SCOPUS 정보 검색 플랫폼

Volumn 6, Issue 6, 2011, Pages 1463-1469

On the role of flexibility in protein-ligand interactions: The example of p53 tetramerization domain

(6) Gordo, Susana a,f Martos, Vera b,c,g Vilaseca, Marta a Menéndez, Margarita d De Mendoza, Javier b,c Giralt, Ernest a,e

a INSTITUTE FOR RESEARCH IN BIOMEDICINE (Spain)

b INSTITUTE OF CHEMICAL RESEARCH OF CATALONIA ICIQ (Spain)

c UNIVERSIDAD AUTÓNOMA DE MADRID (Spain)

d INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO (Spain)

e UNIVERSITY OF BARCELONA (Spain)

f HARVARD MEDICAL SCHOOL (United States)

g LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE (Germany)

Author keywords

ligands; microcalorimetry; molecular recognition; NMR spectroscopy; protein protein interactions

Indexed keywords

BIOMOLECULAR INTERACTIONS; BIOMOLECULAR SURFACE; BIOPHYSICAL STUDIES; CALIXARENES; DRUG DISCOVERY; LOCK-AND-KEY; MACROMOLECULAR COMPLEXES; MICRO-CALORIMETRY; NATURAL MUTANTS; NMR SPECTROSCOPY; PROTEIN DOMAINS; PROTEIN SURFACE; PROTEIN-LIGAND INTERACTIONS; PROTEIN-PROTEIN INTERACTIONS; TETRAMERIZATION; WILD TYPES; WILD-TYPE PROTEINS;

DRUG INTERACTIONS; LIGANDS; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

PROTEINS;

CALIX(4)ARENE; CALIXARENE; LIGAND; PHENOL DERIVATIVE; PROTEIN P53;

ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

CALIXARENES; CALORIMETRY, DIFFERENTIAL SCANNING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MUTATION; PHENOLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79957753415 PISSN: 18614728 EISSN: 1861471X Source Type: Journal
DOI: 10.1002/asia.201000938 Document Type: Article

Times cited : (17)

References (59)

1
- 3142781225
- M. R. Arkin, J. A. Wells, Nat. Rev. Drug Discovery 2004, 3, 301-317
- (2004) Nat. Rev. Drug Discovery , vol.3 , pp. 301-317
- Arkin, M.R.¹ Wells, J.A.²

2
- 33750610998
- P. Chène, ChemMedChem 2006, 1, 400-411
- (2006) ChemMedChem , vol.1 , pp. 400-411
- Chène, P.¹

3
- 47349126684
- M. Strong, D. Eisenberg, Prog. Drug Res. 2007, 64, 193-215
- (2007) Prog. Drug Res. , vol.64 , pp. 193-215
- Strong, M.¹ Eisenberg, D.²

4
- 61449227409
- S. Gordo, E. Giralt, Protein Sci. 2009, 18, 481-493.
- (2009) Protein Sci. , vol.18 , pp. 481-493
- Gordo, S.¹ Giralt, E.²

5
- 0030028728
- S. Jones, J. M. Thornton, Proc. Natl. Acad. Sci. USA 1996, 93, 13-20
- (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13-20
- Jones, S.¹ Thornton, J.M.²

6
- 34548248275
- -380
- K. V. Radha Kishan, Curr. Protein Pept. Sci. 2007, 8, 376 -380.
- (2007) Curr. Protein Pept. Sci. , vol.8 , pp. 376
- Kishan, K.V.R.¹

7
- 0030822252
- P. A. Nygren, M. Uhlen, Curr. Opin. Struct. Biol. 1997, 7, 463-469
- (1997) Curr. Opin. Struct. Biol. , vol.7 , pp. 463-469
- Nygren, P.A.¹ Uhlen, M.²

8
- 27744564465
- S. Fletcher, A. D. Hamilton, Curr. Opin. Chem. Biol. 2005, 9, 632-638
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 632-638
- Fletcher, S.¹ Hamilton, A.D.²

9
- 27744547316
- W. J. Cooper, M. L. Waters, Curr. Opin. Chem. Biol. 2005, 9, 627-631
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 627-631
- Cooper, W.J.¹ Waters, M.L.²

10
- 32044442488
- H. Yin, A. D. Hamilton, Angew. Chem. 2005, 117, 4200-4235
- (2005) Angew. Chem. , vol.117 , pp. 4200-4235
- Yin, H.¹ Hamilton, A.D.²

11
- 22144454687
- Angew. Chem. Int. Ed. 2005, 44, 4130-4163
- (2005) Angew. Chem. Int. Ed. , vol.44 , pp. 4130-4163

12
- 35048895357
- J. K. Murray, S. H. Gellman, Biopolymers 2007, 88, 657-686
- (2007) Biopolymers , vol.88 , pp. 657-686
- Murray, J.K.¹ Gellman, S.H.²

13
- 34249874926
- P. Block, N. Weskamp, A. Wolf, G. Klebe, Proteins Struct. Funct. Bioinf. 2007, 68, 170-186.
- (2007) Proteins Struct. Funct. Bioinf. , vol.68 , pp. 170-186
- Block, P.¹ Weskamp, N.² Wolf, A.³ Klebe, G.⁴

14
- 33748578600
- D. Gonzalez-Ruiz, H. Gohlke, Curr. Med. Chem. 2006, 13, 2607-2625
- (2006) Curr. Med. Chem. , vol.13 , pp. 2607-2625
- Gonzalez-Ruiz, D.¹ Gohlke, H.²

15
- 33745181229
- Y. Che, B. R. Brooks, G. R. Marshall, J. Comput. Aided Mol. Des. 2006, 20, 109-130
- (2006) J. Comput. Aided Mol. Des. , vol.20 , pp. 109-130
- Che, Y.¹ Brooks, B.R.² Marshall, G.R.³

16
- 35448993370
- A. S. Ivanov, O. V. Gnedenko, A. A. Molnar, Y. V. Mezentsev, A. V. Lisitsa, A. I. Archakov, J. Bioinf. Comput. Biol. 2007, 5, 579-592
- (2007) J. Bioinf. Comput. Biol. , vol.5 , pp. 579-592
- Ivanov, A.S.¹ Gnedenko, O.V.² Molnar, A.A.³ Mezentsev, Y.V.⁴ Lisitsa, A.V.⁵ Archakov, A.I.⁶

17
- 35348821202
- C. McInnes, Curr. Opin. Chem. Biol. 2007, 11, 494-502.
- (2007) Curr. Opin. Chem. Biol. , vol.11 , pp. 494-502
- McInnes, C.¹

18
- 0000431920
- M. Mammen, S. K. Choi, G. M. Whitesides, Angew. Chem. 1998, 110, 2908-2953
- (1998) Angew. Chem. , vol.110 , pp. 2908-2953
- Mammen, M.¹ Choi, S.K.² Whitesides, G.M.³

19
- 0032476812
- Angew. Chem. Int. Ed. 1998, 37, 2754-2794
- (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 2754-2794

20
- 0034701264
- E. Fan, Z. Zhang, W. E. Minke, Z. Hou, C. L. M. J. Verlinde, W. G. J. Hol, J. Am. Chem. Soc. 2000, 122, 2663-2664
- (2000) J. Am. Chem. Soc. , vol.122 , pp. 2663-2664
- Fan, E.¹ Zhang, Z.² Minke, W.E.³ Hou, Z.⁴ Verlinde, C.L.M.J.⁵ Hol, W.G.J.⁶

21
- 0034801470
- M. A. Fazal, B. C. Roy, S. Sun, S. Mallik, K. R. Rodgers, J. Am. Chem. Soc. 2001, 123, 6283-6290
- (2001) J. Am. Chem. Soc. , vol.123 , pp. 6283-6290
- Fazal, M.A.¹ Roy, B.C.² Sun, S.³ Mallik, S.⁴ Rodgers, K.R.⁵

22
- 0346981999
- J. E. Gestwicki, C. W. Cairo, L. E. Strong, K. A. Oetjen, L. L. Kiessling, J. Am. Chem. Soc. 2002, 124, 14922-14933
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 14922-14933
- Gestwicki, J.E.¹ Cairo, C.W.² Strong, L.E.³ Oetjen, K.A.⁴ Kiessling, L.L.⁵

23
- 0142104260
- S. N. Gradl, J. P. Felix, E. Y. Isacoff, M. L. Garcia, D. Trauner, J. Am. Chem. Soc. 2003, 125, 12668-12669.
- (2003) J. Am. Chem. Soc. , vol.125 , pp. 12668-12669
- Gradl, S.N.¹ Felix, J.P.² Isacoff, E.Y.³ Garcia, M.L.⁴ Trauner, D.⁵

24
- 33846652144
- L. Baldini, A. Casnati, F. Sansone, R. Ungaro, Chem. Soc. Rev. 2007, 36, 254-266
- (2007) Chem. Soc. Rev. , vol.36 , pp. 254-266
- Baldini, L.¹ Casnati, A.² Sansone, F.³ Ungaro, R.⁴

25
- 76249128092
- M. Torvinen, R. Neitola, F. Sansone, L. Baldini, R. Ungaro, A. Casnati, P. Vainiotalo, E. Kalenius, Org. Biomol. Chem. 2010, 8, 906-915.
- (2010) Org. Biomol. Chem. , vol.8 , pp. 906-915
- Torvinen, M.¹ Neitola, R.² Sansone, F.³ Baldini, L.⁴ Ungaro, R.⁵ Casnati, A.⁶ Vainiotalo, P.⁷ Kalenius, E.⁸

26
- 57549110044
- V. Martos, P. Castreño, J. Valero, J. de Mendoza, Curr. Opin. Chem. Biol. 2008, 12, 698-706.
- (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 698-706
- Martos, V.¹ Castreño, P.² Valero, J.³ De Mendoza, J.⁴

27
- 33846822002
- C. E. Chang, W. Chen, M. K. Gilson, Proc. Natl. Acad. Sci. USA 2007, 104, 1534-1539
- (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 1534-1539
- Chang, C.E.¹ Chen, W.² Gilson, M.K.³

28
- 1842411345
- G. Klebe, H. J. Böhm, J. Recept. Signal Transduction Res. 1997, 17, 459-473
- (1997) J. Recept. Signal Transduction Res. , vol.17 , pp. 459-473
- Klebe, G.¹ Böhm, H.J.²

29
- 0029447446
- K. P. Murphy, E. Freire, Pharm. Biotechnol. 1995, 7, 219-241.
- (1995) Pharm. Biotechnol. , vol.7 , pp. 219-241
- Murphy, K.P.¹ Freire, E.²

30
- 0028272930
- P. R. Connelly, R. A. Aldape, F. J. Bruzzese, S. P. Chambers, M. J. Fitzgibbon, M. A. Fleming, S. Itoh, D. J. Livingston, M. A. Navia, J. A. Thomson, Proc. Natl. Acad. Sci. USA 1994, 91, 1964-1968
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1964-1968
- Connelly, P.R.¹ Aldape, R.A.² Bruzzese, F.J.³ Chambers, S.P.⁴ Fitzgibbon, M.J.⁵ Fleming, M.A.⁶ Itoh, S.⁷ Livingston, D.J.⁸ Navia, M.A.⁹ Thomson, J.A.¹⁰

31
- 14744268745
- A. Cooper, Biophys. Chem. 2005, 115, 89-97
- (2005) Biophys. Chem. , vol.115 , pp. 89-97
- Cooper, A.¹

32
- 0030466444
- J. E. Ladbury, Chem. Biol. 1996, 3, 973-980
- (1996) Chem. Biol. , vol.3 , pp. 973-980
- Ladbury, J.E.¹

33
- 0035852019
- C. Clarke, R. J. Woods, J. Gluska, A. Cooper, M. A. Nutley, G. J. Boons, J. Am. Chem. Soc. 2001, 123, 12238-12247
- (2001) J. Am. Chem. Soc. , vol.123 , pp. 12238-12247
- Clarke, C.¹ Woods, R.J.² Gluska, J.³ Cooper, A.⁴ Nutley, M.A.⁵ Boons, G.J.⁶

34
- 12344276782
- Z. Li, T. Lazaridis, J. Phys. Chem. A J. Phys. Chem. B 2005, 109, 662-670
- (2005) J. Phys. Chem. A J. Phys. Chem. B , vol.109 , pp. 662-670
- Li, Z.¹ Lazaridis, T.²

35
- 33645401062
- F. Yin, R. Cao, A. Goddard, Y. Zhang, E. Oldfield, J. Am. Chem. Soc. 2006, 128, 3524-3525.
- (2006) J. Am. Chem. Soc. , vol.128 , pp. 3524-3525
- Yin, F.¹ Cao, R.² Goddard, A.³ Zhang, Y.⁴ Oldfield, E.⁵

36
- 0030941458
- A. J. Levine, Cell 1997, 88, 323-331.
- (1997) Cell , vol.88 , pp. 323-331
- Levine, A.J.¹

37
- 0027169188
- E. Shaulian, A. Zauberman, J. Milner, E. A. Davies, M. Oren, EMBO J. 1993, 12, 2789-2797.
- (1993) EMBO J. , vol.12 , pp. 2789-2797
- Shaulian, E.¹ Zauberman, A.² Milner, J.³ Davies, E.A.⁴ Oren, M.⁵

38
- 34248379012
- A. Petitjean, E. Mathe, S. Kato, C. Ishioka, S. V. Tavtigian, P. Hainaut, M. Olivier, Hum. Mutat. 2007, 28, 622-629.
- (2007) Hum. Mutat. , vol.28 , pp. 622-629
- Petitjean, A.¹ Mathe, E.² Kato, S.³ Ishioka, C.⁴ Tavtigian, S.V.⁵ Hainaut, P.⁶ Olivier, M.⁷

39
- 0035979262
- R. C. Ribeiro, F. Sandrini, B. Figueiredo, G. P. Zambetti, E. Michalkiewicz, A. R. Lafferty, L. DeLacerda, M. Rabin, C. Cadwell, G. Sampaio, I. Cat, C. A. Stratakis, R. Sandrini, Proc. Natl. Acad. Sci. USA 2001, 98, 9330-9335.
- (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9330-9335
- Ribeiro, R.C.¹ Sandrini, F.² Figueiredo, B.³ Zambetti, G.P.⁴ Michalkiewicz, E.⁵ Lafferty, A.R.⁶ Delacerda, L.⁷ Rabin, M.⁸ Cadwell, C.⁹ Sampaio, G.¹⁰ Cat, I.¹¹ Stratakis, C.A.¹² Sandrini, R.¹³

40
- 0036143771
- E. L. DiGiammarino, A. S. Lee, C. Cadwell, W. Zhang, B. Bothner, R. C. Ribeiro, G. Zambetti, R. W. Kriwacki, Nat. Struct. Biol. 2002, 9, 12-16.
- (2002) Nat. Struct. Biol. , vol.9 , pp. 12-16
- Digiammarino, E.L.¹ Lee, A.S.² Cadwell, C.³ Zhang, W.⁴ Bothner, B.⁵ Ribeiro, R.C.⁶ Zambetti, G.⁷ Kriwacki, R.W.⁸

41
- 33751154561
- A. Arduini, M. Fabbi, M. Mantovani, L. Mirone, A. Pochini, A. Secchi, R. Ungaro, J. Org. Chem. 1995, 60, 1454-1457.
- (1995) J. Org. Chem. , vol.60 , pp. 1454-1457
- Arduini, A.¹ Fabbi, M.² Mantovani, M.³ Mirone, L.⁴ Pochini, A.⁵ Secchi, A.⁶ Ungaro, R.⁷

42
- 55949123477
- S. Gordo, V. Martos, E. Santos, M. Menendez, C. Bo, E. Giralt, J. de Mendoza, Proc. Natl. Acad. Sci. USA 2008, 105, 16426-16431.
- (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16426-16431
- Gordo, S.¹ Martos, V.² Santos, E.³ Menendez, M.⁴ Bo, C.⁵ Giralt, E.⁶ De Mendoza, J.⁷

43
- 0037666888
- S. J. Teague, Nat. Rev. Drug Discovery 2003, 2, 527-541
- (2003) Nat. Rev. Drug Discovery , vol.2 , pp. 527-541
- Teague, S.J.¹

44
- 0034863015
- J. S. Marvin, H. W. Hellinga, Nat. Struct. Biol. 2001, 8, 795-798.
- (2001) Nat. Struct. Biol. , vol.8 , pp. 795-798
- Marvin, J.S.¹ Hellinga, H.W.²

45
- 0025281866
- J. F. Brandts, L. N. Lin, Biochemistry 1990, 29, 6927-6940
- (1990) Biochemistry , vol.29 , pp. 6927-6940
- Brandts, J.F.¹ Lin, L.N.²

46
- 0025238920
- A. Shrake, P. D. Ross, J. Biol. Chem. 1990, 265, 5055-5059.
- (1990) J. Biol. Chem. , vol.265 , pp. 5055-5059
- Shrake, A.¹ Ross, P.D.²

47
- 0029794153
- C. V. Robinson, E. W. Chung, B. B. Kragelund, J. Knudsen, R. T. Aplin, F. M. Poulsen, C. M. Dobson, J. Am. Chem. Soc. 1996, 118, 8646-8653.
- (1996) J. Am. Chem. Soc. , vol.118 , pp. 8646-8653
- Robinson, C.V.¹ Chung, E.W.² Kragelund, B.B.³ Knudsen, J.⁴ Aplin, R.T.⁵ Poulsen, F.M.⁶ Dobson, C.M.⁷

48
- 3242755777
- T. Mittag, B. Schaffhausen, U. L. Gunther, J. Am. Chem. Soc. 2004, 126, 9017-9023
- (2004) J. Am. Chem. Soc. , vol.126 , pp. 9017-9023
- Mittag, T.¹ Schaffhausen, B.² Gunther, U.L.³

49
- 0034127485
- M. Pellecchia, D. L. Montgomery, S. Y. Stevens, C. W. Vander Kooi, H. P. Feng, L. M. Gierasch, E. R. Zuiderweg, Nat. Struct. Biol. 2000, 7, 298-303.
- (2000) Nat. Struct. Biol. , vol.7 , pp. 298-303
- Pellecchia, M.¹ Montgomery, D.L.² Stevens, S.Y.³ Kooi, C.W.V.⁴ Feng, H.P.⁵ Gierasch, L.M.⁶ Zuiderweg, E.R.⁷

50
- 0029000171
- C. R. Johnson, P. E. Morin, C. H. Arrowsmith, E. Freire, Biochemistry 1995, 34, 5309-5316.
- (1995) Biochemistry , vol.34 , pp. 5309-5316
- Johnson, C.R.¹ Morin, P.E.² Arrowsmith, C.H.³ Freire, E.⁴

51
- 0028785287
- A. Weichsel, W. R. Montfort, Nat. Struct. Biol. 1995, 2, 1095-1101.
- (1995) Nat. Struct. Biol. , vol.2 , pp. 1095-1101
- Weichsel, A.¹ Montfort, W.R.²

52
- 0028127923
- K. P. Murphy, D. Xie, K. S. Thompson, L. M. Amzel, E. Freire, Proteins Struct. Funct. Bioinf. 1994, 18, 63-67.
- (1994) Proteins Struct. Funct. Bioinf. , vol.18 , pp. 63-67
- Murphy, K.P.¹ Xie, D.² Thompson, K.S.³ Amzel, L.M.⁴ Freire, E.⁵

53
- 0038333434
- S. Kumar, C. J. Tsai, R. Nussinov, Biochemistry 2003, 42, 4864-4872
- (2003) Biochemistry , vol.42 , pp. 4864-4872
- Kumar, S.¹ Tsai, C.J.² Nussinov, R.³

54
- 4043078415
- A. Barzilai, S. Kumar, H. Wolfson, R. Nussinov, Proteins Struct. Funct. Bioinf. 2004, 56, 635-649
- (2004) Proteins Struct. Funct. Bioinf. , vol.56 , pp. 635-649
- Barzilai, A.¹ Kumar, S.² Wolfson, H.³ Nussinov, R.⁴

55
- 70350340728
- D. D. Boehr, R. Nussinov, P. E. Wright, Nat. Chem. Biol. 2009, 5, 789-796
- (2009) Nat. Chem. Biol. , vol.5 , pp. 789-796
- Boehr, D.D.¹ Nussinov, R.² Wright, P.E.³

56
- 33748781457
- D. D. Boehr, D. McElheny, H. J. Dyson, P. E. Wright, Science 2006, 313, 1638-1642.
- (2006) Science , vol.313 , pp. 1638-1642
- Boehr, D.D.¹ McElheny, D.² Dyson, H.J.³ Wright, P.E.⁴

57
- 0034551548
- A. Casnati, L. Pirondini, N. Pelizzi, R. Ungaro, Supramol. Chem. 2000, 12, 53-65.
- (2000) Supramol. Chem. , vol.12 , pp. 53-65
- Casnati, A.¹ Pirondini, L.² Pelizzi, N.³ Ungaro, R.⁴

58
- 0032515126
- K. Feichtinger, H. L. Sings, T. J. Baker, K. Matthews, M. Goodman, J. Org. Chem. 1998, 63, 8432-8439.
- (1998) J. Org. Chem. , vol.63 , pp. 8432-8439
- Feichtinger, K.¹ Sings, H.L.² Baker, T.J.³ Matthews, K.⁴ Goodman, M.⁵

59
- 0029400480
- F. Delaglio, S. Grzesiek, G. W. Vuister, G. Zhu, J. Pfeifer, A. Bax, J. Biomol. NMR 1995, 6, 277-293.
- (1995) J. Biomol. NMR , vol.6 , pp. 277-293
- Delaglio, F.¹ Grzesiek, S.² Vuister, G.W.³ Zhu, G.⁴ Pfeifer, J.⁵ Bax, A.⁶

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