Interleukin-7 matures suppressive CD127+ forkhead box P3 (FoxP3)+ T cells into CD127- CD25high FoxP3+ regulatory T cells

Clinical and Experimental Immunology

Volumn 165, Issue 1, 2011, Pages 60-76

  Di Caro, V ^a,c   D'Anneo, A ^a,d   Phillips, B ^a   Engman, C ^a   Harnaha, J ^a   Lakomy, R ^a   Styche, A ^a   Trucco, M ^a   Giannoukakis, N ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c RiMED Foundation   (Italy)

^d UNIVERSITY OF PALERMO   (Italy)

Author keywords

Autoimmunity; FoxP3 Tregs; Interleukin 7

Indexed keywords

CD4 ANTIGEN; CD45RA ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL NUCLEUS; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MEDIATOR; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; THYMUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIGENS, CD; ANTIGENS, CD45; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 79958167806     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04334.x     Document Type: Article

References (66)

1. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000; 101:455-8.
2. + suppressor T cells. Immunol Rev 2001; 182:58-67.
3. Shevach EM, McHugh RS, Thornton AM, Piccirillo C, Natarajan K, Margulies DH. Control of autoimmunity by regulatory T cells. Adv Exp Med Biol 2001; 490:21-32.
4. Apostolou I, Verginis P, Kretschmer K, Polansky J, Huhn J, von Boehmer H. Peripherally induced Treg: mode, stability, and role in specific tolerance. J Clin Immunol 2008; 28:619-24.
5. Balato A, Unutmaz D, Gaspari AA. Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions. J Invest Dermatol 2009; 129:1628-42.
6. Jordan MA, Baxter AG. The genetics of immunoregulatory T cells. J Autoimmun 2008; 31:237-44.
7. Ronchi F, Falcone M. Immune regulation by invariant NKT cells in autoimmunity. Front Biosci 2008; 13:4827-37.
8. + Treg-mediated suppression. Trends Immunol 2008; 29:337-42.
9. Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M. Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J Leukoc Biol 2008; 84:468-76.
10. Satoguina JS, Adjobimey T, Arndts K etal. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta. Eur J Immunol 2008; 38:3101-13.
11. Wang L, Toda M, Saito K etal. Post-immune UV irradiation induces Tr1-like regulatory T cells that suppress humoral immune responses. Int Immunol 2008; 20:57-70.
12. + regulatory T cells. J Dermatol Sci 2009; 54:69-75.
13. + T regulatory cell-mediated suppression. Immunity 2009; 30:636-45.
14. + regulatory T cells: more of the same or a division of labor? Immunity 2009; 30:626-35.
15. + regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008; 9:239-44.
16. Roncarolo MG, Gregori S. Is FOXP3 a bona fide marker for human regulatory T cells? Eur J Immunol 2008; 38:925-7.
17. Curiel TJ. Regulatory T-cell development: is Foxp3 the decider? Nat Med 2007; 13:250-3.
18. + regulatory T cells in human thymus and periphery. Immunity 2008; 28:870-80.
19. +CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 2004; 172:5213-21.
20. Wuest TY, Willette-Brown J, Durum SK, Hurwitz AA. The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells. J Leukoc Biol 2008; 84:973-80.
21. + regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int Immunol 2007; 19:785-99.
22. + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006; 108:1571-9.
23. + T regulatory cells. J Immunol 2006; 177:5115-21.
24. +) T regulatory cell development during the neonatal period. J Exp Med 2005; 201:769-77.
25. Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol 2003; 74:961-5.
26. Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004; 4:665-74.
27. Malek TR, Yu A, Vincek V, Scibelli P, Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002; 17:167-78.
28. Mazzucchelli R, Hixon JA, Spolski R etal. Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood 2008; 112:3283-92.
29. + T regulatory cells. J Immunol 2008; 181:225-34.
30. + T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med 2007; 204:547-57.
31. + T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes 2006; 55:158-70.
32. Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N. Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol 2004; 173:4331-41.
33. Seddiki N, Santner-Nanan B, Martinson J etal. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-700.
34. + regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007; 319:41-52.
35. + T reg cells. J Exp Med 2006; 203:1701-11.
36. +) regulatory T cells. Trends Immunol 2006; 27:541-4.
37. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005; 6:1142-51.
38. + immunoregulatory T cells is antigen nonspecific. J Immunol 2000; 164:183-90.
39. + regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum 2005; 52:1180-4.
40. + T cells. Int Immunol 2007; 19:1329-39.
41. Sasson SC, Zaunders JJ, Zanetti G etal. Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis 2006; 193:505-14.
42. Sasson SC, Zaunders JJ, Kelleher AD. The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapy. Curr Drug Targets 2006; 7:1571-82.
43. + T cells expressing the FoxP3 transcription factor. Immunity 2009; 30:899-911.
44. + regulatory T cells through CTLA-4 signaling. J Immunol 2006; 177:5631-8.
45. +) regulatory T cells. J Immunol 2007; 178:1542-52.
46. Sansom DM, Walker LS. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev 2006; 212:131-48.
47. + regulatory T cell function. Science 2008; 322:271-5.
48. + regulatory T cells. J Immunol 2007; 178:280-90.
49. Murawski MR, Litherland SA, Clare-Salzler MJ, Davoodi-Semiromi A. Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes pathogenesis. Ann NY Acad Sci 2006; 1079:198-204.
50. Snow JW, Abraham N, Ma MC, Herndier BG, Pastuszak AW, Goldsmith MA. Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice. J Immunol 2003; 171:5042-50.
51. Yao Z, Kanno Y, Kerenyi M etal. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 2007; 109:4368-75.
52. +CD25- effector T cells. Int Immunol 2008; 20:421-31.
53. Jiang Q, Li WQ, Aiello FB etal. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev 2005; 16:513-33.
54. Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005; 174:6571-6.
55. +T cell memory. Proc Natl Acad Sci USA 2004; 101:9357-62.
56. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002; 99:3892-904.
57. Fry TJ, Mackall CL. Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol 2001; 22:564-71.
58. Putnam AL, Brusko TM, Lee MR etal. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 2009; 58:652-62.
59. + regulatory T cell development. J Immunol 2008; 181:3285-90.
60. Seki Y, Yang J, Okamoto M etal. IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs. J Immunol 2007; 178:262-70.
61. Ma A, Koka R, Burkett P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 2006; 24:657-79.
62. Zubkova I, Mostowski H, Zaitseva M. Up-regulation of IL-7, stromal-derived factor-1 alpha, thymus-expressed chemokine, and secondary lymphoid tissue chemokine gene expression in the stromal cells in response to thymocyte depletion: implication for thymus reconstitution. J Immunol 2005; 175:2321-30.
63. Allman D, Miller JP. Common lymphoid progenitors, early B-lineage precursors, and IL-7: characterizing the trophic and instructive signals underlying early B cell development. Immunol Res 2003; 27:131-40.
64. + T cells. Nat Immunol 2009; 10:149-57.
65. Sorg RV, McLellan AD, Hock BD, Fearnley DB, Hart DN. Human dendritic cells express functional interleukin-7. Immunobiology 1998; 198:514-26.
66. Krawczenko A, Kieda C, Dus D. The biological role and potential therapeutic application of interleukin 7. Arch Immunol Ther Exp 2005; 53:518-25.