Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study

Therapeutics and Clinical Risk Management

Volumn 6, Issue , 2010, Pages 225-231

  McGrath, Daniel R ^a   Frydoonfar, Hamid ^b   Hunt, Joshua J ^c   Dunkley, Chris J ^c   Spigelman, Allan D ^d  

^a IPSWICH HOSPITAL   (United Kingdom)

^b Hunter Valley Pathology Service   (Australia)

^c Newcastle Mater Hospital   (United Kingdom)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

Colorectal cancer; Glutathione transferase; Human; Indole 3 carbinol; Pilot study

Indexed keywords

EID: 79957937170     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control. 1991;2(5):325-357
2. Michaud D, Spiegelman D, Clinton S, Rimm E, Willett W, Giovannucci E. Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst. 1999;91:605-613
3. Cohen J, Kristal A, Stanford J. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst. 2000;92(1):61-68
4. Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst. 2002;94(5):391-398
5. Terry P, Giovannucci E, Michels KB, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl Cancer Inst. 2001;93(7): 525-533
6. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer. 1992;18(1): 1-29
7. McGrath DR, Spigelman AD. Putative mechanisms of action for indole-3-carbinol in th prevention of colorectal cancer. Expert Opin Ther Targets. 2008;12(6):729-738
8. Fenwick GR, Heaney RK, Mullin WJ. Glucosinolates and their breakdown products in food and food plants. Crit Rev Food Sci Nutr. 1983;18(2):123-201
9. Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev. 1996;5(9):733-748
10. Kohlmeier L, Simonsen N, Mottus K. Dietary modifiers of carcinogenesis. Environ Health Perspect. 1995;103(Suppl 8):177-184
11. Frydoonfar HR, McGrath DR, Spigelman AD. Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol. Colorect Dis. 2002;4(3):205-207
12. Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ J Surg. 2003;73(3):154-156
13. Kristal A, Lippman S. Nutritional prevention of cancer: New directions for an increasingly complex challenge. J Natl Cancer Inst. 2009;101(6):363-365
14. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol. 2000;78(2):123-129
15. Gasper AV, Al-Janobi A, Smith JA, et al. Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr. 2005;82(6):1283-1291
16. Joseph MA, Moysich KB, Freudenheim JL, et al. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr Cancer. 2004;50(2):206-213
17. Spitz MR, Duphorne CM, Detry MA, et al. Dietary intake of isothiocyanates: Evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2000;9(10):1017-1020
18. Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B. Isothiocyanates as substrates for human glutathione transferases: Structure-activity studies. Biochem J. 1995;311(Pt 2):453-459
19. Mulder TP, Roelofs HM, Peters WH, Wagenmans MJ, Sier CF, Verspaget HW. Glutathione S-transferases in liver metastases of colorectal cancer. A comparison with normal liver and primary carcinomas. Carcinogenesis. 1994;15(10):2149-2153
20. Engel LS, Taioli E, Pfeiffer R, et al. Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: A HuGE review. Am J Epidemiol. 2002;156(2):95-109
21. Fahey JW, Talalay P. Antioxidant functions of sulforaphane: A potent inducer of Phase II detoxication enzymes. Food Chem Toxicol. 1999;37(9-10):973-979
22. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51-88
23. Villafania A, Anwar K, Amar S, et al. Glutathione-S-transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal kinase. Ann Clin Lab Sci. 2000;30(1):57-64
24. Yeh CC, Hsieh LL, Tang R, Chang-Chieh CR, Sung FC. Vegetable/ fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan. World J Gastroenterol. 2005;11(10): 1473-1480
25. Clapper ML, Szarka CE, Pfeiffer GR, et al. Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity. Clin Cancer Res. 1997;3(1):25-30
26. Grubben MJ, van den Braak CC, Nagengast FM, Peters WH. Low colonic glutathione detoxification capacity in patients at risk for colon cancer. Eur J Clin Invest. 2006;36(3):188-192
27. Pietsch EC, Hurley AL, Scott EE, et al. Oxathiolene oxides: A novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response. Biochem Pharmacol. 2003;65(8):1261-1269
28. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249(22):7130-7139
29. Lampe JW, Peterson S. Brassica, biotransformation and cancer risk: Genetic polymorphisms alter the preventive effects of cruciferous vegetables. J Nutr. 2002;132(10):2991-2994
30. Morse MA. The role of glutathione S-transferase P1-1 in colorectal cancer: Friend or foe? Gastroenterology. 2001;121(4):1010-1013
31. Eaton DL, Bammler TK. Concise review of the glutathione S-transferases and their significance to toxicology. Toxicol Sci. 1999;49(2):156-164
32. Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001;10(9):949-954
33. Spigelman AD, Nugent KP, Penna C, Foulds S, Phillips RK. Glutathione S-transferase Mu phenotype in patients with familial adenomatous polyposis and in unaffected controls. Cancer Detect Prev. 1994;18(4):253-258
34. Szarka CE, Pfeiffer GR, Hum ST, et al. Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer. Cancer Res. 1995;55(13):2789-2793
35. Zhong S, Wyllie AH, Barnes D, Wolf CR, Spurr NK. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993;14(9): 1821-1824
36. Ye Z, Parry JM. A meta-analysis of 20 case-control studies of the glutathione S-transferase M1 (GSTM1) status and colorectal cancer risk. Med Sci Monit. 2003;9(10):SR83-SR91
37. Houlston RS. Glutathione S-transferase M1 status and lung cancer risk: A meta-analysis. Cancer Epidemiol Biomarkers Prev. 1999;8(8): 675-682
38. Ansher SS, Dolan P, Bueding E. Biochemical effects of dithiolthiones. Food Chem Toxicol. 1986;24(5):405-415
39. Bradfield CA, Bjeldanes LF. Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolase activities in the rat. Food Chem Toxicol. 1984;22(12):977-982
40. Gill CI, Haldar S, Porter S, et al. The effect of cruciferous and leguminous sprouts on genotoxicity, in vitro and in vivo. Cancer Epidemiol Biomarkers Prev. 2004;13(7):1199-1205
41. Nijhoff WA, Grubben MJ, Nagengast FM, et al. Effects of consumption of brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans. Carcinogenesis. 1995;16(9):2125-2128
42. Salbe AD, Bjeldanes LF. The effects of dietary brussels sprouts and Schizandra chinensis on the xenobiotic-metabolizing enzymes of the rat small intestine. Food Chem Toxicol. 1985;23(1):57-65
43. Wark PA, Grubben MJ, Peters WH, et al. Habitual consumption of fruits and vegetables: Associations with human rectal glutathione S-transferase. Carcinogenesis. 2004;25(11):2135-2142
44. Whitty JP, Bjeldanes LF. The effects of dietary cabbage on xenobiotic-metabolizing enzymes and the binding of aflatoxin B1 to hepatic DNA in rats. Food Chem Toxicol. 1987;25(8):581-587
45. Bogaards JJ, Verhagen H, Willems MI, van Poppel G, van Bladeren PJ. Consumption of Brussels sprouts results in elevated alpha-class glutathione S-transferase levels in human blood plasma. Carcinogenesi. 1994;15(5):1073-1075
46. Moore LE, Huang WY, Chatterjee N, et al. GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2005;14(7):1823-1827
47. Musk SR, Johnson IT. Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29. Carcinogenesis. 1993;14(10):2079-2083
48. Ge X, Yannai S, Rennert G, Gruener N, Fares FA. 3,3’-Diindolylmethane induces apoptosis in human cancer cells. Biochem Biophys Res Commun. 1996;228(1):153-158