Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler

Molecular and Cellular Biology

Volumn 24, Issue 10, 2004, Pages 4534-4545

  Sevinsky, Joel R ^a,b   Whalen, Anne M ^a,c   Ahn, Natalie G ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b RTI INTERNATIONAL   (United States)

^c AtheroGenics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVIAN PROTEIN; DNA; DNA BINDING PROTEIN; ERYTHROID SPECIFIC DNA BINDING FACTOR; GLYCOPROTEIN IIB; MAFB PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; RECOMBINANT PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR MAFB;

ARTICLE; CELL STRAIN K 562; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOLOGY; MEGAKARYOCYTE; METABOLISM; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

AVIAN PROTEINS; BASE SEQUENCE; DNA; DNA-BINDING PROTEINS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GENE EXPRESSION REGULATION; HUMANS; K562 CELLS; MAFB TRANSCRIPTION FACTOR; MEGAKARYOCYTES; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEINS; PLATELET MEMBRANE GLYCOPROTEIN IIB; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RECOMBINANT PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 2942562848     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.10.4534-4545.2004     Document Type: Article

References (60)

1. Alberola-Ila, J., K. A. Forbush, R. Seger, E. G. Krebs, and R. M. Perlmutter. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620-623.
2. Athanasiou, M., P. A. Clausen, G. J. Mavrothalassitis, X. K. Zhang, D. K. Watson, and D. G. Blair. 1996. Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth Differ. 7:1525-1534.
3. Bennett, A. M., and N. K. Tonks. 1997. Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases. Science 278:1288-1291.
4. Blank, V., and N. C. Andrews. 1997. The Maf transcription factors: regulators of differentiation. Trends Biochem. Sci. 22:437-441.
5. Casserly, I. P., and E. J. Topol. 2002. Glycoprotein IIb/IIIa antagonists - from bench to practice. Cell Mol. Life Sci. 59:478-500.
6. Celis, J. E. 1994. Cell biology: a laboratory handbook. Academic Press, San Diego, Calif.
7. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
8. Crossley, M., and S. H. Orkin. 1994. Phosphorylation of the erythroid transcription factor GATA-1. J. Biol. Chem. 269:16589-16596.
9. Deveaux, S., A. Filipe, V. Lemarchandel, J. Ghysdael, P. H. Romeo, and V. Mignotte. 1996. Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood 87:4678-4685.
10. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
11. Doubeikovski, A., G. Uzan, Z. Doubeikovski, M. H. Prandini, F. Porteu, S. Gisselbrecht, and I. Dusanter-Fourt. 1997. Thrombopoietin-induced expression of the glycoprotein IIb gene involves the transcription factor PU. 1/Spi-1 in UT7-Mpl cells. J. Biol. Chem. 272:24300-24307.
12. Eisbacher, M., L. M. Khachigian, T. H. Khin, M. L. Holmes, and B. H. Chong. 2001. Inducible expression of the megakaryocyte-specific gene glycoprotein IX is mediated through an Ets binding site and involves upstream activation of extracellular signal-regulated kinase. Cell Growth Differ. 12:435-445.
13. Fong, A. M., and S. A. Santoro. 1994. Transcriptional regulation of alpha IIb integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element. J. Biol. Chem. 269:18441-18447.
14. Garcia, J., J. de Gunzburg, A. Eychène, S. Gisselbrecht, and F. Porteu. 2001. Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rapl-B-Raf-dependent pathways. Mol. Cell. Biol. 21:2659-2670.
15. Gille, H., A. D. Sharrocks, and P. E. Shaw. 1992. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414-417.
16. Harada, T., T. Morooka, S. Ogawa, and E. Nishida. 2001. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat. Cell Biol. 3:453-459.
17. Hashimoto, Y., and J. Ware. 1995. Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein Ib alpha gene. J. Biol. Chem. 270:24532-24539.
18. Herrera, R., S. Hubbell, S. Decker, and L. Petruzzelli. 1998. A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells. Exp. Cell Res. 238:407-414.
19. Hickey, M. J., and G. J. Roth. 1993. Characterization of the gene encoding human platelet glycoprotein IX. J. Biol. Chem. 268:3438-3443.
20. Hill, R. J., S. Zozulya, Y. L. Lu, P. W. Hollenbach, B. Joyce-Shaikh, J. Bogenberger, and M. L. Gishizky. 1996. Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant She adaptor protein. Cell Growth Differ. 7:1125-1134.
21. Hu, E., J. B. Kim, P. Sarraf, and B. M. Spiegelman. 1996. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274:2100-2103.
22. Jiang, F., Y. Jia, and I. Cohen. 2002. Fibronectin- and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation. Blood 99:3579-3584.
23. Kelly, L. M., U. Englmeier, I. Lafon, M. H. Sieweke, and T. Graf. 2000. MafB is an inducer of monocytic differentiation. EMBO J. 19:1987-1997.
24. Langer, S. J., D. M. Bortner, M. F. Roussel, C. J. Sherr, and M. C. Ostrowski. 1992. Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. Mol. Cell. Biol. 12:5355-5362.
25. Lanza, F., M. Morales, C. de La Salle, J. P. Cazenave, K. J. Clemetson, T. Shimomura, and D. R. Phillips. 1993. Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. J. Biol. Chem. 268:20801-20807.
26. Lavoie, J. N., G. L'Allemain, A. Brunet, R. Muller, and J. Pouyssegur. 1996. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271:20608-20616.
27. Leclerc, J. R. 2002. Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions. Crit. Care Med. 30:S332-S340.
28. Lemarchandel, V., J. Ghysdael, V. Mignotte, C. Rahuel, and P. H. Roméo. 1993. GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol. Cell. Biol. 13:668-676.
29. Mansour, S. J., J. M. Candia, K. K. Gloor, and N. G. Ahn. 1996. Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses. Cell Growth Differ. 7:243-250.
30. Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966-970.
31. Manzanares, M., S. Cordes, C. T. Kwan, M. H. Sham, G. S. Barsh, and R. Krumlauf. 1997. Segmental regulation of Hoxb-3 by kreisler. Nature 387:191-195.
32. Manzanares, M., J. Nardelli, P. Gilardi-Hebenstreit, H. Marshall, F. Giudicelli, M. T. Martinez-Pastor, R. Krumlauf, and P. Charnay. 2002. Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. EMBO J. 21:365-376.
33. Marini, M. G., K. Chan, L. Casula, Y. W. Kan, A. Cao, and P. Moi. 1997. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. J. Biol. Chem. 272:16490-16497.
34. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
35. Martin, F., M. H. Prandini, D. Thevenon, G. Marguerie, and G. Uzan. 1993. The transcription factor GATA-1 regulates the promoter activity of the platelet glycoprotein IIb gene. J. Biol. Chem. 268:21606-21612.
36. Matsumura, I., A. Kawasaki, H. Tanaka, J. Sonoyama, S. Ezoe, N. Minegishi, K. Nakajima, M. Yamamoto, and Y. Kanakura. 2000. Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines. Blood 96:2440-2450.
37. Matsumura, I., K. Nakajima, H. Wakao, S. Hattori, K. Hashimoto, H. Sugahara, T. Kato, H. Miyazaki, T. Hirano, and Y. Kanakura. 1998. Involvement of prolonged Ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line. Mol. Cell. Biol. 18:4282-4290.
38. Melemed, A. S., J. W. Ryder, and T. A. Vik. 1997. Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells. Blood 90:3462-3470.
39. Mignotte, V., I. Vigon, E. Boucher de Crevecoeur, P. H. Romeo, V. Lemarchandel, and S. Chretien. 1994. Structure and transcription of the human c-mpl gene (MPL). Genomics 20:5-12.
40. Minami, T., K. Tachibana, T. Imanishi, and T. Doi. 1998. Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression. Eur. J. Biochem. 258:879-889.
41. Motohashi, H., F. Katsuoka, J. A. Shavit, J. D. Engel, and M. Yamamoto. 2000. Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins. Cell 103:865-875.
42. Pages, G., P. Lenormand, G. L'Allemain, J. C. Chambard, S. Meloche, and J. Pouyssegur. 1993. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. USA 90:8319-8323.
43. Petropoulos, H., and I. S. Skerjanc. 2002. Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells. J. Biol. Chem. 277:15393-15399.
44. Phillips, D. R., I. F. Charo, L. V. Parise, and L. A. Fitzgerald. 1988. The platelet membrane glycoprotein IIb-IIIa complex. Blood 71:831-843.
45. Prandini, M. H., G. Uzan, F. Martin, D. Thevenon, and G. Marguerie. 1992. Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein IIb promoter. J. Biol. Chem. 267:10370-10374.
46. Racke, F. K., K. Lewandowska, S. Goueli, and A. N. Goldfarb. 1997. Sustained activation of the extracellular signal-regulated kinase/mitogen- activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells. J. Biol. Chem. 272:23366-23370.
47. Rouyez, M. C., C. Boucheron, S. Gisselbrecht, I. Dusanter-Fourt, and F. Porteu. 1997. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17:4991-5000.
48. Schramek, H., E. Feifel, E. Healy, and V. Pollack. 1997. Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby canine kidney-C7 cells. J. Biol. Chem. 272:11426-11433.
49. Sharp, L. L., D. A. Schwarz, C. M. Bott, C. J. Marshall, and S. M. Hedrick. 1997. The influence of the MAPK pathway on T cell lineage commitment. Immunity 7:609-618.
50. Shivdasani, R. A., Y. Fujiwara, M. A. McDevitt, and S. H. Orkin. 1997. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 16:3965-3973.
51. Sieweke, M. H., H. Tekotte, J. Frampton, and T. Graf. 1996. MafB is an interaction partner and represser of Ets-1 that inhibits erythroid differentiation. Cell 85:49-60.
52. Sieweke, M. H., H. Tekotte, J. Frampton, and T. Graf. 1997. MafB represses erythroid genes and differentiation through direct interaction with c-Ets-1. Leukemia 11(Suppl. 3):486-488.
53. Towatari, M., G. E. May, R. Marais, G. R. Perkins, C. J. Marshall, S. Cowley, and T. Enver. 1995. Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3. J. Biol. Chem. 270:4101-4107.
54. Uchida, M., K. Kirito, R. Shimizu, Y. Miura, K. Ozawa, and N. Komatsu. 2001. A functional role of mitogen-activated protein kinases, erk1 and erk2, in the differentiation of a human leukemia cell line, UT-7/GM: a possible key factor for cell fate determination toward erythroid and megakaryocytic lineages. Int. J. Hematol. 73:78-83.
55. Uzan, G., M. Prenant, M. H. Prandini, F. Martin, and G. Marguerie. 1991. Tissue-specific expression of the platelet GPIIb gene. J. Biol. Chem. 266:8932-8939.
56. Visvader, J. E., M. Crossley, J. Hill, S. H. Orkin, and J. M. Adams. 1995. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol. Cell. Biol. 15:634-641.
57. Whalen, A. M., S. C. Galasinski, P. S. Shapiro, T. S. Nahreini, and N. G. Ahn. 1997. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol. Cell. Biol. 17:1947-1958.
58. Yagi, M., S. Edelhoff, C. M. Disteche, and G. J. Roth. 1994. Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta. J. Biol. Chem. 269:17424-17427.
59. Zutter, M. M., A. M. Fong, H. R. Krigman, and S. A. Santoro. 1992. Differential regulation of the alpha 2 beta 1 and alpha IIb beta 3 integrin genes during megakaryocytic differentiation of pluripotential K562 cells. J. Biol. Chem. 267:20233-20238.
60. Zutter, M. M., A. D. Painter, and X. Yang. 1999. The Megakaryocyte/ Platelet-specific enhancer of the α2β1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. Blood 93:1600-1611.