Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells

Cancer Research

Volumn 63, Issue 19, 2003, Pages 6488-6495

  Qiu, Xiaoyan ^a   Zhu, Xiaohui ^a   Zhang, Liang ^a   Mao, Yuntao ^a   Zhang, Jian ^a   Hao, Peng ^a   Li, Guohui ^a   Lv, Peng ^a   Li, Zhixin ^a   Sun, Xin ^a   Wu, Lemeng ^a   Zheng, Jie ^a   Deng, Yuqing ^a   Hou, Chunmei ^b   Tang, Peixian ^b   Zhang, Shuren ^c   Zhang, Youhui ^c  

^a PEKING UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c CANCER HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BREAST CARCINOMA; CANCER INHIBITION; CANCER THERAPY; CARCINOMA; CELL GROWTH; CELL SURVIVAL; COLON CARCINOMA; CONTROLLED STUDY; GROWTH REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOGLOBULIN PRODUCTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER CARCINOMA; LUNG CARCINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; EPITHELIAL CELLS; HELA CELLS; HT29 CELLS; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0141988676     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Olubuyide, I. O., Salimonu, L. S., and Adeniran, S. O. Soluble immune complexes and immunoglobulin (IgG, IgA and IgM) levels in Nigerians with primary liver cell carcinoma. Afr. J. Med. Sci., 22: 57-62, 1993.
2. Manjula, S., Aroor, A. R., Raja, A., Rao, S. N., and Rao, A. Serum immunoglobulins in brain tumors. Acta Neurochir., 115 (3-4): 103-105, 1992.
3. Taylor, D. D., and Gercel-Taylor C. Tumor-reactive immunoglobulins in ovarian cancer: diagnostic and therapeutic significance? Oncol. Rep., 5: 1519-1524, 1998.
4. Güre, A. O., Altorki, N. K., Stockert, E., Scanlan, M. J., Old, L. J., and Chen, Y. T. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. Cancer Res., 58: 1034-1041, 1998.
5. Gure, A. O., Stockert, E., Scanlan, M. J., Keresztes, R. S., Jager, D., Altorki, N. K., Oid, L. J., and Chen, Y. T. serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer. Proc. Natl. Acad. Sci. USA, 97: 4198-4203, 2000.
6. Tenenbaum, N., Meignan, S., and Vincent, J. P. Bi- and tri-clonal gammopathies and the elderly. Ann. Med. Interne (Paris), 143: 89-93, 1992.
7. Maes, B., Vanwalleghem, J., Kuypers, D., Van Damme, B., Waer, M., and Vanrenterghem, Y. IgA antiglomerular basement membrane disease associated with bronchial carcinoma and monoclonal gammopathy. Am. J. Kidney Dis., 33: E3, 1999.
8. Hori, H., Kihara, Y., Nagashio, Y., Hirohata, Y., Abe, S., Murata, I., and Otsuki, M. Signet ring cell carcinoma of the colon with monoclonal gammopathy of undetermined significance. Nippon Shokakibyo Gakkai Zasshi, 97: 1373-1377, 2000.
9. Gregersen, H., Mellemkjaer, I., Ibsen, J. S., Dahlerup, J. F., Thomassen, L., and Sorensen, H. T. The impact of M-component type and immunoglobulin concentration on the risk of malignant transformation in patients with monoclonal gammopathy of undetermined significance. Haematologica, 86: 172-179, 2001.
10. Lynch, S., Kelleher, D., McManus, R., and O'Farrelly, C. RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation. Eur. J. Immunol., 25: 1143-1147, 1995.
11. Phillips, J. O., Everson, M. P., Moldoveanu, Z., Lue, C., and Mestecky, J. Synergistic effect of IL-4 and IFN-γ on the expression of polymeric Ig receptor (sccretory component) and IgA binding by human epithelial cells. J. Immunol., 145: 1740-1744, 1990.
12. Hou, C., Qiu, X., Sun, J., Shen, J., Tang, P., and Mao, N. Detection of Ig-like protein in HeLa MR cells cultured in serum-free medium. Bull. Acad. Mil. Med. Sci., 22: 240, 1998.
13. Lorenz, K. J., Susal, C., Opelz, G., and Maier, H. Relationship between progression of disease and immunoglobulin A-anti-Fab-/F(ab′)2 autoantibodies in patients with head and neck cancer. Otolaryngol. Head Neck Surg., 118: 130-652, 1998
14. Vernino, S., Adamski, J., Kryzer, T. J., Fealey, R. D., and Lennon, V. A. Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer-related syndromes. Neurology, 50: 1806-1813, 1998.