메뉴 건너뛰기




Volumn 230, Issue 1, 2011, Pages 27-34

Statins: Multiple neuroprotective mechanisms in neurodegenerative diseases

Author keywords

Alzheimer's disease; Inflammation; Ischemia; Neuroprotection; Parkinson's disease; Statins

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; ATORVASTATIN; CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATRIX METALLOPROTEINASE; NITRIC OXIDE; PRAVASTATIN; REACTIVE OXYGEN METABOLITE; ROSUVASTATIN; SIMVASTATIN;

EID: 79958027663     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.04.006     Document Type: Review
Times cited : (139)

References (116)
  • 1
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Aelst L.W., D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 1997, 11:2295-2322.
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • Aelst, L.W.1    D'Souza-Schorey, C.2
  • 2
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F. Immune function of microglia. Glia 2001, 36(2):165-179.
    • (2001) Glia , vol.36 , Issue.2 , pp. 165-179
    • Aloisi, F.1
  • 3
    • 67649144077 scopus 로고    scopus 로고
    • Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial
    • SPARCL Investigators
    • Amarenco P., Goldstein L.B., Messig M., O'Neill B.J., Callahan A., Sillesen H., Hennerici M.G., Zivin J.A., Welch K.M. Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial. Stroke 2009, 40(7):2486-2492. SPARCL Investigators.
    • (2009) Stroke , vol.40 , Issue.7 , pp. 2486-2492
    • Amarenco, P.1    Goldstein, L.B.2    Messig, M.3    O'Neill, B.J.4    Callahan, A.5    Sillesen, H.6    Hennerici, M.G.7    Zivin, J.A.8    Welch, K.M.9
  • 4
    • 41149170293 scopus 로고    scopus 로고
    • Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats
    • Aoki T., Kataoka H., Ishibashi R., Nozaki K., Hashimoto N. Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke 2008, 39(4):1276-1285.
    • (2008) Stroke , vol.39 , Issue.4 , pp. 1276-1285
    • Aoki, T.1    Kataoka, H.2    Ishibashi, R.3    Nozaki, K.4    Hashimoto, N.5
  • 7
    • 43549104227 scopus 로고    scopus 로고
    • Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease
    • Bar-On P., Crews L., Koob A.O., Mizuno H., Adame A., Spencer B., Masliah E. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J. Neurochem. 2008, 105(5):1656-1667.
    • (2008) J. Neurochem. , vol.105 , Issue.5 , pp. 1656-1667
    • Bar-On, P.1    Crews, L.2    Koob, A.O.3    Mizuno, H.4    Adame, A.5    Spencer, B.6    Masliah, E.7
  • 8
    • 42449108158 scopus 로고    scopus 로고
    • Use of statins and the risk of Parkinson's disease: a retrospective case-control study in the UK
    • Becker C., Jick S.S., Meier C.R. Use of statins and the risk of Parkinson's disease: a retrospective case-control study in the UK. Drug Saf. 2008, 31(5):399-407.
    • (2008) Drug Saf. , vol.31 , Issue.5 , pp. 399-407
    • Becker, C.1    Jick, S.S.2    Meier, C.R.3
  • 9
    • 45449084852 scopus 로고    scopus 로고
    • Neuroprotection by pravastatin in acute ischemic stroke in rats
    • Berger C., Xia F., Maurer M.H., Schwab S. Neuroprotection by pravastatin in acute ischemic stroke in rats. Brain Res. Rev. 2008, 58(1):48-56.
    • (2008) Brain Res. Rev. , vol.58 , Issue.1 , pp. 48-56
    • Berger, C.1    Xia, F.2    Maurer, M.H.3    Schwab, S.4
  • 10
    • 0034020875 scopus 로고    scopus 로고
    • Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study
    • Bonarek M., Barberger-Gateau P., Letenneur L., Deschamps V., Iron A., Dubroca B., Dartigues J.F. Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study. Neuroepidemiology 2000, 19:141-148.
    • (2000) Neuroepidemiology , vol.19 , pp. 141-148
    • Bonarek, M.1    Barberger-Gateau, P.2    Letenneur, L.3    Deschamps, V.4    Iron, A.5    Dubroca, B.6    Dartigues, J.F.7
  • 11
    • 0032513889 scopus 로고    scopus 로고
    • Blood pressure and mortality in elderly people aged 85 and older: community based study
    • Boshuizen H.C., Izaks G.J., van Buuren S., Ligthart G.J. Blood pressure and mortality in elderly people aged 85 and older: community based study. BMJ 1998, 316:1780-1784.
    • (1998) BMJ , vol.316 , pp. 1780-1784
    • Boshuizen, H.C.1    Izaks, G.J.2    van Buuren, S.3    Ligthart, G.J.4
  • 12
    • 0036550239 scopus 로고    scopus 로고
    • Pharmacological concentrations of the HMG-COA reductase inhibitor lovastatin decrease the formation of the Alzheimer B-amyloid peptide in vitro and in patients
    • Buxbaum J.D., Cullen E.I., Freidhoff L.T. Pharmacological concentrations of the HMG-COA reductase inhibitor lovastatin decrease the formation of the Alzheimer B-amyloid peptide in vitro and in patients. Front. Biosci. 2002, 7:50-59.
    • (2002) Front. Biosci. , vol.7 , pp. 50-59
    • Buxbaum, J.D.1    Cullen, E.I.2    Freidhoff, L.T.3
  • 13
    • 0034990260 scopus 로고    scopus 로고
    • Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide
    • Buxbaum J.D., Geoghagen N.S., Friedhoff L.T. Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J. Alzheimer's Dis. 2001, 3(2):221-229.
    • (2001) J. Alzheimer's Dis. , vol.3 , Issue.2 , pp. 221-229
    • Buxbaum, J.D.1    Geoghagen, N.S.2    Friedhoff, L.T.3
  • 14
    • 70349742221 scopus 로고    scopus 로고
    • Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation
    • Carloni S., Girelli S., Buonocore G., Longini M., Balduini W. Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation. Exp. Neurol. 2009, 220(1):82-89.
    • (2009) Exp. Neurol. , vol.220 , Issue.1 , pp. 82-89
    • Carloni, S.1    Girelli, S.2    Buonocore, G.3    Longini, M.4    Balduini, W.5
  • 16
    • 33749007123 scopus 로고    scopus 로고
    • Statins and cerebral vasomotor reactivity: implications for a new therapy?
    • Carod-Artal F.J. Statins and cerebral vasomotor reactivity: implications for a new therapy?. Stroke 2006, 37(10):2446-2448.
    • (2006) Stroke , vol.37 , Issue.10 , pp. 2446-2448
    • Carod-Artal, F.J.1
  • 18
    • 69749096363 scopus 로고    scopus 로고
    • Chemokine, vascular and therapeutic effects of combination simvastatin and BMSC treatment of stroke
    • Cui X., Chopp M., Zacharek A., Roberts C., Lu M., Savant-Bhonsale S., Chen J. Chemokine, vascular and therapeutic effects of combination simvastatin and BMSC treatment of stroke. Neurobiol. Dis. 2009, 36(1):35-41.
    • (2009) Neurobiol. Dis. , vol.36 , Issue.1 , pp. 35-41
    • Cui, X.1    Chopp, M.2    Zacharek, A.3    Roberts, C.4    Lu, M.5    Savant-Bhonsale, S.6    Chen, J.7
  • 19
    • 0036900697 scopus 로고    scopus 로고
    • Statins and stroke: evidence for cholesterol-independent effects
    • Di Napoli P., Taccardi A.A., Oliver M., De Caterina R. Statins and stroke: evidence for cholesterol-independent effects. Eur. Heart J. 2002, 23(24):1908-1921.
    • (2002) Eur. Heart J. , vol.23 , Issue.24 , pp. 1908-1921
    • Di Napoli, P.1    Taccardi, A.A.2    Oliver, M.3    De Caterina, R.4
  • 20
    • 0017055252 scopus 로고
    • ML-236A, ML-236B, ML-236C, new inhibitors of cholesterogenesis produced by Pennicillium citrinum
    • Endo A., Kuroda M., Tsujita Y. ML-236A, ML-236B, ML-236C, new inhibitors of cholesterogenesis produced by Pennicillium citrinum. J. Antibiot. 1976, 29:1346-1348.
    • (1976) J. Antibiot. , vol.29 , pp. 1346-1348
    • Endo, A.1    Kuroda, M.2    Tsujita, Y.3
  • 21
    • 0032555154 scopus 로고    scopus 로고
    • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
    • Endres M., Laufs U., Huang Z., Nakamura T., Huang P., Moskowitz M.A., Liao J.K. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(15):8880-8885.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , Issue.15 , pp. 8880-8885
    • Endres, M.1    Laufs, U.2    Huang, Z.3    Nakamura, T.4    Huang, P.5    Moskowitz, M.A.6    Liao, J.K.7
  • 23
    • 33645732870 scopus 로고    scopus 로고
    • Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production
    • Erdös B., Snipes J.A., Tulbert C.D., Katakam P., Miller A.W., Busija D.W. Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production. Am. J. Physiol, Heart Circ. Physiol. 2006, 290(3):H1264-H1270.
    • (2006) Am. J. Physiol, Heart Circ. Physiol. , vol.290 , Issue.3
    • Erdös, B.1    Snipes, J.A.2    Tulbert, C.D.3    Katakam, P.4    Miller, A.W.5    Busija, D.W.6
  • 24
    • 0033958076 scopus 로고    scopus 로고
    • Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans
    • Evans R.M., Emsley C.L., Gao S., Sahota A., Hall K.S., Farlow M.R., Hendrie H. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans. Neurology 2000, 54:240-242.
    • (2000) Neurology , vol.54 , pp. 240-242
    • Evans, R.M.1    Emsley, C.L.2    Gao, S.3    Sahota, A.4    Hall, K.S.5    Farlow, M.R.6    Hendrie, H.7
  • 25
    • 66249083144 scopus 로고    scopus 로고
    • Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity
    • Fernández A., Llacuna L., Fernández-Checa J.C., Colell A. Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J. Neurosci. 2009, 29(20):6394-6405.
    • (2009) J. Neurosci. , vol.29 , Issue.20 , pp. 6394-6405
    • Fernández, A.1    Llacuna, L.2    Fernández-Checa, J.C.3    Colell, A.4
  • 26
    • 0032956961 scopus 로고    scopus 로고
    • Natural statins and stroke risk
    • Furberg C.D. Natural statins and stroke risk. Circulation 1999, 99:185-188.
    • (1999) Circulation , vol.99 , pp. 185-188
    • Furberg, C.D.1
  • 27
  • 28
    • 70350555275 scopus 로고    scopus 로고
    • Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease
    • Ghosh A., Roy A., Matras J., Brahmachari S., Gendelman H.E., Pahan K. Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J. Neurosci. 2009, 29(43):13543-13556.
    • (2009) J. Neurosci. , vol.29 , Issue.43 , pp. 13543-13556
    • Ghosh, A.1    Roy, A.2    Matras, J.3    Brahmachari, S.4    Gendelman, H.E.5    Pahan, K.6
  • 31
    • 0033454062 scopus 로고    scopus 로고
    • Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia
    • Glorioso N., Troffa C., Filigheddu F., Dettori F., Soro A., Parpaglia P.P., Collatina S., Pahor M. Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia. Hypertension 1999, 34:1281-1286.
    • (1999) Hypertension , vol.34 , pp. 1281-1286
    • Glorioso, N.1    Troffa, C.2    Filigheddu, F.3    Dettori, F.4    Soro, A.5    Parpaglia, P.P.6    Collatina, S.7    Pahor, M.8
  • 33
    • 15944372262 scopus 로고    scopus 로고
    • Activation and assembly of the NADPH oxidase: a structural perspective
    • Groemping Y., Rittinger K. Activation and assembly of the NADPH oxidase: a structural perspective. Biochem. J. 2005, 386:401-416.
    • (2005) Biochem. J. , vol.386 , pp. 401-416
    • Groemping, Y.1    Rittinger, K.2
  • 34
    • 0023876839 scopus 로고
    • HMG-CoA reductase inhibitors for treatment of hypercholesterolemia
    • Grundy S.M. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N. Engl. J. Med. 1988, 319:24-33.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 24-33
    • Grundy, S.M.1
  • 37
    • 0033532737 scopus 로고    scopus 로고
    • The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons
    • Haan M.N., Shemanski L., Jagust W.J., Manolio T.A., Kuller L. The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA 1999, 282(1):40-46.
    • (1999) JAMA , vol.282 , Issue.1 , pp. 40-46
    • Haan, M.N.1    Shemanski, L.2    Jagust, W.J.3    Manolio, T.A.4    Kuller, L.5
  • 39
    • 68749092225 scopus 로고    scopus 로고
    • Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1
    • Heeba G., Moselhy M., Hassan M., Khalifa M., Gryglewski R., Malinski T. Anti-atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase-1. Br. J. Pharmacol. 2009, 156(8):1256-1266.
    • (2009) Br. J. Pharmacol. , vol.156 , Issue.8 , pp. 1256-1266
    • Heeba, G.1    Moselhy, M.2    Hassan, M.3    Khalifa, M.4    Gryglewski, R.5    Malinski, T.6
  • 41
    • 58849087075 scopus 로고    scopus 로고
    • False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment
    • Hildebrandt H., Haldenwanger A., Eling P. False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment. J. Alzheimer's Dis. 2009, 16(1):157-165.
    • (2009) J. Alzheimer's Dis. , vol.16 , Issue.1 , pp. 157-165
    • Hildebrandt, H.1    Haldenwanger, A.2    Eling, P.3
  • 42
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?
    • Review
    • Hirsch, E. C., Hunot, S., Damier, P., Faucheux, B, 1998. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann Neurol 44(3Suppl 1), S115-120. Review.
    • (1998) Ann Neurol , vol.44 , Issue.3 SUPPL. 1
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 44
    • 23744516018 scopus 로고    scopus 로고
    • Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease
    • Höglund K., Syversen S., Lewczuk P., Wallin A., Wiltfang J., Blennow K. Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease. Exp. Brain Res. 2005, 164:205-214.
    • (2005) Exp. Brain Res. , vol.164 , pp. 205-214
    • Höglund, K.1    Syversen, S.2    Lewczuk, P.3    Wallin, A.4    Wiltfang, J.5    Blennow, K.6
  • 45
    • 33751182650 scopus 로고    scopus 로고
    • Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke
    • Hong H., Zeng J.S., Kreulen D.L., Kaufman D.I., Chen A.F. Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. Am. J. Physiol, Heart Circ. Physiol. 2006, 291(5):H2210-H2215.
    • (2006) Am. J. Physiol, Heart Circ. Physiol. , vol.291 , Issue.5
    • Hong, H.1    Zeng, J.S.2    Kreulen, D.L.3    Kaufman, D.I.4    Chen, A.F.5
  • 50
    • 0030708588 scopus 로고    scopus 로고
    • Blood pressure and cardiovascular morbidity and mortality rates in the elderly
    • Kannel W.B., D'Agostino R.B., Silbershatz H. Blood pressure and cardiovascular morbidity and mortality rates in the elderly. Am. Heart J. 1997, 134:758-763.
    • (1997) Am. Heart J. , vol.134 , pp. 758-763
    • Kannel, W.B.1    D'Agostino, R.B.2    Silbershatz, H.3
  • 51
    • 0030693945 scopus 로고    scopus 로고
    • Autonomic nervous system dysfunction in elderly hypertensive patients with abnormal diurnal blood pressure variation: relation to silent cerebrovascular disease
    • Kario K., Motai K., Mitsuhashi T., Suzuki T., Nakagawa Y., Ikeda U., Matsuo T., Nakayama T., Shimada K. Autonomic nervous system dysfunction in elderly hypertensive patients with abnormal diurnal blood pressure variation: relation to silent cerebrovascular disease. Hypertension 1997, 30:1504-1510.
    • (1997) Hypertension , vol.30 , pp. 1504-1510
    • Kario, K.1    Motai, K.2    Mitsuhashi, T.3    Suzuki, T.4    Nakagawa, Y.5    Ikeda, U.6    Matsuo, T.7    Nakayama, T.8    Shimada, K.9
  • 52
    • 33746080351 scopus 로고    scopus 로고
    • Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis
    • Kelly M.A., Shuaib A., Todd K.G. Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis. Exp. Neurol. 2006, 200:38-49.
    • (2006) Exp. Neurol. , vol.200 , pp. 38-49
    • Kelly, M.A.1    Shuaib, A.2    Todd, K.G.3
  • 53
    • 51349101107 scopus 로고    scopus 로고
    • Ameliorative role of atorvastatin and pitavastatin in l-methionine induced vascular dementia in rats
    • Koladiya R.U., Jaggi A.S., Singh N., Sharma B.K. Ameliorative role of atorvastatin and pitavastatin in l-methionine induced vascular dementia in rats. BMC Pharmacol. 2008, 8:14.
    • (2008) BMC Pharmacol. , vol.8 , pp. 14
    • Koladiya, R.U.1    Jaggi, A.S.2    Singh, N.3    Sharma, B.K.4
  • 54
    • 73949132010 scopus 로고    scopus 로고
    • Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies
    • Koob A.O., Ubhi K., Paulsson J.F., Kelly J., Rockenstein E., Mante M., Adame A., Masliah E. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Exp. Neurol. 2010, 221(2):267-274.
    • (2010) Exp. Neurol. , vol.221 , Issue.2 , pp. 267-274
    • Koob, A.O.1    Ubhi, K.2    Paulsson, J.F.3    Kelly, J.4    Rockenstein, E.5    Mante, M.6    Adame, A.7    Masliah, E.8
  • 56
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y., Luo Z., Shiojima I., Bialik A., Fulton D., Lefer D.J., Sessa W.C., Walsh K. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat. Med. 2000, 6(9):1004-1010.
    • (2000) Nat. Med. , vol.6 , Issue.9 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3    Bialik, A.4    Fulton, D.5    Lefer, D.J.6    Sessa, W.C.7    Walsh, K.8
  • 57
    • 0031451344 scopus 로고    scopus 로고
    • Inhibition of 3.hydroxy-3methylglutaryl (HMG)-CoA reductase blocks hypoxia mediated down-regulation of endothelial nitric oxide synthase
    • Laufs U., La Fata V., Liao J. Inhibition of 3.hydroxy-3methylglutaryl (HMG)-CoA reductase blocks hypoxia mediated down-regulation of endothelial nitric oxide synthase. J. Biol. Chem. 1997, 50:31725-31739.
    • (1997) J. Biol. Chem. , vol.50 , pp. 31725-31739
    • Laufs, U.1    La Fata, V.2    Liao, J.3
  • 58
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U., La Fata V., Plutzky J., Liao J.K. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998, 97:1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 59
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U., Liao J.K. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J. Biol. Chem. 1998, 273:24266-24271.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 60
    • 0034730812 scopus 로고    scopus 로고
    • Targeting Rho in cardiovascular disease
    • Laufs U., Liao J.K. Targeting Rho in cardiovascular disease. Circ. Res. 2000, 87:526-528.
    • (2000) Circ. Res. , vol.87 , pp. 526-528
    • Laufs, U.1    Liao, J.K.2
  • 63
    • 0029847608 scopus 로고    scopus 로고
    • Palmitoylation of nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization
    • Liu J., Garcia-Gardena G., Sessa W.C. Palmitoylation of nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. Biochemistry 1996, 35:13277-13281.
    • (1996) Biochemistry , vol.35 , pp. 13277-13281
    • Liu, J.1    Garcia-Gardena, G.2    Sessa, W.C.3
  • 64
    • 33745726883 scopus 로고    scopus 로고
    • Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection
    • Liu X.S., Zhang Z.G., Zhang L., Morris D.C., Kapke A., Lu M., Chopp M. Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection. J. Cereb. Blood Flow Metab. 2006, 26(6):787-796.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , Issue.6 , pp. 787-796
    • Liu, X.S.1    Zhang, Z.G.2    Zhang, L.3    Morris, D.C.4    Kapke, A.5    Lu, M.6    Chopp, M.7
  • 65
    • 0141841614 scopus 로고    scopus 로고
    • Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    • Maack C., Kartes T., Kilter H., Schäfers H.J., Nickenig G., Böhm M., Laufs U. Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment. Circulation 2003, 108(13):1567-1574.
    • (2003) Circulation , vol.108 , Issue.13 , pp. 1567-1574
    • Maack, C.1    Kartes, T.2    Kilter, H.3    Schäfers, H.J.4    Nickenig, G.5    Böhm, M.6    Laufs, U.7
  • 66
    • 0343247789 scopus 로고    scopus 로고
    • Preferential deposition of amyloid beta protein [A] in the form A 40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E 4 allele
    • Mann D.M., Iwatsubo T., Pickering-Brown S.M., Owen F., Saido T.C., Perry R.H. Preferential deposition of amyloid beta protein [A] in the form A 40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E 4 allele. Neurosci. Lett. 1997, 221:81-84.
    • (1997) Neurosci. Lett. , vol.221 , pp. 81-84
    • Mann, D.M.1    Iwatsubo, T.2    Pickering-Brown, S.M.3    Owen, F.4    Saido, T.C.5    Perry, R.H.6
  • 67
    • 56649115966 scopus 로고    scopus 로고
    • Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia
    • Mayanagi K., Katakam P.V., Gáspár T., Domoki F., Busija D.W. Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia. J. Cereb. Blood Flow Metab. 2008, 28(12):1927-1935.
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , Issue.12 , pp. 1927-1935
    • Mayanagi, K.1    Katakam, P.V.2    Gáspár, T.3    Domoki, F.4    Busija, D.W.5
  • 68
    • 33846920571 scopus 로고    scopus 로고
    • P53 protein, interferongamma, and NF-kappaB levels are elevated in the parkinsonian brain
    • Mogi M., Kondo T., Mizuno Y., Nagatsu T. p53 protein, interferongamma, and NF-kappaB levels are elevated in the parkinsonian brain. Neurosci. Lett. 2007, 414(1):94-97.
    • (2007) Neurosci. Lett. , vol.414 , Issue.1 , pp. 94-97
    • Mogi, M.1    Kondo, T.2    Mizuno, Y.3    Nagatsu, T.4
  • 70
    • 67349156640 scopus 로고    scopus 로고
    • Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease
    • Mutez E., Duhamel A., Defebvre L., Bordet R., Destée A., Kreisler A. Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease. Pharmacol. Res. 2009, 60(1):41-45.
    • (2009) Pharmacol. Res. , vol.60 , Issue.1 , pp. 41-45
    • Mutez, E.1    Duhamel, A.2    Defebvre, L.3    Bordet, R.4    Destée, A.5    Kreisler, A.6
  • 73
    • 65549150954 scopus 로고    scopus 로고
    • Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity
    • Nicholson A.M., Ferreira A. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. J. Neurosci. 2009, 29(14):4640-4651.
    • (2009) J. Neurosci. , vol.29 , Issue.14 , pp. 4640-4651
    • Nicholson, A.M.1    Ferreira, A.2
  • 74
    • 34848835187 scopus 로고    scopus 로고
    • Statins reduce amyloid-beta production through inhibition of protein isoprenylation
    • Ostrowski S.M., Wilkinson B.L., Golde T.E., Landreth G. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J. Biol. Chem. 2007, 282(37):26832-26844.
    • (2007) J. Biol. Chem. , vol.282 , Issue.37 , pp. 26832-26844
    • Ostrowski, S.M.1    Wilkinson, B.L.2    Golde, T.E.3    Landreth, G.4
  • 75
    • 33745066138 scopus 로고    scopus 로고
    • Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway
    • Otto A., Fontaine J., Tschirhart E., Fontaine D., Berkenboom G. Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway. Br. J. Pharmacol. 2006, 148(4):544-552.
    • (2006) Br. J. Pharmacol. , vol.148 , Issue.4 , pp. 544-552
    • Otto, A.1    Fontaine, J.2    Tschirhart, E.3    Fontaine, D.4    Berkenboom, G.5
  • 83
    • 2442489033 scopus 로고    scopus 로고
    • Relation of plasma lipids to Alzheimer disease and vascular dementia
    • Reitz C., Tang M.X., Luchsinger J., Mayeux R. Relation of plasma lipids to Alzheimer disease and vascular dementia. Arch. Neurol. 2004, 61:705-714.
    • (2004) Arch. Neurol. , vol.61 , pp. 705-714
    • Reitz, C.1    Tang, M.X.2    Luchsinger, J.3    Mayeux, R.4
  • 84
    • 33644694919 scopus 로고    scopus 로고
    • Rho GTPases, statins, and nitric oxide
    • Rikitake Y., Liao J.K. Rho GTPases, statins, and nitric oxide. Circ. Res. 2005, 97:1232-1235.
    • (2005) Circ. Res. , vol.97 , pp. 1232-1235
    • Rikitake, Y.1    Liao, J.K.2
  • 86
    • 0036737795 scopus 로고    scopus 로고
    • Matrix metalloproteinases in neuroinflammation
    • Rosenberg G.A. Matrix metalloproteinases in neuroinflammation. Glia 2002, 39:279-291.
    • (2002) Glia , vol.39 , pp. 279-291
    • Rosenberg, G.A.1
  • 87
    • 0035793934 scopus 로고    scopus 로고
    • Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures
    • Rosenberg G.A., Cunningham L.A., Wallace J., Alexander S., Estrada E.Y., Grossetete M., Razhagi A., Miller K., Gearing A. Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res. 2001, 893:104-112.
    • (2001) Brain Res. , vol.893 , pp. 104-112
    • Rosenberg, G.A.1    Cunningham, L.A.2    Wallace, J.3    Alexander, S.4    Estrada, E.Y.5    Grossetete, M.6    Razhagi, A.7    Miller, K.8    Gearing, A.9
  • 88
    • 53349162141 scopus 로고    scopus 로고
    • Statin use and the risk of Parkinson disease: a nested case control study
    • Samii A., Carleton B.C., Etminan M. Statin use and the risk of Parkinson disease: a nested case control study. J. Clin. Neurosci. 2008, 15(11):1272-1273.
    • (2008) J. Clin. Neurosci. , vol.15 , Issue.11 , pp. 1272-1273
    • Samii, A.1    Carleton, B.C.2    Etminan, M.3
  • 89
    • 43749109162 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson's disease
    • Schuster S., Nadjar A., Guo J.T., Li Q., Ittrich C., Hengerer B., Bezard E. The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson's disease. J. Neurosci. 2008, 28(17):4311-4316.
    • (2008) J. Neurosci. , vol.28 , Issue.17 , pp. 4311-4316
    • Schuster, S.1    Nadjar, A.2    Guo, J.T.3    Li, Q.4    Ittrich, C.5    Hengerer, B.6    Bezard, E.7
  • 90
    • 14944350244 scopus 로고    scopus 로고
    • Simvastatin prevents 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice
    • Selley M.L. Simvastatin prevents 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice. Brain Res. 2005, 1037(1-2):1-6.
    • (2005) Brain Res. , vol.1037 , Issue.1-2 , pp. 1-6
    • Selley, M.L.1
  • 91
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw G., Karmen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986, 46:659-667.
    • (1986) Cell , vol.46 , pp. 659-667
    • Shaw, G.1    Karmen, R.2
  • 92
    • 0035949755 scopus 로고    scopus 로고
    • Cholesterol and Alzheimer's disease: is there a link?
    • Simons M., Keller P., Dichgans J., Schulz J.B. Cholesterol and Alzheimer's disease: is there a link?. Neurology 2001, 57(6):1089-1093.
    • (2001) Neurology , vol.57 , Issue.6 , pp. 1089-1093
    • Simons, M.1    Keller, P.2    Dichgans, J.3    Schulz, J.B.4
  • 93
    • 33745739157 scopus 로고    scopus 로고
    • Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    • Sparks D.L., Connor D.J., Sabbagh M.N., Petersen R.B., Lopez J., Browne P. Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial. Acta Neurol. Scand. Suppl. 2006, 185:3-7.
    • (2006) Acta Neurol. Scand. Suppl. , vol.185 , pp. 3-7
    • Sparks, D.L.1    Connor, D.J.2    Sabbagh, M.N.3    Petersen, R.B.4    Lopez, J.5    Browne, P.6
  • 95
    • 2542507788 scopus 로고    scopus 로고
    • Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin converting enzyme inhibitors (enalapril or lisinopril)
    • Sposito A.C., Mansur A.P., Coelho O.R., Nicolau J.C., Ramires J.A. Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin converting enzyme inhibitors (enalapril or lisinopril). Am. J. Cardiol. 1999, 83:1497-1499.
    • (1999) Am. J. Cardiol. , vol.83 , pp. 1497-1499
    • Sposito, A.C.1    Mansur, A.P.2    Coelho, O.R.3    Nicolau, J.C.4    Ramires, J.A.5
  • 96
    • 0035207933 scopus 로고    scopus 로고
    • Pravastatin improves cerebral vasomotor reactivity in patients with subcortical small-vessel disease
    • Sterzer P., Meintzschel F., Rösler A., Lanfermann H., Steinmetz H., Sitzer M. Pravastatin improves cerebral vasomotor reactivity in patients with subcortical small-vessel disease. Stroke 2001, 32(12):2817-2820.
    • (2001) Stroke , vol.32 , Issue.12 , pp. 2817-2820
    • Sterzer, P.1    Meintzschel, F.2    Rösler, A.3    Lanfermann, H.4    Steinmetz, H.5    Sitzer, M.6
  • 97
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • Review
    • Stoll G., Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 1999, 58(3):233-247. Review.
    • (1999) Prog. Neurobiol. , vol.58 , Issue.3 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 98
    • 14844330642 scopus 로고    scopus 로고
    • A study of statin use in the prevention of cognitive impairment of vascular origin in the UK
    • Suribhatla S., Dennis M.S., Potter J.F. A study of statin use in the prevention of cognitive impairment of vascular origin in the UK. J Neurol Sci. 2005, 229-230:47-50.
    • (2005) J Neurol Sci. , pp. 47-50
    • Suribhatla, S.1    Dennis, M.S.2    Potter, J.F.3
  • 99
    • 18144418144 scopus 로고    scopus 로고
    • Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    • Turner N.A., O'Regan D.J., Ball S.G., Porter K.E. Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J. 2005, 19(7):804-806.
    • (2005) FASEB J. , vol.19 , Issue.7 , pp. 804-806
    • Turner, N.A.1    O'Regan, D.J.2    Ball, S.G.3    Porter, K.E.4
  • 100
    • 0034839976 scopus 로고    scopus 로고
    • Do statins afford neuroprotection in patients with cerebral ischaemia and stroke?
    • Vaughan C.J., Delanty N., Basson C.T. Do statins afford neuroprotection in patients with cerebral ischaemia and stroke?. CNS Drugs 2001, 15(8):589-596.
    • (2001) CNS Drugs , vol.15 , Issue.8 , pp. 589-596
    • Vaughan, C.J.1    Delanty, N.2    Basson, C.T.3
  • 101
    • 42049097650 scopus 로고    scopus 로고
    • Statin use and the risk of Parkinson disease
    • Wahner A.D., Bronstein J.M., Bordelon Y.M., Ritz B. Statin use and the risk of Parkinson disease. Neurology 2008, 70(16 Pt 2):1418-1422.
    • (2008) Neurology , vol.70 , Issue.16 PART 2 , pp. 1418-1422
    • Wahner, A.D.1    Bronstein, J.M.2    Bordelon, Y.M.3    Ritz, B.4
  • 102
    • 34250630954 scopus 로고    scopus 로고
    • Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    • Wang H., Lynch J.R., Song P., Yang H.J., Yates R.B., Mace B., Warner D.S., Guyton J.R., Laskowitz D.T. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp. Neurol. 2007, 206(1):59-69.
    • (2007) Exp. Neurol. , vol.206 , Issue.1 , pp. 59-69
    • Wang, H.1    Lynch, J.R.2    Song, P.3    Yang, H.J.4    Yates, R.B.5    Mace, B.6    Warner, D.S.7    Guyton, J.R.8    Laskowitz, D.T.9
  • 103
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • Wang Q., Tang X.N., Yenari M.A. The inflammatory response in stroke. J. Neuroimmunol. 2007, 184(1-2):53-68.
    • (2007) J. Neuroimmunol. , vol.184 , Issue.1-2 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 104
    • 17844411468 scopus 로고    scopus 로고
    • High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase
    • Wang Q., Ting W.L., Yang H., Wong P.T. High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase. Br. J. Pharmacol. 2005, 144(7):933-939.
    • (2005) Br. J. Pharmacol. , vol.144 , Issue.7 , pp. 933-939
    • Wang, Q.1    Ting, W.L.2    Yang, H.3    Wong, P.T.4
  • 105
    • 19444382315 scopus 로고    scopus 로고
    • Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats
    • Wang Q., Wang P.H., McLachlan C., Wong P.T. Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats. Brain Res. 2005, 1045(1-2):229-233.
    • (2005) Brain Res. , vol.1045 , Issue.1-2 , pp. 229-233
    • Wang, Q.1    Wang, P.H.2    McLachlan, C.3    Wong, P.T.4
  • 106
    • 59749088704 scopus 로고    scopus 로고
    • High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain
    • Wang Q., Zengin A., Deng C., Li Y., Newell K.A., Yang G.Y., Lu Y., Wilder-Smith E.P., Zhao H., Huang X.F. High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain. Exp. Neurol. 2009, 216(1):132-138.
    • (2009) Exp. Neurol. , vol.216 , Issue.1 , pp. 132-138
    • Wang, Q.1    Zengin, A.2    Deng, C.3    Li, Y.4    Newell, K.A.5    Yang, G.Y.6    Lu, Y.7    Wilder-Smith, E.P.8    Zhao, H.9    Huang, X.F.10
  • 107
    • 33745950917 scopus 로고    scopus 로고
    • Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes
    • Wang S., Lee S.R., Guo S.Z., Kim W.J., Montaner J., Wang X., Lo E.H. Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes. Stroke 2006, 37(7):1910-1912.
    • (2006) Stroke , vol.37 , Issue.7 , pp. 1910-1912
    • Wang, S.1    Lee, S.R.2    Guo, S.Z.3    Kim, W.J.4    Montaner, J.5    Wang, X.6    Lo, E.H.7
  • 108
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    • Wassmann S., Laufs U., Bäumer A.T., Müller K., Konkol C., Sauer H., Böhm M., Nickenig G. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol. Pharmacol. 2001, 59(3):646-654.
    • (2001) Mol. Pharmacol. , vol.59 , Issue.3 , pp. 646-654
    • Wassmann, S.1    Laufs, U.2    Bäumer, A.T.3    Müller, K.4    Konkol, C.5    Sauer, H.6    Böhm, M.7    Nickenig, G.8
  • 110
    • 0030933212 scopus 로고    scopus 로고
    • Dementia drug development: use of information systems to harmonize global drug development
    • Whitehouse P.J., Sciulli C.G., Mason R.M. Dementia drug development: use of information systems to harmonize global drug development. Psychopharmacol. Bull. 1997, 33(1):129-133.
    • (1997) Psychopharmacol. Bull. , vol.33 , Issue.1 , pp. 129-133
    • Whitehouse, P.J.1    Sciulli, C.G.2    Mason, R.M.3
  • 111
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B., Kellman W., Ruosseau P., Celesia G.G., Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 2000, 57(10):1439-1443.
    • (2000) Arch. Neurol. , vol.57 , Issue.10 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 112
    • 34548299453 scopus 로고    scopus 로고
    • Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
    • Wolozin B., Wang S.W., Li N.C., Lee A., Lee T.A., Kazis L.E. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 2007, 5:20.
    • (2007) BMC Med. , vol.5 , pp. 20
    • Wolozin, B.1    Wang, S.W.2    Li, N.C.3    Lee, A.4    Lee, T.A.5    Kazis, L.E.6
  • 113
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • Yaffe K., Barrett-Connor E., Lin F., Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch. Neurol. 2002, 59:378-384.
    • (2002) Arch. Neurol. , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Connor, E.2    Lin, F.3    Grady, D.4
  • 115
    • 26944494575 scopus 로고    scopus 로고
    • Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition
    • Yamanouchi D., Banno H., Nakayama M., Sugimoto M., Fujita H., Kobayashi M., Kuwano H., Komori K. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition. J. Vasc. Surg. 2005, 42(4):757-764.
    • (2005) J. Vasc. Surg. , vol.42 , Issue.4 , pp. 757-764
    • Yamanouchi, D.1    Banno, H.2    Nakayama, M.3    Sugimoto, M.4    Fujita, H.5    Kobayashi, M.6    Kuwano, H.7    Komori, K.8
  • 116
    • 70449445715 scopus 로고    scopus 로고
    • Rho kinase: an important mediator of atherosclerosis and vascular disease
    • Zhou Q., Liao J.K. Rho kinase: an important mediator of atherosclerosis and vascular disease. Curr. Pharm. Des. 2009, 15(27):3108-3115.
    • (2009) Curr. Pharm. Des. , vol.15 , Issue.27 , pp. 3108-3115
    • Zhou, Q.1    Liao, J.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.