Immunoglobulin gene locus events in epithelial cells of lactating mouse mammary glands

Cellular and Molecular Life Sciences

Volumn 67, Issue 6, 2010, Pages 985-994

  Zhang, Shuai ^a   Mao, Yuntao ^a   Huang, Jing ^a   Ma, Teng ^a   Zhang, Li ^a   Zhu, Xiaohui ^a   Zheng, Jie ^a   Wu, Lemeng ^a   Yin, C Cameron ^b   Qiu, Xiaoyan ^a,b  

^a PEKING UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Colostrum; Immunoglobulin; Mammary gland epithelial cells

Indexed keywords

CD19 ANTIGEN; CYTOKERATIN 18; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCUS; IMMUNOGLOBULIN VARIABLE REGION; INNATE IMMUNITY; LACTATION; MOUSE; NONHUMAN; PREGNANCY; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; EPITHELIUM CELL; GENETIC TRANSCRIPTION; GENETICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; UDDER;

MAMMALIA; MURINAE; MUS;

ANIMALS; BLOTTING, NORTHERN; EPITHELIAL CELLS; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 77949527816     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0231-z     Document Type: Article

References (22)

1. van der Feltz MJ, de Groot N, Bayley JP, Lee SH, Verbeet MP, de Boer HA (2001) Lymphocyte homing and Ig secretion in the murine mammary gland. Scand J Immunol 54:292-300
2. Gapper LW, Copestake DEJ, Otter DE, Indyk HE (2007) Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a review. Anal Bioanal Chem 389:93-109
3. Løland BF, Baerug AB, Nylander G (2007) Human milk, immune responses and health effects. Tidsskr Nor Laegeforen 127:2395-2398
4. Brandtzaeg P, Farstad IN, Johansen F-E, Morton CH, Norderhaug IN, Yamanaka T (1999) The B-cell system of human mucosae and exocrine glands. Immunol Rev 171:45-87 (Pubitemid 29504711)
5. Barrington GM, Besser TE, Davis WC, Gay CC, Reeves JJ, McFadden TB (1997) Expression of immunoglobulin G1 receptors by bovine mammary epithelial cells and mammary leukocytes. J Dairy Sci 80:86-93 (Pubitemid 127029077)
6. Mayer B, Doleschall M, Bender B, Bartyik J, Bosze Z, Frenyo LV, Kacskovics I (2005) Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland. J Dairy Res 72:107-112 (Pubitemid 41323102)
7. Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E (2003) The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Hum Immunol 64:1152-1159 (Pubitemid 37475276)
8. Schnulle PM, Hurley WL (2003) Sequence and expression of the FcRn in the porcine mammary gland. Vet Immunol Immunopathol 91:227-231 (Pubitemid 36173856)
9. Mayer B, Zolnai A, Frenyo LV, Jancsik V, Szentirmay Z, Hammarstrom L, Kacskovics I (2002) Localization of the sheep FcRn in the mammary gland. Vet Immunol Immunopathol 87:327-330
10. Rincheval-Arnold A, Belair L, Cencic A, Djiane J (2002) Upregulation of polymeric immunoglobulin receptor mRNA in mammary epithelial cells by IFN-gamma. Mol Cell Endocrinol 194:95-105 (Pubitemid 35291924)
11. Qiu X, Zhu X, Zhang L, Mao Y, Zhang J, Hao P, Li G, Lv P, Li Z, Sun X, Wu L, Zheng J, Deng Y, Hou C, Tang P, Zhang S, Zhang Y (2003) Human epithelial cancers secrete immunoglobulin G with unidentified specificity to promote growth and survival of tumor cells. Cancer Res 63:6488-6495
12. Zheng J, Huang J, Mao Y, Liu S, Sun X, Zhu X, Ma T, Zhang L, Ji J, Zhang Y, Yin CC, Qiu X (2009) Immunoglobulin gene transcripts have distinct VHDJH recombination characteristics in human epithelial cancer cells. J Biol Chem (in press)
13. Babbage G, Ottensmeier VH, Blaydes J, Stevenson FK, Sabota SS (2006) Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines. Cancer Res 66:3990-4000
14. Chen Z, Gu J (2007) Immunoglobulin G expression in carcinomas and cancer cell lines. FASEB J 21:2931-2938 (Pubitemid 47372759)
15. Bransteitter R, Sneeden J, Allen S, Pham P, Goodman MF (2006) First AID is needed to produce high-affinity isotype-switched antibodies. J Biol Chem 281:16833-16836
16. Longerich S, Tanaka A, Bozek G, Nicolae D, Storb U (2005) The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med 202:1443-1454 (Pubitemid 41668746)
17. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE (2006) Generation of a functional mammary gland from a single stem. cell. Nature 439:84-88
18. Lu W, Zhao Z, Zhao Y, Yu S, Zhao Y, Fan B, Kacskovics I, Hammarström L, Li N (2007) Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology 122:401-408
19. Huang J, Sun X, Mao Y, Zhu X, Zhang P, Zhang L, Du J, Qiu X (2007) Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons. Int J Biochem Cell Biol 40:1604-1615
20. Huang J, Zhang L, Ma T, Zhang P, Qiu X (2009) Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse testis and epididymis. J Histochem Cytochem 57:339-349
21. Seising E (2006) Ig class switching: targeting the recombinational mechanism. Curr Opin Immunol 18:249-254
22. Han S, Zheng B, Schatz DG, Spanopoulou E, Kelsoe G (1996) Neoteny in lymphocytes: Ragl and Rag2 expression in germinal center B Cells. Science 274:2094-2097 (Pubitemid 27020705)