Elf-1 binds to GGAA elements on the FcRγ promoter and represses its expression

Journal of Immunology

Volumn 179, Issue 7, 2007, Pages 4884-4889

  Juang, Yuang Taung ^a,b   Sumibcay, Laarni ^a   Tolnay, Mate ^c   Wang, Ying ^a   Kyttaris, Vasileios C ^b   Tsokos, George C ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; TRANSCRIPTION FACTOR ELF 1;

ARTICLE; BASOPHIL; CONTROLLED STUDY; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BINDING SITES; CELL LINE; DOWN-REGULATION; HUMANS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTORS, IGG; TRANSCRIPTION FACTORS;

EID: 39749084693     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.7.4884     Document Type: Article

References (19)

1. Blank, U., C. Ra, L. Miller, K. White, H. Metzger, and J. P. Kinet. 1989. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 337: 187-189.
2. Ra, C., M. H. Jouvin, U. Blank, and J. P. Kinet. 1989. A macrophage Fc γ receptor and the mast cell receptor for IgE share an identical subunit. Nature 341: 752-754.
3. Krishnan, S., V. G. Warke, M. P. Nambiar, G. C. Tsokos, and D. L. Farber. 2003. The FcR γ subunit and Syk kinase replace the CD3 ζ-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J. Immunol. 170: 4189-4195.
4. Enyedy, E. J., M. P. Nambiar, S. N. Liossis, G. Dennis, G. M. Kammer, and G. C. Tsokos. 2001. Fc ε receptor type I γ-chain replaces the deficient T cell receptor ζ-chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum. 44: 1114-1121.
5. Orloff, D. G., C. S. Ra, S. J. Frank, R. D. Klausner, and J. P. Kinet. 1990. Family of disulphide-linked dimers containing the ζ- and η-chains of the T cell receptor and the γ-chain of Fc receptors. Nature 347: 189-191.
6. Turner, H., and J. P. Kinet. 1999. Signalling through the high-affinity IgE receptor Fc εRI. Nature 402: B24-B30.
7. Taylor, N., T. Jahn, S. Smith, T. Lamkin, L. Uribe, Y. Liu, D. L. Durden, and K. Weinberg. 1997. Differential activation of the tyrosine kinases ZAP-70 and Syk after Fc γ RI stimulation. Blood 89: 388-396.
8. Oliver, J. M., D. L. Burg, B. S. Wilson, J. L. McLaughlin, and R. L. Geahlen. 1994. Inhibition of mast cell FcεR1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J. Biol. Chem. 269: 29697-29703.
9. Nambiar, M. P., C. U. Fisher, A. Kumar, C. G. Tsokos, V. G. Warke, and G. C. Tsokos. 2003. Forced expression of the Fc receptor γ-chain renders human T cells hyperresponsive to TCR/CD3 stimulation. J. Immunol. 170: 2871-2876.
10. Nambiar, M. P., C. U. Fisher, V. G. Warke, S. Krishnan, J. P. Mitchell, N. Delaney, and G. C. Tsokos. 2003. Reconstitution of deficient T cell receptor ζ-chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. Arthritis Rheum. 48: 1948-1955.
11. Rellahan, B. L., J. P. Jensen, T. K. Howcroft, D. S. Singer, E. Bonvini, and A. M. Weissman. 1998. Elf-1 regulates basal expression from the T cell Ag receptor ζ-chain gene promoter. J. Immunol. 160: 2794-2801.
12. Tenbrock, K., V. C. Kyttaris, M. Ahlmann, J. M. Ehrchen, M. Tolnay, H. Melkonyan, C. Mawrin, J. Roth, C. Sorg, Y. T. Juang, and G. C. Tsokos. 2005. The cyclic AMP response element modulator regulates transcription of the TCR ζ-chain. J. Immunol. 175: 5975-5980.
13. Bassuk, A. G., and J. M. Leiden. 1997. The role of Ets transcription factors in the development and function of the mammalian immune system. Adv. Immunol. 64: 65-104.
14. Romano-Spica, V., P. Georgiou, H. Suzuki, T. S. Papas, and N. K. Bhat. 1995. Role of ETS1 in IL-2 gene expression. J. Immunol. 154: 2724-2732.
15. Honda, S., T. Kobayashi, K. Kajino, S. Urakami, M. Igawa, and O. Hino. 2003. Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene. Mol. Carcinog. 37: 122-129.
16. Gottgens, B., A. Nastos, S. Kinston, S. Piltz, E. C. Delabesse, M. Stanley, M. J. Sanchez, A. Ciau-Uitz, R. Patient, and A. R. Green. 2002. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J. 21: 3039-3050.
17. Gottschalk, L. R., D. M. Giannola, and S. G. Emerson. 1993. Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites. J. Exp. Med. 178: 1681-1692.
18. Brini, A. T., G. M. Lee, and J. P. Kinet. 1993. Involvement of Alu sequences in the cell-specific regulation of transcription of the γ-chain of Fc and T cell receptors. J. Biol. Chem. 268: 1355-1361.
19. Juang, Y. T., E. E. Solomou, B. Rellahan, and G. C. Tsokos. 2002. Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR ζ-chain. J. Immunol. 168: 2865-2871.