Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts

Journal of Surgical Research

Volumn 169, Issue 1, 2011, Pages

  Brennan, Todd V ^a   Tang, Qizhi ^b   Liu, Feng Chun ^b   Hoang, Vunghi ^b   Bi, Mingying ^b   Bluestone, Jeffrey A ^b   Kang, Sang Mo ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

alloimmunity; immunology; regulatory T cells; rejection; transgenic T cells; transplantation

Indexed keywords

ANTIBODY CONJUGATE; CD3 ANTIBODY; CYTOKINE; INTERLEUKIN 2; MONOCLONAL ANTIBODY CD28; T LYMPHOCYTE RECEPTOR;

ALLOGRAFT; ALLOSPECIFIC CD4+ T LYMPHOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOCHEMISTRY; IN VITRO STUDY; ISOGRAFT; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PHENOTYPE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; TRANSGENICS; WILD TYPE;

ANIMALS; CELL PROLIFERATION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOCOMPETENCE; IMMUNOMODULATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 79958224706     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.03.021     Document Type: Article

References (47)

1. S. Sakaguchi, T. Yamaguchi, and T. Nomura Regulatory T cells and immune tolerance Cell 133 2008 775
2. C. Baecher-Allan, and D.A. Hafler Human regulatory T cells and their role in autoimmune disease Immunol Rev 212 2006 203
3. S. Sakaguchi, M. Miyara, and C.M. Costantino FOXP3+ regulatory T cells in the human immune system Nat Rev Immunol 10 2010 490
4. J.A. Bluestone, and A.K. Abbas Natural versus adaptive regulatory T cells Nat Rev Immunol 3 2003 253
5. R. Khattri, T. Cox, and S.A. Yasayko An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat Immunol 4 2003 337
6. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 2003 330
7. S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057
8. S. Read, V. Malmstrom, and F. Powrie Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 192 2000 295
9. Q. Tang, K.J. Henriksen, and M. Bi In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes J Exp Med 199 2004 1455
10. T.A. Chatila, F. Blaeser, and N. Ho JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome J Clin Invest 106 2000 R75
11. C.L. Bennett, J. Christie, and F. Ramsdell The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat Genet 27 2001 20
12. J. Ermann, P. Hoffmann, and M. Edinger Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD Blood 105 2005 2220
13. S. Fu, A.C. Yopp, and X. Mao CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential Am J Transplant 4 2004 65
14. K.J. Wood, S. Luo, and A. Akl Regulatory T cells: Potential in organ transplantation Transplantation 77 1 Suppl 2004 S6
15. S. Jiang, and R.I. Lechler Regulatory T cells in the control of transplantation tolerance and autoimmunity Am J Transplant 3 2003 516
16. A. Bushell, E. Jones, A. Gallimore, and K. Wood The generation of CD25+ CD4+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen J Immunol 174 2005 3290
17. O. Joffre, T. Santolaria, and D. Calise Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes Nat Med 14 2008 88
18. W. Gao, Y. Lu, and B. El Essawy Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells Am J Transplant 7 2007 1722
19. M.K.t. Lee, D.J. Moore, and B.P. Jarrett Promotion of allograft survival by CD4+CD25+ regulatory T cells: Evidence for in vivo inhibition of effector cell proliferation J Immunol 172 2004 6539
20. A. Sanchez-Fueyo, S. Sandner, and A. Habicht Specificity of CD4+CD25+ regulatory T cell function in alloimmunity J Immunol 176 2006 329
21. J.Y. Tsang, Y. Tanriver, and S. Jiang Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression Transpl Immunol 21 2009 203
22. M.M. Velasquez-Lopera, V.L. Eaton, and N.M. Lerret Induction of transplantation tolerance by allogeneic donor-derived CD4(+)CD25(+)Foxp3(+) regulatory T cells Transpl Immunol 19 2008 127
23. G. Xia, J. He, and Z. Zhang Targeting acute allograft rejection by immunotherapy with ex vivo-expanded natural CD4+ CD25+ regulatory T cells Transplantation 82 2006 1749
24. P.S. Heeger T-cell allorecognition and transplant rejection: A summary and update Am J Transplant 3 2003 525
25. E.J. Suchin, P.B. Langmuir, and E. Palmer Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question J Immunol 166 2001 973
26. G. Raimondi, T.L. Sumpter, and B.M. Matta Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients J Immunol 184 2010 624
27. T.V. Brennan, V. Hoang, and K.R. Garrod A new T-cell receptor transgenic model of the CD4+ direct pathway: Level of priming determines acute versus chronic rejection Transplantation 85 2008 247
28. R.J. Corry, H.J. Winn, and P.S. Russell Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection Transplantation 16 1973 343
29. L.Y. Pu, X.H. Wang, and F. Zhang Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4(+)CD25(+) regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation Surgery 142 2007 67
30. M.L. Alegre, D.R. Goldstein, and A.S. Chong Toll-like receptor signaling in transplantation Curr Opin Organ Transplant 13 2008 358
31. S.M. Kang, Q. Tang, and J.A. Bluestone CD4+CD25+ regulatory T cells in transplantation: Progress, challenges and prospects Am J Transplant 7 2007 1457
32. Z. Yong, L. Chang, and Y.X. Mei Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance Transpl Immunol 17 2007 120
33. K. Wing, and S. Sakaguchi Regulatory T cells exert checks and balances on self tolerance and autoimmunity Nat Immunol 11 2010 7
34. D.M. Briscoe, and M.H. Sayegh A rendezvous before rejection: Where do T cells meet transplant antigens? Nat Med 8 2002 220
35. T.V. Brennan, A. Jaigirdar, and V. Hoang Preferential priming of alloreactive T cells with indirect reactivity Am J Transplant 9 2009 709
36. K. Honjo, X. Xu, and R.P. Bucy CD4+ T-cell receptor transgenic T cells alone can reject vascularized heart transplants through the indirect pathway of alloantigen recognition Transplantation 77 2004 452
37. H. Auchincloss Jr., R. Lee, and S. Shea The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice Proc Natl Acad Sci U S A 90 1993 3373
38. M. Karim, G. Feng, and K.J. Wood CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: Antigen-specific reactivation in vivo is critical for bystander regulation Blood 105 2005 4871
39. J.Y. Tsang, Y. Tanriver, and S. Jiang Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice J Clin Invest 118 2008 3619
40. M. Lopez, M.R. Clarkson, and M. Albin A novel mechanism of action for anti-thymocyte globulin: Induction of CD4+CD25+Foxp3+ regulatory T cells J Am Soc Nephrol 17 2006 2844
41. N. Pilat, U. Baranyi, and C. Klaus Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning Am J Transplant 10 2010 751
42. K. Kawamoto, A. Pahuja, and B.J. Hering Transforming growth factor beta 1 (TGF-β1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3(+) Tregs Transpl Immunol 2010
43. C. Pasare, and R. Medzhitov Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science 299 2003 1033
44. R.P. Sutmuller, M.H. den Brok, and M. Kramer Toll-like receptor 2 controls expansion and function of regulatory T cells J Clin Invest 116 2006 485
45. G. Peng, Z. Guo, and Y. Kiniwa Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function Science 309 2005 1380
46. H. Liu, M. Komai-Koma, and D. Xu Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells Proc Natl Acad Sci U S A 103 2006 7048
47. A.A. Beg Endogenous ligands of Toll-like receptors: Implications for regulating inflammatory and immune responses Trends Immunol 23 2002 509