Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

Journal of Neurochemistry

Volumn 105, Issue 2, 2008, Pages 445-459

  Hernández Romero, María Del Carmen ^a   Argüelles, Sandro ^a   Villarán, Ruth F ^a   De Pablos, Rocío M ^a   Delgado Cortés, María José ^a   Santiago, Marti ^a   Herrera, Antonio J ^a   Cano, Josefina ^a   Machado, Alberto ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Dopaminergic neurodegeneration; Inflammation; Neuroprotection; Simvastatin; Substantia nigra

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; SIMVASTATIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZOCOR FORTE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOPAMINERGIC SYSTEM; DRUG EFFECT; INFLAMMATION; MACROGLIA; MALE; MICROGLIA; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA; WESTERN BLOTTING;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ARACHIDONIC ACIDS; DOPAMINE; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; INFLAMMATION; MALE; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; SIMVASTATIN; SUBSTANTIA NIGRA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 41749085753     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05148.x     Document Type: Article

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