1    Jaishankar, S.2    Baker, S.J.3
  • 28
    • 40549086265 scopus 로고    scopus 로고
    • A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature.
    • 10.4161/cc.7.2.5229, 18256529
    • Hancock JD, Lessnick SL. A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle 2007, 7:250-256. 10.4161/cc.7.2.5229, 18256529.
    • (2007) Cell Cycle , vol.7 , pp. 250-256
    • Hancock, J.D.1    Lessnick, S.L.2
  • 29
    • 68149164796 scopus 로고    scopus 로고
    • Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: an analysis of 1631 cases from the SEER database, 1973-2005.
    • 10.1002/cncr.24388, 19548262
    • Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP. Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: an analysis of 1631 cases from the SEER database, 1973-2005. Cancer 2009, 115:3526-3536. 10.1002/cncr.24388, 19548262.
    • (2009) Cancer , vol.115 , pp. 3526-3536
    • Jawad, M.U.1    Cheung, M.C.2    Min, E.S.3    Schneiderbauer, M.M.4    Koniaris, L.G.5    Scully, S.P.6
  • 33
    • 0035933847 scopus 로고    scopus 로고
    • EWS/FLI alters 5'-splice site selection.
    • 10.1074/jbc.M008950200, 11301318
    • Knoop LL, Baker SJ. EWS/FLI alters 5'-splice site selection. J Biol Chem 2001, 276:22317-22322. 10.1074/jbc.M008950200, 11301318.
    • (2001) J Biol Chem , vol.276 , pp. 22317-22322
    • Knoop, L.L.1    Baker, S.J.2
  • 34
    • 48849100548 scopus 로고    scopus 로고
    • Coupled alteration of transcription and splicing by a single oncogene: boosting the effect on cyclin D1 activity.
    • Sanchez G, Delattre O, Auboeuf D, Dutertre M. Coupled alteration of transcription and splicing by a single oncogene: boosting the effect on cyclin D1 activity. Cell Cycle 2008, 7:2299-2305.
    • (2008) Cell Cycle , vol.7 , pp. 2299-2305
    • Sanchez, G.1    Delattre, O.2    Auboeuf, D.3    Dutertre, M.4
  • 35
    • 0035328667 scopus 로고    scopus 로고
    • Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein.
    • Chansky HA, Hu M, Hickstein DD, Yang L. Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein. Cancer Res 2001, 61:3586-3590.
    • (2001) Cancer Res , vol.61 , pp. 3586-3590
    • Chansky, H.A.1    Hu, M.2    Hickstein, D.D.3    Yang, L.4
  • 36
    • 0030774839 scopus 로고    scopus 로고
    • The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain.
    • 10.1074/jbc.272.43.27369, 9341188
    • Deloulme JC, Prichard L, Delattre O, Storm DR. The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. J Biol Chem 1997, 272:27369-27377. 10.1074/jbc.272.43.27369, 9341188.
    • (1997) J Biol Chem , vol.272 , pp. 27369-27377
    • Deloulme, J.C.1    Prichard, L.2    Delattre, O.3    Storm, D.R.4
  • 37
    • 0034637482 scopus 로고    scopus 로고
    • The splicing factor U1C represses EWS/FLI-mediated transactivation.
    • 10.1074/jbc.M001661200, 10827180
    • Knoop LL, Baker SJ. The splicing factor U1C represses EWS/FLI-mediated transactivation. J Biol Chem 2000, 275:24865-24871. 10.1074/jbc.M001661200, 10827180.
    • (2000) J Biol Chem , vol.275 , pp. 24865-24871
    • Knoop, L.L.1    Baker, S.J.2
  • 39
    • 0037427070 scopus 로고    scopus 로고
    • Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
    • 10.1038/sj.onc.1206055, 12527902
    • Fukuma M, Okita H, Hata J, Umezawa A. Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene 2003, 22:1-9. 10.1038/sj.onc.1206055, 12527902.
    • (2003) Oncogene , vol.22 , pp. 1-9
    • Fukuma, M.1    Okita, H.2    Hata, J.3    Umezawa, A.4
  • 40
    • 0038689323 scopus 로고    scopus 로고
    • Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein.
    • 10.1074/jbc.M211470200, 12560328
    • Nakatani F, Tanaka K, Sakimura R, Matsumoto Y, Matsunobu T, Li X, Hanada M, Okada T, Iwamoto Y. Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein. J Biol Chem 2003, 278:15105-15115. 10.1074/jbc.M211470200, 12560328.
    • (2003) J Biol Chem , vol.278 , pp. 15105-15115
    • Nakatani, F.1    Tanaka, K.2    Sakimura, R.3    Matsumoto, Y.4    Matsunobu, T.5    Li, X.6    Hanada, M.7    Okada, T.8    Iwamoto, Y.9
  • 41
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.
    • 10.1128/MCB.24.16.7275-7283.2004, 479730, 15282325
    • Prieur A, Tirode F, Cohen P, Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004, 24:7275-7283. 10.1128/MCB.24.16.7275-7283.2004, 479730, 15282325.
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 42
    • 17844370020 scopus 로고    scopus 로고
    • PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's sarcoma tumorigenesis.
    • 10.1038/sj.onc.1208247, 15782144
    • Abaan OD, Levenson A, Khan O, Furth PA, Uren A, Toretsky JA. PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's sarcoma tumorigenesis. Oncogene 2005, 24:2715-2722. 10.1038/sj.onc.1208247, 15782144.
    • (2005) Oncogene , vol.24 , pp. 2715-2722
    • Abaan, O.D.1    Levenson, A.2    Khan, O.3    Furth, P.A.4    Uren, A.5    Toretsky, J.A.6
  • 47
    • 63349090507 scopus 로고    scopus 로고
    • The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function.
    • 10.1371/journal.pone.0004932, 2654724, 19305498
    • Guillon N, Tirode F, Boeva V, Zynovyev A, Barillot E, Delattre O. The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. PLoS ONE 2009, 4:e4932. 10.1371/journal.pone.0004932, 2654724, 19305498.
    • (2009) PLoS ONE , vol.4
    • Guillon, N.1    Tirode, F.2    Boeva, V.3    Zynovyev, A.4    Barillot, E.5    Delattre, O.6
  • 49
    • 70450184674 scopus 로고    scopus 로고
    • GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance.
    • 10.1038/onc.2009.262, 19718047
    • Luo W, Gangwal K, Sankar S, Boucher KM, Thomas D, Lessnick SL. GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. Oncogene 2009, 28:4126-4132. 10.1038/onc.2009.262, 19718047.
    • (2009) Oncogene , vol.28 , pp. 4126-4132
    • Luo, W.1    Gangwal, K.2    Sankar, S.3    Boucher, K.M.4    Thomas, D.5    Lessnick, S.L.6
  • 50
    • 54049141305 scopus 로고    scopus 로고
    • Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure.
    • Gangwal K, Lessnick SL. Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure. Cell Cycle 2008, 7:3127-3132.
    • (2008) Cell Cycle , vol.7 , pp. 3127-3132
    • Gangwal, K.1    Lessnick, S.L.2
  • 51
    • 44849085869 scopus 로고    scopus 로고
    • EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.
    • 10.1371/journal.pone.0001965, 2291578, 18414662
    • Owen LA, Kowalewski AA, Lessnick SL. EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS ONE 2008, 3:e1965. 10.1371/journal.pone.0001965, 2291578, 18414662.
    • (2008) PLoS ONE , vol.3
    • Owen, L.A.1    Kowalewski, A.A.2    Lessnick, S.L.3
  • 53
    • 55349094311 scopus 로고    scopus 로고
    • EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.
    • 10.1158/0008-5472.CAN-08-0573, 18974141
    • Lin PP, Pandey MK, Jin F, Xiong S, Deavers M, Parant JM, Lozano G. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res 2008, 68:8968-8975. 10.1158/0008-5472.CAN-08-0573, 18974141.
    • (2008) Cancer Res , vol.68 , pp. 8968-8975
    • Lin, P.P.1    Pandey, M.K.2    Jin, F.3    Xiong, S.4    Deavers, M.5    Parant, J.M.6    Lozano, G.7
  • 54
    • 36048942033 scopus 로고    scopus 로고
    • EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice.
    • 10.1128/MCB.00099-07, 2169157, 17875932
    • Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol 2007, 27:7918-7934. 10.1128/MCB.00099-07, 2169157, 17875932.
    • (2007) Mol Cell Biol , vol.27 , pp. 7918-7934
    • Torchia, E.C.1    Boyd, K.2    Rehg, J.E.3    Qu, C.4    Baker, S.J.5
  • 55
    • 23944458598 scopus 로고    scopus 로고
    • The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.
    • 10.1371/journal.pbio.0030242, 1159166,1159166, 15974803
    • Codrington R, Pannell R, Forster A, Drynan LF, Daser A, Lobato N, Metzler M, Rabbitts TH. The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. PLoS Biol 2005, 3:e242. 10.1371/journal.pbio.0030242, 1159166,1159166, 15974803.
    • (2005) PLoS Biol , vol.3
    • Codrington, R.1    Pannell, R.2    Forster, A.3    Drynan, L.F.4    Daser, A.5    Lobato, N.6    Metzler, M.7    Rabbitts, T.H.8
  • 56
    • 38549084557 scopus 로고    scopus 로고
    • Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: a study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group.
    • 10.1002/gcc.20523, 18064647
    • Roberts P, Burchill SA, Brownhill S, Cullinane CJ, Johnston C, Griffiths MJ, McMullan DJ, Bown NP, Morris SP, Lewis IJ. Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: a study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group. Genes Chromosomes Cancer 2008, 47:207-220. 10.1002/gcc.20523, 18064647.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 207-220
    • Roberts, P.1    Burchill, S.A.2    Brownhill, S.3    Cullinane, C.J.4    Johnston, C.5    Griffiths, M.J.6    McMullan, D.J.7    Bown, N.P.8    Morris, S.P.9    Lewis, I.J.10
  • 57
    • 60849118372 scopus 로고    scopus 로고
    • Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors.
    • 10.1186/1471-2407-9-17, 2633345, 19144156
    • Savola S, Klami A, Tripathi A, Niini T, Serra M, Picci P, Kaski S, Zambelli D, Scotlandi K, Knuutila S. Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors. BMC Cancer 2009, 9:17. 10.1186/1471-2407-9-17, 2633345, 19144156.
    • (2009) BMC Cancer , vol.9 , pp. 17
    • Savola, S.1    Klami, A.2    Tripathi, A.3    Niini, T.4    Serra, M.5    Picci, P.6    Kaski, S.7    Zambelli, D.8    Scotlandi, K.9    Knuutila, S.10
  • 59
    • 0012730932 scopus 로고    scopus 로고
    • Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma.
    • 10.1016/S0165-4608(97)00028-9, 9428352
    • Maurici D, Perez-Atayde A, Grier HE, Baldini N, Serra M, Fletcher JA. Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma. Cancer Genet Cytogenet 1998, 100:106-110. 10.1016/S0165-4608(97)00028-9, 9428352.
    • (1998) Cancer Genet Cytogenet , vol.100 , pp. 106-110
    • Maurici, D.1    Perez-Atayde, A.2    Grier, H.E.3    Baldini, N.4    Serra, M.5    Fletcher, J.A.6
  • 60
    • 20044367805 scopus 로고    scopus 로고
    • Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse.
    • 10.1200/JCO.2005.02.081, 15659501
    • Huang HY, Illei PB, Zhao Z, Mazumdar M, Huvos AG, Healey JH, Wexler LH, Gorlick R, Meyers P, Ladanyi M. Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse. J Clin Oncol 2005, 23:548-558. 10.1200/JCO.2005.02.081, 15659501.
    • (2005) J Clin Oncol , vol.23 , pp. 548-558
    • Huang, H.Y.1    Illei, P.B.2    Zhao, Z.3    Mazumdar, M.4    Huvos, A.G.5    Healey, J.H.6    Wexler, L.H.7    Gorlick, R.8    Meyers, P.9    Ladanyi, M.10
  • 61
    • 62149139782 scopus 로고    scopus 로고
    • Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage.
    • 10.1042/BJ20082097, 19076070
    • Klevernic IV, Morton S, Davis RJ, Cohen P. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage. Biochem J 2009, 418:625-634. 10.1042/BJ20082097, 19076070.
    • (2009) Biochem J , vol.418 , pp. 625-634
    • Klevernic, I.V.1    Morton, S.2    Davis, R.J.3    Cohen, P.4
  • 62
    • 62049084331 scopus 로고    scopus 로고
    • O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma.
    • 10.1038/onc.2008.484, 19151750
    • Bachmaier R, Aryee DN, Jug G, Kauer M, Kreppel M, Lee KA, Kovar H. O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma. Oncogene 2009, 28:1280-1284. 10.1038/onc.2008.484, 19151750.
    • (2009) Oncogene , vol.28 , pp. 1280-1284
    • Bachmaier, R.1    Aryee, D.N.2    Jug, G.3    Kauer, M.4    Kreppel, M.5    Lee, K.A.6    Kovar, H.7
  • 63
    • 34247478069 scopus 로고    scopus 로고
    • Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
    • 10.1371/journal.pmed.0040122, 1851624,1851624, 17425403
    • Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR. Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med 2007, 4:e122. 10.1371/journal.pmed.0040122, 1851624,1851624, 17425403.
    • (2007) PLoS Med , vol.4
    • Stegmaier, K.1    Wong, J.S.2    Ross, K.N.3    Chow, K.T.4    Peck, D.5    Wright, R.D.6    Lessnick, S.L.7    Kung, A.L.8    Golub, T.R.9
  • 64
    • 58949100145 scopus 로고    scopus 로고
    • Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group.
    • 10.1002/pbc.21822, 2791370, 18989890
    • DuBois SG, Krailo MD, Lessnick SL, Smith R, Chen Z, Marina N, Grier HE, Stegmaier K. Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer 2009, 52:324-327. 10.1002/pbc.21822, 2791370, 18989890.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 324-327
    • DuBois, S.G.1    Krailo, M.D.2    Lessnick, S.L.3    Smith, R.4    Chen, Z.5    Marina, N.6    Grier, H.E.7    Stegmaier, K.8


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